3-((benzyl)(methylaminocarbonyl)methylaminocarbonyl)N-hydroxy-5-methylhexanamide: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 194777 |
| CHEMBL ID | 11306 |
| SCHEMBL ID | 5502507 |
| MeSH ID | M0302027 |
| Synonym |
|---|
| bdbm50031795 |
| (r)-n4-hydroxy-2-isobutyl-n1-((s)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl)succinamide |
| (r)-n*4*-hydroxy-2-isobutyl-n*1*-((s)-1-methylcarbamoyl-2-phenyl-ethyl)-succinamide |
| methylamino-phenylalanyl-leucyl-hydroxamic acid |
| PLH , |
| (n-(2-hydroxamatemethylene-4-methyl-pentoyl)phenylalanyl)methyl amine |
| DB08403 |
| CHEMBL11306 , |
| 108383-58-0 |
| (2r)-n'-hydroxy-n-[(2s)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]-2-(2-methylpropyl)butanediamide |
| 3-((benzyl)(methylaminocarbonyl)methylaminocarbonyl)n-hydroxy-5-methylhexanamide |
| (2r)-n'-hydroxy-n-((1s)-1-(methylcarbamoyl)-2-phenylethyl)-2-(2-methylpropyl)butanediamide |
| 3-bmmhmh |
| 1MNC |
| SCHEMBL5502507 |
| (2r)-n~1~-[(1s)-1-benzyl-2-(methylamino)-2-oxoethyl]-n~4~-hydroxy-2-(2-methylpropyl)butanediamide |
| DTXSID50910706 |
| n~4~-hydroxy-n~1~-[1-hydroxy-1-(methylimino)-3-phenylpropan-2-yl]-2-(2-methylpropyl)butanediimidic acid |
| Q27097614 |
| PD004432 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Interstitial collagenase | Homo sapiens (human) | IC50 (µMol) | 0.0293 | 0.0002 | 0.8502 | 10.0000 | AID108893; AID362874; AID73284 |
| Interstitial collagenase | Homo sapiens (human) | Ki | 0.0070 | 0.0003 | 0.4948 | 7.0000 | AID52368 |
| Low affinity immunoglobulin epsilon Fc receptor | Homo sapiens (human) | IC50 (µMol) | 1.0000 | 0.0400 | 0.3100 | 1.0000 | AID44536 |
| 72 kDa type IV collagenase | Homo sapiens (human) | IC50 (µMol) | 0.0023 | 0.0000 | 1.2848 | 10.0000 | AID310905; AID362875 |
| Stromelysin-1 | Homo sapiens (human) | IC50 (µMol) | 0.0430 | 0.0000 | 1.1484 | 10.0000 | AID362876 |
| Stromelysin-1 | Homo sapiens (human) | Ki | 0.0792 | 0.0003 | 0.5425 | 8.0000 | AID208324; AID310913 |
| Matrilysin | Homo sapiens (human) | IC50 (µMol) | 0.0083 | 0.0014 | 2.0859 | 10.0000 | AID362877 |
| Matrix metalloproteinase-9 | Homo sapiens (human) | IC50 (µMol) | 0.0004 | 0.0000 | 0.7053 | 10.0000 | AID362879 |
| Neutrophil collagenase | Homo sapiens (human) | IC50 (µMol) | 0.0000 | 0.0000 | 0.9272 | 10.0000 | AID362878 |
| Neutrophil collagenase | Homo sapiens (human) | Ki | 0.0020 | 0.0002 | 0.1797 | 2.1000 | AID52372 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID51349 | Inhibition of Cathepsin L from human kidney | 2002 | Bioorganic & medicinal chemistry letters, Feb-11, Volume: 12, Issue:3 | Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin. |
| AID362874 | Inhibition of human recombinant MMP1 | 2008 | European journal of medicinal chemistry, May, Volume: 43, Issue:5 | Peptidyl 3-substituted 1-hydroxyureas as isosteric analogues of succinylhydroxamate MMP inhibitors. |
| AID362876 | Inhibition of human recombinant MMP3 | 2008 | European journal of medicinal chemistry, May, Volume: 43, Issue:5 | Peptidyl 3-substituted 1-hydroxyureas as isosteric analogues of succinylhydroxamate MMP inhibitors. |
| AID362879 | Inhibition of human recombinant MMP9 | 2008 | European journal of medicinal chemistry, May, Volume: 43, Issue:5 | Peptidyl 3-substituted 1-hydroxyureas as isosteric analogues of succinylhydroxamate MMP inhibitors. |
| AID208324 | Inhibitory potency against human stromelysin, MMP-3 | 1995 | Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14 | Inhibition of matrix metalloproteinases by hydroxamates containing heteroatom-based modifications of the P1' group. |
| AID362877 | Inhibition of human recombinant MMP7 | 2008 | European journal of medicinal chemistry, May, Volume: 43, Issue:5 | Peptidyl 3-substituted 1-hydroxyureas as isosteric analogues of succinylhydroxamate MMP inhibitors. |
| AID44536 | Tested for inhibition against CD23 (IgE receptor) proteolysis in membranes derived from RPM18866 cells ( a human B-cell line); value ranges from 1000-4000 | 1998 | Bioorganic & medicinal chemistry letters, Jan-06, Volume: 8, Issue:1 | Selective inhibition of low affinity IgE receptor (CD23) processing. |
| AID362875 | Inhibition of human recombinant MMP2 | 2008 | European journal of medicinal chemistry, May, Volume: 43, Issue:5 | Peptidyl 3-substituted 1-hydroxyureas as isosteric analogues of succinylhydroxamate MMP inhibitors. |
| AID362878 | Inhibition of human recombinant MMP8 | 2008 | European journal of medicinal chemistry, May, Volume: 43, Issue:5 | Peptidyl 3-substituted 1-hydroxyureas as isosteric analogues of succinylhydroxamate MMP inhibitors. |
| AID52368 | Inhibitory potency against human fibroblast collagenase, MMP-1 | 1995 | Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14 | Inhibition of matrix metalloproteinases by hydroxamates containing heteroatom-based modifications of the P1' group. |
| AID310913 | Inhibition of MMP3 | 2007 | Bioorganic & medicinal chemistry, Mar-15, Volume: 15, Issue:6 | Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs. |
| AID73284 | Inhibitory activity towards human recombinant fibroblast collagenase | 1998 | Bioorganic & medicinal chemistry letters, Jan-06, Volume: 8, Issue:1 | Selective inhibition of low affinity IgE receptor (CD23) processing. |
| AID52372 | Inhibition of human neutrophil collagenase (HNC), MMP-8 | 1995 | Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14 | Inhibition of matrix metalloproteinases by hydroxamates containing heteroatom-based modifications of the P1' group. |
| AID108893 | Inhibition of Matrix metalloprotease-1 | 2002 | Bioorganic & medicinal chemistry letters, Feb-11, Volume: 12, Issue:3 | Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin. |
| AID310905 | Inhibition of MMP2 | 2007 | Bioorganic & medicinal chemistry, Mar-15, Volume: 15, Issue:6 | Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs. |
| AID977608 | Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB | 2008 | European journal of medicinal chemistry, May, Volume: 43, Issue:5 | Peptidyl 3-substituted 1-hydroxyureas as isosteric analogues of succinylhydroxamate MMP inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.41) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (16.67%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (83.33%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||