imipramine has been researched along with Anhedonia in 19 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Anhedonia: Inability to experience pleasure due to impairment or dysfunction of normal psychological and neurobiological mechanisms. It is a symptom of many PSYCHOTIC DISORDERS (e.g., DEPRESSIVE DISORDER, MAJOR; and SCHIZOPHRENIA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to evaluate whether chronic treatment with cariprazine, a dopamine D2 and D3 receptor partial agonist with preferential binding to D3 receptors, shows antidepressant-like effects in the chronic mild stress (CMS)-induced anhedonia model." | 7.80 | Attenuation of anhedonia by cariprazine in the chronic mild stress model of depression. ( Adham, N; Gruca, P; Gyertyán, I; Kiss, B; Lasoń-Tyburkiewicz, M; Papp, M, 2014) |
| "Parkinson's disease is a chronic neurodegenerative disorder characterized by cardinal motor features, such as bradykinesia, but also vocal deficits (e." | 5.48 | Effects of ketamine on vocal impairment, gait changes, and anhedonia induced by bilateral 6-OHDA infusion into the substantia nigra pars compacta in rats: Therapeutic implications for Parkinson's disease. ( Andreatini, R; Bruginski, E; Campos, FR; de Almeida Soares Hocayen, P; Kanazawa, LKS; Miyoshi, E; Schwarting, RKW; Stern, CAJ; Vecchia, DD; Vital, MABF; Wendler, E; Wöhr, M, 2018) |
| "Anhedonia is a relevant symptom in depression and schizophrenia." | 5.42 | Impramine, fluoxetine and clozapine differently affected reactivity to positive and negative stimuli in a model of motivational anhedonia in rats. ( De Montis, MG; Ferrari, A; Gambarana, C; Pelliccia, T; Scheggi, S, 2015) |
| " Imipramine was administered for the next 5 weeks, and it reversed anhedonia in majority of animals (imipramine-reactive); however, in some animals, it did not (imipramine-non-reactive)." | 3.88 | Regulation of somatostatin receptor 2 in the context of antidepressant treatment response in chronic mild stress in rat. ( Antkiewicz-Michaluk, L; Dziedzicka-Wasylewska, M; Faron-Górecka, A; Gruca, P; Kolasa, M; Kuśmider, M; Pabian, P; Papp, M; Romańska, I; Solich, J; Szlachta, M; Żurawek, D, 2018) |
| " In CMS, anhedonia in rats is manifested by reduced consumption of sucrose solution while administration of antidepressant drugs reverses anhedonia." | 3.85 | Basal prolactin levels in rat plasma correlates with response to antidepressant treatment in animal model of depression. ( Dziedzicka-Wasylewska, M; Faron-Górecka, A; Gruca, P; Kolasa, M; Kuśmider, M; Pabian, P; Papp, M; Solich, J; Szafran-Pilch, K; Żurawek, D, 2017) |
| "Agmatine, an endogenous neuromodulator, is a potential candidate to constitute an adjuvant/monotherapy for the management of depression." | 3.83 | Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice. ( Buendia, I; Casas, AI; Cuadrado, A; Egea, J; Freitas, AE; Gómez-Rangel, V; Lopez, MG; Navarro, E; Ortiz, JA; Parada, E; Rodrigues, ALS; Ruiz-Nuño, A; Wojnicz, A, 2016) |
| " Using the transient right middle cerebral artery occlusion- (MCAO-, 90 min) operated rats as an ischemia model in this study, we first observed that aggravation of anhedonia spontaneously occurred especially after 20 weeks of MCAO, and it was prevented by chronic antidepressants treatment (imipramine or fluvoxamine)." | 3.83 | Postischemic Anhedonia Associated with Neurodegenerative Changes in the Hippocampal Dentate Gyrus of Rats. ( Kasahara, J; Oka, N; Tezuka, K; Uchida, H, 2016) |
| "The aim of this study was to evaluate whether chronic treatment with cariprazine, a dopamine D2 and D3 receptor partial agonist with preferential binding to D3 receptors, shows antidepressant-like effects in the chronic mild stress (CMS)-induced anhedonia model." | 3.80 | Attenuation of anhedonia by cariprazine in the chronic mild stress model of depression. ( Adham, N; Gruca, P; Gyertyán, I; Kiss, B; Lasoń-Tyburkiewicz, M; Papp, M, 2014) |
| " Here, sucrose intake, forced swimming, immobility in the modified tail suspension test, novelty exploration, grooming, anxiety and locomotor activity were compared in naïve 3- and 18-month-old male C57BL/6 mice." | 3.78 | Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL/6 mice: Implications for modeling elderly depression. ( Bachurin, S; Bolkunov, A; Kubatiev, A; Malatynska, E; Redkozubova, O; Steinbusch, HW; Strekalova, T; Vignisse, J; Yeritsyan, NB, 2012) |
| "Parkinson's disease is a chronic neurodegenerative disorder characterized by cardinal motor features, such as bradykinesia, but also vocal deficits (e." | 1.48 | Effects of ketamine on vocal impairment, gait changes, and anhedonia induced by bilateral 6-OHDA infusion into the substantia nigra pars compacta in rats: Therapeutic implications for Parkinson's disease. ( Andreatini, R; Bruginski, E; Campos, FR; de Almeida Soares Hocayen, P; Kanazawa, LKS; Miyoshi, E; Schwarting, RKW; Stern, CAJ; Vecchia, DD; Vital, MABF; Wendler, E; Wöhr, M, 2018) |
| " With 14-day stress, a comparison of the activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPX) and accumulation of malondialdehyde (MDA) revealed a decrease of the first two measures in susceptible, but not in resilient animals or in stressed mice chronically dosed with imipramine (7mg/kg/day)." | 1.42 | Lasting downregulation of the lipid peroxidation enzymes in the prefrontal cortex of mice susceptible to stress-induced anhedonia. ( Anokhin, K; Anthony, DC; Cline, BH; Dolgov, O; Kubatiev, A; Lesch, KP; Lysko, A; Malin, D; Schroeter, C; Steinbusch, HW; Strekalova, T, 2015) |
| "Anhedonia is a relevant symptom in depression and schizophrenia." | 1.42 | Impramine, fluoxetine and clozapine differently affected reactivity to positive and negative stimuli in a model of motivational anhedonia in rats. ( De Montis, MG; Ferrari, A; Gambarana, C; Pelliccia, T; Scheggi, S, 2015) |
| "Pneumococcal meningitis is a severe infectious disease of the central nervous system, associated with acute inflammation and might cause damage to the host, such as deafness, blindness, seizure, and learning deficits." | 1.38 | Imipramine reverses depressive-like parameters in pneumococcal meningitis survivor rats. ( Barichello, T; Cipriano, AL; Comim, CM; Costa, CS; Generoso, JS; Milioli, G; Moreira, AP; Quevedo, J; Teixeira, AL; Vilela, MC, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 19 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Faron-Górecka, A | 2 |
| Kuśmider, M | 2 |
| Szafran-Pilch, K | 1 |
| Kolasa, M | 2 |
| Żurawek, D | 2 |
| Gruca, P | 5 |
| Papp, M | 6 |
| Solich, J | 2 |
| Pabian, P | 2 |
| Dziedzicka-Wasylewska, M | 2 |
| Duric, V | 1 |
| Banasr, M | 1 |
| Franklin, T | 1 |
| Lepack, A | 1 |
| Adham, N | 2 |
| Kiss, B | 2 |
| Gyertyán, I | 2 |
| Duman, RS | 1 |
| Muñoz-Cobo, I | 2 |
| Belloch, FB | 1 |
| Díaz-Perdigón, T | 1 |
| Puerta, E | 2 |
| Tordera, RM | 2 |
| Vecchia, DD | 1 |
| Kanazawa, LKS | 1 |
| Wendler, E | 1 |
| de Almeida Soares Hocayen, P | 1 |
| Bruginski, E | 1 |
| Campos, FR | 1 |
| Stern, CAJ | 1 |
| Vital, MABF | 1 |
| Miyoshi, E | 1 |
| Wöhr, M | 1 |
| Schwarting, RKW | 1 |
| Andreatini, R | 2 |
| Romańska, I | 1 |
| Szlachta, M | 1 |
| Antkiewicz-Michaluk, L | 2 |
| Bessa, JM | 1 |
| Morais, M | 1 |
| Marques, F | 1 |
| Pinto, L | 1 |
| Palha, JA | 1 |
| Almeida, OF | 1 |
| Sousa, N | 1 |
| Kim, KS | 2 |
| Kang, YM | 1 |
| Kang, Y | 1 |
| Park, TS | 1 |
| Park, HY | 1 |
| Kim, YJ | 1 |
| Han, BS | 1 |
| Kim, CH | 1 |
| Lee, CH | 1 |
| Ardayfio, PA | 1 |
| Han, PL | 1 |
| Jung, BH | 1 |
| Cline, BH | 1 |
| Anthony, DC | 1 |
| Lysko, A | 1 |
| Dolgov, O | 1 |
| Anokhin, K | 1 |
| Schroeter, C | 1 |
| Malin, D | 1 |
| Kubatiev, A | 2 |
| Steinbusch, HW | 2 |
| Lesch, KP | 1 |
| Strekalova, T | 2 |
| Lasoń-Tyburkiewicz, M | 1 |
| Scheggi, S | 1 |
| Pelliccia, T | 1 |
| Ferrari, A | 1 |
| De Montis, MG | 1 |
| Gambarana, C | 1 |
| Freitas, AE | 1 |
| Egea, J | 1 |
| Buendia, I | 1 |
| Gómez-Rangel, V | 1 |
| Parada, E | 1 |
| Navarro, E | 1 |
| Casas, AI | 1 |
| Wojnicz, A | 1 |
| Ortiz, JA | 1 |
| Cuadrado, A | 1 |
| Ruiz-Nuño, A | 1 |
| Rodrigues, ALS | 1 |
| Lopez, MG | 1 |
| Erburu, M | 1 |
| Cajaleon, L | 1 |
| Guruceaga, E | 1 |
| Venzala, E | 1 |
| Beltrán, E | 1 |
| Rossetti, AC | 1 |
| Paladini, MS | 1 |
| Racagni, G | 1 |
| Riva, MA | 1 |
| Molteni, R | 1 |
| Duda, W | 1 |
| Curzytek, K | 1 |
| Kubera, M | 1 |
| Iciek, M | 1 |
| Kowalczyk-Pachel, D | 1 |
| Bilska-Wilkosz, A | 1 |
| Lorenc-Koci, E | 1 |
| Leśkiewicz, M | 1 |
| Basta-Kaim, A | 1 |
| Budziszewska, B | 1 |
| Regulska, M | 1 |
| Ślusarczyk, J | 1 |
| Maes, M | 1 |
| Lasoń, W | 1 |
| Kasahara, J | 1 |
| Uchida, H | 1 |
| Tezuka, K | 1 |
| Oka, N | 1 |
| Martynhak, BJ | 1 |
| Hogben, AL | 1 |
| Zanos, P | 1 |
| Georgiou, P | 1 |
| Kitchen, I | 1 |
| Archer, SN | 1 |
| von Schantz, M | 1 |
| Bailey, A | 1 |
| van der Veen, DR | 1 |
| Marston, HM | 1 |
| Martin, FD | 1 |
| Gold, L | 1 |
| Wong, EH | 1 |
| Shahid, M | 1 |
| Barichello, T | 1 |
| Milioli, G | 1 |
| Generoso, JS | 1 |
| Cipriano, AL | 1 |
| Costa, CS | 1 |
| Moreira, AP | 1 |
| Vilela, MC | 1 |
| Comim, CM | 1 |
| Teixeira, AL | 1 |
| Quevedo, J | 1 |
| Malatynska, E | 1 |
| Redkozubova, O | 1 |
| Bolkunov, A | 1 |
| Yeritsyan, NB | 1 |
| Vignisse, J | 1 |
| Bachurin, S | 1 |
19 other studies available for imipramine and Anhedonia
| Article | Year |
|---|---|
Basal prolactin levels in rat plasma correlates with response to antidepressant treatment in animal model of depression.
Topics: Anhedonia; Animals; Antidepressive Agents; Depression; Imipramine; Male; Prolactin; Rats; Stress, Ps | 2017 |
Cariprazine Exhibits Anxiolytic and Dopamine D3 Receptor-Dependent Antidepressant Effects in the Chronic Stress Model.
Topics: Anhedonia; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Aripiprazole; Chronic Disea | 2017 |
SIRT2 inhibition reverses anhedonia in the VGLUT1+/- depression model.
Topics: Anhedonia; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Glutamic Acid; Histon | 2017 |
Effects of ketamine on vocal impairment, gait changes, and anhedonia induced by bilateral 6-OHDA infusion into the substantia nigra pars compacta in rats: Therapeutic implications for Parkinson's disease.
Topics: Anhedonia; Animals; Depression; Disease Models, Animal; Gait; Imipramine; Ketamine; Male; Nerve Dege | 2018 |
Regulation of somatostatin receptor 2 in the context of antidepressant treatment response in chronic mild stress in rat.
Topics: Anhedonia; Animals; Antidepressive Agents; Autoradiography; Brain; Depression; Disease Models, Anima | 2018 |
Stress-induced anhedonia is associated with hypertrophy of medium spiny neurons of the nucleus accumbens.
Topics: Anhedonia; Animals; Antidepressive Agents; Behavior, Animal; Fluoxetine; Hypertrophy; Imipramine; Ma | 2013 |
Pitx3 deficient mice as a genetic animal model of co-morbid depressive disorder and parkinsonism.
Topics: Anhedonia; Animals; Antidepressive Agents; Brain; Comorbidity; Corticosterone; Depressive Disorder; | 2014 |
Lasting downregulation of the lipid peroxidation enzymes in the prefrontal cortex of mice susceptible to stress-induced anhedonia.
Topics: Aggression; Anhedonia; Animals; Catalase; Down-Regulation; Food Preferences; Gene Expression Profili | 2015 |
Attenuation of anhedonia by cariprazine in the chronic mild stress model of depression.
Topics: Anhedonia; Animals; Antidepressive Agents; Aripiprazole; Chronic Disease; Depressive Disorder; Dieta | 2014 |
Impramine, fluoxetine and clozapine differently affected reactivity to positive and negative stimuli in a model of motivational anhedonia in rats.
Topics: Anhedonia; Animals; Antidepressive Agents; Antipsychotic Agents; Clozapine; Dietary Sucrose; Disease | 2015 |
Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice.
Topics: Agmatine; Anhedonia; Animals; Antidepressive Agents; Astrocytes; Behavior, Animal; Biomarkers; Corti | 2016 |
Chronic mild stress and imipramine treatment elicit opposite changes in behavior and in gene expression in the mouse prefrontal cortex.
Topics: Anhedonia; Animals; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; Circadian Rhythm; G | 2015 |
Stress-induced anhedonia is associated with the activation of the inflammatory system in the rat brain: Restorative effect of pharmacological intervention.
Topics: Acetamides; Anhedonia; Animals; Antidepressive Agents; Antipsychotic Agents; Brain; CD11b Antigen; C | 2016 |
The Effect of Chronic Mild Stress and Imipramine on the Markers of Oxidative Stress and Antioxidant System in Rat Liver.
Topics: Analysis of Variance; Anhedonia; Animals; Antidepressive Agents, Tricyclic; Antioxidants; Dietary Su | 2016 |
Postischemic Anhedonia Associated with Neurodegenerative Changes in the Hippocampal Dentate Gyrus of Rats.
Topics: Anhedonia; Animals; Antidepressive Agents; Brain Ischemia; Cell Proliferation; Dentate Gyrus; Diseas | 2016 |
Transient anhedonia phenotype and altered circadian timing of behaviour during night-time dim light exposure in Per3
Topics: Anhedonia; Animals; Brain-Derived Neurotrophic Factor; Circadian Clocks; Circadian Rhythm; Gene Expr | 2017 |
Attenuation of chronic mild stress-induced 'anhedonia' by asenapine is not associated with a 'hedonic' profile in intracranial self-stimulation.
Topics: Anhedonia; Animals; Antipsychotic Agents; Benzodiazepines; Brain; Chronic Disease; Dibenzocyclohepte | 2011 |
Imipramine reverses depressive-like parameters in pneumococcal meningitis survivor rats.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Anhedonia; Animals; Antidepressive Agents, Tricyclic; B | 2012 |
Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL/6 mice: Implications for modeling elderly depression.
Topics: Aging; Anhedonia; Animals; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; Depressive D | 2012 |