Page last updated: 2024-09-28

Acute Retinal Necrosis

Mild to fulminant necrotizing vaso-occlusive retinitis associated with a high incidence of retinal detachment and poor vision outcome.

Synonyms(2)

Synonym
Acute Retinal Necrosis
Retinal Necrosis Syndrome, Acute

Research Excerpts

Overview

ExcerptReference
"Acute retinal necrosis is a severe form of necrotizing retinitis."( Culbertson, WW; Robertson, JE; Rosenbaum, JT; Smiddy, WE; Thompson, WS, 1994)
"Acute retinal necrosis is a severe complication and potentially blinding disease of herpes zoster, and can occur in association with herpes zoster immunization, in particular, in immune suppressed patients."( Balaratnasingam, C; Constable, IJ; Menghini, M; Raiter, J; Raja, V, 2021)
"Acute retinal necrosis is considered a rare infectious uveitis."( Ahmadraji, A; Cheraqpour, K; Irannejad, M; Rashidinia, A; Shahriari, M, 2021)
"Acute retinal necrosis is a rare necrotizing retinitis."( Anwarzai, J; Krásnik, V; Šulavíková, Z, 2022)
"Acute retinal necrosis is a rare, sight-threatening condition typically found in immunocompromised patients and is most commonly caused by varicella zoster virus."( Kamo, SF; Marquez, MA; Tran, NT, 2022)

Context

ExcerptReference
"Acute retinal necrosis has been demonstrated to be caused by varicella-zoster virus and herpes simplex virus type 1."( Culbertson, WW; Robertson, JE; Rosenbaum, JT; Smiddy, WE; Thompson, WS, 1994)

Treatment

ExcerptReference
"To document a case of acute retinal necrosis syndrome in an immunocompetent patient who was successfully treated with famciclovir after unsuccessful treatment with acyclovir."( Figueroa, MS; Fortun, J; Garabito, I; Gutierrez, C, 1997)
"After diagnosing acute retinal necrosis syndrome in the patient's left eye, we treated him with 13 mg/kg/24 hours of intravenous acyclovir in three daily doses for 14 days, followed by 800 mg of acyclovir five times per day orally."( Figueroa, MS; Fortun, J; Garabito, I; Gutierrez, C, 1997)
"Famciclovir can effectively treat acute retinal necrosis syndrome in immunocompetent patients."( Figueroa, MS; Fortun, J; Garabito, I; Gutierrez, C, 1997)

Research

Studies (270)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (0.37)23.3326
1990's68 (25.19)12.5806
2000's82 (30.37)18.1394
2010's88 (32.59)28.8240
2020's31 (11.48)9.53
DrugIndicatedRelationship StrengthStudiesTrials
cytosine0low20
dimethyl sulfoxide0low10
aspirin0low50
azathioprine0low10
cefuroxime0low10
chlorambucil0low10
chloroquine0low10
cyclopentolate0low20
brl 428100low100
foscarnet0low360
2-propanol0low10
ketoconazole0low10
mebendazole0low10
pyrimethamine0low30
sulfadiazine0low20
prednisolone0low230
prednisolone acetate0low30
prednisone0low130
methylprednisolone acetate0low10
penicillin g0low30
bromodeoxyuridine0low20
cytarabine0low10
valine0low320
triamcinolone acetonide0low90
methylprednisolone0low80
benzathine0low10
2-aminopurine0low100
methylprednisolone hemisuccinate0low10
streptomycin0low10
vidarabine0low10
levamisole0low10
triamcinolone0low10
timolol0low10
etoposide0low10
propiconazole0low10
itraconazole0low10
cidofovir anhydrous0low20
chloroquine diphosphate0low10
tetrandrine0low10
atropine0low10
organophosphonates0low20
trimethoprim, sulfamethoxazole drug combination0low20
leupeptins0low10
acetylleucyl-leucyl-norleucinal0low10
mycophenolic acid0low20
clindamycin0low20
brivudine0low20
fludarabine0low10
sorivudine0low30
sirolimus0low10
indocyanine green0low30
arabinofuranosyluracil0low30
phosphatidylcholines0low20
flucloronide0low10
calpain0low10
ro13-99040low10
almagate0low10
agar0low10
acyclovir0medium1610
ganciclovir0medium531
valacyclovir0low480
valganciclovir0low70
eye0low110

Protein Targets (899)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Beta-lactamase6006
thioredoxin reductase140014
aldehyde dehydrogenase 1 family, member A1130013
IDH1130013
Phosphatidylinositol 4-kinase alpha0202
Xanthine dehydrogenase/oxidase0101
Guanine nucleotide-binding protein G3003
TAR DNA-binding protein 435005
Phosphatidylinositol 4-kinase type 2-beta0202
Phosphatidylinositol 4-kinase type 2-alpha0202
Phosphatidylinositol 4-kinase beta0202
hypoxia-inducible factor 1 alpha subunit6006
RAR-related orphan receptor gamma150015
GLI family zinc finger 3170017
AR protein240024
retinoic acid nuclear receptor alpha variant 1150015
retinoid X nuclear receptor alpha140014
estrogen nuclear receptor alpha230023
peroxisome proliferator-activated receptor delta100010
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a140014
activating transcription factor 67007
v-jun sarcoma virus 17 oncogene homolog (avian)8008
Histone H2A.x100010
thyroid hormone receptor beta isoform a3003
heat shock protein beta-16006
nuclear factor erythroid 2-related factor 2 isoform 1150015
lamin isoform A-delta10150015
Voltage-dependent calcium channel gamma-2 subunit120012
Glutamate receptor 2121013
Chain A, Cruzipain3003
TDP1 protein240024
nuclear receptor ROR-gamma isoform 16006
survival motor neuron protein isoform d9009
Calpain small subunit 10101
Calpain-1 catalytic subunit0101
Cathepsin B0101
ATP-dependent translocase ABCB10507
Replicase polyprotein 1ab0213
Replicase polyprotein 1ab0314
Calpain-1 catalytic subunit0101
Inositol monophosphatase 12002
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein8008
Chain B, HADH2 protein8008
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Ferritin light chain4004
Thymidine kinase 0404
phosphopantetheinyl transferase5005
GLS protein4004
Smad36006
thyroid stimulating hormone receptor4004
EWS/FLI fusion protein140014
arylsulfatase A6006
euchromatic histone-lysine N-methyltransferase 2160016
Bloom syndrome protein isoform 18008
hemoglobin subunit beta2002
atrial natriuretic peptide receptor 1 precursor2002
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
Solute carrier family 22 member 1 0305
ATP-binding cassette sub-family C member 3019019
Multidrug resistance-associated protein 4019020
Solute carrier family 22 member 60204
Bile salt export pump0505
Bile salt export pump024024
Purine nucleoside phosphorylase0101
Thymidine kinase, cytosolic0406
POU domain, class 2, transcription factor 20002
Cytochrome P450 2C9 0606
Cytochrome P450 2J20303
Disintegrin and metalloproteinase domain-containing protein 172002
Purine nucleoside phosphorylase0022
Solute carrier family 22 member 60105
Thymidine kinase 0101
Solute carrier family 22 member 80104
Canalicular multispecific organic anion transporter 1020021
Thymidine kinase0404
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE9009
Chain A, TYROSYL-DNA PHOSPHODIESTERASE8008
Chain A, Phospholipase A2 isoform 30011
Chain A, 2-oxoglutarate Oxygenase6006
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 84004
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 4100010
glucocorticoid receptor [Homo sapiens]170017
estrogen-related nuclear receptor alpha180018
cytochrome P450 2D67007
glucocerebrosidase1001
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 14004
DNA polymerase iota isoform a (long)100010
DNA polymerase kappa isoform 13003
muscarinic acetylcholine receptor M15005
lethal factor (plasmid)3003
Prostaglandin-H2 D-isomerase0101
Prostaglandin G/H synthase 1 0202
Prostaglandin G/H synthase 2 0202
Epidermal growth factor receptor0112
Carbonic anhydrase 10405
Carbonic anhydrase 20516
Fatty acid-binding protein, liver0202
Integrin beta-32103
Myeloperoxidase0101
Prostaglandin G/H synthase 10101
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb2103
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10202
Adenosine receptor A10101
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin G/H synthase 20303
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma6006
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-16118
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Sigma non-opioid intracellular receptor 10112
Sigma non-opioid intracellular receptor 10011
nuclear receptor subfamily 1, group I, member 3150015
pregnane X nuclear receptor140014
cystic fibrosis transmembrane conductance regulator0101
DNA polymerase beta2002
short transient receptor potential channel 6 isoform 10011
5-hydroxytryptamine receptor 40202
Muscarinic acetylcholine receptor M20519
Muscarinic acetylcholine receptor M40316
Muscarinic acetylcholine receptor M10316
Muscarinic acetylcholine receptor M30316
Muscarinic acetylcholine receptor M40316
Muscarinic acetylcholine receptor M50316
Muscarinic acetylcholine receptor M50316
Muscarinic acetylcholine receptor M20317
Muscarinic acetylcholine receptor M10317
Muscarinic acetylcholine receptor M10001
Muscarinic acetylcholine receptor M30316
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2C0202
Muscarinic acetylcholine receptor M40101
Histamine H2 receptor3004
5-hydroxytryptamine receptor 70101
Reverse transcriptase/RNaseH 0113
Muscarinic acetylcholine receptor0112
acetylcholinesterase5005
SMAD family member 28008
ATAD5 protein, partial6006
Fumarate hydratase6006
SMAD family member 38008
Microtubule-associated protein tau5005
thioredoxin glutathione reductase5005
farnesoid X nuclear receptor7007
G5005
polyprotein6006
P531001
peroxisome proliferator activated receptor gamma6006
aryl hydrocarbon receptor6006
thyroid stimulating hormone receptor3003
peripheral myelin protein 22 isoform 14004
cellular tumor antigen p53 isoform a5005
thyroid hormone receptor beta isoform 2150015
geminin200020
peripheral myelin protein 22100010
cytochrome P450 3A4 isoform 16006
M-phase phosphoprotein 82002
muscleblind-like protein 1 isoform 15005
Gamma-aminobutyric acid receptor subunit pi6017
Interferon beta110011
HLA class I histocompatibility antigen, B alpha chain 5005
Cellular tumor antigen p53140014
Gamma-aminobutyric acid receptor subunit beta-16017
Gamma-aminobutyric acid receptor subunit delta6017
Gamma-aminobutyric acid receptor subunit gamma-26017
Gamma-aminobutyric acid receptor subunit alpha-56017
Gamma-aminobutyric acid receptor subunit alpha-36017
Gamma-aminobutyric acid receptor subunit gamma-16017
Gamma-aminobutyric acid receptor subunit alpha-26017
Gamma-aminobutyric acid receptor subunit alpha-46017
Gamma-aminobutyric acid receptor subunit gamma-36017
Gamma-aminobutyric acid receptor subunit alpha-66017
Gamma-aminobutyric acid receptor subunit beta-36017
Gamma-aminobutyric acid receptor subunit beta-26017
GABA theta subunit6017
Inositol hexakisphosphate kinase 15005
ATPase family AAA domain-containing protein 5130013
Ataxin-2150015
Gamma-aminobutyric acid receptor subunit epsilon6017
Protein-arginine deiminase type-40505
cytochrome P450 2C9, partial5005
neuropeptide S receptor isoform A1001
Thymidine kinase0202
relaxin receptor 1 isoform 11001
pregnane X receptor4004
progesterone receptor130013
bromodomain adjacent to zinc finger domain 2B3003
nuclear receptor subfamily 1, group I, member 27007
Nuclear hormone receptor family member daf-120011
chromobox protein homolog 1110011
nuclear factor erythroid 2-related factor 2 isoform 2140014
serine/threonine-protein kinase mTOR isoform 12002
oxysterols receptor LXR-beta isoform 10011
urokinase-type plasminogen activator precursor8008
plasminogen precursor8008
urokinase plasminogen activator surface receptor precursor8008
Thymidine phosphorylase0001
Thymidylate kinase0101
Spike glycoprotein7119
Thymidine kinase0002
Thymidylate kinase0101
Luciferase3003
NFKB1 protein, partial4004
GALC protein5005
Thrombopoietin1001
caspase 7, apoptosis-related cysteine protease2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)9009
vitamin D (1,25- dihydroxyvitamin D3) receptor9009
caspase-32002
vitamin D3 receptor isoform VDRA5005
potassium voltage-gated channel subfamily H member 2 isoform d3003
FAD-linked sulfhydryl oxidase ALR0001
Carbonic anhydrase 120101
Cytochrome P450 2D60202
Carbonic anhydrase 90202
Solute carrier organic anion transporter family member 1B30405
ATP-dependent phosphofructokinase6006
PPM1D protein4004
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
Spike glycoprotein0112
Replicase polyprotein 1ab0112
glucose-6-phosphate 1-dehydrogenase isoform b0101
flap endonuclease 14004
Transmembrane protease serine 20112
Dihydrofolate reductase 0303
DNA ligase0101
Riboflavin-binding protein0011
Major prion protein0011
Amyloid-beta precursor protein0101
Histidine-rich protein PFHRP-II0102
Procathepsin L0112
Cytochrome P450 3A40708
Alpha-2A adrenergic receptor0303
Replicase polyprotein 1a0112
Replicase polyprotein 1ab0112
Spike glycoprotein0101
Ribosyldihydronicotinamide dehydrogenase [quinone]0112
Alpha-2B adrenergic receptor0303
Alpha-2C adrenergic receptor0101
DNA ligase 10101
Serine/threonine-protein kinase mTOR0213
Nuclear receptor subfamily 4 group A member 20011
Beta-secretase 10101
Calcium-dependent protein kinase 10011
MO15-related protein kinase Pfmrk 0101
DNA ligase A0101
Potassium voltage-gated channel subfamily H member 20303
Sigma intracellular receptor 20101
Phosphoethanolamine N-methyltransferase0101
Angiotensin-converting enzyme 2 0112
Cysteine proteinase falcipain 2a 0101
Cysteine proteinase falcipain 2a 0101
endonuclease IV3003
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
glp-1 receptor, partial8008
USP1 protein, partial5005
67.9K protein8008
LMP1 [Human herpesvirus 4]0003
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0303
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
transactivating tegument protein VP16 [Human herpesvirus 1]0303
nuclear receptor coactivator 3 isoform a0303
Thymidine kinase 2, mitochondrial0303
Thymidylate synthase0203
Thymidine kinase0202
Deoxycytidine kinase0012
Probable deoxycytidylate deaminase0001
Cytidine deaminase0102
D(1A) dopamine receptor1001
E3 ubiquitin-protein ligase Mdm20101
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
Deoxynucleoside kinase0202
Deoxycytidine kinase0001
Cereblon isoform 40202
Insulin-like growth factor-binding protein 50011
Choline O-acetyltransferase 0101
Protein cereblon0202
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a6006
Prothrombin0001
Regulatory protein E20011
ATP-dependent translocase ABCB10303
DNA topoisomerase 10102
DNA topoisomerase 2-alpha0128
Polyunsaturated fatty acid lipoxygenase ALOX150202
DNA topoisomerase 20001
ATP-dependent translocase ABCB10303
UDP-glucuronosyltransferase 1A1 0103
Serum paraoxonase/arylesterase 10101
Glutamate receptor ionotropic, NMDA 1 0001
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta0129
Glutamate receptor ionotropic, NMDA 2D0001
Tubulin beta-2B chain0101
Integrase 0101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
Glutamate receptor ionotropic, NMDA 3B0001
Glutamate receptor ionotropic, NMDA 3A0001
corticotropin-releasing hormone receptor 20112
corticotropin releasing factor-binding protein0112
glycogen synthase kinase-3 beta isoform 10022
5'-nucleotidase0101
Adenosine receptor A30101
Adenosine deaminase 0002
Chain A, probable fosfomycin resistance protein0011
Chain B, probable fosfomycin resistance protein0011
DNA polymerase catalytic subunit0101
DNA polymerase catalytic subunit0101
DNA polymerase alpha catalytic subunit0101
Carbonic anhydrase 40101
DNA polymerase delta catalytic subunit0101
Carbonic anhydrase 5A, mitochondrial0101
ClpP2002
Transitional endoplasmic reticulum ATPase0101
estrogen receptor 2 (ER beta)7007
Cytochrome P450 1440011
Steroid C26-monooxygenase0011
Steroid C26-monooxygenase0011
Estrogen receptor beta0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0202
Cytochrome P450 26A10101
3',5'-cyclic-AMP phosphodiesterase 0101
Camphor 5-monooxygenase0001
Phospholipase A2, major isoenzyme0101
Chymotrypsinogen A0101
Beta-lactamase0101
Steroid 17-alpha-hydroxylase/17,20 lyase0202
Epoxide hydrolase 10001
Aldo-keto reductase family 1 member B10202
Cytochrome P450 2C11 0101
Steroid 21-hydroxylase0101
Cytochrome P450 2C80101
Aromatase0202
Steroid 17-alpha-hydroxylase/17,20 lyase 0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Cholesterol side-chain cleavage enzyme, mitochondrial 0101
5-hydroxytryptamine receptor 2A0202
Indoleamine 2,3-dioxygenase 10101
Cytochrome P450 2A20101
Cytochrome P450 11B1, mitochondrial 0202
Cytochrome P450 11B1, mitochondrial0101
Translocator protein0101
Cytochrome P450 7A1 0101
Cytochrome P450 11B2, mitochondrial0101
Estrogen receptor0101
Substance-K receptor0202
Sodium-dependent noradrenaline transporter 0202
Thromboxane-A synthase 0101
Histamine H2 receptor0202
Gonadotropin-releasing hormone receptor0112
Sodium-dependent serotonin transporter0202
Type-1 angiotensin II receptor0101
Malate dehydrogenase, cytoplasmic0101
Delta-type opioid receptor0202
Cytochrome P450 4F20101
Sodium-dependent dopamine transporter 0202
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0202
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0101
Sodium/bile acid cotransporter0101
Lanosterol 14-alpha demethylase0213
Cytochrome P450 7A10101
Lanosterol 14-alpha demethylase 0202
dopamine D1 receptor2002
Alkaline phosphatase, tissue-nonspecific isozyme0202
Alkaline phosphatase, placental type0101
Alkaline phosphatase, tissue-nonspecific isozyme 0202
Intestinal-type alkaline phosphatase0101
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
Phospholipase A-2-activating protein0101
cytochrome P450 2C9 precursor1001
histone deacetylase 9 isoform 31001
huntingtin isoform 21001
Tyrosine-protein kinase ABL10224
Methionine aminopeptidase0101
Proto-oncogene tyrosine-protein kinase Src0213
Vascular endothelial growth factor receptor 20101
Fatty-acid amide hydrolase 10101
Calmodulin-domain protein kinase 10101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
acid sphingomyelinase1001
15-lipoxygenase, partial1001
Thymidylate synthase 0101
alpha-galactosidase2002
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
transcriptional regulator ERG isoform 33003
importin subunit beta-1 isoform 12002
snurportin-12002
DNA polymerase eta isoform 11001
histone acetyltransferase KAT2A isoform 12002
caspase-1 isoform alpha precursor1001
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0405
Dihydrofolate reductase0203
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0438
Glucose-6-phosphate 1-dehydrogenase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0303
Folate receptor beta0101
Folate receptor alpha0101
Dihydrofolate reductase0404
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20022
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10202
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Dihydrofolate reductase 0101
Dihydrofolate reductase0202
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier family 22 member 110001
Broad substrate specificity ATP-binding cassette transporter ABCG20102
nonstructural protein 12002
Nuclear receptor subfamily 1 group I member 20022
Glucocorticoid receptor010217
Glycine receptor subunit alpha-1010010
Androgen receptor0303
Glycine receptor subunit beta010010
Glycine receptor subunit alpha-2010010
Glycine receptor subunit alpha-3010010
Nuclear receptor subfamily 1 group I member 20011
GTP-binding nuclear protein Ran isoform 11001
Chain A, Inosine-5'-Monophosphate Dehydrogenase 20101
UDP-glucuronosyltransferase 1A90001
Inosine-5'-monophosphate dehydrogenase 20213
Glutamate receptor 10101
Glutamate receptor 30101
Glutamate receptor 40101
Inosine-5'-monophosphate dehydrogenase 1 0202
Sodium-dependent serotonin transporter0101
Peroxisome proliferator-activated receptor gamma0011
Alpha-synuclein2002
Inosine-5'-monophosphate dehydrogenase0102
UDP-glucuronosyltransferase 1A70001
UDP-glucuronosyltransferase 1A100001
UDP-glucuronosyltransferase 1A80001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
streptokinase A precursor0022
Beta-lactamase0001
Solute carrier family 22 member 80102
Beta-lactamase0001
Beta-lactamase 10001
Beta-lactamase0001
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Beta-lactamase OXA-100001
Beta-lactamase0001
Beta-lactamase0001
Kappa-type opioid receptor0001
Solute carrier family 15 member 10304
Beta-lactamase TEM0102
Beta-lactamase0001
B2 metallo-beta-lactamase 0001
Solute carrier family 15 member 20101
Metallo-beta-lactamase VIM-130001
Beta-lactamase 0001
Beta-lactamase 0001
Efflux transporter 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Beta-lactamase 0001
Class D beta-lactamase0001
Beta-lactamase 0001
Solute carrier family 15 member 20202
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-b-lactamase 0001
Beta-lactamase IMP-1 0001
BlaVIM-1 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Beta-lactamase class B VIM-2 0001
Beta-lactamase 0001
Solute carrier family 22 member 80102
Beta-lactamase VIM-1 0001
luciferase0001
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Histamine H1 receptor0022
Nociceptin receptor0011
Estrogen receptor beta0202
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
heat shock protein HSP 90-alpha isoform 20001
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
heat shock protein 90, putative0001
cytochrome P450 2D6 isoform 12002
dual specificity protein phosphatase 30101
low molecular weight phosphotyrosine protein phosphatase isoform c0101
tyrosine-protein phosphatase non-receptor type 22 isoform 10101
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 10101
Estrogen receptor0011
Beta-hexosaminidase subunit alpha0102
Beta-hexosaminidase subunit beta0101
Substance-K receptor0101
Dihydrofolate reductase0101
Low molecular weight phosphotyrosine protein phosphatase0101
Dipeptidyl peptidase 40202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Trace amine-associated receptor 50011
Estrogen receptor beta0011
Bifunctional dihydrofolate reductase-thymidylate synthase0202
Multidrug and toxin extrusion protein 10101
Bone morphogenetic protein receptor type-1B0011
Cell division cycle 7-related protein kinase0011
Serine/threonine-protein kinase PLK40011
ATP-dependent RNA helicase DDX3X0011
Pyridoxal kinase0011
Citron Rho-interacting kinase0011
Serine/threonine-protein kinase Chk10011
Aurora kinase A0112
Cyclin-G-associated kinase0011
Ephrin type-B receptor 60011
Peroxisomal acyl-coenzyme A oxidase 30011
Receptor-interacting serine/threonine-protein kinase 20011
Mitotic checkpoint serine/threonine-protein kinase BUB10011
Dynamin-like 120 kDa protein, mitochondrial0011
Tyrosine-protein kinase JAK20011
Eukaryotic translation initiation factor 5B0011
Rho-associated protein kinase 20011
Serine/threonine-protein kinase ULK10011
Serine/threonine-protein kinase/endoribonuclease IRE10011
Ribosomal protein S6 kinase alpha-50011
U5 small nuclear ribonucleoprotein 200 kDa helicase0011
Ribosomal protein S6 kinase alpha-40011
Serine/threonine-protein kinase 160011
Cyclin-dependent kinase-like 50011
Serine/threonine-protein kinase 100011
Serine/threonine-protein kinase D30011
Structural maintenance of chromosomes protein 20011
Mitogen-activated protein kinase kinase kinase 60011
Mitogen-activated protein kinase kinase kinase kinase 40011
Serine/threonine-protein kinase LATS10011
Serine/threonine-protein kinase PAK 40011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
High affinity nerve growth factor receptor0011
ADP/ATP translocase 20011
Protein kinase C beta type0011
Insulin receptor0011
Tyrosine-protein kinase Lck0011
Tyrosine-protein kinase Fyn0011
Cyclin-dependent kinase 10011
Eukaryotic translation initiation factor 4E0011
Glycogen phosphorylase, liver form0011
Tyrosine-protein kinase Fes/Fps0011
Adenine phosphoribosyltransferase0011
Tyrosine-protein kinase Yes0011
Tyrosine-protein kinase Lyn0011
Proto-oncogene tyrosine-protein kinase receptor Ret0011
Insulin-like growth factor 1 receptor0011
Signal recognition particle receptor subunit alpha0011
Cytochrome c1, heme protein, mitochondrial0011
Hepatocyte growth factor receptor0011
Tyrosine-protein kinase HCK0011
Platelet-derived growth factor receptor beta0011
Tyrosine-protein kinase Fgr0011
Serine/threonine-protein kinase A-Raf0011
Glycogen phosphorylase, brain form0011
Breakpoint cluster region protein0011
Serine/threonine-protein kinase pim-10011
Fibroblast growth factor receptor 10011
Cyclin-dependent kinase 40011
ADP/ATP translocase 30011
cAMP-dependent protein kinase type II-alpha regulatory subunit0011
Serine/threonine-protein kinase B-raf0011
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0011
Tyrosine-protein kinase Fer0011
Protein kinase C alpha type0011
cAMP-dependent protein kinase catalytic subunit alpha0011
General transcription and DNA repair factor IIH helicase subunit XPD0011
Casein kinase II subunit alpha'0011
Ras-related protein Rab-6A0011
Ephrin type-A receptor 10011
Multifunctional protein ADE20011
cAMP-dependent protein kinase catalytic subunit beta0011
Ferrochelatase, mitochondrial0011
Ribosomal protein S6 kinase beta-10011
Tyrosine-protein kinase JAK10011
Beta-adrenergic receptor kinase 10011
Probable ATP-dependent RNA helicase DDX60011
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
Mitogen-activated protein kinase 3 0011
MAP/microtubule affinity-regulating kinase 30011
Mitogen-activated protein kinase 10011
Ephrin type-A receptor 20011
Ephrin type-B receptor 20011
Non-receptor tyrosine-protein kinase TYK20011
UMP-CMP kinase 0011
Phosphatidylethanolamine-binding protein 10011
Wee1-like protein kinase0011
Heme oxygenase 20011
S-adenosylmethionine synthase isoform type-20011
DnaJ homolog subfamily A member 10011
RAC-alpha serine/threonine-protein kinase0011
RAC-beta serine/threonine-protein kinase0011
Cytochrome P450 2C190101
Dual specificity protein kinase TTK0011
DNA replication licensing factor MCM40011
Myosin-100011
Dual specificity mitogen-activated protein kinase kinase 20011
Receptor-type tyrosine-protein kinase FLT30011
Bone morphogenetic protein receptor type-1A0011
Activin receptor type-1B0011
TGF-beta receptor type-10011
Serine/threonine-protein kinase receptor R30011
TGF-beta receptor type-20011
Electron transfer flavoprotein subunit beta0011
Tyrosine-protein kinase CSK0011
Glycine--tRNA ligase0011
Protein kinase C iota type0011
Exosome RNA helicase MTR40011
Tyrosine-protein kinase Tec0011
Tyrosine-protein kinase ABL20011
Tyrosine-protein kinase FRK0011
G protein-coupled receptor kinase 60011
Tyrosine-protein kinase SYK0011
26S proteasome regulatory subunit 6B0011
Mitogen-activated protein kinase 80011
Mitogen-activated protein kinase 90011
Dual specificity mitogen-activated protein kinase kinase 30011
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0011
Casein kinase I isoform alpha0011
Casein kinase I isoform delta0011
MAP kinase-activated protein kinase 20011
Elongation factor Tu, mitochondrial0011
Choline-phosphate cytidylyltransferase A0011
Cysteine--tRNA ligase, cytoplasmic0011
Casein kinase I isoform epsilon0011
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0011
Dual specificity protein kinase CLK10011
Dual specificity protein kinase CLK20011
Dual specificity protein kinase CLK30011
Glycogen synthase kinase-3 alpha0011
Glycogen synthase kinase-3 beta0011
Cyclin-dependent kinase 70011
Cyclin-dependent kinase 90011
Ras-related protein Rab-27A0011
Interleukin-1 receptor-associated kinase 10011
Ribosomal protein S6 kinase alpha-30011
Serine/threonine-protein kinase Nek20011
Serine/threonine-protein kinase Nek30011
Dual specificity mitogen-activated protein kinase kinase 60011
Serine/threonine-protein kinase PLK10011
LIM domain kinase 10011
LIM domain kinase 20011
Mitogen-activated protein kinase 100011
Tyrosine--tRNA ligase, cytoplasmic0011
5'-AMP-activated protein kinase subunit gamma-10011
Ephrin type-B receptor 30011
Ephrin type-A receptor 50011
Ephrin type-B receptor 40011
Ephrin type-A receptor 40011
Adenylate kinase 2, mitochondrial0011
Adenosine kinase0011
Ras-related protein Rab-100011
Actin-related protein 30011
Actin-related protein 20011
GTP-binding nuclear protein Ran0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Casein kinase I isoform gamma-20011
Cyclin-dependent kinase 60011
Cyclin-dependent-like kinase 5 0011
Cyclin-dependent kinase 160011
Cyclin-dependent kinase 170011
ATP-dependent 6-phosphofructokinase, platelet type0011
Dual specificity mitogen-activated protein kinase kinase 10011
Protein kinase C theta type0011
Activin receptor type-10011
Macrophage-stimulating protein receptor0011
Focal adhesion kinase 10011
Protein kinase C zeta type0011
Protein kinase C delta type0011
Tyrosine-protein kinase BTK0011
Cyclin-dependent kinase 180011
Activated CDC42 kinase 10011
Epithelial discoidin domain-containing receptor 10011
Mitogen-activated protein kinase kinase kinase kinase 20011
Tyrosine-protein kinase Mer0011
Serine/threonine-protein kinase 40011
5'-AMP-activated protein kinase catalytic subunit alpha-10011
Dual specificity mitogen-activated protein kinase kinase 50011
Mitogen-activated protein kinase 70011
Serine/threonine-protein kinase PAK 20011
Serine/threonine-protein kinase 30011
Mitogen-activated protein kinase kinase kinase 10011
Integrin-linked protein kinase0011
Peptidyl-prolyl cis-trans isomerase FKBP50101
Rho-associated protein kinase 10011
Non-receptor tyrosine-protein kinase TNK10011
Calcium/calmodulin-dependent protein kinase type II subunit gamma0011
Calcium/calmodulin-dependent protein kinase type II subunit delta0011
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0011
Activin receptor type-2B0011
Bone morphogenetic protein receptor type-20011
Protein-tyrosine kinase 60011
cGMP-dependent protein kinase 1 0011
Cyclin-dependent kinase 130011
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0011
Protein-tyrosine kinase 2-beta0011
Maternal embryonic leucine zipper kinase0011
Structural maintenance of chromosomes protein 1A0011
Chromodomain-helicase-DNA-binding protein 40011
Peroxisomal acyl-coenzyme A oxidase 10011
Delta(24)-sterol reductase0011
Ribosomal protein S6 kinase alpha-10011
Dual specificity testis-specific protein kinase 10011
Myosin light chain kinase, smooth muscle0011
Mitogen-activated protein kinase 110011
Serine/threonine-protein kinase STK110011
Serine/threonine-protein kinase N10011
Serine/threonine-protein kinase N20011
Mitogen-activated protein kinase 140011
Calcium/calmodulin-dependent protein kinase type IV0011
Mitogen-activated protein kinase kinase kinase 110011
Discoidin domain-containing receptor 20011
AP2-associated protein kinase 10011
Myosin light chain kinase 30011
Uncharacterized aarF domain-containing protein kinase 50011
Programmed cell death protein 40011
Putative heat shock protein HSP 90-beta 20011
Serine/threonine-protein kinase MRCK alpha0011
Serine/threonine-protein kinase MRCK gamma0011
Acyl-CoA dehydrogenase family member 100011
Serine/threonine-protein kinase N30011
Serine/threonine-protein kinase ULK30011
Uncharacterized protein FLJ452520011
Acyl-CoA dehydrogenase family member 110011
Serine/threonine-protein kinase/endoribonuclease IRE20011
Serine/threonine-protein kinase MARK20011
ATP-dependent RNA helicase DHX300011
Serine/threonine-protein kinase TAO10011
STE20-related kinase adapter protein alpha0011
Myosin-140011
AarF domain-containing protein kinase 10011
Mitogen-activated protein kinase kinase kinase kinase 30011
MAP kinase-activated protein kinase 50011
Regulatory-associated protein of mTOR0101
Misshapen-like kinase 10011
Atypical kinase COQ8A, mitochondrial0011
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0011
Mitogen-activated protein kinase 150011
Serine/threonine-protein kinase Nek90011
ATP-dependent RNA helicase DDX10011
Mitogen-activated protein kinase kinase kinase kinase 10011
Aurora kinase B0011
MAP/microtubule affinity-regulating kinase 40011
Calcium/calmodulin-dependent protein kinase type 1G0011
Serine/threonine-protein kinase Nek10011
PAS domain-containing serine/threonine-protein kinase0011
Calcium/calmodulin-dependent protein kinase kinase 20011
EKC/KEOPS complex subunit TP53RK0011
Dual specificity testis-specific protein kinase 20011
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0011
Mitogen-activated protein kinase kinase kinase 50011
Mitogen-activated protein kinase kinase kinase 30011
Eukaryotic translation initiation factor 2-alpha kinase 10011
Target of rapamycin complex subunit LST80101
Nucleolar GTP-binding protein 10011
Serine/threonine-protein kinase D20011
RNA cytidine acetyltransferase0011
Serine/threonine-protein kinase SIK20011
STE20-like serine/threonine-protein kinase 0011
Serine/threonine-protein kinase TAO30011
dCTP pyrophosphatase 10011
Dual specificity protein kinase CLK40011
Casein kinase I isoform gamma-10011
Serine/threonine-protein kinase mTOR 0101
Phenylalanine--tRNA ligase beta subunit0011
Isoleucine--tRNA ligase, mitochondrial0011
BMP-2-inducible protein kinase0011
Obg-like ATPase 10011
Midasin0011
Interleukin-1 receptor-associated kinase 40011
Mitogen-activated protein kinase kinase kinase 200011
Cyclin-dependent kinase 120011
Serine/threonine-protein kinase 260011
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0011
Serine/threonine-protein kinase NLK0011
5'-AMP-activated protein kinase subunit gamma-20011
Serine/threonine-protein kinase TBK10011
Septin-90011
Ribosomal protein S6 kinase alpha-60011
TRAF2 and NCK-interacting protein kinase0011
Serine/threonine-protein kinase TAO20011
Serine/threonine-protein kinase ICK0011
RAC-gamma serine/threonine-protein kinase0011
Serine/threonine-protein kinase SIK30011
Mitogen-activated protein kinase kinase kinase 20011
Thyroid hormone receptor-associated protein 30011
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0011
Mitogen-activated protein kinase kinase kinase kinase 50011
Receptor-interacting serine/threonine-protein kinase 30011
Serine/threonine-protein kinase MRCK beta0011
Interleukin-1 receptor-associated kinase 30011
Serine/threonine-protein kinase 240011
Solute carrier organic anion transporter family member 1B10101
Casein kinase I isoform gamma-30011
Mitogen-activated protein kinase kinase kinase 40011
Enoyl-[acyl-carrier-protein] reductase [NADH]0001
Carbonic anhydrase 60101
Chain A, JmjC domain-containing histone demethylation protein 3A1001
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
regulator of G-protein signaling 41001
Beta-1 adrenergic receptor 0011
Beta-2 adrenergic receptor0202
Beta-1 adrenergic receptor0202
Beta-3 adrenergic receptor0202
Beta-1 adrenergic receptor0101
5-hydroxytryptamine receptor 1A0213
5-hydroxytryptamine receptor 1B0202
Beta-2 adrenergic receptor0011
procathepsin L isoform 1 preproprotein0101
Solute carrier family 15 member 10101
Valacyclovir hydrolase0001
Chain A, Arginase 10101
Large neutral amino acids transporter small subunit 10101
Adenosylhomocysteinase0101
RNA-directed RNA polymerase 0112
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]