Compounds > 3-deazaaristeromycin
Page last updated: 2024-12-06

3-deazaaristeromycin

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Description

3-Deazaaristeromycin is a synthetic nucleoside analog that has shown promising activity against various viruses, including HIV, hepatitis B, and herpes simplex virus. Its mechanism of action involves inhibiting viral DNA polymerase, preventing the replication of the virus. The compound has been studied extensively for its antiviral properties and potential therapeutic applications. Synthesis of 3-deazaaristeromycin involves a multi-step process starting from readily available starting materials. The compound has demonstrated efficacy in preclinical studies, and its safety profile is being evaluated in ongoing clinical trials.'

3-deazaaristeromycin: antagonist of S-adenosylhomocysteinase [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID72501
CHEMBL ID268272
MeSH IDM0106526

Synonyms (18)

Synonym
58316-88-4
1,2-cyclopentanediol, 3-(4-amino-1h-imidazo(4,5-c)pyridin-1-yl)-5-(hydroxymethyl)-, (1r-(1-alpha,2-alpha,3-beta,5-beta))-
3-deazaaristeromycin
brn 5093015
dzari
sri-6251
1,2-cyclopentanediol, 3-(4-amino-1h-imidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)-, rel-(1r,2s,3r,5r)-
(+/-)-3-deazaaristeromycin
(1r,2s,3r,5r)-3-(4-aminoimidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol
3-deazaaristeromycin a
CHEMBL268272 ,
bdbm50367250
DTXSID50207047
c-c3 ado
(-)-3-deazaaristeromycin
ccado
1,2-cyclopentanediol, 3-(4-amino-1h-imidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)-, (-)-(1r,2s,3r,5r)-
carbocyclic-3-deazaadenonsine
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
AdenosylhomocysteinaseHomo sapiens (human)Ki0.00400.00000.18991.9300AID199940
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (2)

Processvia Protein(s)Taxonomy
one-carbon metabolic processAdenosylhomocysteinaseHomo sapiens (human)
S-adenosylmethionine cycleAdenosylhomocysteinaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
adenosylhomocysteinase activityAdenosylhomocysteinaseHomo sapiens (human)
protein bindingAdenosylhomocysteinaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (5)

Processvia Protein(s)Taxonomy
nucleusAdenosylhomocysteinaseHomo sapiens (human)
endoplasmic reticulumAdenosylhomocysteinaseHomo sapiens (human)
cytosolAdenosylhomocysteinaseHomo sapiens (human)
melanosomeAdenosylhomocysteinaseHomo sapiens (human)
extracellular exosomeAdenosylhomocysteinaseHomo sapiens (human)
cytosolAdenosylhomocysteinaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (169)

Assay IDTitleYearJournalArticle
AID218006Minimum inhibitory concentration against vaccinia virus in primary rabbit kidney cell cultures of experiment 11989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation.
AID216390Inhibitory dose against vesicular stomatitis viral strain Indiana in L929 cell line1989Journal of medicinal chemistry, Jul, Volume: 32, Issue:7
Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities.
AID218251Evaluation for antiviral activity against Coxsackie virus B4 in Vero cell cultures (Concentration required to reduce virus-induced cytopathogenicity by 50%)1992Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID218254Evaluation for antiviral activity against parainfluenza-3 virus in Vero cell cultures (Concentration required to reduce virus-induced cytopathogenicity by 50%)1992Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID87166Minimum inhibitory concentration (MIC) required to reduce virus-induced cytopathogenicity by 50% against Polio virus-1 in HeLa cells1987Journal of medicinal chemistry, Jun, Volume: 30, Issue:6
Systematic synthesis and biological evaluation of alpha- and beta-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases.
AID235892Ratio of minimum toxic compound concentration to inhibitory dose against vesicular stomatitis viral strain Indiana in L929 cell line1989Journal of medicinal chemistry, Jul, Volume: 32, Issue:7
Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities.
AID218128Minimum inhibitory concentration against Vaccinia virus1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation.
AID156688Antiviral activity was measured against Herpes simplex virus (HSV-2 G) in rabbit kidney cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID199933Evaluated for the inhibition of bovine liver S-adenosyl-homocysteine hydrolase at concentration 0.2 mM1985Journal of medicinal chemistry, Apr, Volume: 28, Issue:4
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 8. Molecular dissections of carbocyclic 3-deazaadenosine as inhibitors of S-adenosylhomocysteine hydrolase.
AID218376Evaluation for antiviral activity against reo virus-1 in Vero cell cultures (Concentration required to reduce virus-induced cytopathogenicity by 50%)1992Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID218044Minimum inhibitory concentration (MIC) required to reduce virus-induced cytopathogenicity by 50% against Coxsackie virus B4 in African green monkey kidney (Vero B)cells1987Journal of medicinal chemistry, Jun, Volume: 30, Issue:6
Systematic synthesis and biological evaluation of alpha- and beta-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases.
AID63775Minimal inhibitory concentration (MIC) required to reduce TK(Thymidine kinase)-HSV-1 (B2006) cytopathicity in E6SM cells1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
An epimer of 5'-noraristeromycin and its antiviral properties.
AID192610Inhibition of oncogenic transformation expressed as %control cell number on day 3 in HL-23 virus infected rat kidney cells (NRK 153C17) at 0.5 uM1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID94708Percentage control of incorporation of [3H]thymidine into DNA of uninfected L-cell cultures after 72 hr exposure1985Journal of medicinal chemistry, Apr, Volume: 28, Issue:4
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 9. 2',3'-Dialdehyde derivatives of carbocyclic purine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase.
AID87146Evaluation for antiviral activity against Coxsackie virus B4 in HeLa cell cultures (Concentration required to reduce virus-induced cytopathogenicity by 50%)1992Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID218004Minimum inhibitory concentration against vaccinia virus in Vero cell cultures of experiment 11989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation.
AID216377Minimal inhibitory concentration (MIC) required to reduce forest virus in Vero cells1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
An epimer of 5'-noraristeromycin and its antiviral properties.
AID156704Evaluation for antiviral activity against herpes simplex virus-1 (McIntyre) in primary rabbit kidney cell cultures(PRK) (Concentration required to reduce virus-induced cytopathogenicity by 50%)1992Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID185232Percent inhibition of oncogenic transformation of HL-23 virus infected rat kidney cells (NRK 153C17) at 0 uM1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID217893Minimum inhibitory concentration against forest virus in Vero cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID87281Minimum inhibitory concentration (MIC) required to reduce virus-induced cytopathogenicity by 50% against Vesicular stomatitis virus in HeLa cells1987Journal of medicinal chemistry, Jun, Volume: 30, Issue:6
Systematic synthesis and biological evaluation of alpha- and beta-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases.
AID218127Minimum inhibitory concentration against vaccinia virus in primary rabbit kidney cell cultures of experiment 21989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation.
AID185234Percent inhibition of oncogenic transformation of HL-23 virus infected rat kidney cells (NRK 153C17) at 0.5 uM1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID87137Evaluation in HeLa cell cultures for cytotoxicity that is to cause microscopically detectable alteration of normal cell morphology1992Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID224345Minimum inhibitory concentration (MIC) required to reduce virus-induced cytopathogenicity by 50% against KOS strain of Herpes simplex virus-1 in primary rabbit kidney cells1987Journal of medicinal chemistry, Jun, Volume: 30, Issue:6
Systematic synthesis and biological evaluation of alpha- and beta-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases.
AID83340Minimal inhibitory concentration (MIC) required to reduce VZV (YS) in HEL cells1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
An epimer of 5'-noraristeromycin and its antiviral properties.
AID216436Concentration required for microscopically detectable alteration of the normal cell morphology in Wi-38 cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID217884Minimum cytotoxic concentration in Vero cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID216389Inhibitory dose of compound required to inhibit cytopathogenic effects of vesicular stomatitis RNA virus with indiana strain in L929 cells1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID87143Minimum cytotoxic concentration (MCC) required to cause a microscopically detectable alteration of host cell morphology, when incubated with HeLa cells1987Journal of medicinal chemistry, Jun, Volume: 30, Issue:6
Systematic synthesis and biological evaluation of alpha- and beta-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases.
AID218405Minimum inhibitory concentration required to reduce reovirus-1 induced cytopathogenicity by 50% in african green monkey (VeroB)cells1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID216397Viral rating activity against vesicular stomatitis viral strain Indiana in L929 cell line1989Journal of medicinal chemistry, Jul, Volume: 32, Issue:7
Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities.
AID185235Percent inhibition of oncogenic transformation of HL-23 virus infected rat kidney cells (NRK 153C17) at 1 uM1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID156699Minimum cytotoxic concentration (MCC) required to cause a microscopically detectable alteration of host cell morphology, when incubated with PRK cells1987Journal of medicinal chemistry, Jun, Volume: 30, Issue:6
Systematic synthesis and biological evaluation of alpha- and beta-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases.
AID218167Minimum inhibitory concentration (MIC) required to reduce virus-induced cytopathogenicity by 50% against Reo virus-1 in African green monkey kidney (Vero B)cells1987Journal of medicinal chemistry, Jun, Volume: 30, Issue:6
Systematic synthesis and biological evaluation of alpha- and beta-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases.
AID86508Minimal inhibitory concentration (MIC) required to reduce VSV in HeLa cells1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
An epimer of 5'-noraristeromycin and its antiviral properties.
AID224347Minimum inhibitory concentration (MIC) required to reduce virus-induced cytopathogenicity by 50% against Vesicular stomatitis virus in primary rabbit kidney cells1987Journal of medicinal chemistry, Jun, Volume: 30, Issue:6
Systematic synthesis and biological evaluation of alpha- and beta-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases.
AID216399Tested for inhibition of virus-induced cytopathogenic effect and cytotoxicity of compound against vesicular stomatitis RNA virus with indiana strain in L929 cell1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID226095Minimum inhibitory concentration against Herpes simplex virus 2 (G) in primary rabbit kidney cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID218404Minimum inhibitory concentration required to reduce parainfluenza virus-3 induced cytopathogenicity by 50% in african green monkey (VeroB) cells1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID226094Minimum inhibitory concentration against Herpes simplex virus 1(KOS) in primary rabbit kidney cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID63777Minimal inhibitory concentration (MIC) required to reduce VV (vaccinia virus) cytopathicity in E6SM cells1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
An epimer of 5'-noraristeromycin and its antiviral properties.
AID218031Antiviral activity was measured against Reo virus-1 in african green monkey kidney (Vero B) cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID87135Antiviral activity was measured against polio virus-1 in HeLa cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID218432Minimum cytotoxic concentration (MCC) required to cause a microscopically detectable alteration of host cell morphology, when incubated with WI-38 cells1987Journal of medicinal chemistry, Jun, Volume: 30, Issue:6
Systematic synthesis and biological evaluation of alpha- and beta-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases.
AID87136Antiviral activity was measured against vesicular stomatitis virus in HeLa cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID87153Evaluated for minimum inhibitory concentration against HeLa cells (human carcinoma) infected with VSV, Coxs, B4, polio-1 virus1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogues derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one.
AID161449Minimum cytotoxic concentration required to cause a microscopically detectable alteration of normal cell morphology and show antiviral activity in primary rabbit kidney (PRK) cells1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID218430Antiviral activity was measured against Rhino virus-1A in human diploid (WI-38) cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID86506Minimal inhibitory concentration (MIC) required to reduce Polio-1 in HeLa cells1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
An epimer of 5'-noraristeromycin and its antiviral properties.
AID83339Minimal inhibitory concentration (MIC) required to reduce CMV (cytomegalo virus) (AD-169) in HEL cells1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
An epimer of 5'-noraristeromycin and its antiviral properties.
AID94560Percentage inhibition of plaque formation, after 72 hr of incubation in virus plaque assay, prepared from monolayer cultures of mouse L 929 cells1985Journal of medicinal chemistry, Apr, Volume: 28, Issue:4
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 9. 2',3'-Dialdehyde derivatives of carbocyclic purine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase.
AID156706Evaluation for antiviral activity against herpes simplex virus-2(196) in primary rabbit kidney cell cultures(PRK) (Concentration required to reduce virus-induced cytopathogenicity by 50%)1992Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID156710Evaluation for antiviral activity against vesicular stomatitis virus in primary rabbit kidney cell cultures(PRK) (Concentration required to reduce virus-induced cytopathogenicity by 50%)1992Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID87139Concentration required for microscopically detectable alteration of the normal cell morphology in HeLa cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID185233Percent inhibition of oncogenic transformation of HL-23 virus infected rat kidney cells (NRK 153C17) at 0.25 uM1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID63774Minimal inhibitory concentration (MIC) required to reduce HSV(herpes simplex virus)-2 cytopathicity E6SM cells1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
An epimer of 5'-noraristeromycin and its antiviral properties.
AID218170Minimum inhibitory concentration (MIC) required to reduce virus-induced cytopathogenicity by 50% against Sindbis virus in African green monkey kidney (Vero B)cells1987Journal of medicinal chemistry, Jun, Volume: 30, Issue:6
Systematic synthesis and biological evaluation of alpha- and beta-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases.
AID218005Minimum inhibitory concentration against vaccinia virus in Vero cell cultures of experiment 21989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation.
AID156709Evaluation for antiviral activity against vaccinia virus in primary rabbit kidney cell cultures(PRK) (Concentration required to reduce virus-induced cytopathogenicity by 50%)1992Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID185237Percent inhibition of oncogenic transformation of HL-23 virus infected rat kidney cells (NRK 153C17) at 4 uM1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID156849Minimum inhibitory concentration required to reduce vaccinia virus induced cytopathogenicity by 50% in primary rabbit kidney cells (PRK)1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID218029Antiviral activity was measured against Coxsackie virus B4 in african green monkey kidney (Vero B) cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID195778Inhibition of oncogenic transformation expressed as number of foci on day 5 in HL-23 virus infected rat kidney cells (NRK 153C17) at 2 uM1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID195777Inhibition of oncogenic transformation expressed as number of foci on day 5 in HL-23 virus infected rat kidney cells (NRK 153C17) at 1 uM1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID216497Minimal inhibitory concentration (MIC) required to reduce Tacaribe virus in Vero cells1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
An epimer of 5'-noraristeromycin and its antiviral properties.
AID127395Effect in mouse infected with vaccinia virus; observed effects seen1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID218402Minimum inhibitory concentration required to reduce Sindbis virus induced cytopathogenicity by 50% in african green monkey (VeroB) cells1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID192614Inhibition of oncogenic transformation was assayed by infecting normal rat kidney cells (NRK 153C17) with HL-23 virus and counting the %control cell number on day 3 at a concentration of 0 uM1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID216392Minimum inhibitory concentration against Vesicular stomatitis virus1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation.
AID156707Evaluation for antiviral activity against herpes simplex virus-2(G) in primary rabbit kidney cell cultures(PRK) (Concentration required to reduce virus-induced cytopathogenicity by 50%)1992Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID195774Inhibition of oncogenic transformation expressed as number of foci on day 5 in HL-23 virus infected rat kidney cells (NRK 153C17) at 0 uM1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID192611Inhibition of oncogenic transformation expressed as %control cell number on day 3 in HL-23 virus infected rat kidney cells (NRK 153C17) at 1 uM1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID218253Evaluation for antiviral activity against Sindbis virus in Vero cell cultures (Concentration required to reduce virus-induced cytopathogenicity by 50%)1992Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID235605Ratio of minimum drug concentration to ID50 of the compound (Indiana strain)1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.
AID216496Minimal inhibitory concentration (MIC) required to reduce Sindbis in virus in Vero cells1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
An epimer of 5'-noraristeromycin and its antiviral properties.
AID156843Minimum inhibitory concentration required to reduce herpes simplex virus-1 (KOS)induced cytopathogenicity by 50% in primary rabbit kidney cells (PRK)1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID218169Minimum inhibitory concentration (MIC) required to reduce virus-induced cytopathogenicity by 50% against forest virus in African green monkey kidney (Vero B)cells1987Journal of medicinal chemistry, Jun, Volume: 30, Issue:6
Systematic synthesis and biological evaluation of alpha- and beta-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases.
AID139114In vitro antiviral activity against herpes simplex virus type 1 (strain E-377) grown in mouse fibroblasts cells, clone L-929, expressed as virus rating (VR)1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID218030Antiviral activity was measured against Parainfluenza virus-3 in african green monkey kidney (Vero B) cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID155600Minimum inhibitory concentration (MIC) required to reduce virus-induced cytopathogenicity by 50% against Parainfluenza virus-3 in African green monkey kidney (Vero B)cells1987Journal of medicinal chemistry, Jun, Volume: 30, Issue:6
Systematic synthesis and biological evaluation of alpha- and beta-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases.
AID218032Antiviral activity was measured against forest virus in african green monkey kidney (Vero B) cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID195775Inhibition of oncogenic transformation expressed as number of foci on day 5 in HL-23 virus infected rat kidney cells (NRK 153C17) at 0.25 uM1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID87165Minimum inhibitory concentration (MIC) required to reduce virus-induced cytopathogenicity by 50% against Coxsackie virus B4 in HeLa cells1987Journal of medicinal chemistry, Jun, Volume: 30, Issue:6
Systematic synthesis and biological evaluation of alpha- and beta-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases.
AID87162Minimum inhibitory concentration required to reduce polio virus -1 induced cytopathogenicity by 50% in HeLa cells1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID218249Evaluation in Vero cell cultures for cytotoxicity that is to cause microscopically detectable alteration of normal cell morphology1992Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID218434Minimum inhibitory concentration (MIC) required to reduce virus-induced cytopathogenicity by 50% against Rhinovirus-1A in human diploid (WI-38)cells1987Journal of medicinal chemistry, Jun, Volume: 30, Issue:6
Systematic synthesis and biological evaluation of alpha- and beta-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases.
AID218431Antiviral activity was measured against Rhino virus-9 in human diploid (WI-38) cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID167743Minimum cytotoxic concentration in primary rabbit kidney cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID192612Inhibition of oncogenic transformation expressed as %control cell number on day 3 in HL-23 virus infected rat kidney cells (NRK 153C17) at 2 uM1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID224344Minimum inhibitory concentration (MIC) required to reduce virus-induced cytopathogenicity by 50% against G strain of Herpes simplex virus-2 in primary rabbit kidney cells1987Journal of medicinal chemistry, Jun, Volume: 30, Issue:6
Systematic synthesis and biological evaluation of alpha- and beta-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases.
AID218433Minimum inhibitory concentration (MIC) required to reduce virus-induced cytopathogenicity by 50% against Rhinovirus 9 in human diploid (WI-38)cells1987Journal of medicinal chemistry, Jun, Volume: 30, Issue:6
Systematic synthesis and biological evaluation of alpha- and beta-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases.
AID133277Minimum Inhibitory concentration of the drug required for 50% inhibition of vaccinia virus (strain Lederle chorioallantoic) -induced cytopathogenic effects in infected cell cultures.1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID105795Minimal inhibitory concentration (MIC) required to reduce Influenza A virus in MDCK cells1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
An epimer of 5'-noraristeromycin and its antiviral properties.
AID156694Evaluation in PRK cell cultures for cytotoxicity that is to cause microscopically detectable alteration of normal cell morphology1992Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID139115In vitro antiviral activity against vaccinia virus (strain Lederle chorioallantoic) grown in mouse fibroblasts cells, clone L-929, expressed as VR1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID63776Minimal inhibitory concentration (MIC) required to reduce TK-HSV-1 (VMW 1837) cytopathicity in E6SM cells1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
An epimer of 5'-noraristeromycin and its antiviral properties.
AID217890Evaluated for minimum inhibitory concentration against Vero cells (African green monkey) infected with PV-3, RV-1, SV, Coxs B4, SFV virus1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogues derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one.
AID95255Compound was evaluated for cellular toxicity by [3H]thymidine incorporation into DNA of uninfected L-929 cells after 72 hr exposure1985Journal of medicinal chemistry, Apr, Volume: 28, Issue:4
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 8. Molecular dissections of carbocyclic 3-deazaadenosine as inhibitors of S-adenosylhomocysteine hydrolase.
AID192609Inhibition of oncogenic transformation expressed as %control cell number on day 3 in HL-23 virus infected rat kidney cells (NRK 153C17) at 0.25 uM1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID156705Evaluation for antiviral activity against herpes simplex virus-1(TK-) (B2006) in primary rabbit kidney cell cultures(PRK) (Concentration required to reduce virus-induced cytopathogenicity by 50%)1992Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID33367Minimum cytotoxic concentration required to cause a microscopically detectable alteration of normal cell morphology and show antiviral activity in african green monkey (Vero B) cells1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID195776Inhibition of oncogenic transformation expressed as number of foci on day 5 in HL-23 virus infected rat kidney cells (NRK 153C17) at 0.5 uM1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID88278Evaluated for minimum inhibitory concentration against TK-B2006 strain of Herpes simplex virus (HSV-1) in primary rabbit kidney cells1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogues derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one.
AID217892Minimum inhibitory concentration against Coxsackie virus B4 in Vero cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID87131Antiviral activity was measured against Coxsackie virus B4 in HeLa cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID87320Minimum inhibitory concentration against Herpes simplex virus 2(G)1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation.
AID87147Evaluation for antiviral activity against polio virus-1 in HeLa cell cultures (Concentration required to reduce virus-induced cytopathogenicity by 50%)1992Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID87156Minimum inhibitory concentration against polio virus 1 in HeLa cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID87154Minimum inhibitory concentration against Coxsackie virus B4 in HeLa cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID87163Minimum inhibitory concentration required to reduce vesicular stomatitis virus induced cytopathogenicity by 50% in HeLa cells1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID156845Minimum inhibitory concentration required to reduce herpes simplex virus-2 (G)induced cytopathogenicity by 50% in primary rabbit kidney cells (PRK)1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID87155Minimum inhibitory concentration against Vesicular stomatitis virus in HeLa cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID133276Minimum Inhibitory concentration of the drug required for 50% inhibition of herpes simplex virus type 1 (strain E-377) -induced cytopathogenic effects in infected cell cultures.1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID217895Minimum inhibitory concentration against parainfluenza 3 virus in Vero cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID156696Concentration required for microscopically detectable alteration of the normal cell morphology in PRK cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID156692Antiviral activity was measured against vesicular stomatitis virus in rabbit kidney cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID156703Evaluated for antiviral activity against herpes simplex virus-1(KOS) in primary rabbit kidney cell cultures(PRK) (Concentration required to reduce virus-induced cytopathogenicity by 50%)1992Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID83341Minimal inhibitory concentration (MIC) required to reduce VZV (varicella zoster virus) (OKA) in HEL cells1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
An epimer of 5'-noraristeromycin and its antiviral properties.
AID218035Concentration required for microscopically detectable alteration of the normal cell morphology in Vero B cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID217990Minimum cytotoxic concentration against vaccinia virus in HeLa cell cultures1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation.
AID105797Minimal inhibitory concentration (MIC) required to reduce Influenza B virus in MDCK cells1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
An epimer of 5'-noraristeromycin and its antiviral properties.
AID156691Antiviral activity was measured against vaccinia virus in rabbit kidney cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID224346Minimum inhibitory concentration (MIC) required to reduce virus-induced cytopathogenicity by 50% against Vaccinia virus in primary rabbit kidney cells1987Journal of medicinal chemistry, Jun, Volume: 30, Issue:6
Systematic synthesis and biological evaluation of alpha- and beta-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases.
AID195779Inhibition of oncogenic transformation expressed as number of foci on day 5 in HL-23 virus infected rat kidney cells (NRK 153C17) at 4 uM1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID185236Percent inhibition of oncogenic transformation of HL-23 virus infected rat kidney cells (NRK 153C17) at 2 uM1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID199935Evaluated for the inhibition of bovine liver S-adenosyl-homocysteine hydrolase at concentration 2.0 mM; ND means not determined1985Journal of medicinal chemistry, Apr, Volume: 28, Issue:4
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 8. Molecular dissections of carbocyclic 3-deazaadenosine as inhibitors of S-adenosylhomocysteine hydrolase.
AID156851Minimum inhibitory concentration required to reduce vesicular stomatitis virus induced cytopathogenicity by 50% in primary rabbit kidney cells (PRK)1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID216375Minimal inhibitory concentration (MIC) required to reduce Parainfluenza-3 virus in Vero cells1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
An epimer of 5'-noraristeromycin and its antiviral properties.
AID217896Minimum inhibitory concentration against reovirus in Vero cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID87141Minimum cytotoxic concentration in HeLa cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID86507Minimal inhibitory concentration (MIC) required to reduce RSV (long) in HeLa cells1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
An epimer of 5'-noraristeromycin and its antiviral properties.
AID218007Minimum inhibitory concentration against vaccinia virus in primary rabbit kidney cell cultures of experiment 21989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation.
AID218406Minimum inhibitory concentration required to reduce semliki forest virus induced cytopathogenicity by 50% in african green monkey (VeroB) cells1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID192613Inhibition of oncogenic transformation expressed as %control cell number on day 3 in HL-23 virus infected rat kidney cells (NRK 153C17) at 4 uM1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID87149Evaluation for antiviral activity against vesicular stomatitis virus in HeLa cell cultures (Concentration required to reduce virus-induced cytopathogenicity by 50%)1992Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID88297Evaluated for minimum inhibitory concentration against G,196, Lyons strains of Herpes simplex virus (HSV-2) in primary rabbit kidney cells1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogues derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one.
AID95256Ability to inhibit Vaccinia virus plaque formation after 72 hr in monolayer cultures of mouse L-929 cells1985Journal of medicinal chemistry, Apr, Volume: 28, Issue:4
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 8. Molecular dissections of carbocyclic 3-deazaadenosine as inhibitors of S-adenosylhomocysteine hydrolase.
AID156693Minimum cytotoxic concentration in primary rabbit kidney (PRK) cell cultures1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation.
AID87142Minimum cytotoxic concentration required to cause a microscopically detectable alteration of normal cell morphology and show antiviral activity in HeLa cells1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID63778Mnimal inhibitory concentration (MIC) required to reduce VSV (vesicular stomatitis virus) in E6SM cells1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
An epimer of 5'-noraristeromycin and its antiviral properties.
AID87192Minimum inhibitory concentration against Herpes simplex virus 1(KOS)1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation.
AID216376Minimal inhibitory concentration (MIC) required to reduce Reovirus-1 in Vero cells1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
An epimer of 5'-noraristeromycin and its antiviral properties.
AID88277Evaluated for minimum inhibitory concentration against KOS, F, McIntyre strains of Herpes simplex virus (HSV-1) in primary rabbit kidney cells1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogues derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one.
AID199931Inhibition of bovine liver S-adenosyl-homocysteine hydrolase at 0.2 mM1985Journal of medicinal chemistry, Apr, Volume: 28, Issue:4
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 9. 2',3'-Dialdehyde derivatives of carbocyclic purine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase.
AID216374Minimal inhibitory concentration (MIC) required to reduce Junin virus in Vero cells1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
An epimer of 5'-noraristeromycin and its antiviral properties.
AID217894Minimum inhibitory concentration against Sindbis virus in Vero cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID156687Antiviral activity was measured against Herpes simplex virus (HSV-1 KOS) in rabbit kidney cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID87161Minimum inhibitory concentration required to reduce Coxsackie virus B4 induced cytopathogenicity by 50% in HeLa cells1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID226097Minimum inhibitory concentration against Vesicular stomatitis virus in primary rabbit kidney cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID63773Minimal inhibitory concentration (MIC) required to reduce HSV(herpes simplex virus)-1 (KOS) cytopathicity in E6SM cells1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
An epimer of 5'-noraristeromycin and its antiviral properties.
AID86509Minimal inhibitory concentration (MIC) required to reduce coxsackie B4 in HeLa cells1994Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9
An epimer of 5'-noraristeromycin and its antiviral properties.
AID199940Binding affinity against S-adenosyl-homocysteine hydrolase1985Journal of medicinal chemistry, Apr, Volume: 28, Issue:4
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 9. 2',3'-Dialdehyde derivatives of carbocyclic purine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase.
AID94707Percentage control of incorporation of [3H]thymidine into DNA of uninfected L-cell cultures after 36h exposure1985Journal of medicinal chemistry, Apr, Volume: 28, Issue:4
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 9. 2',3'-Dialdehyde derivatives of carbocyclic purine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase.
AID217993Minimum cytotoxic concentration against vaccinia virus in primary rabbit kidney cell cultures1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation.
AID218002Minimum inhibitory concentration against vaccinia virus embryonic skin muscle cell cultures1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation.
AID218036Minimum cytotoxic concentration (MCC) required to cause a microscopically detectable alteration of host cell morphology, when incubated with Vero B cells1987Journal of medicinal chemistry, Jun, Volume: 30, Issue:6
Systematic synthesis and biological evaluation of alpha- and beta-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases.
AID217991Minimum cytotoxic concentration against vaccinia virus in Vero cell cultures1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation.
AID217998Evaluated for minimum inhibitory concentration against Vaccinia virus (VV) in primary rabbit kidney cells1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogues derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one.
AID156702Evaluation for antiviral activity against herpes simplex virus-1(F) in primary rabbit kidney cell cultures(PRK) (Concentration required to reduce virus-induced cytopathogenicity by 50%)1992Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID218401Minimum inhibitory concentration required to reduce Coxsackie virus B4 induced cytopathogenicity by 50% in african green monkey (VeroB) cells1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID156708Evaluation for antiviral activity against herpes simplex virus-2(Lyons) in primary rabbit kidney cell cultures(PRK) (Concentration required to reduce virus-induced cytopathogenicity by 50%)1992Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID95254Compound was evaluated for cellular toxicity by [3H]thymidine incorporation into DNA of uninfected L-929 cells after 36h exposure1985Journal of medicinal chemistry, Apr, Volume: 28, Issue:4
Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 8. Molecular dissections of carbocyclic 3-deazaadenosine as inhibitors of S-adenosylhomocysteine hydrolase.
AID226096Minimum inhibitory concentration against Vaccinia virus in primary rabbit kidney cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID127393Effect in mouse infected with herpes simplex virus type-1; observed effects diminished with time1982Journal of medicinal chemistry, Jun, Volume: 25, Issue:6
Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target.
AID218252Evaluation for antiviral activity against forest virus in Vero cell cultures (Concentration required to reduce virus-induced cytopathogenicity by 50%)1992Journal of medicinal chemistry, Aug-21, Volume: 35, Issue:17
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.
AID218033Antiviral activity was measured against Sindbis virus in african green monkey kidney (Vero B) cells.1986Journal of medicinal chemistry, Feb, Volume: 29, Issue:2
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID217989Minimum cytotoxic concentration against vaccinia virus embryonic skin muscle cell cultures1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation.
AID216410Evaluated for minimum inhibitory concentration against Vesicular stomatitis virus (VSV) in primary rabbit kidney cells1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogues derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (44)

TimeframeStudies, This Drug (%)All Drugs %
pre-199027 (61.36)18.7374
1990's14 (31.82)18.2507
2000's1 (2.27)29.6817
2010's2 (4.55)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (2.27%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other43 (97.73%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
adenine
[no description available]		3.75306-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
choline
[no description available]		6.9710cholinesallergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite
gallic acid
gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.		1.9610trihydroxybenzoic acidantineoplastic agent;
antioxidant;
apoptosis inducer;
astringent;
cyclooxygenase 2 inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
geroprotector;
human xenobiotic metabolite;
plant metabolite
cytosine
[no description available]		1.9710aminopyrimidine;
pyrimidine nucleobase;
pyrimidone		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
9-(2',3'-dihydroxycyclopent-4'-enyl)adenine
9-(2',3'-dihydroxycyclopent-4'-enyl)adenine: structure given in first source; S-adenosyl homocysteine hydrolase antagonist		1.9810
aurintricarboxylic acid
Aurintricarboxylic Acid: A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.. aurintricarboxylic acid : A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'.		1.9710monohydroxybenzoic acid;
quinomethanes;
tricarboxylic acid		fluorochrome;
histological dye;
insulin-like growth factor receptor 1 antagonist
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.		1.9610aromatic ether;
nitrile;
polyether;
tertiary amino compound
stallimycin
[no description available]		2.3820
9-(2-hydroxy-3-nonyl)adenine
9-(2-hydroxy-3-nonyl)adenine: specific inhibitor of adenosine deaminase		3.4720
felodipine
Felodipine: A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels.. felodipine : The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.		1.9610dichlorobenzene;
dihydropyridine;
ethyl ester;
methyl ester		anti-arrhythmia drug;
antihypertensive agent;
calcium channel blocker;
vasodilator agent
1-methyl-3-isobutylxanthine
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES. 3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.		1.96103-isobutyl-1-methylxanthine
netropsin
Netropsin: A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research.		2.3820
nifedipine
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.		1.9610C-nitro compound;
dihydropyridine;
methyl ester		calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent
nitrendipine
Nitrendipine: A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.. nitrendipine : A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.		1.9610C-nitro compound;
dicarboxylic acids and O-substituted derivatives;
diester;
dihydropyridine;
ethyl ester;
methyl ester		antihypertensive agent;
calcium channel blocker;
geroprotector;
vasodilator agent
8-(n,n-diethylamino)octyl-3,4,5-trimethoxybenzoate
8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate: intracellular calcium antagonist; RN given refers to parent cpd		1.9610trihydroxybenzoic acid
thymidine
[no description available]		1.9610pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
uridine
[no description available]		1.9610uridinesdrug metabolite;
fundamental metabolite;
human metabolite
methionine
Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.		2.6630aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid		antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical
colchicine
(S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.		1.9710alkaloid;
colchicine		anti-inflammatory agent;
gout suppressant;
mutagen
tubercidin
Tubercidin: An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic acids.. tubercidin : An N-glycosylpyrrolopyrimidine that is adenosine in which the in the 5-membered ring that is not attached to the ribose moiety is replaced by a carbon. Tubercidin is produced in the culture broth of Streptomyces tubericidus.		5.67260antibiotic antifungal agent;
N-glycosylpyrrolopyrimidine;
ribonucleoside		antimetabolite;
antineoplastic agent;
bacterial metabolite
cytarabine
[no description available]		1.9610beta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside		antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent
2-chloroadenosine
5-chloroformycin A: structure given in first source		1.9810purine nucleoside
vidarabine
adenine arabinoside : A purine nucleoside in which adenine is attached to arabinofuranose via a beta-N(9)-glycosidic bond.		2.8840beta-D-arabinoside;
purine nucleoside		antineoplastic agent;
bacterial metabolite;
nucleoside antibiotic
3-deazaadenosine
3-deazaadenosine: RN given refers to parent cpd.		5.51220
zidovudine
Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.		1.9710azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
ribavirin
Rebetron: Rebetron is tradename		3.58901-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
adenosine
quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit		5.87320adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
5-methylcytosine
5-Methylcytosine: A methylated nucleotide base found in eukaryotic DNA. In ANIMALS, the DNA METHYLATION of CYTOSINE to form 5-methylcytosine is found primarily in the palindromic sequence CpG. In PLANTS, the methylated sequence is CpNpGp, where N can be any base.. 5-methylcytosine : A pyrimidine that is a derivative of cytosine, having a methyl group at the 5-position.		1.9710methylcytosine;
pyrimidines		human metabolite
aristeromycin
aristeromycin: RN given refers to (1R-(1alpha,2alpha,3beta,5alpha)-isomer		7.3720
glutathione disulfide
Glutathione Disulfide: A GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized.		1.9710glutathione derivative;
organic disulfide		Escherichia coli metabolite;
mouse metabolite
nebularine
nebularine: structure. nebularine : A purine ribonucleoside that is 9H-purine attached to a beta-D-ribofuranosyl residue at position 9 via a glycosidic (N-glycosyl) linkage.		1.9810purine ribonucleoside;
purines D-ribonucleoside		fungal metabolite
cyclopentenyl cytosine
cyclopentenyl cytosine: inhibits CTP synthetase; used in therapy of colonic neoplasms; structure given in first source; RN given refers to the (1R-(1alpha,4beta,5beta))-isomer		1.9710
neplanocin a
neplanocin A: neplanocins are antitumor antibiotics & carbocyclic analogs of purine nucleosides from Ampullarilla regularis A11079; see also neplanocin B, neplanocin C, neplanocin D & neplanocin F; structure in first source; a potent inhibitor of S-adenosylhomocysteine hydrolase		2.8940
3-deazaneplanocin
3-deazaneplanocin: S-adenosylhomocysteine hydrolase antagonist		3.150
9-(2,3-dihydroxypropyl)adenine, (s)-isomer
[no description available]		2.6630
homocysteine
Homocysteine: A thiol-containing amino acid formed by a demethylation of METHIONINE.. homocysteine : A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain.. L-homocysteine : A homocysteine that has L configuration.		8.0750amino acid zwitterion;
homocysteine;
serine family amino acid		fundamental metabolite;
mouse metabolite
s-(3-deazaadenosyl)homocysteine
S-(3-deazaadenosyl)homocysteine: structure in first source		1.9610
triiodothyronine
L-homocysteine thiolactone : A thiolactone arising from formal condensation of the mercapto (sulfanyl) and carboxylic acid groups of L-homocysteine.		1.9910tetrahydrothiophenes;
thiolactone		human metabolite
eritadenine
eritadenine: isolated from Lentinula edodes (Shiitake mushroom); inhibits S-adenosyl-L-homocysteine hydrolase activity		1.9610
2'-deoxyaristeromycin
[no description available]		1.9710
s-adenosylhomocysteine
S-Adenosylhomocysteine: 5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions.. S-adenosyl-L-homocysteine : An organic sulfide that is the S-adenosyl derivative of L-homocysteine.		4.86110adenosines;
amino acid zwitterion;
homocysteine derivative;
homocysteines;
organic sulfide		cofactor;
EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor;
EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor;
epitope;
fundamental metabolite
monensin
Monensin: An antiprotozoal agent produced by Streptomyces cinnamonensis. It exerts its effect during the development of first-generation trophozoites into first-generation schizonts within the intestinal epithelial cells. It does not interfere with hosts' development of acquired immunity to the majority of coccidial species. Monensin is a sodium and proton selective ionophore and is widely used as such in biochemical studies.. monensin A : A spiroketal, monensin A is the major component of monensin, a mixture of antibiotic substances produced by Streptomyces cinnamonensis. An antiprotozoal, it is used as the sodium salt as a feed additive for the prevention of coccidiosis in poultry and as a growth promoter in cattle.		1.9610cyclic hemiketal;
monocarboxylic acid;
polyether antibiotic;
spiroketal		antifungal agent;
coccidiostat;
ionophore
tretinoin
Tretinoin: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).. retinoic acid : A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).. all-trans-retinoic acid : A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.		1.9810retinoic acid;
vitamin A		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
AP-1 antagonist;
human metabolite;
keratolytic drug;
retinoic acid receptor agonist;
retinoid X receptor agonist;
signalling molecule
ribothymidine
ribothymidine : A methyluridine having a single methyl substituent at the 5-position on the uracil ring.		1.9610methyluridineantigen;
Escherichia coli metabolite;
human metabolite
brivudine
brivudine: anti-herpes agent		2.3820
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		1.9610prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
cytochalasin b
Cytochalasin B: A cytotoxic member of the CYTOCHALASINS.. cytochalasin B : An organic heterotricyclic compound, that is a mycotoxin which is cell permeable an an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments.		1.9710cytochalasin;
lactam;
lactone;
organic heterotricyclic compound		actin polymerisation inhibitor;
metabolite;
mycotoxin;
platelet aggregation inhibitor
phosphatidylcholines
Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.		1.97101,2-diacyl-sn-glycero-3-phosphocholine
s-adenosylmethionine
(R)-S-adenosyl-L-methionine : An S-adenosyl-L-methionine that has R-configuration.. S-adenosyl-L-methionine zwitterion : A zwitterionic tautomer of S-adenosyl-L-methionine arising from shift of the proton from the carboxy group to the amino group.. (R)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has R-configuration; major species at pH 7.3.. (S)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has S-configuration; major species at pH 7.3.. S-adenosyl-L-methionine : A sulfonium compound that is the S-adenosyl derivative of L-methionine. It is an intermediate in the metabolic pathway of methionine.		4.3260organic cation;
sulfonium compound		coenzyme;
cofactor;
human metabolite;
micronutrient;
Mycoplasma genitalium metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
3-deazauridine
3-Deazauridine: 4-Hydroxy-1-(beta-D-ribofuranosyl)-2-pyridinone. Analog of uridine lacking a ring-nitrogen in the 3-position. Functions as an antineoplastic agent.		1.9710N-glycosyl compound
thromboplastin
Thromboplastin: Constituent composed of protein and phospholipid that is widely distributed in many tissues. It serves as a cofactor with factor VIIa to activate factor X in the extrinsic pathway of blood coagulation.		1.9610
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.		2.66302-aminopurines;
oxopurine		antimetabolite;
antiviral drug
hypoxanthine
[no description available]		1.9610nucleobase analogue;
oxopurine;
purine nucleobase		fundamental metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia L 1210
[description not available]		02.3820
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.3820
HIV
Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.		02.3820
Cancer of Lung
[description not available]		01.9710
Malignant Melanoma
[description not available]		01.9710
Experimental Neoplasms
[description not available]		01.9710
EHS Tumor
[description not available]		01.9710
Experimental Mammary Neoplasms
[description not available]		01.9710
Lung Neoplasms
Tumors or cancer of the LUNG.		01.9710
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		01.9710
Herpes Simplex Virus Infection
[description not available]		01.9710
Herpes Simplex
A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)		01.9710
Leucocythaemia
[description not available]		01.9710
Leukemia
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)		01.9710
Acute Promyelocytic Leukemia
[description not available]		01.9710
Leukemia, Promyelocytic, Acute
An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.		01.9710
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		01.9610
Acute Myelogenous Leukemia
[description not available]		02.3720
Leukemia, Myeloid, Acute
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.		02.3720
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.		01.9610
Cancer of Colon
[description not available]		01.9610
Colonic Neoplasms
Tumors or cancer of the COLON.		01.9610