| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
adenine
[no description available] | 1.99 | 1 | 0 | 6-aminopurines;
purine nucleobase | Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
thymine
[no description available] | 2.88 | 4 | 0 | pyrimidine nucleobase;
pyrimidone | Escherichia coli metabolite;
human metabolite;
mouse metabolite |
uracil
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder | 3.85 | 12 | 0 | pyrimidine nucleobase;
pyrimidone | allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite |
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth. | 2.67 | 3 | 0 | nucleobase analogue;
organofluorine compound | antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic |
thymidine
[no description available] | 2.37 | 2 | 0 | pyrimidine 2'-deoxyribonucleoside | Escherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite |
bromouracil
Bromouracil: 5-Bromo-2,4(1H,3H)-pyrimidinedione. Brominated derivative of uracil that acts as an antimetabolite, substituting for thymine in DNA. It is used mainly as an experimental mutagen, but its deoxyriboside (BROMODEOXYURIDINE) is used to treat neoplasms.. 5-bromouracil : A pyrimidine having keto groups at the 2- and 4-positions and a bromo group at the 5-position. Used mainly as an experimental mutagen. | 2.66 | 3 | 0 | nucleobase analogue;
pyrimidines | mutagen |
uridine
[no description available] | 2.43 | 2 | 0 | uridines | drug metabolite;
fundamental metabolite;
human metabolite |
bromodeoxyuridine
Bromodeoxyuridine: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors. | 1.96 | 1 | 0 | pyrimidine 2'-deoxyribonucleoside | antimetabolite;
antineoplastic agent |
fluorodeoxyuridylate
Fluorodeoxyuridylate: 5-Fluoro-2'-deoxyuridylate. An inhibitor of thymidylate synthetase. Formed from 5-fluorouracil or 5-fluorodeoxyuridine. | 2 | 1 | 0 | pyrimidine 2'-deoxyribonucleoside 5'-monophosphate | |
pentoxyl
Pentoxyl: 5-Hydroxymethyl-6-methyl- 2,4-(1H,3H)-pyrimidinedione. Uracil derivative used in combination with toxic antibiotics to lessen their toxicity; also to stimulate leukopoiesis and immunity. Synonyms: pentoksil; hydroxymethylmethyluracil. | 2.07 | 1 | 0 | pyrimidone | |
pyrimidine
pyrimidine : The parent compound of the pyrimidines; a diazine having the two nitrogens at the 1- and 3-positions. | 1.93 | 1 | 0 | diazine;
pyrimidines | Daphnia magna metabolite |
2-aminopurine
2-Aminopurine: A purine that is an isomer of ADENINE (6-aminopurine).. aminopurine : Any purine having at least one amino substituent.. 2-aminopurine : The parent compound of the 2-aminopurines, comprising a purine core carrying an amino substituent at the 2-position. | 2.39 | 2 | 0 | 2-aminopurines;
nucleobase analogue | antimetabolite |
5-aminouracil
[no description available] | 1.93 | 1 | 0 | | |
deoxyuridine
[no description available] | 2.89 | 4 | 0 | pyrimidine 2'-deoxyribonucleoside | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
2,6-diaminopurine
9H-purine-2,6-diamine : A member of the class of 2,6-diaminopurines that is 9H-purine in which the hydrogens at positions 2 and 6 are replaced by amino groups. | 2.39 | 2 | 0 | 2,6-diaminopurines;
primary amino compound | antineoplastic agent |
6-aminothymine
6-aminothymine: inhibits degradation of nucleosides (idoxuridine, thymidine) & pyrimidine bases | 1.96 | 1 | 0 | | |
edoxudin
[no description available] | 2.89 | 4 | 0 | pyrimidine 2'-deoxyribonucleoside | |
5-diazouracil
5-diazouracil: RN given refers to parent cpd; structure | 1.96 | 1 | 0 | | |
5-cyanouracil
[no description available] | 1.97 | 1 | 0 | | |
5-hydroxymethyluracil
[no description available] | 2.07 | 1 | 0 | primary alcohol;
pyrimidone | human metabolite |
5-fluorodihydrouracil
5-fluorodihydrouracil: metabolite of 5-fluorouracil; RN given refers to parent cpd | 2 | 1 | 0 | pyrimidone | |
brivudine
brivudine: anti-herpes agent | 1.96 | 1 | 0 | | |
5-(2-chloroethyl)-2'-deoxyuridine
5-(2-chloroethyl)-2'-deoxyuridine: inhibitor of herpes viruses; structure given in first source | 1.96 | 1 | 0 | pyrimidine 2'-deoxyribonucleoside | |
5-(2-bromovinyl)uracil
5-(2-bromovinyl)uracil: RN given refers to (E)-isomer | 2.37 | 2 | 0 | | |
phosphoramidite
phosphoramidite: structure in first source. phosphoramidite : A compound with the general formula (RO)2PNR2. Phosphoramidites can be regarded as phosphites that have an NR2 instead of an OH group, or as amides of phosphorous acid. | 2.06 | 1 | 0 | | |
guanine
[no description available] | 1.99 | 1 | 0 | 2-aminopurines;
oxopurine;
purine nucleobase | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
hypoxanthine
[no description available] | 2.39 | 2 | 0 | nucleobase analogue;
oxopurine;
purine nucleobase | fundamental metabolite |
ganciclovir
[no description available] | 1.98 | 1 | 0 | 2-aminopurines;
oxopurine | antiinfective agent;
antiviral drug |