phytic acid has been researched along with Cancer of Colon in 48 studies
Phytic Acid: Complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent.
myo-inositol hexakisphosphate : A myo-inositol hexakisphosphate in which each hydroxy group of myo-inositol is monophosphorylated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inositol hexaphosphate (IP6), a widely found natural bioactive substance in grains, effectively inhibits the progression of colorectal cancer (CRC) when used in combination with inositol (INS)." | 8.31 | The Combination of Inositol Hexaphosphate and Inositol Inhibits Metastasis of Colorectal Cancer Cells by Upregulating Claudin 7. ( Chen, Z; Han, Y; Lan, T; Li, H; Ma, X; Song, Y; Tao, M; Wang, C; Wang, H; Xu, Z; Yang, N, 2023) |
| "Inositol hexaphosphate (IP6), a widely found natural bioactive substance in grains, effectively inhibits the progression of colorectal cancer (CRC) when used in combination with inositol (INS)." | 4.31 | The Combination of Inositol Hexaphosphate and Inositol Inhibits Metastasis of Colorectal Cancer Cells by Upregulating Claudin 7. ( Chen, Z; Han, Y; Lan, T; Li, H; Ma, X; Song, Y; Tao, M; Wang, C; Wang, H; Xu, Z; Yang, N, 2023) |
| " injections of azoxymethane (AOM) at a dose rate of 15 mg/kg body weight/week." | 3.70 | Preventive potential of wheat bran fractions against experimental colon carcinogenesis: implications for human colon cancer prevention. ( Cohen, LA; Cooma, I; Hirose, Y; Rao, CV; Reddy, BS; Simi, B, 2000) |
| "To test the hypothesis that the antineoplastic activity of phytic acid [inositol hexaphosphate (InsP6)] is a result of rapid intake by the cells and its conversion to lower inositol phosphates (InsP1-5), thereby affecting the intracellular inositol phosphate pool, YAC-1 (mouse T cell leukemia), K562 (human erythroleukemia) and HT-29 (human colon adenocarcinoma) cell lines were incubated at 37 degrees C with [3H]InsP6." | 3.69 | [3H]inositol hexaphosphate (phytic acid) is rapidly absorbed and metabolized by murine and human malignant cells in vitro. ( Shamsuddin, AM; Vucenik, I, 1994) |
| "A striking anticancer effect of IP6 was demonstrated in different experimental models." | 2.42 | Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic. ( Shamsuddin, AM; Vucenik, I, 2003) |
| " The binding can result in very insoluble salts that are poorly absorbed from the gastrointestinal tract, which results in poor bioavailability (BV) of minerals." | 2.39 | Phytic acid in health and disease. ( Erdman, JW; Zhou, JR, 1995) |
| "Phytic acid is a natural plant antioxidant constituting 1-5% of most cereals, nuts, legumes, oil seeds, pollen and spores." | 2.38 | Antioxidant functions of phytic acid. ( Eaton, JW; Graf, E, 1990) |
| " Therefore, a suitable dosage form that can prevent the drugs from being absorbed from the upper gastrointestinal tract is required to be prepared, to target it to the colon." | 1.51 | Optimization of Inositol Hexaphosphate Colon Targeted Formulation for Anticarcinogenic Marker Modulation. ( Arya, M; Gupta, KP; Mishra, N; Saraf, SA, 2019) |
| "Phytic acid (PA) has momentous chemotherapeutic potential." | 1.51 | Pectin-encrusted gold nanocomposites containing phytic acid and jacalin: 1,2-dimethylhydrazine-induced colon carcinogenesis in Wistar rats, PI3K/Akt, COX-2, and serum metabolomics as potential targets. ( Arya, M; Guleria, A; Gupta, KP; Kaithwas, G; Kanoujia, J; Parashar, P; Saraf, SA; Singh, M; Singh, P; Tripathi, CB, 2019) |
| "Phytic acid (PA) is a polyphosphorylated carbohydrate that can be found in high amounts in most cereals, legumes, nut oil, seeds and soy beans." | 1.39 | Suppression of β-catenin and cyclooxygenase-2 expression and cell proliferation in azoxymethane-induced colonic cancer in rats by rice bran phytic acid (PA). ( Esa, NM; Ithnin, H; Saad, N, 2013) |
| "Phytic acid (PA) also acts as a natural antioxidant and may have numerous health benefits." | 1.37 | Green tea, phytic acid, and inositol in combination reduced the incidence of azoxymethane-induced colon tumors in Fisher 344 male rats. ( Davis, S; Khatiwada, J; Verghese, M; Williams, LL, 2011) |
| "The treatments of phytic acid were given in two concentrations: 0." | 1.36 | Anticarcinogenic efficacy of phytic acid extracted from rice bran on azoxymethane-induced colon carcinogenesis in rats. ( Hairuszah, I; Norashareena, MS; Norazalina, S; Norhaizan, ME, 2010) |
| "The azoxymethane increase expression SOD1, while inositol hexaphosphate decreases in a significant way the expression of SOD1 promoted by the administration of the carcinogen azoxymethane." | 1.33 | Study of superoxide dismutase's expression in the colon produced by azoxymethane and inositol hexaphosfate's paper, in mice. ( Amaral, EG; Fagundes, DJ; Inouye, CM; Marks, G, 2006) |
| " In conclusion, CPP improved zinc and calcium bioavailability from high phytate meals in the rat pup model." | 1.29 | The effect of casein phosphopeptides on zinc and calcium absorption from high phytate infant diets assessed in rat pups and Caco-2 cells. ( Hansen, M; Lönnerdal, B; Sandström, B, 1996) |
| "The incidence of colonic cancer differs widely between various human populations." | 1.27 | Dietary suppression of colonic cancer. Fiber or phytate? ( Eaton, JW; Graf, E, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (10.42) | 18.7374 |
| 1990's | 17 (35.42) | 18.2507 |
| 2000's | 10 (20.83) | 29.6817 |
| 2010's | 12 (25.00) | 24.3611 |
| 2020's | 4 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Han, Y | 1 |
| Lan, T | 1 |
| Ma, X | 1 |
| Yang, N | 1 |
| Wang, C | 1 |
| Xu, Z | 1 |
| Chen, Z | 1 |
| Tao, M | 1 |
| Li, H | 1 |
| Wang, H | 1 |
| Song, Y | 3 |
| Mishra, N | 1 |
| Arya, M | 2 |
| Gupta, KP | 2 |
| Saraf, SA | 2 |
| Kapral, M | 4 |
| Wawszczyk, J | 4 |
| Węglarz, L | 4 |
| Ciro, Y | 1 |
| Rojas, J | 1 |
| Di Virgilio, AL | 1 |
| Alhajj, MJ | 1 |
| Carabali, GA | 1 |
| Salamanca, CH | 1 |
| Vucenik, I | 3 |
| Druzijanic, A | 1 |
| Druzijanic, N | 1 |
| Markiewicz, LH | 1 |
| Ogrodowczyk, AM | 1 |
| Wiczkowski, W | 1 |
| Wróblewska, B | 1 |
| Sośnicki, S | 1 |
| Jesse, K | 2 |
| Paul-Samojedny, M | 1 |
| Kuśmierz, D | 1 |
| Singh, P | 1 |
| Tripathi, CB | 1 |
| Parashar, P | 1 |
| Singh, M | 1 |
| Kanoujia, J | 1 |
| Guleria, A | 1 |
| Kaithwas, G | 1 |
| Saad, N | 1 |
| Esa, NM | 1 |
| Ithnin, H | 1 |
| Andrews, M | 1 |
| Briones, L | 1 |
| Jaramillo, A | 1 |
| Pizarro, F | 1 |
| Arredondo, M | 1 |
| Okazaki, Y | 1 |
| Katayama, T | 1 |
| Yin, MX | 1 |
| Catimel, B | 1 |
| Gregory, M | 1 |
| Condron, M | 1 |
| Kapp, E | 1 |
| Holmes, AB | 1 |
| Burgess, AW | 1 |
| Norazalina, S | 1 |
| Norhaizan, ME | 1 |
| Hairuszah, I | 1 |
| Norashareena, MS | 1 |
| Khatiwada, J | 1 |
| Verghese, M | 1 |
| Davis, S | 1 |
| Williams, LL | 1 |
| Jurzak, M | 1 |
| Hollek, A | 1 |
| Jenab, M | 3 |
| Thompson, LU | 4 |
| Shamsuddin, AM | 6 |
| Tovar, LR | 1 |
| Larios-Saldaña, A | 1 |
| Zhang, Z | 1 |
| Wang, XL | 1 |
| Tian, Y | 1 |
| Amaral, EG | 2 |
| Fagundes, DJ | 2 |
| Marks, G | 2 |
| Inouye, CM | 1 |
| Aydos, RD | 1 |
| Pontes, ER | 1 |
| Takita, LC | 1 |
| Rossini, A | 1 |
| Ynouye, CM | 1 |
| Sakamoto, K | 1 |
| Venkatraman, G | 1 |
| Graf, E | 3 |
| Eaton, JW | 3 |
| Pretlow, TP | 2 |
| O'Riordan, MA | 2 |
| Spancake, KM | 1 |
| Pretlow, TG | 2 |
| Shivapurkar, N | 2 |
| Tang, ZC | 1 |
| Frost, A | 1 |
| Alabaster, O | 2 |
| Tang, Z | 1 |
| Zhou, JR | 1 |
| Erdman, JW | 1 |
| Hansen, M | 1 |
| Sandström, B | 1 |
| Lönnerdal, B | 1 |
| Corpet, DE | 1 |
| Taché, S | 1 |
| Peiffer, G | 1 |
| Barrett, JE | 1 |
| Klopfenstein, CF | 1 |
| Leipold, HW | 1 |
| Ferguson, LR | 1 |
| Harris, PJ | 1 |
| Reddy, BS | 1 |
| Hirose, Y | 1 |
| Cohen, LA | 1 |
| Simi, B | 1 |
| Cooma, I | 1 |
| Rao, CV | 1 |
| Levin, B | 1 |
| Horwitz, D | 1 |
| Pasquier, J | 1 |
| de Laforte, C | 1 |
| Roux, F | 1 |
| Bisset, JP | 1 |
| Paulin, R | 1 |
| Somich, GA | 1 |
| Amini, SB | 1 |
| Messina, M | 1 |
| Zhang, L | 1 |
| Elsayed, AM | 1 |
| Ullah, A | 2 |
8 reviews available for phytic acid and Cancer of Colon
| Article | Year |
|---|---|
Inositol Hexaphosphate (IP6) and Colon Cancer: From Concepts and First Experiments to Clinical Application.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Colonic Neoplasms; Humans; Phytic Acid; Signal | 2020 |
Inositol hexaphosphate. Monograph.
Topics: Animals; Anti-HIV Agents; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Hepatocellular; Cardio | 2002 |
Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Carcinogens; Colonic Neoplasms; Disease Mod | 2003 |
Suppression of colonic cancer by dietary phytic acid.
Topics: Colonic Neoplasms; Dietary Fiber; Free Radicals; Humans; Iron Chelating Agents; Lipid Peroxidation; | 1993 |
Phytic acid in health and disease.
Topics: Animals; Antioxidants; Biological Availability; Colonic Neoplasms; Humans; Inositol Phosphates; Mine | 1995 |
Protection against cancer by wheat bran: role of dietary fibre and phytochemicals.
Topics: Animals; Anticarcinogenic Agents; Breast Neoplasms; Colonic Neoplasms; Dietary Fiber; Disease Models | 1999 |
Dietary fiber.
Topics: Animals; Blood Glucose; Cellulose; Colon; Colonic Neoplasms; Cross-Cultural Comparison; Dietary Fibe | 1979 |
Antioxidant functions of phytic acid.
Topics: Animals; Antioxidants; Chelating Agents; Chemical Phenomena; Chemistry; Colonic Neoplasms; Food Pres | 1990 |
40 other studies available for phytic acid and Cancer of Colon
| Article | Year |
|---|---|
The Combination of Inositol Hexaphosphate and Inositol Inhibits Metastasis of Colorectal Cancer Cells by Upregulating Claudin 7.
Topics: Animals; Cell Line, Tumor; Claudins; Colonic Neoplasms; Colorectal Neoplasms; Epithelial-Mesenchymal | 2023 |
Optimization of Inositol Hexaphosphate Colon Targeted Formulation for Anticarcinogenic Marker Modulation.
Topics: Animals; Biomarkers; Colonic Neoplasms; Drug Liberation; Female; Humans; Male; Microspheres; Particl | 2019 |
Regulation of MicroRNA-155 and Its Related Genes Expression by Inositol Hexaphosphate in Colon Cancer Cells.
Topics: 3' Untranslated Regions; Caco-2 Cells; Cell Line, Tumor; Colonic Neoplasms; Gene Expression Profilin | 2019 |
Production, physicochemical characterization, and anticancer activity of methotrexate-loaded phytic acid-chitosan nanoparticles on HT-29 human colon adenocarcinoma cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Chitosan; Colonic Neoplasms; Drug Carriers; Drug Liberation; | 2020 |
Phytate and Butyrate Differently Influence the Proliferation, Apoptosis and Survival Pathways in Human Cancer and Healthy Colonocytes.
Topics: Apoptosis; Butyrates; Cell Proliferation; Colon; Colonic Neoplasms; Diet; HCT116 Cells; HT29 Cells; | 2021 |
Modulating effect of inositol hexaphosphate on arachidonic acid-dependent pathways in colon cancer cells.
Topics: Arachidonic Acid; Caco-2 Cells; Colonic Neoplasms; Dinoprostone; Gene Expression Regulation, Neoplas | 2017 |
Inositol Hexaphosphate Inhibits Proliferation and Induces Apoptosis of Colon Cancer Cells by Suppressing the AKT/mTOR Signaling Pathway.
Topics: Antineoplastic Agents; Apoptosis; Caco-2 Cells; Cell Proliferation; Colonic Neoplasms; Humans; Phyti | 2017 |
Pectin-encrusted gold nanocomposites containing phytic acid and jacalin: 1,2-dimethylhydrazine-induced colon carcinogenesis in Wistar rats, PI3K/Akt, COX-2, and serum metabolomics as potential targets.
Topics: 1,2-Dimethylhydrazine; Animals; Chlorides; Colonic Neoplasms; Cyclooxygenase 2; Drug Compounding; Ge | 2019 |
Suppression of β-catenin and cyclooxygenase-2 expression and cell proliferation in azoxymethane-induced colonic cancer in rats by rice bran phytic acid (PA).
Topics: Adenoma; Animals; Apoptosis; Azoxymethane; beta Catenin; Blotting, Western; Carcinogens; Cell Prolif | 2013 |
Effect of calcium, tannic acid, phytic acid and pectin over iron uptake in an in vitro Caco-2 cell model.
Topics: Adenocarcinoma; Analysis of Variance; Caco-2 Cells; Calcium; Calcium Chloride; Colonic Neoplasms; Do | 2014 |
Dietary phytic acid modulates characteristics of the colonic luminal environment and reduces serum levels of proinflammatory cytokines in rats fed a high-fat diet.
Topics: Acetates; Animals; beta-Glucosidase; Bile Acids and Salts; Butyrates; Cecum; Colon; Colonic Neoplasm | 2014 |
Synthesis of an inositol hexakisphosphate (IP6) affinity probe to study the interactome from a colon cancer cell line.
Topics: Affinity Labels; beta-Arrestin 2; Carrier Proteins; Cell Line, Tumor; Colonic Neoplasms; Humans; Met | 2016 |
Anticarcinogenic efficacy of phytic acid extracted from rice bran on azoxymethane-induced colon carcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Colonic Neoplasms; Dietary Fiber; Male; | 2010 |
Green tea, phytic acid, and inositol in combination reduced the incidence of azoxymethane-induced colon tumors in Fisher 344 male rats.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protoco | 2011 |
The effect of inositol hexaphosphate on the expression of selected metalloproteinases and their tissue inhibitors in IL-1β-stimulated colon cancer cells.
Topics: Caco-2 Cells; Collagenases; Colonic Neoplasms; Gelatinases; Gene Expression Regulation, Enzymologic; | 2012 |
Purified and endogenous phytic acid in wheat bran affects early biomarkers of colon cancer risk.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Biomarkers; Biomarkers, Tumor; Cell Division; Colonic N | 2002 |
Iron and zinc fortification of corn tortilla made either at the household or at industrial scale.
Topics: Antioxidants; Calcium; Calcium Compounds; Colonic Neoplasms; Food Handling; Food, Fortified; Humans; | 2005 |
Inositol hexaphosphate-induced enhancement of natural killer cell activity correlates with suppression of colon carcinogenesis in rats.
Topics: Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Killer Cells, Natural; Male; Phytic Aci | 2005 |
Effects of inositol hexaphosphate on proliferation of HT-29 human colon carcinoma cell line.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclin-Dependent Kin | 2006 |
Study of superoxide dismutase's expression in the colon produced by azoxymethane and inositol hexaphosfate's paper, in mice.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Male; Phytic Acid; Precancerous Conditions; R | 2006 |
Modulation of transforming growth factor beta2 (TGF-beta2) by inositol hexaphosphate in colon carcinogenesis in rats.
Topics: Animals; Azoxymethane; Carcinogenicity Tests; Carcinogens; Colon; Colonic Neoplasms; Disease Models, | 2006 |
Growth inhibition and differentiation of HT-29 cells in vitro by inositol hexaphosphate (phytic acid).
Topics: Adenocarcinoma; Carcinoembryonic Antigen; Cell Differentiation; Cell Division; Colonic Neoplasms; Do | 1993 |
[3H]inositol hexaphosphate (phytic acid) is rapidly absorbed and metabolized by murine and human malignant cells in vitro.
Topics: Adenocarcinoma; Animals; Cell Transformation, Neoplastic; Chromatography, Ion Exchange; Colonic Neop | 1994 |
Two types of putative preneoplastic lesions identified by hexosaminidase activity in whole-mounts of colons from F344 rats treated with carcinogen.
Topics: Animals; Azoxymethane; Carcinogens; Clinical Enzyme Tests; Colon; Colonic Neoplasms; Hexosaminidases | 1993 |
A rapid dual organ rat carcinogenesis bioassay for evaluating the chemoprevention of breast and colon cancer.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Breast Neoplasms; Carcinogenicity Tests; Carcinogens | 1996 |
Dietary fiber and the chemopreventive modelation of colon carcinogenesis.
Topics: Animals; Azoxymethane; beta Carotene; Carcinogens; Carotenoids; Colon; Colonic Neoplasms; Diet; Diet | 1996 |
The effect of casein phosphopeptides on zinc and calcium absorption from high phytate infant diets assessed in rat pups and Caco-2 cells.
Topics: Animals; Avena; Caco-2 Cells; Calcium; Calcium Radioisotopes; Caseins; Colonic Neoplasms; Glycine ma | 1996 |
Colon tumor promotion: is it a selective process? Effects of cholate, phytate, and food restriction in rats on proliferation and apoptosis in normal and aberrant crypts.
Topics: Analysis of Variance; Animals; Apoptosis; Body Weight; Cell Division; Cholic Acid; Cholic Acids; Col | 1997 |
Protective effects of cruciferous seed meals and hulls against colon cancer in mice.
Topics: Animals; Brassicaceae; Colonic Neoplasms; Diet; Dietary Fiber; Glucosinolates; Male; Mice; Phenol; P | 1998 |
The influence of phytic acid in wheat bran on early biomarkers of colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Cell Division; Colonic Neoplasms; Dietary Fiber | 1998 |
Phytic acid in wheat bran affects colon morphology, cell differentiation and apoptosis.
Topics: Animals; Apoptosis; Azoxymethane; Biomarkers, Tumor; Carcinogens; Cell Differentiation; Colon; Colon | 2000 |
Preventive potential of wheat bran fractions against experimental colon carcinogenesis: implications for human colon cancer prevention.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Azoxymethane; Blotting, Western; Body Weight; Carc | 2000 |
[Analysis of one thousand liver scans carried out using technetium phytate (author's transl)].
Topics: Adult; Aged; Colonic Neoplasms; Echinococcosis, Hepatic; Female; Hepatomegaly; Humans; Liver Abscess | 1977 |
Aberrant crypts correlate with tumor incidence in F344 rats treated with azoxymethane and phytate.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Phytic Acid; Precancerous Conditions; Rats; Rats, Inbred F | 1992 |
Phytate and colon-cancer risk.
Topics: Colonic Neoplasms; Humans; Phytic Acid | 1992 |
Phytate's potential role in reducing colon-cancer risk.
Topics: Animals; Colonic Neoplasms; Diet; Humans; Phytic Acid; Rats | 1991 |
Phytic acid and minerals: effect on early markers of risk for mammary and colon carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Calcium, Dietary; Cell Division; Chromosome Aberrations; | 1991 |
Suppression of large intestinal cancer in F344 rats by inositol hexaphosphate.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Electron Spin Resonance Spectroscopy; Free Radicals; Hydro | 1988 |
Inositol hexaphosphate inhibits large intestinal cancer in F344 rats 5 months after induction by azoxymethane.
Topics: Animals; Azo Compounds; Azoxymethane; Colonic Neoplasms; Phytic Acid; Rats; Rats, Inbred F344; Recta | 1989 |
Dietary suppression of colonic cancer. Fiber or phytate?
Topics: Colonic Neoplasms; Diet; Dietary Fiber; Edible Grain; Europe; Humans; Hydroxides; Hydroxyl Radical; | 1985 |