mecamylamine has been researched along with Anhedonia in 5 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Anhedonia: Inability to experience pleasure due to impairment or dysfunction of normal psychological and neurobiological mechanisms. It is a symptom of many PSYCHOTIC DISORDERS (e.g., DEPRESSIVE DISORDER, MAJOR; and SCHIZOPHRENIA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nicotine was delivered chronically through osmotic minipumps for 28 days (40 mg/kg/day, base), and withdrawal was induced by either administering the broad-spectrum nicotinic receptor antagonist mecamylamine (i." | 5.42 | Null mutation of the β2 nicotinic acetylcholine receptor subunit attenuates nicotine withdrawal-induced anhedonia in mice. ( Markou, A; Marks, MJ; Stoker, AK, 2015) |
| " The nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine induced a larger increase in reward thresholds (ie, anhedonia) in the LgA rats than the ShA rats." | 3.96 | Relationship Between Nicotine Intake and Reward Function in Rats With Intermittent Short Versus Long Access to Nicotine. ( Bruijnzeel, AW; Esser, KA; Febo, M; Geste, JR; Levin, B; O'Dell, L; Pompilus, M; Wilks, I; Zhang, X, 2020) |
| "Nicotine discontinuation produces behaviors in rats that are congruent with anhedonia, and these symptoms may be related to the devaluation of non-nicotine reinforcers." | 3.81 | Reinforcer devaluation as a consequence of acute nicotine exposure and withdrawal. ( Fay, M; Green, J; Kirshenbaum, A; Parks, A; Phillips, J; Roy, T; Stone, J, 2015) |
| "Anhedonia was assessed with the discrete-trial current-intensity intracranial self-stimulation (ICSS) procedure after the termination of cocaine (180 mg kg(-1) day(-1), salt, 3 days, i." | 3.78 | Involvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal. ( Markou, A; Olivier, B; Stoker, AK, 2012) |
| "Nicotine was delivered chronically through osmotic minipumps for 28 days (40 mg/kg/day, base), and withdrawal was induced by either administering the broad-spectrum nicotinic receptor antagonist mecamylamine (i." | 1.42 | Null mutation of the β2 nicotinic acetylcholine receptor subunit attenuates nicotine withdrawal-induced anhedonia in mice. ( Markou, A; Marks, MJ; Stoker, AK, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Geste, JR | 2 |
| Pompilus, M | 2 |
| Febo, M | 2 |
| Bruijnzeel, AW | 2 |
| Levin, B | 1 |
| Wilks, I | 1 |
| Zhang, X | 1 |
| Esser, KA | 1 |
| O'Dell, L | 1 |
| Stoker, AK | 2 |
| Marks, MJ | 1 |
| Markou, A | 2 |
| Kirshenbaum, A | 1 |
| Green, J | 1 |
| Fay, M | 1 |
| Parks, A | 1 |
| Phillips, J | 1 |
| Stone, J | 1 |
| Roy, T | 1 |
| Olivier, B | 1 |
5 other studies available for mecamylamine and Anhedonia
| Article | Year |
|---|---|
Self-administration of the synthetic cathinone MDPV enhances reward function via a nicotinic receptor dependent mechanism.
Topics: Anhedonia; Animals; Benzodioxoles; Brain; Conditioning, Operant; Dopamine Uptake Inhibitors; Feeding | 2018 |
Relationship Between Nicotine Intake and Reward Function in Rats With Intermittent Short Versus Long Access to Nicotine.
Topics: Anhedonia; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrodes, Impl | 2020 |
Null mutation of the β2 nicotinic acetylcholine receptor subunit attenuates nicotine withdrawal-induced anhedonia in mice.
Topics: Anhedonia; Animals; Gene Deletion; Male; Mecamylamine; Mice; Mice, Knockout; Microinjections; Nicoti | 2015 |
Reinforcer devaluation as a consequence of acute nicotine exposure and withdrawal.
Topics: Anhedonia; Animals; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; R | 2015 |
Involvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal.
Topics: Anhedonia; Animals; Brain; Cocaine; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Ni | 2012 |