benzofurans and Anhedonia

While the alteration of I. LSL 60101 was administered in adult male Sprague-Dawley rats daily during 16 days (doses of 10 and 20 mg/kg, ip) and its antidepressant-like potential was assessed through the course of treatment in the forced-swim test, novelty-suppressed feeding test and two-bottle choice test (sucrose preference). The regulation of several key neuroplasticity markers (i.e., FADD, p-ERK1/2, ERK1/2, p-JNK1/2, JNK1/2, mBDNF) was evaluated 24-h post-treatment by western blot analysis in the right hippocampus and the proliferation of neural progenitors was quantified in the left hippocampus by immunohistochemistry.. The results showed that LSL 60101 did not induce an antidepressant-like effect over the course of treatment in any of the behavioral tests conducted, and it did not alter any of the hippocampal neuroplasticity markers evaluated.. These results add to the existing literature by suggesting that not all I

Topics: Anhedonia; Animals; Antidepressive Agents; Benzofurans; Feeding Behavior; Hippocampus; Imidazoles; Imidazoline Receptors; Male; Neural Stem Cells; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Swimming; Weight Gain