| Assay ID | Title | Year | Journal | Article |
|---|
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3
| High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID1797191 | Enzyme Assay and Determination of the Inhibition Constants from Article 10.1021/bi060173m: \\Structure-guided design of peptide-based tryptase inhibitors.\\ | 2006 | Biochemistry, May-16, Volume: 45, Issue:19
| Structure-guided design of peptide-based tryptase inhibitors. |
| AID1802035 | bBiDomain assay from Article 10.1021/acs.biochem.6b00786: \\Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors.\\ | 2016 | Biochemistry, Oct-04, Volume: 55, Issue:39
| Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors. |
| AID1797424 | BACE-1 Inhibition Assay from Article 10.1021/jm061197u: \\Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase.\\ | 2007 | Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
| Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase. |
| AID375066 | Displacement of gentamycin from Escherichia coli 16S ribosomal 27-nucleotide A-site RNA by water Logsy NMR spectroscopy based noncompetitive binding assay | 2009 | Journal of medicinal chemistry, Jun-25, Volume: 52, Issue:12
| Design and implementation of an ribonucleic acid (RNA) directed fragment library. |
| AID334367 | Anthelmintic activity against fourth stage of Nippostrongylus brasiliensis larvae assessed as reduction of viability at 50 ug/ml | 1988 | Journal of natural products, Sep, Volume: 51, Issue:5
| Isolation and Bioactivity of 2-Aminoquinoline from Leucopaxillus albissimus. |
| AID1582674 | Binding affinity to recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 1 mM incubated for 10 to 15 mins by SYPRO orange dye based thermal shi | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery. |
| AID334365 | Antibacterial activity against Penicillium inflatum ATCC 48995 at 100 ug/disk after 1 to 5 days | 1988 | Journal of natural products, Sep, Volume: 51, Issue:5
| Isolation and Bioactivity of 2-Aminoquinoline from Leucopaxillus albissimus. |
| AID1893771 | Inhibition of recombinant human QC using H-Gln-AMC hydrobromide as fluorogenic substrate incubated for 6 hrs by fluorometric microplate reader analysis | 2022 | ACS medicinal chemistry letters, Sep-08, Volume: 13, Issue:9
| 2-Amino-1,3,4-thiadiazoles as Glutaminyl Cyclases Inhibitors Increase Phagocytosis through Modification of CD47-SIRPα Checkpoint. |
| AID280414 | Inhibition of human BACE1 at 1 mM | 2007 | Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
| Application of fragment screening by X-ray crystallography to beta-secretase. |
| AID3697 | Displacement of [3H]5-HT from 5-hydroxytryptamine 1 receptor of rat cortical membrane homogenates | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11
| 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. |
| AID68131 | Inhibitory activity against endothelial nitric oxide synthase (eNOS) | 2000 | Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17
| Substituted 2-aminopyridines as inhibitors of nitric oxide synthases. |
| AID240379 | Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization | 2004 | Journal of medicinal chemistry, Oct-21, Volume: 47, Issue:22
| Identification and specificity studies of small-molecule ligands for SH3 protein domains. |
| AID240378 | Displacement of PRP-1 peptide from human Nck kinase SH3 domain by fluorescence polarization | 2004 | Journal of medicinal chemistry, Oct-21, Volume: 47, Issue:22
| Identification and specificity studies of small-molecule ligands for SH3 protein domains. |
| AID1582675 | Binding affinity to recombinant human His-tagged p47phox SH3-AB domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 2 mM incubated for 10 to 15 mins by SYPRO orange dye based thermal shi | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery. |
| AID238162 | Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization | 2004 | Journal of medicinal chemistry, Oct-21, Volume: 47, Issue:22
| Identification and specificity studies of small-molecule ligands for SH3 protein domains. |
| AID240380 | Displacement of PRP-2 peptide from human Hck kinase SH3 domain by fluorescence polarization | 2004 | Journal of medicinal chemistry, Oct-21, Volume: 47, Issue:22
| Identification and specificity studies of small-molecule ligands for SH3 protein domains. |
| AID1582694 | Binding affinity to recombinant human His-tagged 15N-labeled p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as compound interaction with protein at Trp264 in SH3A/SH3B domain at protein:compound ratio o | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery. |
| AID239887 | Ionization constant (pKa) for the compound | 2004 | Journal of medicinal chemistry, Oct-21, Volume: 47, Issue:22
| Identification and specificity studies of small-molecule ligands for SH3 protein domains. |
| AID1582697 | Binding affinity to immobilized recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as interaction with protein at two-binding sites at 1 mM by SPR assay | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery. |
| AID1582676 | Binding affinity to immobilized recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by SPR assay | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery. |
| AID653988 | Binding affinity to BACE1 by surface plasmon resonance method | 2012 | Journal of medicinal chemistry, Jan-26, Volume: 55, Issue:2
| Fragment based drug discovery: practical implementation based on ¹⁹F NMR spectroscopy. |
| AID1582690 | Binding affinity to recombinant human His-tagged 15N-labeled p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as compound interaction with protein at Trp193 in SH3A domain at protein:compound ratio of 1:0 | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery. |
| AID234086 | Selectivity for inhibition of neuronal nitric oxide synthases to that of inhibition of inducible nitric oxide synthases; Not determined | 2000 | Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17
| Substituted 2-aminopyridines as inhibitors of nitric oxide synthases. |
| AID334363 | Antibacterial activity against Cytophaga johnsoniae ATCC 29589 at 100 ug/disk after 1 to 5 days | 1988 | Journal of natural products, Sep, Volume: 51, Issue:5
| Isolation and Bioactivity of 2-Aminoquinoline from Leucopaxillus albissimus. |
| AID1582668 | Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells interaction with Cy5-p22phox149-162 incubated for 10 mins by fluorescence polarization competition assay | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery. |
| AID1582695 | Binding affinity to recombinant human His-tagged 15N-labeled p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as interaction with compact protein conformation at 2 to 4 mM by SAXS study analysis | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery. |
| AID219087 | Association constant with ferriprotoporphyrin IX. | 2000 | Journal of medicinal chemistry, Jan-27, Volume: 43, Issue:2
| Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity. |
| AID234084 | Selectivity for inhibition of inducible nitric oxide synthases to that of inhibition of endothelial cell nitric oxide synthases; Not determined | 2000 | Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17
| Substituted 2-aminopyridines as inhibitors of nitric oxide synthases. |
| AID334364 | Antibacterial activity against Streptomyces galilaeus ATCC 14969 at 100 ug/disk after 1 to 5 days | 1988 | Journal of natural products, Sep, Volume: 51, Issue:5
| Isolation and Bioactivity of 2-Aminoquinoline from Leucopaxillus albissimus. |
| AID375073 | Displacement of gentamycin from Escherichia coli 16S ribosomal 27-nucleotide A-site RNA by T2 filter NMR spectroscopy based noncompetitive binding assay | 2009 | Journal of medicinal chemistry, Jun-25, Volume: 52, Issue:12
| Design and implementation of an ribonucleic acid (RNA) directed fragment library. |
| AID1582699 | Inhibition of immobilized recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells interaction with p22phox149-168 at 1 mM in presence of 10 uM p22phox149-168 by SPR competitive binding assay | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery. |
| AID1582691 | Binding affinity to recombinant human His-tagged 15N-labeled p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as compound interaction with protein at Trp194 in SH3A/SH3B domain at protein:compound ratio o | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery. |
| AID1582673 | Binding affinity to recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 0.5 mM incubated for 10 to 15 mins by SYPRO orange dye based thermal s | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery. |
| AID1582689 | Binding affinity to immobilized recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as inhibition of responses at 1 mM in presence of 10 uM p22phox149-168 by SPR inhibition assay | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery. |
| AID226297 | Inhibition of Beta-hematin (hemozoin) formation; No inhibition. | 2000 | Journal of medicinal chemistry, Jan-27, Volume: 43, Issue:2
| Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity. |
| AID615815 | Binding affinity to BACE1 after 90 seconds by surface plasmon resonance assay | 2011 | Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
| From fragment screening to in vivo efficacy: optimization of a series of 2-aminoquinolines as potent inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1). |
| AID29176 | Dissociation constent of compound at 20 degree C | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
| 2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 11. Quinolylmethyl analogues with basic substituents conveying specificity. |
| AID615816 | Inhibition of BACE1 using 19F-labeled EVNLDAEF(CF3) as substrate after 20 mins by NMR spectrometry | 2011 | Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
| From fragment screening to in vivo efficacy: optimization of a series of 2-aminoquinolines as potent inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1). |
| AID334368 | Anthelmintic activity against fourth stage of Nippostrongylus brasiliensis larvae assessed as reduction in cast formation at 50 ug/ml | 1988 | Journal of natural products, Sep, Volume: 51, Issue:5
| Isolation and Bioactivity of 2-Aminoquinoline from Leucopaxillus albissimus. |
| AID1582700 | Binding affinity to recombinant human His-tagged 15N-labeled p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as interaction with extended protein conformation by SAXS study analysis | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery. |
| AID334366 | Anthelmintic activity against fourth stage of Nippostrongylus brasiliensis larvae assessed as reduction of motility at 50 ug/ml | 1988 | Journal of natural products, Sep, Volume: 51, Issue:5
| Isolation and Bioactivity of 2-Aminoquinoline from Leucopaxillus albissimus. |
| AID240395 | Displacement of PRP-1 peptide from human Fyn kinase SH3 domain by fluorescence polarization; No competition | 2004 | Journal of medicinal chemistry, Oct-21, Volume: 47, Issue:22
| Identification and specificity studies of small-molecule ligands for SH3 protein domains. |
| AID1582692 | Binding affinity to recombinant human His-tagged 15N-labeled p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as compound interaction with protein at Trp204 in SH3A/SH3B domain at protein:compound ratio o | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery. |
| AID158544 | In vitro antiplasmodial activity against Plasmodium falciparum D10 | 2000 | Journal of medicinal chemistry, Jan-27, Volume: 43, Issue:2
| Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity. |
| AID92001 | Inhibitory activity against inducible nitric oxide synthase (iNOS) | 2000 | Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17
| Substituted 2-aminopyridines as inhibitors of nitric oxide synthases. |
| AID5267 | Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor of rat cortical membrane homogenates | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11
| 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. |
| AID1582672 | Binding affinity to recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 0.25 mM incubated for 10 to 15 mins by SYPRO orange dye based thermal | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery. |
| AID146109 | Inhibitory activity against neuronal nitric oxide synthase | 2000 | Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17
| Substituted 2-aminopyridines as inhibitors of nitric oxide synthases. |
| AID1582693 | Binding affinity to recombinant human His-tagged 15N-labeled p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as compound interaction with protein at Trp263 in SH3B domain at protein:compound ratio of 1:0 | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery. |
| AID280415 | Inhibition of BACE1 | 2007 | Journal of medicinal chemistry, Mar-22, Volume: 50, Issue:6
| Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2011 | Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
| From fragment screening to in vivo efficacy: optimization of a series of 2-aminoquinolines as potent inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1). |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |