zinc glycinate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

zinc glycinate: glycoprotein marker of gastrointestinal cancer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	151910
SCHEMBL ID	121072
MeSH ID	M0067084

Synonyms (41)

Synonym
7214-08-6
zinc glycinate
zinc 2-aminoacetate
FT-0651858
FT-0690187
G0215
glycine zinc salt
14281-83-5
A837432
zinc 2-azanylethanoate
zinc bisglycinate
unii-681vjx72fe
(t-4)-bis(glycinato-n,o)zinc
zinc, bis(glycinato-kappan,kappao)-, (t-4)-
681vjx72fe ,
zinc chelazome
einecs 238-173-1
zinc(ii) glycinate
bis(glycinato-n,o)zinc
bis(glycinato)zinc
zinc glycinate [inci]
glycine zinc chelate
zinc amino acid chelate [vandf]
glycine, zinc salt (2:1)
zinc bis(aminoacetate)
zinc amino acid chelate [who-dd]
zinc glycinate [who-dd]
zinc bis glycinate chelate [who-dd]
AKOS015914968
SCHEMBL121072
zinc bis-glycinate
UOXSXMSTSYWNMH-UHFFFAOYSA-L
DTXSID60162193
glycine zinc salt monohydrate [for protein research]
zinc(ii) 2-aminoacetate
DB14493
Q27264191
zinc;2-aminoacetate
D95398
zinc(2+) bis(2-aminoacetate)
glycine zinc salt (2:1)

Research Excerpts

Bioavailability

Excerpt	Reference	Relevance
"The objective of this study was to quantify the bioavailability of zinc (Zn) from sulphate and glycinate as representatives of inorganic and organic zinc sources."	( Bioavailability of zinc glycinate in comparison with zinc sulphate in the presence of dietary phytate in an animal model with Zn labelled rats. Schlegel, P; Windisch, W, 2006)	0.66
" The aim of the present study was to compare the oral bioavailability of zinc bis-glycinate (a new formulation) with zinc gluconate (reference formulation)."	( A bioavailability study comparing two oral formulations containing zinc (Zn bis-glycinate vs. Zn gluconate) after a single administration to twelve healthy female volunteers. Béjot, M; Bour, D; Donazzolo, Y; Duchène, P; Gandia, P; Houin, G; Maurette, JM, 2007)	0.34
" Bioavailability was then evaluated by analyzing plasma samples of horses supplemented with glycinates-rich feed."	( Determination of Zn-, Cu- and Mn-glycinate complexes in feed samples and in-vitro and in-vivo assays to assess their bioaccessibility in feed samples. Ionescu, C; Lobinski, R; Oguey, S; Vacchina, V, 2013)	0.39
" Compared with ZnSO (100%), relative bioavailability values of ZnGly were 115 and 118%, based on tibia and pancreatic Zn, respectively, and relative bioavailability values of ZnPOS were 152 and 142%, respectively."	( Effects of sources and concentrations of zinc on growth performance, nutrient digestibility, and fur quality of growing-furring female mink ( Cui, H; Gao, XH; Nie, H; Shi, B; Wang, ZC; Yang, FH; Zhang, TT; Zhang, XL, 2017)	0.46

Dosage Studied

Excerpt	Relevance	Reference
" Possible reasons for difference from mideastern reports include endemic diets, population genetics, relative rate of zinc deficiency, difference in background nutrition, insufficient dosage or absorption, or wrong anion (sulfate may be necessary for reported benefit)."	( Zinc for attention-deficit/hyperactivity disorder: placebo-controlled double-blind pilot trial alone and combined with amphetamine. Abdel-Rasoul, M; Arnold, LE; Bozzolo, D; Bozzolo, H; Crowl, L; Disilvestro, RA; Fernandez, S; Joseph, E; Mo, X; Ramadan, Y; Thompson, S, 2011)	0.37
" The focus of this research was to investigate the dosage effect of zinc glycine chelate (Zn-Gly) on zinc metabolism and the gene expression of zinc transporters in intestinal segments."	( Dosage Effect of Zinc Glycine Chelate on Zinc Metabolism and Gene Expression of Zinc Transporter in Intestinal Segments on Rat. Fang, S; Feng, J; Hu, Q; Huang, D, 2016)	0.43
" Therefore, Zn-Gly supplementation at 70 mg/kg Zn had positive effects in promoting growth performance by regulating intestinal morphology, barrier function, and gut microbiota of ducks when compared with the same dosage use of ZnSO4 in feed."	( Organic zinc glycine chelate is better than inorganic zinc in improving growth performance of cherry valley ducks by regulating intestinal morphology, barrier function, and the gut microbiome. Cai, J; Chang, Y; Chen, X; Jia, G; Liu, G; Wang, K; Wen, M; Wu, B; Zhao, H, 2023)	0.91

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (12.50)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (16.67)	29.6817
2010's	13 (54.17)	24.3611
2020's	4 (16.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 43.36

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	43.36 (24.57)
Research Supply Index	3.47 (2.92)
Research Growth Index	4.78 (4.65)
Search Engine Demand Index	125.47 (26.88)
Search Engine Supply Index	3.99 (0.95)

This Compound (43.36)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	6 (24.00%)	5.53%
Reviews	1 (4.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	18 (72.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
hydrogen sulfide Hydrogen Sulfide: A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed). hydrogen sulfide : A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.. thiol : An organosulfur compound in which a thiol group, -SH, is attached to a carbon atom of any aliphatic or aromatic moiety.	2.01	1	0	gas molecular entity; hydracid; mononuclear parent hydride; sulfur hydride	Escherichia coli metabolite; genotoxin; metabolite; signalling molecule; toxin; vasodilator agent
glycine [no description available]	8.36	22	5	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
phytic acid Phytic Acid: Complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent.. myo-inositol hexakisphosphate : A myo-inositol hexakisphosphate in which each hydroxy group of myo-inositol is monophosphorylated.	2.03	1	0	inositol phosphate
orotic acid Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.. orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.	2.01	1	0	pyrimidinemonocarboxylic acid	Escherichia coli metabolite; metabolite; mouse metabolite
reserpine Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.. reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.	1.97	1	0	alkaloid ester; methyl ester; yohimban alkaloid	adrenergic uptake inhibitor; antihypertensive agent; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; environmental contaminant; first generation antipsychotic; plant metabolite; xenobiotic
dextroamphetamine Dextroamphetamine: The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.. (S)-amphetamine : A 1-phenylpropan-2-amine that has S configuration.	4.41	2	2	1-phenylpropan-2-amine	adrenergic agent; adrenergic uptake inhibitor; dopamine uptake inhibitor; dopaminergic agent; neurotoxin; sympathomimetic agent
aspartic acid Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.. aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent. L-aspartic acid : The L-enantiomer of aspartic acid.	2.39	2	0	aspartate family amino acid; aspartic acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; mouse metabolite; neurotransmitter
methionine Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.	2.21	1	0	aspartate family amino acid; L-alpha-amino acid; methionine zwitterion; methionine; proteinogenic amino acid	antidote to paracetamol poisoning; human metabolite; micronutrient; mouse metabolite; nutraceutical
gluconic acid gluconic acid: zinc gluconate has anti-inflammatory activity; RN given refers to (D)-isomer; all RRs refers to (D)-isomer unless otherwise noted. ketogluconic acid : A gluconic acid that contains a ketonic carbonyl group.. D-gluconic acid : A gluconic acid having D-configuration.	3.85	2	1	gluconic acid	chelator; Penicillium metabolite
copper gluconate Gluconates: Derivatives of gluconic acid (the structural formula HOCH2(CHOH)4COOH), including its salts and esters.	4.12	3	1	organic molecular entity
zinc oxide Zinc Oxide: A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.	8.99	1	1	zinc molecular entity
manganese Manganese: A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035). manganese(4+) : A manganese cation that is monoatomic and has a formal charge of +4.	2.08	1	0	elemental manganese; manganese group element atom	Escherichia coli metabolite; micronutrient
zinc sulfate Zinc Sulfate: A compound given in the treatment of conditions associated with zinc deficiency such as acrodermatitis enteropathica. Externally, zinc sulfate is used as an astringent in lotions and eye drops. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995). zinc sulfate : A metal sulfate compound having zinc(2+) as the counterion.	3.22	5	0	metal sulfate; zinc molecular entity	fertilizer
pectins Pectins: High molecular weight polysaccharides present in the cell walls of all plants. Pectins cement cell walls together. They are used as emulsifiers and stabilizers in the food industry. They have been tried for a variety of therapeutic uses including as antidiarrheals, where they are now generally considered ineffective, and in the treatment of hypercholesterolemia.. alpha-D-galacturonic acid : The alpha-anomer of D-galacturonic acid.	2.57	2	0	D-galactopyranuronic acid
cupric glycinate cupric glycinate: RN given refers to cpd without isomeric designation	2.08	1	0
sulfur Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.	2.01	1	0	chalcogen; nonmetal atom	macronutrient
zinc methionine [no description available]	2.21	1	0
metallothionein Metallothionein: A low-molecular-weight (approx. 10 kD) protein occurring in the cytoplasm of kidney cortex and liver. It is rich in cysteinyl residues and contains no aromatic amino acids. Metallothionein shows high affinity for bivalent heavy metals.	3.55	2	0

Condition	Relationship Strength	Studies	Trials
E coli Infections [description not available]	3.99	1	1
Swine Diseases Diseases of domestic swine and of the wild boar of the genus Sus.	3.99	1	1
Escherichia coli Infections Infections with bacteria of the species ESCHERICHIA COLI.	3.99	1	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	4.07	2	1
Innate Inflammatory Response [description not available]	2.25	1	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.25	1	0
Catarrh Inflammation of a mucous membrane with increased flow of mucous in humans or animals. Catarrh is used mostly in a historical context.	3.47	1	1
Common Cold A catarrhal disorder of the upper respiratory tract, which may be viral or a mixed infection. It generally involves a runny nose, nasal congestion, and sneezing.	3.47	1	1
ADDH [description not available]	4.41	2	2
Attention Deficit Disorder with Hyperactivity A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)	4.41	2	2
Skin Aging The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.	2.99	1	0
Halitosis An offensive, foul breath odor resulting from a variety of causes such as poor oral hygiene, dental or oral infections, or the ingestion of certain foods.	2.01	1	0
Cancer of Colon [description not available]	1.95	1	0
Colonic Neoplasms Tumors or cancer of the COLON.	1.95	1	0
Gastric Ulcer [description not available]	1.97	1	0
Stomach Ulcer Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).	1.97	1	0

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