Page last updated: 2024-10-18

kynurenine and Anhedonia

kynurenine has been researched along with Anhedonia in 9 studies

Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.

Anhedonia: Inability to experience pleasure due to impairment or dysfunction of normal psychological and neurobiological mechanisms. It is a symptom of many PSYCHOTIC DISORDERS (e.g., DEPRESSIVE DISORDER, MAJOR; and SCHIZOPHRENIA).

Research Excerpts

ExcerptRelevanceReference
"Geriatric depression is a costly health issue, but little is known about its physiological underpinnings."1.39Aging leads to prolonged duration of inflammation-induced depression-like behavior caused by Bacillus Calmette-Guérin. ( Dantzer, R; Kelley, KW; Lawson, MA; McCusker, RH; O'Connor, JC; Rodriguez-Zas, SL, 2013)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's8 (88.89)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Orrico-Sanchez, A1
Guiard, BP1
Manta, S1
Callebert, J1
Launay, JM1
Louis, F1
Paccard, A1
Gruszczynski, C1
Betancur, C1
Vialou, V1
Gautron, S1
DeWitt, SJ1
Bradley, KA2
Lin, N1
Yu, C1
Gabbay, V3
de Gomes, MG1
Souza, LC1
Goes, AR1
Del Fabbro, L1
Filho, CB1
Donato, F1
Prigol, M1
Luchese, C1
Roman, SS1
Puntel, RL1
Boeira, SP1
Jesse, CR1
Kelley, KW1
O'Connor, JC1
Lawson, MA1
Dantzer, R3
Rodriguez-Zas, SL1
McCusker, RH1
Savitz, J2
Drevets, WC2
Smith, CM1
Victor, TA2
Wurfel, BE2
Bellgowan, PS1
Bodurka, J2
Teague, TK2
Case, JA1
Khan, O1
Ricart, T1
Hanna, A1
Alonso, CM1
Meier, TB1
McIntosh, SA1
Ford, BN1
Morris, HM1
Barat, P1
Meiffred, MC1
Brossaud, J1
Fuchs, D1
Corcuff, JB1
Thibault, H1
Capuron, L1
Ely, BA1
Babb, J1
Liebes, L1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Longitudinal Study of Inflammatory Pathways in Depression[NCT04159207]160 participants (Anticipated)Observational2019-10-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

9 other studies available for kynurenine and Anhedonia

ArticleYear
Organic cation transporter 2 contributes to SSRI antidepressant efficacy by controlling tryptophan availability in the brain.
    Translational psychiatry, 2023, 09-29, Volume: 13, Issue:1

    Topics: Anhedonia; Animals; Antidepressive Agents; Brain; Corticosterone; Depressive Disorder, Major; Fluoxe

2023
A pilot resting-state functional connectivity study of the kynurenine pathway in adolescents with depression and healthy controls.
    Journal of affective disorders, 2018, Volume: 227

    Topics: Adolescent; Anhedonia; Brain; Case-Control Studies; Depressive Disorder, Major; Female; Gray Matter;

2018
Fish oil ameliorates sickness behavior induced by lipopolysaccharide in aged mice through the modulation of kynurenine pathway.
    The Journal of nutritional biochemistry, 2018, Volume: 58

    Topics: Aging; Anhedonia; Animals; Behavior, Animal; Biomarkers; Body Weight; Brain; Cytokines; Fish Oils; I

2018
Aging leads to prolonged duration of inflammation-induced depression-like behavior caused by Bacillus Calmette-Guérin.
    Brain, behavior, and immunity, 2013, Volume: 32

    Topics: Aging; Anhedonia; Animals; Behavior, Animal; Body Weight; Chronic Disease; Depression; Hindlimb Susp

2013
Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, Volume: 40, Issue:2

    Topics: Adult; Amygdala; Anhedonia; Brain-Derived Neurotrophic Factor; C-Reactive Protein; Depressive Disord

2015
The role of the kynurenine pathway in suicidality in adolescent major depressive disorder.
    Psychiatry research, 2015, Jun-30, Volume: 227, Issue:2-3

    Topics: Adolescent; Anhedonia; Biomarkers; Depressive Disorder, Major; Female; Humans; Kynurenine; Male; Sui

2015
Activation of the kynurenine pathway is associated with striatal volume in major depressive disorder.
    Psychoneuroendocrinology, 2015, Volume: 62

    Topics: Adult; Anhedonia; Biomarkers; Corpus Striatum; Depressive Disorder, Major; Female; Humans; Kynurenic

2015
Inflammatory, endocrine and metabolic correlates of fatigue in obese children.
    Psychoneuroendocrinology, 2016, Volume: 74

    Topics: Adolescent; Anhedonia; Apathy; Body Mass Index; C-Reactive Protein; Child; Fatigue; Female; Humans;

2016
The possible role of the kynurenine pathway in anhedonia in adolescents.
    Journal of neural transmission (Vienna, Austria : 1996), 2012, Volume: 119, Issue:2

    Topics: Adolescent; Anhedonia; Biomarkers; Depressive Disorder, Major; Female; Humans; Kynurenine; Male; Neu

2012