Compounds > phakellistatin 2
Page last updated: 2024-11-12

phakellistatin 2

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Description

phakellistatin 2: isolated from the marine sponge Phakellia carteri; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10418023
CHEMBL ID499175
MeSH IDM0305172

Synonyms (4)

Synonym
CHEMBL499175
phakellistatin 2
phekellistatin 2
cyclo(tyr-pro-phe-pro-ile-ile-pro)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (8)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Sodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)IC50 (µMol)100.00000.00480.78076.0000AID1355348
Sodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)IC50 (µMol)100.00000.00480.81346.0000AID1355348
Sodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)IC50 (µMol)100.00000.00480.81346.0000AID1355348
Sodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)IC50 (µMol)100.00000.00480.81346.0000AID1355348
Sodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)IC50 (µMol)100.00000.00480.81346.0000AID1355348
Sodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)IC50 (µMol)100.00000.00480.81346.0000AID1355348
Sodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)IC50 (µMol)100.00000.00480.81346.0000AID1355348
Sodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)IC50 (µMol)100.00000.00480.81346.0000AID1355348
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (95)

Processvia Protein(s)Taxonomy
regulation of the force of heart contractionSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
regulation of sodium ion transportSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
osmosensory signaling pathwaySodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
regulation of blood pressureSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
response to xenobiotic stimulusSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
establishment or maintenance of transmembrane electrochemical gradientSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
negative regulation of glucocorticoid biosynthetic processSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
negative regulation of heart contractionSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
positive regulation of heart contractionSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
positive regulation of striated muscle contractionSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
relaxation of cardiac muscleSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
cellular response to steroid hormone stimulusSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
cardiac muscle cell action potential involved in contractionSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
membrane repolarizationSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
membrane repolarization during cardiac muscle cell action potentialSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
cell communication by electrical coupling involved in cardiac conductionSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
proton transmembrane transportSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
response to glycosideSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
intracellular calcium ion homeostasisSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
cell adhesionSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
establishment or maintenance of transmembrane electrochemical gradientSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
regulation of gene expressionSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
regulation of cardiac muscle contraction by calcium ion signalingSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
positive regulation of ATP-dependent activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
sodium ion transmembrane transportSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
protein transport into plasma membrane raftSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
innate immune responseSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
ATP metabolic processSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
protein stabilizationSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
relaxation of cardiac muscleSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
cardiac muscle contractionSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
protein localization to plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
membrane repolarizationSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
membrane repolarization during cardiac muscle cell action potentialSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
cell communication by electrical coupling involved in cardiac conductionSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
monoatomic cation transmembrane transportSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
positive regulation of potassium ion transmembrane transporter activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
proton transmembrane transportSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
positive regulation of sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
positive regulation of calcium:sodium antiporter activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
positive regulation of potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
positive regulation of P-type sodium:potassium-exchanging transporter activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
establishment or maintenance of transmembrane electrochemical gradientSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
regulation of resting membrane potentialSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
cellular response to steroid hormone stimulusSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
cell communication by electrical coupling involved in cardiac conductionSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
response to glycosideSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
cellular response to amyloid-betaSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
neuron projection maintenanceSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
proton transmembrane transportSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
retina homeostasisSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
lateral ventricle developmentSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
third ventricle developmentSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
neuronal-glial interaction involved in hindbrain glial-mediated radial cell migrationSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
photoreceptor cell maintenanceSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
motor behaviorSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
plasma membrane bounded cell projection organizationSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
positive regulation of neuron projection developmentSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
cell-substrate adhesionSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
positive regulation of ATP-dependent activitySodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
protein stabilizationSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
membrane repolarizationSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
cell communication by electrical coupling involved in cardiac conductionSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
transport across blood-brain barrierSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
positive regulation of potassium ion transmembrane transporter activitySodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
positive regulation of sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
positive regulation of potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
negative regulation of glial cell migrationSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
behavioral fear responseSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of the force of heart contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of respiratory gaseous exchange by nervous system processSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of muscle contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
amygdala developmentSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
olfactory cortex developmentSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
locomotionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
negative regulation of heart contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
positive regulation of heart contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
negative regulation of cytosolic calcium ion concentrationSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
neurotransmitter uptakeSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
potassium ion transportSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
sodium ion transportSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of smooth muscle contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of striated muscle contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of blood pressureSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
adult locomotory behaviorSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
visual learningSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
establishment or maintenance of transmembrane electrochemical gradientSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
response to auditory stimulusSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
neuronal action potential propagationSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of vasoconstrictionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
L-ascorbic acid metabolic processSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
response to nicotineSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
locomotory exploration behaviorSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
sodium ion transmembrane transportSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
response to potassium ionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
negative regulation of striated muscle contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
ATP metabolic processSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of glutamate uptake involved in transmission of nerve impulseSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of synaptic transmission, glutamatergicSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
relaxation of cardiac muscleSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
cardiac muscle contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
cellular response to mechanical stimulusSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
cellular response to steroid hormone stimulusSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
potassium ion transmembrane transportSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of cardiac muscle cell contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
membrane repolarizationSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
membrane depolarization during cardiac muscle cell action potentialSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
cell communication by electrical coupling involved in cardiac conductionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
monoatomic cation transmembrane transportSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
transport across blood-brain barrierSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
negative regulation of calcium ion transmembrane transportSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
negative regulation of calcium:sodium antiporter activitySodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
response to glycosideSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
proton transmembrane transportSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
positive regulation of ATP-dependent activitySodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
sodium ion transmembrane transportSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
protein stabilizationSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
potassium ion transmembrane transportSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
protein localization to plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
membrane repolarizationSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
positive regulation of potassium ion transmembrane transporter activitySodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
positive regulation of sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
positive regulation of potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
establishment or maintenance of transmembrane electrochemical gradientSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
transmembrane transportSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
proton transmembrane transportSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
positive regulation of P-type sodium:potassium-exchanging transporter activitySodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
regulation of sodium ion transmembrane transporter activitySodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
monoatomic ion transportSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
potassium ion transportSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
sodium ion transportSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
cell surface receptor signaling pathwaySodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
spermatogenesisSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
fertilizationSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
establishment or maintenance of transmembrane electrochemical gradientSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
flagellated sperm motilitySodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
regulation of cellular pHSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
sodium ion transmembrane transportSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
regulation of membrane potentialSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
establishment of localization in cellSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
potassium ion transmembrane transportSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
transport across blood-brain barrierSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
proton transmembrane transportSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (22)

Processvia Protein(s)Taxonomy
P-type sodium:potassium-exchanging transporter activitySodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
protein bindingSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
ATP bindingSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
phosphatase activitySodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
ATP hydrolysis activitySodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
potassium ion bindingSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
sodium ion bindingSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
transmembrane transporter bindingSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
protein heterodimerization activitySodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
protein-folding chaperone bindingSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
steroid hormone bindingSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
ATPase activator activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
P-type sodium:potassium-exchanging transporter activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
protein bindingSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
protein kinase bindingSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
MHC class II protein complex bindingSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
protein-macromolecule adaptor activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
protein heterodimerization activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
ATPase bindingSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
amyloid-beta bindingSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
P-type sodium:potassium-exchanging transporter activitySodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
protein bindingSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
ATP bindingSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
ATP hydrolysis activitySodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
metal ion bindingSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
protein-folding chaperone bindingSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
steroid hormone bindingSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
ATPase activator activitySodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
protein bindingSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
protein-macromolecule adaptor activitySodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
protein heterodimerization activitySodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
ATPase bindingSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
P-type sodium:potassium-exchanging transporter activitySodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
steroid bindingSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
protein bindingSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
ATP bindingSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
phosphatase activitySodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
ATP hydrolysis activitySodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
ATPase-coupled monoatomic cation transmembrane transporter activitySodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
potassium ion bindingSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
sodium ion bindingSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
protein heterodimerization activitySodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
protein-folding chaperone bindingSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
steroid hormone bindingSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
ATPase activator activitySodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
protein bindingSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
protein-macromolecule adaptor activitySodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
ATPase bindingSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
ATPase activator activitySodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
protein-macromolecule adaptor activitySodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
sodium channel regulator activitySodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
P-type sodium:potassium-exchanging transporter activitySodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
protein bindingSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
ATP bindingSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
ATP hydrolysis activitySodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
ATPase-coupled monoatomic cation transmembrane transporter activitySodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
kinase bindingSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
metal ion bindingSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (41)

Processvia Protein(s)Taxonomy
endoplasmic reticulumSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
Golgi apparatusSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
postsynaptic densitySodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
basolateral plasma membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
apical plasma membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
lateral plasma membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
T-tubuleSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
axonSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
organelle membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
sperm flagellumSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
sarcolemmaSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
melanosomeSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
membrane raftSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
photoreceptor inner segment membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
extracellular exosomeSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
extracellular vesicleSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
protein-containing complexSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
sarcolemmaSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
intercalated discSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
basolateral plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
apical plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
lateral plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
T-tubuleSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
organelle membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
sperm flagellumSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
sarcolemmaSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
extracellular exosomeSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
extracellular vesicleSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
photoreceptor inner segmentSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
endoplasmic reticulumSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
Golgi apparatusSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
axonSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
organelle membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
neuronal cell body membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
neuronal cell bodySodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
synapseSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
photoreceptor inner segment membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
neuron to neuron synapseSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
extracellular vesicleSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
photoreceptor inner segmentSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
cytoplasmSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
external side of plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
apical plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
lateral plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
cell projection membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
cell body membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
cell peripherySodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
astrocyte projectionSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
astrocyte end-footSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
neuron to neuron synapseSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
cytoplasmSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
endosomeSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
endoplasmic reticulumSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
caveolaSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
cell surfaceSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
intercalated discSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
membraneSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
T-tubuleSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
organelle membraneSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
cell projectionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
neuronal cell bodySodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
dendritic spineSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
extracellular vesicleSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
cell projectionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
basolateral plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
apical plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
sperm flagellumSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
melanosomeSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
extracellular exosomeSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
extracellular exosomeSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
membrane raftSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
sperm midpieceSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
photoreceptor cell ciliumSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
rod photoreceptor outer segmentSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
cell projectionSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (22)

Assay IDTitleYearJournalArticle
AID1355344Cytotoxicity against human K562 cells after 72 hrs by sulforhodamine B assay2018Journal of natural products, 06-22, Volume: 81, Issue:6
Cyclopeptides from the Sponge Stylissa flabelliformis.
AID1355342Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay2018Journal of natural products, 06-22, Volume: 81, Issue:6
Cyclopeptides from the Sponge Stylissa flabelliformis.
AID1355352Antibacterial activity against Bacillus subtilis ATCC 6633 measured after 24 hrs2018Journal of natural products, 06-22, Volume: 81, Issue:6
Cyclopeptides from the Sponge Stylissa flabelliformis.
AID378771Growth inhibition of mouse P388 cells1999Journal of natural products, Mar, Volume: 62, Issue:3
Antineoplastic agents. 400. Synthesis of the Indian Ocean marine sponge cyclic heptapeptide phakellistatin 2.
AID1355343Cytotoxicity against human HCT116 cells after 72 hrs by sulforhodamine B assay2018Journal of natural products, 06-22, Volume: 81, Issue:6
Cyclopeptides from the Sponge Stylissa flabelliformis.
AID1355353Antibacterial activity against Micrococcus luteus IFC 12708 measured after 24 hrs2018Journal of natural products, 06-22, Volume: 81, Issue:6
Cyclopeptides from the Sponge Stylissa flabelliformis.
AID1355349Inhibition of Magnaporthe grisea Guy 11 isocitrate lyase2018Journal of natural products, 06-22, Volume: 81, Issue:6
Cyclopeptides from the Sponge Stylissa flabelliformis.
AID1355347Cytotoxicity against human SNU638 cells after 72 hrs by sulforhodamine B assay2018Journal of natural products, 06-22, Volume: 81, Issue:6
Cyclopeptides from the Sponge Stylissa flabelliformis.
AID1355356Antibacterial activity against Escherichia coli ATCC 25922 measured after 24 hrs2018Journal of natural products, 06-22, Volume: 81, Issue:6
Cyclopeptides from the Sponge Stylissa flabelliformis.
AID1355351Antibacterial activity against Staphylococcus aureus ATCC 6538P measured after 24 hrs2018Journal of natural products, 06-22, Volume: 81, Issue:6
Cyclopeptides from the Sponge Stylissa flabelliformis.
AID1355350Inhibition of recombinant bacterial sortase A using Dabcyl-QALPETGEE-Edans as substrate measured after 1 hr by fluorescence assay2018Journal of natural products, 06-22, Volume: 81, Issue:6
Cyclopeptides from the Sponge Stylissa flabelliformis.
AID1355357Antifungal activity against Candida albicans ATCC 10231 measured after 48 to 72 hrs2018Journal of natural products, 06-22, Volume: 81, Issue:6
Cyclopeptides from the Sponge Stylissa flabelliformis.
AID1355354Antibacterial activity against Proteus vulgaris ATCC 3851 measured after 24 hrs2018Journal of natural products, 06-22, Volume: 81, Issue:6
Cyclopeptides from the Sponge Stylissa flabelliformis.
AID356733Cytotoxicity against mouse P388 cells2001Journal of natural products, Jul, Volume: 64, Issue:7
Synthesis of phakellistatin 11: a micronesia (Chuuk) marine sponge cyclooctapeptide.
AID1355359Antifungal activity against Trichophyton rubrum IFO 9185 measured after 48 to 72 hrs2018Journal of natural products, 06-22, Volume: 81, Issue:6
Cyclopeptides from the Sponge Stylissa flabelliformis.
AID1355346Cytotoxicity against human SKHEP1 cells after 72 hrs by sulforhodamine B assay2018Journal of natural products, 06-22, Volume: 81, Issue:6
Cyclopeptides from the Sponge Stylissa flabelliformis.
AID1355355Antibacterial activity against Salmonella typhimurium ATCC 14028 measured after 24 hrs2018Journal of natural products, 06-22, Volume: 81, Issue:6
Cyclopeptides from the Sponge Stylissa flabelliformis.
AID1355358Antifungal activity against Aspergillus fumigatus HIC 6094 measured after 48 to 72 hrs2018Journal of natural products, 06-22, Volume: 81, Issue:6
Cyclopeptides from the Sponge Stylissa flabelliformis.
AID1355348Inhibition of potassium-activated sodium/potassium ATPase in human placenta using 3-O-methylfluorescein phosphate as substrate measured for 90 secs by fluorescence assay2018Journal of natural products, 06-22, Volume: 81, Issue:6
Cyclopeptides from the Sponge Stylissa flabelliformis.
AID1355360Antifungal activity against Trichophyton mentagrophytes IFO 40996 measured after 48 to 72 hrs2018Journal of natural products, 06-22, Volume: 81, Issue:6
Cyclopeptides from the Sponge Stylissa flabelliformis.
AID405759Anticancer activity against mouse P388 cells2008Journal of natural products, Jun, Volume: 71, Issue:6
Solid-phase total synthesis of cyclic decapeptide phakellistatin 12.
AID1355345Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay2018Journal of natural products, 06-22, Volume: 81, Issue:6
Cyclopeptides from the Sponge Stylissa flabelliformis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's3 (60.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.87 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.87)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
etoposide
[no description available]		2.1710beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.0410
Granulocytic Leukemia
[description not available]		02.0110
Cancer of Ovary
[description not available]		02.0110
Leukemia, Myeloid
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.		02.0110
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		02.0110