brivudine and Pruritus

brivudine has been researched along with Pruritus* in 1 studies

Other Studies

1 other study(ies) available for brivudine and Pruritus

Article	Year
Chemotherapy of Aujeszky's disease (pseudorabies) in the mouse by means of nucleoside analogues: bromovinyldeoxyuridine, acyclovir, and dihydroxypropoxymethylguanine. Antiviral research, 1985, Volume: 5, Issue:3 Pseudorabies virus (PRV) infection was established in mice by means of inoculating the ear flap. The infection was universally fatal once clinical signs appeared. Bromovinyldeoxyuridine (BVDU) was a potent inhibitor of PRV in vitro, but this drug failed to protect mice and produced only marginal reductions in virus titre and slight prolongation of survival. Acyclovir (ACV) and dihydroxypropoxymethylguanine (DHPG) were both less active than BVDU when tested against the virus in BHK cells, yet DHPG therapy was extremely effective in mice; it reduced virus titres markedly and resulted in the long-term survival of mice given a potentially lethal infection. When ACV and DHPG were tested in vitro using murine rather than hamster cells, these compounds, especially DHPG, were shown to be much more active against PRV. Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Cells, Cultured; Cricetinae; Female; Ganciclovir; Herpesvirus 1, Suid; Mice; Mice, Inbred BALB C; Pruritus; Pseudorabies; Time Factors; Viral Plaque Assay	1985

Article

Year

Chemotherapy of Aujeszky's disease (pseudorabies) in the mouse by means of nucleoside analogues: bromovinyldeoxyuridine, acyclovir, and dihydroxypropoxymethylguanine.

Antiviral research, 1985, Volume: 5, Issue:3

Pseudorabies virus (PRV) infection was established in mice by means of inoculating the ear flap. The infection was universally fatal once clinical signs appeared. Bromovinyldeoxyuridine (BVDU) was a potent inhibitor of PRV in vitro, but this drug failed to protect mice and produced only marginal reductions in virus titre and slight prolongation of survival. Acyclovir (ACV) and dihydroxypropoxymethylguanine (DHPG) were both less active than BVDU when tested against the virus in BHK cells, yet DHPG therapy was extremely effective in mice; it reduced virus titres markedly and resulted in the long-term survival of mice given a potentially lethal infection. When ACV and DHPG were tested in vitro using murine rather than hamster cells, these compounds, especially DHPG, were shown to be much more active against PRV.

Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Cells, Cultured; Cricetinae; Female; Ganciclovir; Herpesvirus 1, Suid; Mice; Mice, Inbred BALB C; Pruritus; Pseudorabies; Time Factors; Viral Plaque Assay

1985