Compounds > bistris
Page last updated: 2024-11-06

bistris

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Bistris (bis-tris propane) is a zwitterionic buffer commonly used in biochemical and biological research. It is synthesized by reacting tris(hydroxymethyl)aminomethane (Tris) with propane-1,3-diol. Bistris is a good buffer for many applications because it has a high buffering capacity over a wide pH range (pH 6.0-7.5), and it is relatively non-toxic. It is also a good choice for studying enzymatic reactions because it does not interact strongly with most enzymes. Bistris is often used in protein crystallization and purification, as well as in cell culture and other biological assays. Its importance lies in its versatility and effectiveness as a buffer, enabling accurate and reliable experimental results in various biological contexts.'

Bistris: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID81462
CHEBI ID41250
SCHEMBL ID35757
MeSH IDM0086490

Synonyms (62)

Synonym
unii-q1xc3631cp
einecs 230-237-7
q1xc3631cp ,
2-(bis(2-hydroxyethyl)amino))-2-hydroxymethyl-1,3-propanediol
2-(bis(2-hydroxyethyl)amino)-2-(hydroxymethyl)propane-1,3-diol
nsc 119932
1,3-propanediol, 2-(bis(2-hydroxyethyl)amino)-2-(hydroxymethyl)-
nsc 24868
bistris
6976-37-0
nsc119932
1, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-
2-[bis(2-hydroxyethyl)amino)]-2-hydroxymethyl-1,3-propanediol
nsc-119932
nsc24868
nsc-24868
2-[bis-(2-hydroxy-ethyl)-amino]-2-hydroxymethyl-propane-1,3-diol
bis-tris, bioxtra, >=98.0% (titration)
bis-tris, >=98.0% (titration)
bis-tris, bioperformance certified, cell culture tested, suitable for insect cell culture, >=98.0%
2,2-bis(hydroxymethyl)-2,2',2''-nitrilotriethanol
bis-tris ,
CHEBI:41250 ,
2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol
bis-2-hydroxy-imino-tris-hydroxymethyl-methane
2-(bis(2-hydroxyethyl)amino)-2-(hydroxymethyl)-1,3-propanediol
bis-tris buffer
bis-tris, bioultra, >=99.0% (nt)
bis(2-hydroxyethyl)aminotris(hydroxymethyl)methane
B1493 ,
bis(2-hydroxyethyl)iminotris(hydroxymethyl)methane bis-tris
AKOS015964206
FT-0609185
EPITOPE ID:161731
bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane ,
BP-20533
1,3-propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-
SCHEMBL35757
DTXSID6064537
2,2-bishydroxymethyl-2,2',2''-nitriloethanol
2,2-bis[hydroxymethyl]-2,2',2''-nitrilotriethanol
bis(2-hydroxyethyl)-(iminotris)hydroxymethyl)methane
2-[bis(2-hydroxyethyl)imino]-2-(hydroxymethyl)-1,3-propanediol
bis-(2-hydroxyethyl)aminotris(hydroxymethyl)methane
2,2 - bis(hydroxyethyl)-(iminotris)-(hydroxymethyl)methane
bis-hydroxyethyl tromethamine [inci]
mfcd00002853
sr-01000883740
SR-01000883740-1
bis-tris, >=98%
bis-tris, bioxtra, >=99.0% (nt)
CS-0015166
bis-tris, vetec(tm) reagent grade, >=98%, rnase and dnase free
bis-tris, anhydrous, free-flowing, redi-dri(tm), >=98.0%
SY012935
Q865956
bistris; nsc 119932; nsc 24868; nupage bis-tris
AMY26987
D70475
SB78428
bis-hydroxyethyl tromethamine
HY-D0856
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
bufferAny substance or mixture of substances that, in solution (typically aqueous), resists change in pH upon addition of small amounts of acid or base.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
pentolA polyol with five hydroxy groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (21)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (23.81)18.7374
1990's3 (14.29)18.2507
2000's8 (38.10)29.6817
2010's5 (23.81)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 52.98

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index52.98 (24.57)
Research Supply Index3.09 (2.92)
Research Growth Index4.53 (4.65)
Search Engine Demand Index85.50 (26.88)
Search Engine Supply Index2.11 (0.95)

This Compound (52.98)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other21 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
choline
[no description available]		2.0710cholinesallergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite
chlorine
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.		1.9910halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
lactic acid
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.		1.99102-hydroxy monocarboxylic acidalgal metabolite;
Daphnia magna metabolite
glycine
[no description available]		2.730alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
iodine
Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.. diiodine : Molecule comprising two covalently bonded iodine atoms with overall zero charge..		1.9410diatomic iodinenutrient
phytic acid
Phytic Acid: Complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent.. myo-inositol hexakisphosphate : A myo-inositol hexakisphosphate in which each hydroxy group of myo-inositol is monophosphorylated.		1.9610inositol phosphate
nitrites
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)		1.9610monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species		human metabolite
4-aminobenzoic acid
4-Aminobenzoic Acid: An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.. 4-ammoniobenzoate : A zwitterion obtained by transfer of a proton from the carboxy to the amino group of 4-aminobenzoic acid.. 4-aminobenzoic acid : An aminobenzoic acid in which the amino group is para to the carboxy group.		1.9910aminobenzoic acid;
aromatic amino-acid zwitterion		allergen;
Escherichia coli metabolite;
plant metabolite
phosphorylcholine
Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.. phosphocholine : The phosphate of choline; and the parent compound of the phosphocholine family.		2.0710phosphocholinesallergen;
epitope;
hapten;
human metabolite;
mouse metabolite
2,2'-dipyridyl
2,2'-Dipyridyl: A reagent used for the determination of iron.. 2,2'-bipyridine : A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'.		2.1110bipyridinechelator;
ferroptosis inhibitor
diethyl pyrocarbonate
Diethyl Pyrocarbonate: Preservative for wines, soft drinks, and fruit juices and a gentle esterifying agent.. diethyl pyrocarbonate : The diethyl ester of dicarbonic acid.		210acyclic carboxylic anhydride
glutaral
Glutaral: One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.. glutaraldehyde : A dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5.		1.9710dialdehydecross-linking reagent;
disinfectant;
fixative
lithium hydroxide
lithium hydroxide: used for tryptophan determinations in proteins & foods; RN given refers to cpd with MF of Li-OH		1.9910alkali metal hydroxide
adenosine diphosphate
Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.		1.9610adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate		fundamental metabolite;
human metabolite
edetic acid
Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.		2.420ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid		anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector
tromethamine
Tromethamine: An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424)		4.4210primary amino compound;
triol		buffer
acrylamide
[no description available]		2.0210acrylamides;
N-acylammonia;
primary carboxamide		alkylating agent;
carcinogenic agent;
Maillard reaction product;
mutagen;
neurotoxin
triethanolamine
triethanolamine: RN given refers to parent cpd. triethanolamine : A tertiary amino compound that is ammonia in which each of the hydrogens is substituted by a 2-hydroxyethyl group.		2.0410amino alcohol;
tertiary amino compound;
triol		buffer;
surfactant
diethanolamine
diethanolamine: RN given refers to parent cpd. diethanolamine : A member of the class of ethanolamines that is ethanolamine having a N-hydroxyethyl substituent.		2.0410ethanolamineshuman xenobiotic metabolite
shikimic acid
Shikimic Acid: A tri-hydroxy cyclohexene carboxylic acid important in biosynthesis of so many compounds that the shikimate pathway is named after it.. shikimic acid : A cyclohexenecarboxylic acid that is cyclohex-1-ene-1-carboxylic acid substituted by hydroxy groups at positions 3, 4 and 5 (the 3R,4S,5R stereoisomer). It is an intermediate metabolite in plants and microorganisms.		1.9910alpha,beta-unsaturated monocarboxylic acid;
cyclohexenecarboxylic acid;
hydroxy monocarboxylic acid		Escherichia coli metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
n,n-bis(2-hydroxyethyl)glycine
N,N-bis(2-hydroxyethyl)glycine: RN given refers to parent cpd. N,N-bis(2-hydroxyethyl)glycine : A bicine that is a Good's buffer substance, pKa = 8.35 at 20 degreeC.		1.9710bicine
dansyl chloride
dansyl chloride: RN given refers to unlabeled cpd		1.9710aminonaphthalene;
sulfonic acid derivative
c.i. 42510
Rosaniline Dyes: Compounds that contain the triphenylmethane aniline structure found in rosaniline. Many of them have a characteristic magenta color and are used as COLORING AGENTS.. basic fuchsin : A four-component mixture of chemically related dyes comprising pararosanilin, rosanilin, magenta II and new fuchsin in varying amounts. rosanilin : A hydrochloride that is the monohydrochloride of 4-[(4-aminophenyl)(4-iminocyclohexa-2,5-dien-1-ylidene)methyl]-2-methylaniline. One of the major constituents of Basic fuchsin, together with pararosanilin, magenta II and new fuchsin.		1.9710
hepes
[no description available]		2.4220HEPES;
organosulfonic acid
ruthenium
Ruthenium: A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.		2.1110iron group element atom;
platinum group metal atom
cadmium
Cadmium: An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.. elemental cadmium : An element in the zinc group of the periodic table with atomic number 48, atomic mass 112, M.P. 321degreeC, and B.P. 765degreeC). An odourless, tasteless, and highly poisonous soft, ductile, lustrous metal with electropositive properties. It has eight stable isotopes: (106)Cd, (108)Cd,(110)Cd, (111)Cd, (112)Cd, (113)Cd, (114)Cd and (116)Cd, with (112)Cd and (114)Cd being the most common.		2.0410cadmium molecular entity;
zinc group element atom
gold
Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.		1.9710copper group element atom;
elemental gold
iodine
[no description available]		1.9410halide anion;
monoatomic iodine		human metabolite
1,7-phenanthroline
[no description available]		2.0310phenanthroline
serinol
serinol: RN given refers to cpd without isomeric designation		2.0410
morpholinopropane sulfonic acid
3-(N-morpholino)propanesulfonic acid : A Good's buffer substance, pKa = 7.2 at 20 degreeC.		2.2110MOPS;
morpholines;
organosulfonic acid
2-(n-morpholino)ethanesulfonic acid
2-(N-morpholino)ethanesulfonic acid: RN given refers to parent cpd. 2-(N-morpholino)ethanesulfonic acid : A Good's buffer substance, pKa = 6.15 at 20 degreeC.		2.520MES;
organosulfonic acid;
zwitterion
cobalt
Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.. cobalt(1+) : A monovalent inorganic cation obtained from cobalt.. cobalt atom : A cobalt group element atom that has atomic number 27.		2.0410cobalt group element atom;
metal allergen		micronutrient
sodium dodecyl sulfate
Sodium Dodecyl Sulfate: An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.. sodium dodecyl sulfate : An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.		1.9710organic sodium saltdetergent;
protein denaturant
1-palmitoyl-2-oleoylglycero-3-phosphoserine
{1-O-hexadecanoyl-2-O-[(Z)-octadec-9-enoyl]-sn-glycero-3-phospho}serine : A 3-sn-phosphatidyl-L-serine compound with a palmitoyl group at the 1-position and an oleoyl group at the 2-position.		2.11103-sn-phosphatidyl-L-serine
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		2.0210cysteiniumfundamental metabolite
coomassie brilliant blue
[no description available]		1.9710
oxalates
Oxalates: Derivatives of OXALIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that are derived from the ethanedioic acid structure.		1.9910
phosphocreatine
Phosphocreatine: An endogenous substance found mainly in skeletal muscle of vertebrates. It has been tried in the treatment of cardiac disorders and has been added to cardioplegic solutions. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1996). phosphagen : Any of a group of guanidine or amidine phosphates that function as storage depots for high-energy phosphate in muscle with the purpose of regenerating ATP from ADP during muscular contraction.. N-phosphocreatine : A phosphoamino acid consisting of creatine having a phospho group attached at the primary nitrogen of the guanidino group.		1.9610phosphagen;
phosphoamino acid		human metabolite;
mouse metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Electrolytes
Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)		02.4420