4'-demethylamino-4'-hydroxystaurosporine: structure given in first source; produced by Streptomyces sp. RK-286 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 10671376 |
| CHEMBL ID | 4762923 |
| MeSH ID | M0175115 |
| Synonym |
|---|
| rk 286c |
| 126572-73-4 |
| 9,13-epoxy-1h,9h-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,4)benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-11-hydroxy-10-methoxy-9-methyl-, (9r-(9alpha,10beta,11beta,13alpha))- |
| 4'-demethylamino-4'-hydroxy-staurosporine |
| 4'-demethylamino-4'-hydroxystaurosporine |
| 4/'-demethylamino-4/'-hydroxystaurosporine |
| (2s,3r,4r,6r)-4-hydroxy-3-methoxy-2-methyl-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one |
| (+)-rk-286c |
| bdbm50547723 |
| chembl4762923 , |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Protein kinase C theta type | Homo sapiens (human) | IC50 (µMol) | 1.3000 | 0.0001 | 0.9897 | 10.0000 | AID1678147 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| protein kinase activity | Protein kinase C theta type | Homo sapiens (human) |
| protein serine/threonine kinase activity | Protein kinase C theta type | Homo sapiens (human) |
| diacylglycerol-dependent serine/threonine kinase activity | Protein kinase C theta type | Homo sapiens (human) |
| protein binding | Protein kinase C theta type | Homo sapiens (human) |
| ATP binding | Protein kinase C theta type | Homo sapiens (human) |
| metal ion binding | Protein kinase C theta type | Homo sapiens (human) |
| protein serine kinase activity | Protein kinase C theta type | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| immunological synapse | Protein kinase C theta type | Homo sapiens (human) |
| cytosol | Protein kinase C theta type | Homo sapiens (human) |
| plasma membrane | Protein kinase C theta type | Homo sapiens (human) |
| aggresome | Protein kinase C theta type | Homo sapiens (human) |
| centriolar satellite | Protein kinase C theta type | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1678147 | Inhibition of PKCtheta (unknown origin) by HTRF assay | |||
| AID1678146 | Inhibition of PKCtheta (unknown origin) at 2.5 ug/ml by HTRF assay relative to control | |||
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.66) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||