| Assay ID | Title | Year | Journal | Article |
|---|
| AID137213 | Antitumor activity against leukemia P388/DX cells at 6.3 mg/kg/day expressed as mean survival of treated mice (T) to untreated (C) was reported | 1987 | Journal of medicinal chemistry, Sep, Volume: 30, Issue:9
| Improved synthesis and antitumor activity of 1-deazaadenosine. |
| AID130613 | The compound was tested in vitro for antitumor activity(50% inhibition of tumor cell growth) against the P388/doxorubicin resistant murine cell lines after 72 hours | 1987 | Journal of medicinal chemistry, Sep, Volume: 30, Issue:9
| Improved synthesis and antitumor activity of 1-deazaadenosine. |
| AID30328 | Maximal inhibition of adenylate cyclase activity relative to R-PIA for Adenosine A1 receptor (Inhibition by R-PIA=53+/-10%) | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives. |
| AID93850 | The compound was tested in vitro for antitumor activity(50% inhibition of tumor cell growth) against KB human cell lines after 72 hr | 1987 | Journal of medicinal chemistry, Sep, Volume: 30, Issue:9
| Improved synthesis and antitumor activity of 1-deazaadenosine. |
| AID233029 | A1 selectivity as ratio of EC50 at A2 receptor to IC50 at A1 receptor | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives. |
| AID84236 | 50% effective concentration required to reduce herpes simplex virus-1 (HSV- (TK) B2006 strain)-induced cytopathicity | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues. |
| AID97475 | Antitumor activity against leukemia L1210 cells at 25.0 mg/kg/day expressed as mean survival of treated mice (T) to untreated (C) was reported | 1987 | Journal of medicinal chemistry, Sep, Volume: 30, Issue:9
| Improved synthesis and antitumor activity of 1-deazaadenosine. |
| AID100508 | The compound was tested in vitro for antitumor activity(50% inhibition of tumor cell growth) against the L1210 murine cell lines after 72 hours | 1987 | Journal of medicinal chemistry, Sep, Volume: 30, Issue:9
| Improved synthesis and antitumor activity of 1-deazaadenosine. |
| AID30791 | Maximal stimulation of adenylate cyclase activity relative to NECA for A2-receptor. (Stimulation by NECA=250+/-30%) | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives. |
| AID137211 | Antitumor activity against leukemia P388/DX cells at 3.1 mg/kg/day expressed as mean survival of treated mice (T) to untreated (C) was reported | 1987 | Journal of medicinal chemistry, Sep, Volume: 30, Issue:9
| Improved synthesis and antitumor activity of 1-deazaadenosine. |
| AID155643 | Percentage of apoptotic cells in human peripheral blood mononuclear cells after 72 hour incubation at the concentration 1 uM | 1998 | Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
| Modulation of apoptosis in human lymphocytes by adenosine analogues. |
| AID87474 | The compound was tested in vitro for antitumor activity(50% inhibition of tumor cell growth) against HeLa human cell lines after 144 hr | 1987 | Journal of medicinal chemistry, Sep, Volume: 30, Issue:9
| Improved synthesis and antitumor activity of 1-deazaadenosine. |
| AID84237 | 50% effective concentration required to reduce herpes simplex virus-1 (HSV- (TK) VMW 1837 strain)-induced cytopathicity | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues. |
| AID87475 | The compound was tested in vitro for antitumor activity(50% inhibition of tumor cell growth) against HeLa human cell lines after 72 hr | 1987 | Journal of medicinal chemistry, Sep, Volume: 30, Issue:9
| Improved synthesis and antitumor activity of 1-deazaadenosine. |
| AID97233 | Antitumor activity against leukemia L1210 cells at 25.0 mg/kg/day expressed as Number of mice died for toxicity to number of treated mice; 6/10 mice | 1987 | Journal of medicinal chemistry, Sep, Volume: 30, Issue:9
| Improved synthesis and antitumor activity of 1-deazaadenosine. |
| AID218511 | Effective concentration required to reduce reovirus-1-induced cytopathicity in vero cells | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues. |
| AID554264 | Inhibition of adenosine deaminase | 2011 | Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
| Investigations into the origin of the molecular recognition of several adenosine deaminase inhibitors. |
| AID44801 | In vitro evaluation of anti-HIV-1 activity in C8166 cells infected with HIV-1 IIIB. | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
| Synthesis and biological evaluation of N6-cycloalkyl derivatives of 1-deazaadenine nucleosides: a new class of anti-human immunodeficiency virus agents. |
| AID31414 | Inhibition of Adenylate cyclase activity in rat fat cell membrane at adenosine A1 receptor | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives. |
| AID126731 | Antitumor activity against leukemia P388/DX cells at 6.3 mg/kg/day expressed as toxic deaths in mice was reported; 0/10 mice | 1987 | Journal of medicinal chemistry, Sep, Volume: 30, Issue:9
| Improved synthesis and antitumor activity of 1-deazaadenosine. |
| AID97476 | Antitumor activity against leukemia L1210 cells at 6.3 mg/kg/day expressed as mean survival of treated mice (T) to untreated (C) was reported | 1987 | Journal of medicinal chemistry, Sep, Volume: 30, Issue:9
| Improved synthesis and antitumor activity of 1-deazaadenosine. |
| AID84792 | 50% effective concentration required to reduce herpes simplex virus-2 (HSV-2 G strain)-induced cytopathicity | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues. |
| AID126727 | Antitumor activity against leukemia P388/DX cells at 12.5 mg/kg/day expressed as toxic deaths in mice was reported; 0/10 mice | 1987 | Journal of medicinal chemistry, Sep, Volume: 30, Issue:9
| Improved synthesis and antitumor activity of 1-deazaadenosine. |
| AID97234 | Antitumor activity against leukemia L1210 cells at 6.3 mg/kg/day expressed as Number of mice died for toxicity to number of treated mice; 0/10 mice | 1987 | Journal of medicinal chemistry, Sep, Volume: 30, Issue:9
| Improved synthesis and antitumor activity of 1-deazaadenosine. |
| AID33657 | Binding affinity against calf intestine adenosine deaminase enzyme | 1984 | Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
| Adenosine deaminase inhibitors. Synthesis of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine. |
| AID63602 | Minimum inhibitory concentration required to effect a microscopically visible change of cell morphology in human embryonic skin-muscle (E6SM) cell culture. | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues. |
| AID30634 | Stimulation of adenylate cyclase activity in human platelet membrane at A2 receptor | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives. |
| AID218509 | Effective concentration required to reduce coxsackie virus B4-induced cytopathicity in vero cells | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues. |
| AID218513 | Effective concentration required to reduce vesicular stomatitis virus (VSV)-induced cytopathicity in vero cells | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues. |
| AID85883 | 50% effective concentration required to reduce herpes simplex virus-1 (HSV-1 KOS strain)-induced cytopathicity | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues. |
| AID32182 | Displacement of [3H]PIA from adenosine A1 receptor of rat brain membranes | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives. |
| AID33665 | Inhibition calf intestine adenosine deaminase | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
| Synthesis and biological evaluation of N6-cycloalkyl derivatives of 1-deazaadenine nucleosides: a new class of anti-human immunodeficiency virus agents. |
| AID217975 | 50% effective concentration required to reduce vaccinia virus-induced cytopathicity | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues. |
| AID33682 | Inhibitory activity against adenosine deaminase | 1997 | Journal of medicinal chemistry, Oct-10, Volume: 40, Issue:21
| Effect of a chemical modification on the hydrated adenosine intermediate produced by adenosine deaminase and a model reaction for a potential mechanism of action of 5-aminoimidazole ribonucleotide carboxylase. |
| AID33677 | Inhibition of calf intestinal adenosine deaminase | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Adenosine deaminase inhibitors: synthesis and structure-activity relationships of imidazole analogues of erythro-9-(2-hydroxy-3-nonyl)adenine. |
| AID152592 | The compound was tested in vitro for antitumor activity(50% inhibition of tumor cell growth) against the P388 murine cell lines after 72 hours | 1987 | Journal of medicinal chemistry, Sep, Volume: 30, Issue:9
| Improved synthesis and antitumor activity of 1-deazaadenosine. |
| AID225762 | Concentration that inhibits platelet aggregation induced by ADP (7 uM) by 50% | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives. |
| AID155782 | Percentage of apoptotic cells in human peripheral blood mononuclear cells after 72 hour incubation at the concentration 60 uM | 1998 | Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
| Modulation of apoptosis in human lymphocytes by adenosine analogues. |
| AID97474 | Antitumor activity against leukemia L1210 cells at 12.5 mg/kg/day expressed as mean survival of treated mice (T) to untreated (C) was reported | 1987 | Journal of medicinal chemistry, Sep, Volume: 30, Issue:9
| Improved synthesis and antitumor activity of 1-deazaadenosine. |
| AID44812 | In vitro evaluation of cytotoxicity in C8166 cells infected with HIV-1 IIIB. | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20
| Synthesis and biological evaluation of N6-cycloalkyl derivatives of 1-deazaadenine nucleosides: a new class of anti-human immunodeficiency virus agents. |
| AID97232 | Antitumor activity against leukemia L1210 cells at 12.5 mg/kg/day expressed as Number of mice died for toxicity to number of treated mice; 0/10 mice | 1987 | Journal of medicinal chemistry, Sep, Volume: 30, Issue:9
| Improved synthesis and antitumor activity of 1-deazaadenosine. |
| AID137209 | Antitumor activity against leukemia P388/DX cells at 12.5 mg/kg/day expressed as mean survival of treated mice (T) to untreated (C) was reported | 1987 | Journal of medicinal chemistry, Sep, Volume: 30, Issue:9
| Improved synthesis and antitumor activity of 1-deazaadenosine. |
| AID126729 | Antitumor activity against leukemia P388/DX cells at 3.1 mg/kg/day expressed as toxic deaths in mice was reported; 0/10 mice | 1987 | Journal of medicinal chemistry, Sep, Volume: 30, Issue:9
| Improved synthesis and antitumor activity of 1-deazaadenosine. |
| AID93849 | The compound was tested in vitro for antitumor activity(50% inhibition of tumor cell growth) against KB human cell lines after 144 hr | 1987 | Journal of medicinal chemistry, Sep, Volume: 30, Issue:9
| Improved synthesis and antitumor activity of 1-deazaadenosine. |
| AID155644 | Percentage of apoptotic cells in human peripheral blood mononuclear cells after 72 hour incubation at the concentration 10 uM | 1998 | Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
| Modulation of apoptosis in human lymphocytes by adenosine analogues. |
| AID233030 | A1 selectivity as ratio of Ki for A2 receptor to Ki for A1 receptor | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives. |
| AID155645 | Percentage of apoptotic cells in human peripheral blood mononuclear cells after 72 hour incubation at the concentration 30 uM | 1998 | Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
| Modulation of apoptosis in human lymphocytes by adenosine analogues. |
| AID218510 | Effective concentration required to reduce parainfluenza-3-induced cytopathicity in vero cells | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues. |
| AID218512 | Effective concentration required to reduce sindbis virus-induced cytopathicity in vero cells | 1997 | Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
| Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues. |
| AID30656 | Displacement of [3H]NECA from A2-receptor of rat striatal membranes | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1802102 | Radioligand Binding Assay from Article 10.1021/acschembio.6b00357: \\Structure-Based Screening of Uncharted Chemical Space for Atypical Adenosine Receptor Agonists\\ | 2016 | ACS chemical biology, 10-21, Volume: 11, Issue:10
| Structure-Based Screening of Uncharted Chemical Space for Atypical Adenosine Receptor Agonists. |
| AID1811 | Experimentally measured binding affinity data derived from PDB | 1993 | Biochemistry, Feb-23, Volume: 32, Issue:7
| A pre-transition-state mimic of an enzyme: X-ray structure of adenosine deaminase with bound 1-deazaadenosine and zinc-activated water. |
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 1993 | Biochemistry, Feb-23, Volume: 32, Issue:7
| A pre-transition-state mimic of an enzyme: X-ray structure of adenosine deaminase with bound 1-deazaadenosine and zinc-activated water. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |