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gamma-aminobutyric acid and Anhedonia

gamma-aminobutyric acid has been researched along with Anhedonia in 6 studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Anhedonia: Inability to experience pleasure due to impairment or dysfunction of normal psychological and neurobiological mechanisms. It is a symptom of many PSYCHOTIC DISORDERS (e.g., DEPRESSIVE DISORDER, MAJOR; and SCHIZOPHRENIA).

Research Excerpts

ExcerptRelevanceReference
"Anhedonia was induced by chronic stress in male mice and assayed by preferences for sucrose and female urine (n = 5-7 mice/group)."8.12Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at α5 Subunit-Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice. ( Georgiou, P; Gould, TD; Rudolph, U; Thompson, SM; Troppoli, TA; Zanos, P, 2022)
"Anhedonia was induced by chronic stress in male mice and assayed by preferences for sucrose and female urine (n = 5-7 mice/group)."5.72Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at α5 Subunit-Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice. ( Georgiou, P; Gould, TD; Rudolph, U; Thompson, SM; Troppoli, TA; Zanos, P, 2022)
"Anhedonia was induced by chronic stress in male mice and assayed by preferences for sucrose and female urine (n = 5-7 mice/group)."4.12Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at α5 Subunit-Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice. ( Georgiou, P; Gould, TD; Rudolph, U; Thompson, SM; Troppoli, TA; Zanos, P, 2022)
" We assessed fluoxetine's effects on motivated behaviors in pubescent female hamsters - anhedonia in the reward investigational preference (RIP) test as well as anxiety in the anxiety-related feeding/exploration conflict (AFEC) test."3.83Fluoxetine disrupts motivation and GABAergic signaling in adolescent female hamsters. ( DuBois, DW; Fincher, AS; Frye, GD; Henry, MM; Morgan, C; Shannonhouse, JL; Vela, AM; Wellman, PJ, 2016)
"Anhedonia was induced by chronic stress in male mice and assayed by preferences for sucrose and female urine (n = 5-7 mice/group)."1.72Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at α5 Subunit-Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice. ( Georgiou, P; Gould, TD; Rudolph, U; Thompson, SM; Troppoli, TA; Zanos, P, 2022)
"Anhedonia, a core symptom of major depressive disorder (MDD) and highly variable among adolescents with MDD, may involve alterations in the major inhibitory amino acid neurotransmitter system of γ-aminobutyric acid (GABA)."1.38Anterior cingulate cortex γ-aminobutyric acid in depressed adolescents: relationship to anhedonia. ( Alonso, CM; Babb, JS; Ely, BA; Gabbay, V; Klein, RG; Mao, X; Panzer, AM; Shungu, DC, 2012)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (83.33)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Troppoli, TA1
Zanos, P1
Georgiou, P1
Gould, TD1
Rudolph, U1
Thompson, SM1
Ho, YC1
Lin, TB1
Hsieh, MC1
Lai, CY1
Chou, D1
Chau, YP1
Chen, GD1
Peng, HY1
Gabbay, V2
Bradley, KA1
Mao, X2
Ostrover, R1
Kang, G1
Shungu, DC2
Shao, B1
Zhou, YL1
Wang, H1
Lin, YS1
Shannonhouse, JL1
DuBois, DW1
Fincher, AS1
Vela, AM1
Henry, MM1
Wellman, PJ1
Frye, GD1
Morgan, C1
Klein, RG1
Ely, BA1
Babb, JS1
Panzer, AM1
Alonso, CM1

Other Studies

6 other studies available for gamma-aminobutyric acid and Anhedonia

ArticleYear
Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at α5 Subunit-Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice.
    Biological psychiatry, 2022, 08-01, Volume: 92, Issue:3

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anhedonia; Animals; Benzodiazepines; Femal

2022
Periaqueductal Gray Glutamatergic Transmission Governs Chronic Stress-Induced Depression.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, Volume: 43, Issue:2

    Topics: Anhedonia; Animals; Behavior, Animal; Depression; Disease Models, Animal; gamma-Aminobutyric Acid; G

2018
Anterior cingulate cortex γ-aminobutyric acid deficits in youth with depression.
    Translational psychiatry, 2017, 08-22, Volume: 7, Issue:8

    Topics: Adolescent; Anhedonia; Brain; Child; Depression; Depressive Disorder, Major; Female; gamma-Aminobuty

2017
The role of calcitonin gene-related peptide in post-stroke depression in chronic mild stress-treated ischemic rats.
    Physiology & behavior, 2015, Volume: 139

    Topics: Anhedonia; Animals; Antidepressive Agents; Brain Ischemia; Calcitonin Gene-Related Peptide; Chronic

2015
Fluoxetine disrupts motivation and GABAergic signaling in adolescent female hamsters.
    Progress in neuro-psychopharmacology & biological psychiatry, 2016, 08-01, Volume: 69

    Topics: Anhedonia; Animals; Anxiety; Brain-Derived Neurotrophic Factor; Conflict, Psychological; Cricetinae;

2016
Anterior cingulate cortex γ-aminobutyric acid in depressed adolescents: relationship to anhedonia.
    Archives of general psychiatry, 2012, Volume: 69, Issue:2

    Topics: Adolescent; Anhedonia; Case-Control Studies; Child; Cross-Sectional Studies; Depressive Disorder, Ma

2012