| Assay ID | Title | Year | Journal | Article |
|---|
| AID32355 | Displacement of [3H]DPCPX from rat cortical membranes Adenosine A1 receptor | 1999 | Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8
| N6,5'-Disubstituted adenosine derivatives as partial agonists for the human adenosine A3 receptor. |
| AID32892 | Displacement of [3H]-CGS- 21680 from Adenosine A2A receptor of rat striatal membranes | 1999 | Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8
| N6,5'-Disubstituted adenosine derivatives as partial agonists for the human adenosine A3 receptor. |
| AID330912 | Binding affinity to ENT1 transporter | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
| Constrained NBMPR analogue synthesis, pharmacophore mapping and 3D-QSAR modeling of equilibrative nucleoside transporter 1 (ENT1) inhibitory activity. |
| AID539780 | Cytotoxicity against human T24 cells assessed as inhibition of clones formation at 10 uM after 1 week by clonogenic assay | 2010 | Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23
| N⁶-Alkyladenosines: Synthesis and evaluation of in vitro anticancer activity. |
| AID30353 | Affinity constant for inhibition of A1 receptor control of adenylate cyclase in adipocytes, heart and brain cells | 1982 | Journal of medicinal chemistry, Mar, Volume: 25, Issue:3
| Adenosine receptors: targets for future drugs. |
| AID32015 | Binding affinity to adenosine A1 receptor in rat whole brain membranes by [3H]N6-cyclohexyladenosine displacement. | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10
| N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity. |
| AID138966 | Antitumor activity against slow growing spontaneous mammary tumors in the DBA/2 Ha-DD mouse number of days reacquired fro tumor growth 3.8 mg/kg/day x 5 melphalan once in 5 days | 1980 | Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
| Some short-chain N6-substituted adenosine analogues with antitumor properties. |
| AID201887 | Concentration required for 50% growth inhibition of the following cell lines sarcoma S-180 cells | 1980 | Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
| Some short-chain N6-substituted adenosine analogues with antitumor properties. |
| AID288175 | Activation of Arabidopsis thaliana CRE1/AHK4 cytokinin receptor relative to trans-zeatin | 2007 | Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11
| Preparation, biological activity and endogenous occurrence of N6-benzyladenosines. |
| AID155527 | evaluated for the inhibition of Trypanosoma brucei Phosphoglycerate kinase (PGK) | 2000 | Journal of medicinal chemistry, Nov-02, Volume: 43, Issue:22
| Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine. |
| AID288182 | Antitumor activity against mouse B16 cells after 72 hrs by Calcein AM assay | 2007 | Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11
| Preparation, biological activity and endogenous occurrence of N6-benzyladenosines. |
| AID75710 | Inhibition of Leishmania mexicana GAPDH(glyceraldehyde-3-phosphate dehydrogenase) | 1998 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 8, Issue:24
| Synthesis and structure-activity relationships of adenosine analogs as inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase. Modifications at positions 5' and 8. |
| AID1293510 | Cytotoxicity against human RD cells | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Modification of the length and structure of the linker of N(6)-benzyladenosine modulates its selective antiviral activity against enterovirus 71. |
| AID30337 | Evaluated for binding affinity against Adenosine A1 receptor | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4
| A steric and electrostatic comparison of three models for the agonist/antagonist binding site on the adenosine A1 receptor. |
| AID288176 | Antitumor activity against human HOS cells after 72 hrs by Calcein AM assay | 2007 | Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11
| Preparation, biological activity and endogenous occurrence of N6-benzyladenosines. |
| AID340153 | Antitumor activity against human K562 cells after 48 hrs by MTS assay | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives. |
| AID138631 | Antitumor activity against slow growing spontaneous mammary tumors in the DBA/2 Ha-DD mouse mean life span in days at 50 mg/kg give 5 times once in 5 days | 1980 | Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
| Some short-chain N6-substituted adenosine analogues with antitumor properties. |
| AID130977 | Antitumor activity against slow growing spontaneous mammary tumors in the DBA/2 Ha-DD mouse % increased in life span 3.8 mg/kg/day x 5 melphalan + 50 mg/kg/day compound | 1980 | Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
| Some short-chain N6-substituted adenosine analogues with antitumor properties. |
| AID539783 | Induction of MMP9 activity in human T24 cells after 1 hr by zymography | 2010 | Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23
| N⁶-Alkyladenosines: Synthesis and evaluation of in vitro anticancer activity. |
| AID30499 | Acidic dissociation constant(pKa) against A2 adenosine receptor of coronary artery | 1986 | Journal of medicinal chemistry, Jun, Volume: 29, Issue:6
| Dog coronary artery adenosine receptor: structure of the N6-aryl subregion. |
| AID33337 | Binding affinity determined by displacement of specific binding of [125I]N-(4-amino-3-iodophenethyl)-adenosine in membranes of CHO cells stably transfected with the rat adenosine A3 receptor | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors. |
| AID34879 | Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]AB-MECA displacement. | 1999 | Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8
| N6,5'-Disubstituted adenosine derivatives as partial agonists for the human adenosine A3 receptor. |
| AID34158 | Inhibition of adenyl cyclase via P site in adipocytes; Inactive | 1982 | Journal of medicinal chemistry, Mar, Volume: 25, Issue:3
| Adenosine receptors: targets for future drugs. |
| AID1430043 | Cytotoxicity against PEK cells after 24 hrs | 2017 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
| New tools in nucleoside toolbox of tick-borne encephalitis virus reproduction inhibitors. |
| AID31885 | Binding affinity to adenosine A1 receptor in rat brain membranes by measuring displacement of specific [3H]PIA as radioligand. | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors. |
| AID33588 | Binding affinity towards adenosine A2 receptor on rat striatal membrane using [3H]NECA as radioligand | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1
| N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor. |
| AID340161 | Growth inhibition of 1 uM 1,4-dihydro-2-methyl-6-phenyl-4-(phenylethyl)-3,5-pyridine-dicarboxylic acid 3-ethyl-5-[(3-nitrophenyl) methyl] ester pretreated human K562 cells after 72 hrs by MTS assay | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives. |
| AID48652 | Concentration required for 50% growth inhibition of the following cell lines Carcinoma TA-3 cells | 1980 | Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
| Some short-chain N6-substituted adenosine analogues with antitumor properties. |
| AID1430041 | Antiviral activity against TEBV Absettarov infected in PEK cells assessed as inhibition of viral reproduction at 50 uM preincubated with virus for 1 hr followed by addition to PEK cells measured after 1 hr by gentian violet staining based plaque reduction | 2017 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
| New tools in nucleoside toolbox of tick-borne encephalitis virus reproduction inhibitors. |
| AID340158 | Growth inhibition of 0.1 uM 1,4-dihydro-2-methyl-6-phenyl-4-(phenylethyl)-3,5-pyridine-dicarboxylic acid 3-ethyl-5-[(3-nitrophenyl) methyl] ester pretreated human K562 cells after 48 hrs by MTS assay | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives. |
| AID32195 | Binding affinity towards adenosine A1 receptor on rat whole brain membrane using [3H]N6-cyclohexyladenosine | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1
| N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor. |
| AID539782 | Inhibition of human T24 cells invasion on Matrigel after 24 hrs | 2010 | Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23
| N⁶-Alkyladenosines: Synthesis and evaluation of in vitro anticancer activity. |
| AID539777 | Cytotoxicity against human J82 cells at 10 uM after 72 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23
| N⁶-Alkyladenosines: Synthesis and evaluation of in vitro anticancer activity. |
| AID32503 | Inhibition of binding of [3H]N6-cyclohexyladenosine to adenosine A1 receptor of rat whole brain membranes. | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
| C2,N6-disubstituted adenosines: synthesis and structure-activity relationships. |
| AID130975 | Antitumor activity against mouse leukemia, L-1210(DBA/2 Ha Mice) % increase in life span at 3.12 mg/kg of dose per day | 1980 | Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
| Some short-chain N6-substituted adenosine analogues with antitumor properties. |
| AID32324 | Inhibition of [3H]-CHA binding to rat brain membrane Adenosine A1 receptor | 1990 | Journal of medicinal chemistry, Dec, Volume: 33, Issue:12
| A novel synthesis of xanthines: support for a new binding mode for xanthines with respect to adenosine at adenosine receptors. |
| AID288179 | Antitumor activity against human CEM cells after 72 hrs by Calcein AM assay | 2007 | Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11
| Preparation, biological activity and endogenous occurrence of N6-benzyladenosines. |
| AID330859 | Agonist activity human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase relative to NECA | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Probing distal regions of the A2B adenosine receptor by quantitative structure-activity relationship modeling of known and novel agonists. |
| AID34545 | Inhibition of forskolin-stimulated cAMP production mediated by human adenosine A3 receptor expressed in CHO cells at 10 uM | 1999 | Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8
| N6,5'-Disubstituted adenosine derivatives as partial agonists for the human adenosine A3 receptor. |
| AID340157 | Inhibition of human adenosine A3 receptor | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives. |
| AID30496 | Molar potency ratio (MPR) against adenosine A2 receptor of canine coronary artery | 1986 | Journal of medicinal chemistry, Jun, Volume: 29, Issue:6
| Dog coronary artery adenosine receptor: structure of the N6-aryl subregion. |
| AID340156 | Antitumor activity against human MCF7 cells after 48 hrs by MTS assay | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives. |
| AID33591 | Binding of Adenosine A2 receptor in whole rat brain membrane using [3H]CHA as a Radioligand | 1990 | Journal of medicinal chemistry, Dec, Volume: 33, Issue:12
| A novel synthesis of xanthines: support for a new binding mode for xanthines with respect to adenosine at adenosine receptors. |
| AID33733 | Inhibition of binding of [3H]NECA to adenosine A2 receptor of rat striatal membranes. | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
| C2,N6-disubstituted adenosines: synthesis and structure-activity relationships. |
| AID138630 | Antitumor activity against mouse leukemia, L-1210(DBA/2 Ha Mice) mean life span (days) of the mouse after fractionated dosage(dose divided in two halves and administered in two daily injections) at 6.25 mg/kg of dose per day | 1980 | Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
| Some short-chain N6-substituted adenosine analogues with antitumor properties. |
| AID288174 | Activation of Arabidopsis thaliana AHK3 cytokinin receptor relative to trans-zeatin | 2007 | Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11
| Preparation, biological activity and endogenous occurrence of N6-benzyladenosines. |
| AID340159 | Growth inhibition of 1 uM 1,4-dihydro-2-methyl-6-phenyl-4-(phenylethyl)-3,5-pyridine-dicarboxylic acid 3-ethyl-5-[(3-nitrophenyl) methyl] ester pretreated human K562 cells after 48 hrs by MTS assay | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives. |
| AID33909 | Affinity constant for A2 receptor control of adenylate cyclase in adipocytes, heart and brain cells | 1982 | Journal of medicinal chemistry, Mar, Volume: 25, Issue:3
| Adenosine receptors: targets for future drugs. |
| AID1293509 | Antiviral activity against Enterovirus 71 infected in human RD cells assessed as cell viability after 3 days by MTS assay | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Modification of the length and structure of the linker of N(6)-benzyladenosine modulates its selective antiviral activity against enterovirus 71. |
| AID138629 | Antitumor activity against mouse leukemia, L-1210(DBA/2 Ha Mice) mean life span ( days) of the mouse after the dosage at 1.56 mg/kg of dose per day | 1980 | Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
| Some short-chain N6-substituted adenosine analogues with antitumor properties. |
| AID340160 | Growth inhibition of 0.1 uM 1,4-dihydro-2-methyl-6-phenyl-4-(phenylethyl)-3,5-pyridine-dicarboxylic acid 3-ethyl-5-[(3-nitrophenyl) methyl] ester pretreated human K562 cells after 72 hrs by MTS assay | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives. |
| AID33567 | Binding affinity to A2 adenosine receptor in rat striatal membranes by [3H]NECA (1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide) displacement. | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10
| N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity. |
| AID175313 | Reduction of heart rate (A1 response) in isolated rat heart preparation | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1
| N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor. |
| AID539779 | Cytotoxicity against human MDA-MB-231 cells at 10 uM after 72 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23
| N⁶-Alkyladenosines: Synthesis and evaluation of in vitro anticancer activity. |
| AID25506 | Index of hydrophobicity (k') | 1986 | Journal of medicinal chemistry, Jun, Volume: 29, Issue:6
| Dog coronary artery adenosine receptor: structure of the N6-aryl subregion. |
| AID229799 | Ratio of Ki at adenosine A2 and A1 receptors | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1
| N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor. |
| AID232472 | Selectivity ratio for A1 receptor to that of A2 receptor in vitro in rat tissues | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
| C2,N6-disubstituted adenosines: synthesis and structure-activity relationships. |
| AID33492 | Selectivity for cloned rat A3 receptor | 1994 | Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
| 2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors. |
| AID175310 | Enhancement of coronary flow (A2 response) in isolated rat heart preparation | 1988 | Journal of medicinal chemistry, Jan, Volume: 31, Issue:1
| N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor. |
| AID34160 | Inhibition of Adenylate Cyclase in Rat adipocytes | 1990 | Journal of medicinal chemistry, Dec, Volume: 33, Issue:12
| A novel synthesis of xanthines: support for a new binding mode for xanthines with respect to adenosine at adenosine receptors. |
| AID539784 | Inhibition of human T24 cell migration by wound healing assay | 2010 | Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23
| N⁶-Alkyladenosines: Synthesis and evaluation of in vitro anticancer activity. |
| AID288177 | Antitumor activity against human K562 cells after 72 hrs by Calcein AM assay | 2007 | Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11
| Preparation, biological activity and endogenous occurrence of N6-benzyladenosines. |
| AID1293511 | Selectivity index, ratio of CC50 for human RD cells to EC50 for Enterovirus 71 | 2016 | European journal of medicinal chemistry, Mar-23, Volume: 111 | Modification of the length and structure of the linker of N(6)-benzyladenosine modulates its selective antiviral activity against enterovirus 71. |
| AID288178 | Antitumor activity against human MCF cells after 72 hrs by Calcein AM assay | 2007 | Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11
| Preparation, biological activity and endogenous occurrence of N6-benzyladenosines. |
| AID201700 | Concentration required for 50% growth inhibition of human breast tumor cells SW-613 human breast adenocarcinoma cells | 1980 | Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
| Some short-chain N6-substituted adenosine analogues with antitumor properties. |
| AID539776 | Cytotoxicity against human T24 cells at 10 uM after 72 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23
| N⁶-Alkyladenosines: Synthesis and evaluation of in vitro anticancer activity. |
| AID101497 | Concentration required for 50% growth inhibition of the following cell lines Leukemia L-1210 cells | 1980 | Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
| Some short-chain N6-substituted adenosine analogues with antitumor properties. |
| AID34268 | Effective concentration for stimulation of [35S]GTP-gamma-S, binding to human adenosine A3 receptor | 1999 | Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8
| N6,5'-Disubstituted adenosine derivatives as partial agonists for the human adenosine A3 receptor. |
| AID34544 | Inhibition of forskolin-induced c-AMP production by adenosine A3 receptor with 10 uM NECA | 1999 | Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8
| N6,5'-Disubstituted adenosine derivatives as partial agonists for the human adenosine A3 receptor. |
| AID131362 | Effect on Ataxia in mouse following i.p. administration. | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10
| N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity. |
| AID340154 | Antitumor activity against human CaCo2 cells after 48 hrs by MTS assay | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives. |
| AID33057 | Percentage of [35S]GTP-gamma-S, binding to the human adenosine A3 receptor stimulated at 10E-4 M | 1999 | Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8
| N6,5'-Disubstituted adenosine derivatives as partial agonists for the human adenosine A3 receptor. |
| AID131363 | Effect on Motor activity in mouse following i.p. administration. | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10
| N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity. |
| AID75595 | Inhibitory activity measured for Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in Leishmania. mexicana | 1998 | Journal of medicinal chemistry, Nov-19, Volume: 41, Issue:24
| Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design. |
| AID288181 | Antitumor activity against human G361 cells after 72 hrs by Calcein AM assay | 2007 | Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11
| Preparation, biological activity and endogenous occurrence of N6-benzyladenosines. |
| AID340155 | Antitumor activity against human HT29 cells after 48 hrs by MTS assay | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives. |
| AID33792 | Binding affinity to adenosine A2A receptor in rat striatal membranes by measuring displacement of specific [3H]-CGS- 21680 as radioligand | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors. |
| AID330858 | Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Probing distal regions of the A2B adenosine receptor by quantitative structure-activity relationship modeling of known and novel agonists. |
| AID90274 | Concentration required for 50% growth inhibition of the following cell lines human burkitt lymphoma cells | 1980 | Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
| Some short-chain N6-substituted adenosine analogues with antitumor properties. |
| AID288183 | Cytotoxicity against mouse NIH 3T3 cells after 72 hrs by Calcein AM assay | 2007 | Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11
| Preparation, biological activity and endogenous occurrence of N6-benzyladenosines. |
| AID1175339 | Inhibition of collagen-induced human platelet aggregation after 3 mins by light transmission aggregometry | 2014 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 24, Issue:24
| Naturally occurring N(6)-substituted adenosines (cytokinin ribosides) are in vitro inhibitors of platelet aggregation: an in silico evaluation of their interaction with the P2Y(12) receptor. |
| AID1430042 | Antiviral activity against TEBV Absettarov infected in PEK cells assessed as inhibition of viral reproduction preincubated with virus for 1 hr followed by addition to PEK cells measured after 1 hr by gentian violet staining based plaque reduction assay | 2017 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
| New tools in nucleoside toolbox of tick-borne encephalitis virus reproduction inhibitors. |
| AID1646835 | Activation of human STING expressed in monocytes co-expressing IFN assessed as alkaline phosphatase secretion by SEAP reporter gene assay | 2020 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2
| Structure activity relationship, 6-modified purine riboside analogues to activate hSTING, stimulator of interferon genes. |
| AID539781 | Growth inhibition of human T24 cells assessed as reduction of cell count after trypsinization at 10 uM after 72 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23
| N⁶-Alkyladenosines: Synthesis and evaluation of in vitro anticancer activity. |
| AID103053 | Concentration required for 50% growth inhibition of human breast tumor cells MCF-7 human breast carcinoma cells | 1980 | Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
| Some short-chain N6-substituted adenosine analogues with antitumor properties. |
| AID539778 | Cytotoxicity against human Caco-2 cells at 10 uM after 72 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23
| N⁶-Alkyladenosines: Synthesis and evaluation of in vitro anticancer activity. |
| AID1430044 | Cytotoxicity against PEK cells after 7 days | 2017 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
| New tools in nucleoside toolbox of tick-borne encephalitis virus reproduction inhibitors. |
| AID288180 | Antitumor activity against human HL60 cells after 72 hrs by Calcein AM assay | 2007 | Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11
| Preparation, biological activity and endogenous occurrence of N6-benzyladenosines. |
| AID184413 | Inhibition of [3H]S-(4-Nitrobenzyl)-6-thioinosine binding to adenosine uptake sites in rat brain membranes | 1994 | Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
| 2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |