brivudine and Penile-Diseases

Herpes simplex virus (HSV) was isolated from penile lesions of 15 college men. Using (E)-5-(2-bromovinyl)-2'-deoxyuridine sensitivity, monoclonal antibody immunofluorescence, and restriction endonuclease EcoRI digestion of viral DNA, 4 of 15 (26%) isolates were found to be HSV-1, and 11 of 15 (74%) isolates were found to be HSV-2. It is likely that some of the genital HSV-1 infections are related to oral genital contact, but this fact could not be established for all cases, since the females in this group had previously been shown to have a high incidence of genital HSV-1.

Topics: Adult; Antibodies, Monoclonal; Antibodies, Viral; Bromodeoxyuridine; Deoxyribonuclease EcoRI; DNA Restriction Enzymes; DNA, Viral; Female; Herpes Genitalis; Humans; Male; Penile Diseases; Penis; Simplexvirus