| Assay ID | Title | Year | Journal | Article |
|---|
| AID1714644 | Induction of oligomerization of compound-ligated activated form of calf brain tubulin assessed as formation of double rings by measuring sedimentation coefficient at 55 uM incubated for 30 mins in presence of GDP and 3.31 mM Mg2+ by analytical ultracentri | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3
| Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites. |
| AID763707 | Cytotoxicity against human HT-29 cells | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Efficient construction of novel D-ring modified steroidal dienamides and their cytotoxic activities. |
| AID1714645 | Covalent modification of compound-ligated activated form of calf brain dimeric tubulin assessed as effect on nucleotide binding affinity at E-site by measuring ratio of GTP concentration to tubulin concentration incubated for 1.5 hrs in presence or absenc | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3
| Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites. |
| AID1402138 | Cytotoxicity against human SKM1 cells incubated for 48 hrs by SRB assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Recent advances in microtubule-stabilizing agents. |
| AID441624 | Cytotoxicity against human HL60 cells assessed as increase in cell diameter at 2 nM after 48 hrs by Giemsa staining | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID1587840 | Antiproliferative activity against human SKM1 cells assessed as reduction in cell growth | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Anti-tubulin agents of natural origin: Targeting taxol, vinca, and colchicine binding domains. |
| AID1423277 | Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay | 2018 | Journal of natural products, 11-26, Volume: 81, Issue:11
| Zampanolides B-E from the Marine Sponge Cacospongia mycofijiensis: Potent Cytotoxic Macrolides with Microtubule-Stabilizing Activity. |
| AID1587835 | Antiproliferative activity against human MEL28 cells assessed as reduction in cell growth | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Anti-tubulin agents of natural origin: Targeting taxol, vinca, and colchicine binding domains. |
| AID441620 | Cytotoxicity against human 1A9 cells after 72 hrs by MTT assay | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID441639 | Selectivity ratio of IC50 for p-glycoprotein overexpressing human A2780AD cells to IC50 for human A2780 cells | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID441625 | Cytotoxicity against human HL60 cells assessed as increase in cell diameter at 4 nM after 48 hrs by Giemsa staining | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID1714660 | Induction of oligomerization of compound-ligated activated form of calf brain tubulin at 55 uM incubated for 30 mins in presence of 0.1 mM GTP and 0.028 mM Mg2+ by analytical ultracentrifugation | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3
| Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites. |
| AID1714658 | Induction of oligomerization of compound-ligated activated form of calf brain tubulin assessed as oligomer formation by measuring sedimentation coefficient at 55 uM incubated for 30 mins in presence of GTP/GDP and 0.14 mM Mg2+ by analytical ultracentrifug | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3
| Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites. |
| AID1714656 | Induction of oligomerization of compound-ligated activated form of calf brain tubulin assessed as formation of microtubule by measuring sedimentation coefficient at 55 uM incubated for 30 mins in presence of GDP and 3.31 mM Mg2+ by electron micrography an | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3
| Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites. |
| AID441628 | Cytotoxicity against human 1A9 cells assessed as interphase cells with microtubule bundles at 5 nM after 12 hrs by immunocytochemistry | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID1404290 | Cytotoxicity against human A549 cells | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3
| Marine Invertebrate Natural Products that Target Microtubules. |
| AID441630 | Cytotoxicity against human 1A9 cells assessed as interphase cells with microtubule bundles at 10 nM after 12 hrs by immunocytochemistry | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID1423279 | Cell cycle arrest in human HL60 cells assessed as accumulation at S phase at 1 uM after 18 hrs by propidium iodide staining based flow cytometry (Rvb = 27%) | 2018 | Journal of natural products, 11-26, Volume: 81, Issue:11
| Zampanolides B-E from the Marine Sponge Cacospongia mycofijiensis: Potent Cytotoxic Macrolides with Microtubule-Stabilizing Activity. |
| AID441627 | Cell cycle arrest in human HL60 cells assessed as accumulation in G2/M phase at 2 to 10 nM after 16 hrs by flow cytometry | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID441634 | Cytotoxicity against human 1A9 cells assessed as mitotic cells with multiple asters at 10 nM after 12 hrs by immunocytochemistry | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID1714662 | Induction of oligomerization of compound-ligated activated form of calf brain tubulin assessed as tubulin-tubulin interaction causing aggregation formation at 55 uM incubated for 30 mins in presence of GTP and 1.5 mM Mg2+ by analytical ultracentrifugation | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3
| Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites. |
| AID1714646 | Covalent modification of compound-ligated activated form of calf brain dimeric tubulin assessed as effect on nucleotide binding affinity at E-site by measuring ratio of GDP nucleotide concentration to tubulin concentration incubated for 1.5 hrs in presenc | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3
| Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites. |
| AID1587836 | Antiproliferative activity against human A549 cells assessed as reduction in cell growth | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Anti-tubulin agents of natural origin: Targeting taxol, vinca, and colchicine binding domains. |
| AID763706 | Cytotoxicity against human A549 cells | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Efficient construction of novel D-ring modified steroidal dienamides and their cytotoxic activities. |
| AID441640 | Cytotoxicity against human A2780 cells by MTT cell proliferation assay | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID1587837 | Antiproliferative activity against human HT-29 cells assessed as reduction in cell growth | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Anti-tubulin agents of natural origin: Targeting taxol, vinca, and colchicine binding domains. |
| AID1404289 | Cytotoxicity against mouse P388 cells | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3
| Marine Invertebrate Natural Products that Target Microtubules. |
| AID1587839 | Antiproliferative activity against mouse P388 cells assessed as reduction in cell growth | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Anti-tubulin agents of natural origin: Targeting taxol, vinca, and colchicine binding domains. |
| AID763705 | Cytotoxicity against human MEL28 cells | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Efficient construction of novel D-ring modified steroidal dienamides and their cytotoxic activities. |
| AID1714647 | Covalent modification of GAB-buffer assembled microtubule (unknown origin) assessed as effect on nucleotide binding affinity at E-site by measuring ratio of GTP concentration to tubulin concentration incubated for 30 mins in presence or absence of 1 mM GT | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3
| Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites. |
| AID441631 | Cytotoxicity against human 1A9 cells assessed as interphase cells with microtubule bundles at 20 nM after 12 hrs by immunocytochemistry | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID441635 | Cytotoxicity against human 1A9 cells assessed as mitotic cells with multiple asters at 20 nM after 12 hrs by immunocytochemistry | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID1402139 | Cytotoxicity against human U937 cells incubated for 48 hrs by SRB assay | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Recent advances in microtubule-stabilizing agents. |
| AID441638 | Induction of bovine tubulin polymerization at 10 uM after 1hr in presence of 1 mM GTP | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID1404292 | Cytotoxicity against human MEL28 cells | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3
| Marine Invertebrate Natural Products that Target Microtubules. |
| AID1575945 | Induction of microtubule stabilization in human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by Celltiter reagent-based assay | 2019 | MedChemComm, May-01, Volume: 10, Issue:5
| Synthesis, conformational preferences, and biological activity of conformational analogues of the microtubule-stabilizing agents, (-)-zampanolide and (-)-dactylolide. |
| AID1714661 | Induction of oligomerization of compound-ligated activated form of calf brain tubulin assessed as formation of microtubule at 55 uM incubated for 30 mins in presence of GTP and 3 mM Mg2+ by electron micrography analysis | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3
| Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites. |
| AID441626 | Cytotoxicity against human HL60 cells assessed as increase in cell diameter at 8 nM after 48 hrs by Giemsa staining | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID441641 | Cytotoxicity against p-glycoprotein overexpressing human A2780AD cells by MTT cell proliferation assay | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID441632 | Cytotoxicity against human 1A9 cells assessed as mitotic cells with multiple asters at 5 nM after 12 hrs by immunocytochemistry | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID1423280 | Cell cycle arrest in human HL60 cells assessed as accumulation at G2/M phase at 1 uM after 18 hrs by propidium iodide staining based flow cytometry (Rvb = 22%) | 2018 | Journal of natural products, 11-26, Volume: 81, Issue:11
| Zampanolides B-E from the Marine Sponge Cacospongia mycofijiensis: Potent Cytotoxic Macrolides with Microtubule-Stabilizing Activity. |
| AID1714652 | Induction of oligomerization of compound modified microtubule (unknown origin) assessed as peloruside binding constant at 25 degreeC incubated for 30 mins followed by GTP addition and measured after 30 mins by HPLC analysis | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3
| Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites. |
| AID441622 | Cytotoxicity against human HL60 cells assessed as cell death at 10 nM after 48 hrs by Trypan blue exclusion test | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID441621 | Cytotoxicity against human HL60 cells at 2 nM after 24 hrs by Trypan blue exclusion test | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID441637 | Induction of tubulin polymerization in human 1A9 cells at 100 nM after 16 hrs by Western blotting | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID1404291 | Cytotoxicity against human HT-29 cells | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3
| Marine Invertebrate Natural Products that Target Microtubules. |
| AID763708 | Cytotoxicity against mouse P388 cells | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Efficient construction of novel D-ring modified steroidal dienamides and their cytotoxic activities. |
| AID1423281 | Induction of porcine tubulin polymerization assessed as microtubule stabilization at 2.8 uM measured at 1 min interval over 100 mins | 2018 | Journal of natural products, 11-26, Volume: 81, Issue:11
| Zampanolides B-E from the Marine Sponge Cacospongia mycofijiensis: Potent Cytotoxic Macrolides with Microtubule-Stabilizing Activity. |
| AID1575944 | Induction of microtubule stabilization in human PC3 cells assessed as inhibition of cell growth incubated for 72 hrs by Celltiter reagent-based assay | 2019 | MedChemComm, May-01, Volume: 10, Issue:5
| Synthesis, conformational preferences, and biological activity of conformational analogues of the microtubule-stabilizing agents, (-)-zampanolide and (-)-dactylolide. |
| AID441633 | Cytotoxicity against human 1A9 cells assessed as mitotic cells with multiple asters at 8 nM after 12 hrs by immunocytochemistry | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID1714655 | Induction of oligomerization of compound-ligated activated form of calf brain tubulin assessed as formation of dimers by measuring sedimentation coefficient at 55 uM incubated for 30 mins in presence of GDP and 3.31 mM Mg2+ by electron microscopy analysis | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3
| Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites. |
| AID1587838 | Antiproliferative activity against human U937 cells assessed as reduction in cell growth | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Anti-tubulin agents of natural origin: Targeting taxol, vinca, and colchicine binding domains. |
| AID1714659 | Induction of oligomerization of compound-ligated activated form of calf brain tubulin at 55 uM incubated for 30 mins in presence of 0.1 mM GDP and 0.039 mM Mg2+ by analytical ultracentrifugation | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3
| Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites. |
| AID1423278 | Cell cycle arrest in human HL60 cells assessed as accumulation at G1 phase at 1 uM after 18 hrs by propidium iodide staining based flow cytometry (Rvb = 51%) | 2018 | Journal of natural products, 11-26, Volume: 81, Issue:11
| Zampanolides B-E from the Marine Sponge Cacospongia mycofijiensis: Potent Cytotoxic Macrolides with Microtubule-Stabilizing Activity. |
| AID441636 | Induction of tubulin polymerization in human 1A9 cells after 16 hrs by Western blotting | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID1575946 | Induction of microtubule stabilization in human 1A9 cells assessed as inhibition of cell growth incubated for 72 hrs by Celltiter reagent-based assay | 2019 | MedChemComm, May-01, Volume: 10, Issue:5
| Synthesis, conformational preferences, and biological activity of conformational analogues of the microtubule-stabilizing agents, (-)-zampanolide and (-)-dactylolide. |
| AID1714648 | Covalent modification of GAB-buffer assembled microtubule (unknown origin) assessed as effect on nucleotide binding affinity at E-site by measuring ratio of GDP concentration to microtubule concentration incubated for 30 mins in presence or absence of 1 m | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3
| Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites. |
| AID441629 | Cytotoxicity against human 1A9 cells assessed as interphase cells with microtubule bundles at 8 nM after 12 hrs by immunocytochemistry | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID1714654 | Induction of oligomerization of compound-ligated activated form of calf brain tubulin assessed as formation of tetramers by measuring sedimentation coefficient at 55 uM incubated for 30 mins in presence of GDP and 3.31 mM Mg2+ by analytical ultracentrifug | 2018 | Journal of natural products, 03-23, Volume: 81, Issue:3
| Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites. |
| AID441623 | Cytotoxicity against human HL60 cells assessed as increase in cell diameter after 48 hrs by Giemsa staining | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| AID441619 | Cytotoxicity against human HL60 cells after 48 hrs by MTT assay | 2009 | Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
| Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |