isoquinoline-1,3,4-trione: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 10640 |
| CHEMBL ID | 206435 |
| SCHEMBL ID | 1122624 |
| MeSH ID | M0505177 |
| Synonym |
|---|
| unii-bm68cv5x6q |
| 5-21-11-00575 (beilstein handbook reference) |
| bm68cv5x6q , |
| LS-13574 |
| nsc 407248 |
| 1,3,4-(2h)isoquinolinetrione |
| phthalonimide |
| 1,3,4(2h)-isoquinolinetrione |
| brn 0383773 |
| isoquinoline-1,3,4(2h)-trione |
| RXA , |
| nsc-407248 |
| nsc407248 |
| 1,4(2h)-isoquinolinetrione |
| 521-73-3 |
| isoquinoline-1,3,4-trione 1 |
| 1,2,3,4-tetrahydroisoquinoline-1,3,4-trione |
| bdbm10247 |
| isoquinoline-1,3,4-trione |
| CHEMBL206435 |
| AKOS006276226 |
| 3DEH |
| SCHEMBL1122624 |
| DTXSID40200103 |
| Q27465167 |
| FT-0753531 |
| mfcd01717158 |
| D81951 |
| CS-0149741 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain C, Caspase-3 | Homo sapiens (human) | IC50 (µMol) | 0.1490 | 0.1490 | 0.1490 | 0.1490 | AID977608 |
| Chain C, Caspase-3 | Homo sapiens (human) | IC50 (µMol) | 0.1490 | 0.1490 | 0.1490 | 0.1490 | AID977608 |
| Chain C, Caspase-3 | Homo sapiens (human) | IC50 (µMol) | 0.1490 | 0.1490 | 0.1490 | 0.1490 | AID977608 |
| Chain A, Caspase-3 | Homo sapiens (human) | IC50 (µMol) | 0.1490 | 0.1490 | 0.1490 | 0.1490 | AID977608 |
| Prothrombin | Homo sapiens (human) | IC50 (µMol) | 5.0000 | 0.0000 | 0.7107 | 10.0000 | AID261396 |
| Papain | Carica papaya (papaya) | IC50 (µMol) | 5.0000 | 0.0020 | 1.5045 | 10.0000 | AID261394 |
| Calpain small subunit 1 | Homo sapiens (human) | IC50 (µMol) | 5.0000 | 7.0000 | 7.0000 | 7.0000 | AID261392 |
| Calpain-1 catalytic subunit | Homo sapiens (human) | IC50 (µMol) | 5.0000 | 0.0002 | 1.0592 | 10.0000 | AID261392 |
| Trypsin-1 | Homo sapiens (human) | IC50 (µMol) | 5.0000 | 0.0035 | 1.5321 | 10.0000 | AID261395 |
| Trypsin-2 | Homo sapiens (human) | IC50 (µMol) | 5.0000 | 0.0035 | 1.5846 | 4.4000 | AID261395 |
| Trypsin-3 | Homo sapiens (human) | IC50 (µMol) | 5.0000 | 0.0035 | 1.5846 | 4.4000 | AID261395 |
| Caspase-3 | Homo sapiens (human) | IC50 (µMol) | 0.7663 | 0.0002 | 1.1979 | 8.8000 | AID1796413; AID261391 |
| Caspase-2 | Homo sapiens (human) | IC50 (µMol) | 0.9965 | 0.0210 | 1.5556 | 5.0000 | AID1796413; AID261397 |
| Caspase-7 | Homo sapiens (human) | IC50 (µMol) | 0.8058 | 0.0022 | 0.5477 | 5.0000 | AID1796413; AID261399 |
| Caspase-6 | Homo sapiens (human) | IC50 (µMol) | 0.8205 | 0.0022 | 0.8652 | 5.0000 | AID1796413; AID261398 |
| Caspase-8 | Homo sapiens (human) | IC50 (µMol) | 1.0598 | 0.0022 | 0.6845 | 5.0000 | AID1796413; AID261400 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||