quinophthalone
Description
Quinophthalone is a synthetic organic compound classified as a quinoline derivative. It is a potent inhibitor of NADH-dependent reductases, particularly those involved in the mitochondrial electron transport chain. Quinophthalone has shown promising activity as an anti-cancer agent, exhibiting cytotoxicity against various cancer cell lines, including leukemia, lung, and colon cancer cells. The mechanism of its anti-cancer action is believed to involve the disruption of mitochondrial function, leading to apoptosis. The compound is also known to possess anti-inflammatory and anti-bacterial properties. Quinophthalone's importance lies in its potential to serve as a lead compound for the development of new anti-cancer drugs. Researchers are studying its mechanism of action, structure-activity relationships, and potential clinical applications. However, further research is needed to evaluate its safety and efficacy in humans.'
quinophthalone: found in hair preparations; causes contact dermatitis [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
quinoline yellow : A quinoline derivative with a 1,3-dioxoindan-2-yl substituent at C-2. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 6731 |
| CHEMBL ID | 1486465 |
| CHEBI ID | 53700 |
| SCHEMBL ID | 42716 |
| MeSH ID | M0166234 |
Synonyms (99)
| Synonym |
|---|
| quinoline yellow 2sf |
| nsc3047 |
| quinophthalone |
| nsc-7503 |
| nsc7503 |
| 83-08-9 |
| 11641 yellow |
| 2-(2-quinolyl)-1,3-indandione |
| erio chinoline yellow 4g |
| 1h-indene-1, 2-(2-quinolinyl)- |
| nsc-3047 |
| 2-(2-quinolyl)-1,3-indanedione |
| MLS000037978 |
| nsc18950 |
| nsc-18950 |
| d & c yellow no. 11 |
| 8003-22-3 |
| NCGC00021766-02 |
| c.i. solvent yellow 33 |
| solvent yellow 33 |
| c.i. 47000 |
| ci 47000 |
| d&c yellow no. 11 |
| quinoline yellow ss |
| d and c yellow no. 11 |
| 2-(2-quinolinyl)-1h-indene-1,3(2h)-dione |
| 2-(quinolin-2-yl)-1h-indene-1,3(2h)-dione |
| STK367449 |
| quinoline yellow, dye content 95 % |
| NCGC00021766-03 |
| smr000035456 |
| quinoline yellow |
| c.i. 4700 |
| d & c yellow 11 |
| 2-quinolin-2-yl-1h-indene-1,3(2h)-dione |
| NCGC00020851-01 |
| NCGC00020851-07 |
| AKOS000282972 |
| 2-quinolin-2-ylindene-1,3-dione |
| 2-(1h-quinolin-2-ylidene)indene-1,3-dione |
| d and c yellow 11 |
| CHEBI:53700 , |
| d&c yellow no 11 |
| NCGC00020851-06 |
| NCGC00020851-02 |
| NCGC00020851-10 |
| NCGC00021766-05 |
| NCGC00020851-03 |
| NCGC00020851-04 |
| NCGC00020851-05 |
| NCGC00020851-09 |
| NCGC00020851-08 |
| NCGC00021766-04 |
| dsstox_gsid_24906 |
| tox21_202504 |
| dsstox_cid_4906 |
| cas-8003-22-3 |
| NCGC00260053-01 |
| dsstox_rid_77574 |
| CCG-103550 |
| HMS2417K18 |
| 44f3hyl954 , |
| FT-0674285 |
| nsc 18950 |
| 2-(2-quinolyl)-1h-indene-1,3(2h)-dione |
| einecs 201-453-9 |
| 1h-indene-1,3(2h)-dione, 2-(2-quinolinyl)- |
| quinophthalone (van) |
| yellow 11 |
| ki204 [inci] |
| ki204 |
| dc yellow no. 11 |
| solvent yellow 33 [inci] |
| yellow 11 [inci] |
| ci 47000 [inci] |
| EPITOPE ID:116214 |
| CHEMBL1486465 |
| BBL027785 |
| SCHEMBL42716 |
| chinophthalon |
| 2-(1h-quinolin-2-ylidene)indane-1,3-quinone |
| bdbm32227 |
| 2-(2-quinolyl)indane-1,3-quinone |
| cid_5355280 |
| W-109300 |
| quinoline yellow (c.i. 47000) |
| mfcd00011593 |
| DTXSID00873130 |
| quinoline yellow 2sf, analytical standard |
| quinoline yellow, 95.0% |
| SR-01000002715-2 |
| sr-01000002715 |
| AS-13999 |
| Q7272330 |
| solvent yellow 33 / quinoline yellow |
| quinolineyellow |
| F87556 |
| SY349355 |
| amarelo quinolina |
Research Excerpts
Overview
Quinophthalone was found to be a strong sensitizer in guinea pigs by means of a modified testing technique. Its threshold concentration for induction and challenge was 10 ppm.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Quinophthalone was found to be a strong sensitizer in guinea pigs by means of a modified testing technique, and its threshold concentration for induction and challenge was 10 ppm." | ( D&C nos. 10 and 11: chemical composition analysis and delayed contact hypersensitivity testing in the guinea pig. Kobayashi, T; Kutsuna, H; Mitsui, T; Sato, Y, 1984) | 0.99 |
Toxicity
| Excerpt | Reference | Relevance |
|---|---|---|
| " With the exception of the quinolines, food colors are relatively weak mutagens and are certified as safe additives despite reports that some people have allergic reactions to them." | ( The evaluation of the genotoxicity of two commonly used food colors: Quinoline Yellow (E 104) and Brilliant Black BN (E 151). Kononowicz, AK; Macioszek, VK, 2004) | 0.32 |
| " Although the use of single food additives at their regulated concentrations is believed to be relatively safe in terms of neuronal development, their combined effects remain unclear." | ( Synergistic interactions between commonly used food additives in a developmental neurotoxicity test. Howard, CV; Lau, K; McLean, WG; Williams, DP, 2006) | 0.33 |
Occurs in Manufacturing (1 Product(s))
Product Categories
| Product Category | Products |
|---|---|
| Beauty & Personal Care | 1 |
Products
| Product | Brand | Category | Compounds Matched from Ingredients | Date Retrieved |
|---|---|---|---|---|
| Mineral Fusion Cuticle Oil Nail Treatment -- 0.33 fl oz | Mineral Fusion | Beauty & Personal Care | tocopherol, tocopherol, geraniol, yellow 11, red 17 | 2024-11-29 10:47:42 |