Compounds > sb t-1214
Page last updated: 2024-11-12

sb t-1214

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Cross-References

ID SourceID
PubMed CID9897471
CHEMBL ID126916
SCHEMBL ID17971155
MeSH IDM0266568

Synonyms (4)

Synonym
sb-t-1214
CHEMBL126916
SCHEMBL17971155
[(1s,2s,3r,4s,7r,9s,10s,12r,15s)-4-acetyloxy-12-(cyclopropanecarbonyloxy)-1,9-dihydroxy-15-[(2r,3s)-2-hydroxy-5-methyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]hex-4-enoyl]oxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Tubulin beta-2B chainBos taurus (cattle)Activity0.90000.90002.50004.2000AID1184668
Similar to alpha-tubulin isoform 1 Bos taurus (cattle)Activity0.90000.90002.50004.2000AID1184668
Similar to alpha-tubulin isoform 1 Bos taurus (cattle)Activity0.90000.90002.50004.2000AID1184668
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (3)

Processvia Protein(s)Taxonomy
microtubule-based processTubulin beta-2B chainBos taurus (cattle)
nervous system developmentTubulin beta-2B chainBos taurus (cattle)
positive regulation of axon guidanceTubulin beta-2B chainBos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (3)

Processvia Protein(s)Taxonomy
GTPase activityTubulin beta-2B chainBos taurus (cattle)
metal ion bindingTubulin beta-2B chainBos taurus (cattle)
protein heterodimerization activityTubulin beta-2B chainBos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
microtubule cytoskeletonTubulin beta-2B chainBos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (113)

Assay IDTitleYearJournalArticle
AID422256Toxicity in SCID mouse xenografted with human DLD1 cells expressing P-glycoprotein assessed as decrease in body weight at 10 mg/kg, iv administered on day 5, 8, 11 post tumor implantation2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
AID260666Cytotoxicity against human mammary tumor cell line MCF7-R2006Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4
Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents.
AID1184665Cell cycle arrest at G2/M phase in human A2780AD cells at 60 nM after 20 hrs by flow cytometry2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID1404368Cytotoxicity against human paclitaxel-resistant MCF7 cells after 72 hrs by MTT assay2018Journal of natural products, 03-23, Volume: 81, Issue:3
Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery.
AID422240Cytotoxicity against multidrug-resistant human NCI/ADR cells after 72 hrs2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
AID407763Antitumor activity against Pgp expressing multidrug resistant human DLD1 cells xenografted SCID mouse assessed as tumor growth delay at 20 mg/kg, iv administered for 3 days2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID260667Efficacy against Pgp+ human colon tumor xenograft DLD1 in SCID mice at 240 mg/kg, iv2006Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4
Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents.
AID1184672Binding affinity to microtubule (unknown origin) after 30 mins at 32 degC by flutax-2 displacement method2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID422251Activity ratio of compound IC50 to SB-T-1214 IC50 for human multidrug-resistant human NCI/ADR cells expressing P-glycoprotein2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
AID407761Induction of calf brain tubulin polymerization at 10 uM after 12 mins in presence of GTP by spectrophotometric assay2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID1404500Cytotoxicity against human SKOV3 cells after 72 to 120 hrs in presence of verapamil by sulforhodamine B assay2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID1404502Substrate activity at P-gp in human SKVLB1 cells assessed as inhibition of cell growth after 72 to 120 hrs in presence of verapamil by sulforhodamine B assay2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID407758Antitumor activity against mdr1 expressing multidrug resistant human CFPAC1 cells xenografted Swiss mouse assessed as reduction in tumor volume at 20 mg/kg, iv administered for 3 days after 8 weeks2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID407750Resistance index, Ratio of IC50 for paclitaxel resistant human 1A9PTX10 cells to IC50 for human A2780 cells2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID1184647Cytotoxicity against human MCF7 cells by MTT assay2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID422239Cytotoxicity against P-glycoprotein deficient wild type human MCF7 cells after 72 hrs2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
AID422242Cytotoxicity against human A2780 cells after 72 hrs2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
AID1184653Cytotoxicity against human 1A9 cells by MTT assay2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID1404505Ratio of fold resistance for substrate activity at P-gp in human SKVLB1 cells relative to sensitive human SKOV3 cells in absence of verapamil to fold resistance for substrate activity at P-gp in human SKVLB1 cells relative to sensitive human SKOV3 cells i2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID1404495Resistance index, ratio of IC50 for human HEY/Ixab80 cells to IC50 for human HEY cells2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID1184687Cytotoxicity against human A2780 cells by MTT assay2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID1404496Resistance index, ratio of IC50 for human HEY/EpoB8 cells to IC50 for human HEY cells2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID422247Cytotoxicity against human MIAPaCa2 cells expressing mrp1, mrp2, lrp genes after 72 hrs2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
AID407752Resistance index, Ratio of IC50 for paclitaxel resistant human 1A9PTX22 cells to IC50 for human A2780 cells2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID1184649Resistance ratio of IC50 for human MCF7/R cells to IC50 for human MCF7 cells2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID1404492Cytotoxicity against human Hey/Ixab80 cells after 72 to 120 hrs by sulforhodamine B assay2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID1194651Cytotoxicity against folate receptor deficient human WI38 cells after 72 hrs by MTT assay2015Bioorganic & medicinal chemistry, May-01, Volume: 23, Issue:9
Design, synthesis and biological evaluation of a highly-potent and cancer cell selective folate-taxoid conjugate.
AID407768Antitumor activity against Pgp expressing multidrug resistant human DLD1 cells xenografted SCID mouse assessed as tumor growth at 20 mg/kg, iv administered for 3 days after 167 days2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID407766Toxicity in Pgp expressing multidrug resistant human DLD1 cells xenografted SCID mouse at 20 mg/kg, iv administered for 3 days2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID407751Cytotoxicity against paclitaxel resistant human 1A9PTX22 cells expressing class 1 beta-tubulin mutant after 72 hrs2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID1184651Cytotoxicity against human HeLa cells transfected with wild-type tubulin beta3 by MTT assay2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID1404484Inhibition of [3H]2-m-AzTax binding to bovine brain beta-tubulin at 20 uM treated for 30 mins followed by UV irradiation for 10 mins by fluorographic method relative to control2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID1404499Resistance index, ratio of IC50 for vinblastine-resistant human SKVLB1 cells to IC50 for human SKOV3 cells2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID407769Antitumor activity against Pgp expressing multidrug resistant human DLD1 cells xenografted SCID mouse assessed as tumor growth at 10 mg/kg, iv administered for 3 days after 167 days2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID1184656Cytotoxicity against human 1A9PTX22 cells by MTT assay2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID422257Antitumor activity against human DLD1 cells expressing P-glycoprotein xenografted in SCID mouse assessed as no palpable tumors at 20 mg/kg, iv administered on day 5, 8, 11 post tumor implantation measured on day 1672009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
AID1184669Binding affinity to microtubule (unknown origin) after 30 mins at 26 degC by flutax-2 displacement method2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID1184666Cell cycle arrest at G2/M phase in human A549 cells at 30 nM after 20 hrs by flow cytometry2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID1184673Binding affinity to microtubule (unknown origin) after 30 mins at 35 degC by flutax-2 displacement method2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID1404366Cytotoxicity against CD133 positive human HCT116 cells2018Journal of natural products, 03-23, Volume: 81, Issue:3
Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery.
AID1194648Cytotoxicity against folate receptor over-expressing mouse L1210 cells after 72 hrs by MTT assay2015Bioorganic & medicinal chemistry, May-01, Volume: 23, Issue:9
Design, synthesis and biological evaluation of a highly-potent and cancer cell selective folate-taxoid conjugate.
AID407754Cytotoxicity against multidrug resistant human CFPAC1 cells after 72 hrs by MTT assay2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID407755Cytotoxicity against multidrug resistant human BxPC3 cells after 72 hrs by MTT assay2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID1404503Resistance index, ratio of IC50 for substrate activity at P-gp in human SKVLB1 cells assessed as inhibition of cell growth to IC50 for human SKOV3 cells2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID1184688Cytotoxicity against human A2780AD cells by MTT assay2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID407749Cytotoxicity against paclitaxel resistant human 1A9PTX10 cells expressing class 1 beta-tubulin mutant after 72 hrs2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID407748Cytotoxicity against human A2780 cells after 72 hrs2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID1404487Binding affinity to P-gp in human SKVLB1 cells assessed as increase in [3H]vinblastine accumulation at 40 uM after 1 hr by liquid scintillation counting method2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID1404490Cytotoxicity against human HEY cells after 72 to 120 hrs by sulforhodamine B assay2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID407764Antitumor activity against Pgp expressing multidrug resistant human DLD1 cells xenografted SCID mouse assessed as tumor growth delay at 10 mg/kg, iv administered for 3 days2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID1184655Resistance ratio of IC50 for human 1A9PTX10 cells to IC50 for human 1A9 cells2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID1184668Induction of calf brain tubulin polymerization assessed as tubulin concentration required to form microtubules by electron microscopy2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID1404486Inhibition of [3H]2-m-AzTax binding to P-gp in human SKVLB1 cell plasma membranes at 40 uM treated for 30 mins followed by UV irradiation for 10 mins by fluorographic method relative to control2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID1194645Cytotoxicity against folate receptor over-expressing human MX1 cells after 72 hrs by MTT assay2015Bioorganic & medicinal chemistry, May-01, Volume: 23, Issue:9
Design, synthesis and biological evaluation of a highly-potent and cancer cell selective folate-taxoid conjugate.
AID1404497Cytotoxicity against human SKOV3 cells after 72 to 120 hrs by sulforhodamine B assay2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID1184667Cell cycle arrest at G2/M phase in human A549 cells at 60 nM after 20 hrs by flow cytometry2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID106479Concentration required to inhibit growth of human tumor MFC7-R (breast) cell line.1996Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
Syntheses and structure-activity relationships of the second-generation antitumor taxoids: exceptional activity against drug-resistant cancer cells.
AID1184654Cytotoxicity against human 1A9PTX10 cells by MTT assay2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID1404504Resistance index, ratio of IC50 for substrate activity at P-gp in human SKVLB1 cells assessed as inhibition of cell growth in presence of verapamil to IC50 for human SKOV3 cells in presence of verapamil2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID422245Cytotoxicity against paclitaxel-resistant human 1A9PTX22 cells harboring point mutation in beta-tubulin after 72 hrs2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
AID103916Concentration required to inhibit growth of human tumor MCF-7 (breast) cell line.1996Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
Syntheses and structure-activity relationships of the second-generation antitumor taxoids: exceptional activity against drug-resistant cancer cells.
AID1404485Inhibition of [3H]2-m-AzTax binding to chicken erythrocyte beta-tubulin 4 at 20 uM treated for 30 mins followed by UV irradiation for 10 mins by fluorographic method relative to control2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID1184658Cytotoxicity against human 1A9/A8 cells by MTT assay2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID1184689Resistance ratio of IC50 for human A2780AD cells to IC50 for human A2780 cells2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID407757Cytotoxicity against human primary pancreatic ductal cells after 72 hrs by MTT assay2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID407765Antitumor activity against Pgp expressing multidrug resistant human DLD1 cells xenografted SCID mouse assessed as tumor growth delay at 40 mg/kg, iv administered for 3 days2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID422249Cytotoxicity against human BxPC3 cells expressing mrp1, mrp2, lrp genes after 72 hrs2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
AID407753Cytotoxicity against multidrug resistant human MIAPaCa2 cells after 72 hrs by MTT assay2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID422255Toxicity in SCID mouse xenografted with human DLD1 cells assessed as decrease in body weight at 20 mg/kg, iv administered on day 5, 8, 11 post tumor implantation2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
AID1404489Inhibition of [3H]2-m-AzTax binding to P-gp in human SKVLB1 cell plasma membranes assessed as residual [3H]2-m-AzTax binding at 40 uM treated for 30 mins followed by UV irradiation measured after 10 mins by fluorographic method relative to control2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID83579Concentration required to inhibit growth of human tumor HT-29 (colon) cell line.1996Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
Syntheses and structure-activity relationships of the second-generation antitumor taxoids: exceptional activity against drug-resistant cancer cells.
AID1404501Substrate activity at P-gp in human SKVLB1 cells assessed as inhibition of cell growth after 72 to 120 hrs by sulforhodamine B assay2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID407756Cytotoxicity against multidrug resistant human PANC1 cells after 72 hrs by MTT assay2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID1404493Cytotoxicity against human Hey/EpoB8 cells after 72 to 120 hrs by sulforhodamine B assay2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID1404494Resistance index, ratio of IC50 for human HEY/Tx100 cells to IC50 for human HEY cells2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID1184671Binding affinity to microtubule (unknown origin) after 30 mins at 30 degC by flutax-2 displacement method2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID1184652Resistance ratio of IC50 for human HeLa cells transfected with wild-type tubulin beta3 to IC50 for human HeLa cells2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID1184661Effect on microtubule cytoskeleton in human A549 cells assessed as induction of micronuleated cells with short microtubules in cytoplasm at 60 to 120 nM after 24 hrs by immunofluorescence assay2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID422260Cytotoxicity against human primary pancreatic ductal cells up to 10 uM2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
AID407746Cytotoxicity against multidrug resistant Pgp expressing human NCI/ADR cells after 72 hrs by sulforhodamine B test2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID1184670Binding affinity to microtubule (unknown origin) after 30 mins at 27 degC by flutax-2 displacement method2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID1404491Cytotoxicity against human Hey/Tx100 cells after 72 to 120 hrs by sulforhodamine B assay2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID1184659Resistance ratio of IC50 for human 1A9/A8 cells to IC50 for human 1A9 cells2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID422248Cytotoxicity against human Cf-Pac-1 cells expressing mdr1, mrp1, mrp2, lrp genes after 72 hrs2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
AID1184676Binding affinity to microtubule (unknown origin) after 30 mins at 42 degC by flutax-2 displacement method2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID1184657Resistance ratio of IC50 for human 1A9PTX22 cells to IC50 for human 1A9 cells2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID422259Antitumor activity against human DLD1 cells expressing P-glycoprotein xenografted in SCID mouse assessed as no palpable tumors at 10 mg/kg, iv administered on day 5, 8, 11 post tumor implantation measured on day 1672009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
AID422241Resistance factor, ratio of IC50 for P-glycoprotein deficient wild type human MCF7 cells to IC50 for multidrug-resistant human NCI/ADR cells2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
AID407745Cytotoxicity against Pgp deficient human MCF7 cells after 72 hrs by sulforhodamine B test2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID422244Resistance factor, ratio of IC50 for human A2780 cells to IC50 for paclitaxel-resistant human 1A9PTX10 cells harboring point mutation in beta-tubulin2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
AID1404488Effect on [3H]vinblastine accumulation in human SKOV3 cells at 40 uM after 1 hr by liquid scintillation counting method2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID407767Toxicity in Pgp expressing multidrug resistant human DLD1 cells xenografted SCID mouse at 10 mg/kg, iv administered for 3 days2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID422258Toxicity in SCID mouse assessed as decrease in body weight after day 15 to day 202009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
AID260665Cytotoxicity against human mammary tumor cell line MCF7-S2006Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4
Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents.
AID1404498Cytotoxicity against vinblastine-resistant human SKVLB1 cells after 72 to 120 hrs by sulforhodamine B assay2018Journal of natural products, 03-23, Volume: 81, Issue:3
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
AID422252Antitumor activity against human DLD1 cells expressing P-glycoprotein xenografted in SCID mouse assessed as tumor growth delay at 20 mg/kg, iv administered on day 5, 8, 11 post tumor implantation2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
AID1184675Binding affinity to microtubule (unknown origin) after 30 mins at 40 degC by flutax-2 displacement method2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID407759Induction of calf brain tubulin polymerization at 10 uM in presence of GTP by spectrophotometric assay2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID422243Cytotoxicity against paclitaxel-resistant human 1A9PTX10 cells harboring point mutation in beta-tubulin after 72 hrs2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
AID1184663Cell cycle arrest at G2/M phase in human A2780 cells at 60 nM after 20 hrs by flow cytometry2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID1194642Cytotoxicity against folate receptor over-expressing mouse ID8 cells after 72 hrs by MTT assay2015Bioorganic & medicinal chemistry, May-01, Volume: 23, Issue:9
Design, synthesis and biological evaluation of a highly-potent and cancer cell selective folate-taxoid conjugate.
AID1184648Cytotoxicity against human MCF7/R cells by MTT assay2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID1184650Cytotoxicity against human HeLa cells by MTT assay2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID9790Concentration required to inhibit growth of human tumor A121 (ovarian) cell line.1996Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
Syntheses and structure-activity relationships of the second-generation antitumor taxoids: exceptional activity against drug-resistant cancer cells.
AID422253Antitumor activity against human DLD1 cells expressing P-glycoprotein xenografted in SCID mouse assessed as tumor growth delay at 10 mg/kg, iv administered on day 5, 8, 11 post tumor implantation2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
AID8657Concentration required to inhibit growth of human tumor A549 (NSCL) cell line.1996Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
Syntheses and structure-activity relationships of the second-generation antitumor taxoids: exceptional activity against drug-resistant cancer cells.
AID407747Resistance index, Ratio of IC50 for multidrug resistant Pgp expressing human NCI/ADR cells to IC50 for Pgp deficient human MCF7 cells2008Journal of medicinal chemistry, Jun-12, Volume: 51, Issue:11
Design, synthesis, and biological evaluation of new-generation taxoids.
AID1184664Cell cycle arrest at G2/M phase in human A2780AD cells at 30 nM after 20 hrs by flow cytometry2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID1184674Binding affinity to microtubule (unknown origin) after 30 mins at 37 degC by flutax-2 displacement method2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID1184662Cell cycle arrest at G2/M phase in human A2780 cells at 30 nM after 20 hrs by flow cytometry2014Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
AID422246Resistance factor, ratio of IC50 for human A2780 cells to IC50 for paclitaxel-resistant human 1A9PTX22 cells harboring point mutation in beta-tubulin2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
AID422254Antitumor activity against human DLD1 cells expressing P-glycoprotein xenografted in SCID mouse assessed as tumor growth delay at 40 mg/kg, iv administered on day 5, 8, 11 post tumor implantation2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
AID422250Cytotoxicity against human PANC1 cells expressing mdr1, mrp1, mrp2, lrp genes after 72 hrs2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Recent advances in the chemistry and biology of new generation taxoids.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's3 (37.50)29.6817
2010's4 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.66 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.86 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.66)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (25.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (75.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		5.1780taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
topotecan
Topotecan: An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.. topotecan : A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.		3.2710pyranoindolizinoquinolineantineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor
methotrexate
[no description available]		3.2710dicarboxylic acid;
monocarboxylic acid amide;
pteridines		abortifacient;
antimetabolite;
antineoplastic agent;
antirheumatic drug;
dermatologic drug;
DNA synthesis inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
immunosuppressive agent
docetaxel
[no description available]		4.2350hydrate;
secondary alpha-hydroxy ketone		antineoplastic agent
docetaxel anhydrous
Docetaxel: A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.. docetaxel anhydrous : A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group.		2.1710secondary alpha-hydroxy ketone;
tetracyclic diterpenoid		antimalarial;
antineoplastic agent;
photosensitizing agent
eleutherobin
eleutherobin: structure in first source		3.2710
sb t-1213
[no description available]		4.0440
idn 5390
IDN 5390: structure in first source		3.1410
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		01.9910
B16 Melanoma
[description not available]		01.9910
Cancer of Ovary
[description not available]		02.4420
Breast Neoplasms
Tumors or cancer of the human BREAST.		01.9910
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		02.4420
Benign Neoplasms
[description not available]		03.0910
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.0910