Page last updated: 2024-12-08

gamma-glutamyl hydroxamate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

glutamine hydroxamate : A hydroxamic acid that is L-glutamine hydroxylated at N-5. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID449178
CHEMBL ID63893
CHEBI ID75305
SCHEMBL ID4321249
MeSH IDM0144429

Synonyms (35)

Synonym
glunhoh
glutamine hydroxamate
HGA ,
gamma-glutamyl hydroxamate
glutamate-gamma-hydroxamate
glutamate-gamma-hydroxamic acid
l-glutamic acid gamma-hydroxamic acid
glutamyl-gamma-hydroxamate
DB02446
l-gamma-glutamyl hydroxamate
glutamic acid gamma-monohydroxamate
(2s)-2-amino-5-(hydroxyamino)-5-oxopentanoic acid
bdbm50129196
(s)-2-amino-4-hydroxycarbamoyl-butyric acid
(s)-2-amino-5-(hydroxyamino)-5-oxopentanoic acid
chebi:75305 ,
CHEMBL63893 ,
SCHEMBL4321249
1955-67-5
AKOS006274869
l-glutamine, n-hydroxy-
n-hydroxy-l-glutamine
l-glutamic acid -monohydroxamate
amino acid hydroxamates l-glutamic acid gamma- monohydroxamate
gamma-glutamylhydroxylamine
(s,z)-2-amino-5-hydroxy-5-(hydroxyimino)pentanoic acid
Q27093441
amino acid hydroxamates l-glutamic acid gamma-monohydroxamate
CS-0142494
l-glutamic |a-monohydroxamate
HY-137874
l-glutamic acid gamma monohydroxamate
F87844
nsc823860
nsc-823860
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

ClassDescription
glutamic acid derivativeAn amino acid derivative resulting from reaction of glutamic acid at the amino group or either of the carboxy groups, or from the replacement of any hydrogen by a heteroatom. The definition normally excludes peptides containing glutamic acid residues.
hydroxamic acidA compound, RkE(=O)lNHOH, derived from an oxoacid RkE(=O)l(OH) (l =/= 0) by replacing -OH with -NHOH, and derivatives thereof. Specific examples of hydroxamic acids are preferably named as N-hydroxy amides.
amino acid zwitterionThe zwitterionic form of an amino acid having a negatively charged carboxyl group and a positively charged amino group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Glutamate carboxypeptidase 2Homo sapiens (human)IC50 (µMol)100.00000.00030.83169.5000AID74531
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (3)

Processvia Protein(s)Taxonomy
proteolysisGlutamate carboxypeptidase 2Homo sapiens (human)
folic acid-containing compound metabolic processGlutamate carboxypeptidase 2Homo sapiens (human)
C-terminal protein deglutamylationGlutamate carboxypeptidase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (7)

Processvia Protein(s)Taxonomy
metallocarboxypeptidase activityGlutamate carboxypeptidase 2Homo sapiens (human)
peptidase activityGlutamate carboxypeptidase 2Homo sapiens (human)
dipeptidase activityGlutamate carboxypeptidase 2Homo sapiens (human)
metal ion bindingGlutamate carboxypeptidase 2Homo sapiens (human)
Ac-Asp-Glu bindingGlutamate carboxypeptidase 2Homo sapiens (human)
tetrahydrofolyl-poly(glutamate) polymer bindingGlutamate carboxypeptidase 2Homo sapiens (human)
carboxypeptidase activityGlutamate carboxypeptidase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (5)

Processvia Protein(s)Taxonomy
cytoplasmGlutamate carboxypeptidase 2Homo sapiens (human)
plasma membraneGlutamate carboxypeptidase 2Homo sapiens (human)
cell surfaceGlutamate carboxypeptidase 2Homo sapiens (human)
membraneGlutamate carboxypeptidase 2Homo sapiens (human)
extracellular exosomeGlutamate carboxypeptidase 2Homo sapiens (human)
plasma membraneGlutamate carboxypeptidase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID274639Inhibition of CSK at 25 uM in presence of 12 mM MgCl22006Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25
Design and evaluation of hydroxamate derivatives as metal-mediated inhibitors of a protein tyrosine kinase.
AID74531Inhibition of Glutamate carboxypeptidase II2003Bioorganic & medicinal chemistry letters, Jul-07, Volume: 13, Issue:13
Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II.
AID274640Inhibition of CSK at 25 uM in presence of 12 mM MgCl2 and 0.2 mM CoCl22006Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25
Design and evaluation of hydroxamate derivatives as metal-mediated inhibitors of a protein tyrosine kinase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (5.26)18.7374
1990's9 (47.37)18.2507
2000's9 (47.37)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.51

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.51 (24.57)
Research Supply Index3.09 (2.92)
Research Growth Index5.42 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.51)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other21 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]