Compounds > 4-phenyl-3H-thiazole-2-thione

Page last updated: 2024-12-10

4-phenyl-3H-thiazole-2-thione

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	3000729
CHEMBL ID	571436
CHEBI ID	109516
SCHEMBL ID	178051
SCHEMBL ID	11460891

Synonyms (53)

Synonym
HMS1749G07
4-phenyl-2-thiazolethiol
4-phenyl-2-mercaptothiazole
nsc-678
4-thiazoline-2-thione, 4-phenyl-
2(3h)-thiazolethione, 4-phenyl-
2-mercapto-4-phenylthiazole
2103-88-0
4-phenylthiazole-2-thiol
nsc678
4-phenylthiazole-2-thiol, technical grade, 90%
MLS001006837
smr000384406
einecs 218-274-7
nsc 678
4-phenylthiazole-2(3h)-thione
2-thiazolethiol, 4-phenyl-
CHEBI:109516
AKOS000271043
CHEMBL571436 ,
4-phenyl-3h-1,3-thiazole-2-thione
F3358-0395
bdbm50303910
NCGC00246093-01
BBL000524
4-phenyl-thiazole-2-thiol
4-phenyl-1,3-thiazole-2-thiol
STK506492
FT-0612743
REGID_FOR_CID_3000729
2(3h)-thiazolethione, 4-phenyl-;4-phenyl-2(3h)-thiazolethion;4-phenyl-2-mercaptothiazole;4-phenyl-2-thiazolethio
c9h7ns2
AB00609485-07
SCHEMBL178051
2-mercapto-4-phenyl-1,3-thiazole
4-phenyl-3h-thiazole-2-thione
DTXSID0062181
2-mercapto-4-phenylthiazol
SCHEMBL11460891
Z56946057
4-phenyl-1,3-thiazole-2-thiol #
Q27188664
mfcd00014508
VU0321942-2
J-013782
NS-01865
E78039
A846592
NCGC00246093-02
EN300-17511
PD182324
Y3E ,
4-phenyl-1,3-thiazole-2(3h)-thione

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
benzenes	Any benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (20)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	22.3872	0.6310	35.7641	100.0000	AID504339
Luciferase	Photinus pyralis (common eastern firefly)	Potency	16.9441	0.0072	15.7588	89.3584	AID588342
WRN	Homo sapiens (human)	Potency	50.1187	0.1683	31.2583	100.0000	AID651768
phosphopantetheinyl transferase	Bacillus subtilis	Potency	79.4328	0.1413	37.9142	100.0000	AID1490
ATAD5 protein, partial	Homo sapiens (human)	Potency	23.0999	0.0041	10.8903	31.5287	AID504467
GLS protein	Homo sapiens (human)	Potency	22.3872	0.3548	7.9355	39.8107	AID624170
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	3.5481	0.0112	12.4002	100.0000	AID1030
hypothetical protein, conserved	Trypanosoma brucei	Potency	15.8489	0.2239	11.2451	35.4813	AID624173
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	17.7828	0.5318	15.4358	37.6858	AID504845
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	39.8107	0.7079	36.9043	89.1251	AID504333
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	1.4125	0.0355	20.9770	89.1251	AID504332
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	89.1251	0.3548	28.0659	89.1251	AID504847
chromobox protein homolog 1	Homo sapiens (human)	Potency	56.2341	0.0060	26.1688	89.1251	AID540317
serine/threonine-protein kinase PLK1	Homo sapiens (human)	Potency	21.1923	0.1683	16.4040	67.0158	AID720504
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	100.0000	0.0501	27.0736	89.1251	AID588590
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	21.2804	0.0079	8.2332	1,122.0200	AID2546; AID2551
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)	IC50 (µMol)	25.6086	0.0537	3.0757	10.0000	AID1487211; AID443993; AID443996
Indoleamine 2,3-dioxygenase 1	Mus musculus (house mouse)	IC50 (µMol)	20.0000	0.0060	1.6251	10.0000	AID443995
Tryptophan 2,3-dioxygenase	Mus musculus (house mouse)	IC50 (µMol)	80.0000	1.0000	2.4867	5.0000	AID443997
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
toxin B	Clostridioides difficile 630	AC50	36.3900	20.8700	31.2600	37.0600	AID720512
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (19)

Process	via Protein(s)	Taxonomy
regulation of activated T cell proliferation	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
positive regulation of T cell tolerance induction	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
positive regulation of chronic inflammatory response	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
positive regulation of type 2 immune response	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
tryptophan catabolic process	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
inflammatory response	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
female pregnancy	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
tryptophan catabolic process to kynurenine	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
response to lipopolysaccharide	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
negative regulation of interleukin-10 production	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
positive regulation of interleukin-12 production	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
multicellular organismal response to stress	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
kynurenic acid biosynthetic process	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
swimming behavior	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
T cell proliferation	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
negative regulation of T cell proliferation	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
negative regulation of T cell apoptotic process	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
positive regulation of T cell apoptotic process	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
'de novo' NAD biosynthetic process from tryptophan	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Process	via Protein(s)	Taxonomy
electron transfer activity	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
heme binding	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
indoleamine 2,3-dioxygenase activity	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
metal ion binding	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
tryptophan 2,3-dioxygenase activity	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Process	via Protein(s)	Taxonomy
cytosol	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
smooth muscle contractile fiber	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
stereocilium bundle	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
cytoplasm	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (25)

Assay ID	Title	Year	Journal	Article
AID1487211	Inhibition of human IDO1 pre-incubated for 10 mins before L-Trp as substrate addition and measured after 30 mins by colorimetry	2017	Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15	Synthesis of 4- and 5-arylthiazolinethiones as inhibitors of indoleamine 2,3-dioxygenase.
AID1487209	Inhibition of human IDO1 at 100 uM pre-incubated for 10 mins before L-Trp as substrate addition and measured after 30 mins by colorimetry	2017	Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15	Synthesis of 4- and 5-arylthiazolinethiones as inhibitors of indoleamine 2,3-dioxygenase.
AID443998	Cytotoxicity against mouse P815B cells expressing mouse recombinant IDO by MTT assay	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Rational design of indoleamine 2,3-dioxygenase inhibitors.
AID443995	Inhibition of mouse recombinant IDO expressed in mouse P815B cells assessed as blockade of tryptophan degradation by HPLC	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Rational design of indoleamine 2,3-dioxygenase inhibitors.
AID1487210	Inhibition of human IDO1 at 10 uM pre-incubated for 10 mins before L-Trp as substrate addition and measured after 30 mins by colorimetry	2017	Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15	Synthesis of 4- and 5-arylthiazolinethiones as inhibitors of indoleamine 2,3-dioxygenase.
AID443999	Cytotoxicity against HEK293 cells expressing human recombinant IDO by MTT assay	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Rational design of indoleamine 2,3-dioxygenase inhibitors.
AID443996	Inhibition of human recombinant IDO expressed in HEK293 cells assessed as blockade of tryptophan degradation by HPLC	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Rational design of indoleamine 2,3-dioxygenase inhibitors.
AID443997	Inhibition of mouse recombinant TDO expressed in mouse P815B cells assessed as blockade of tryptophan degradation by HPLC	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Rational design of indoleamine 2,3-dioxygenase inhibitors.
AID444000	Cytotoxicity against mouse P815B cells expressing mouse recombinant TDO by MTT assay	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Rational design of indoleamine 2,3-dioxygenase inhibitors.
AID443993	Inhibition of human recombinant IDO expressed in Escherichia coli BL21 AI	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Rational design of indoleamine 2,3-dioxygenase inhibitors.
AID540299	A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis	2010	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21	Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519	A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities	2011	Antiviral research, Sep, Volume: 91, Issue:3	High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (11.11)	29.6817
2010's	7 (77.78)	24.3611
2020's	1 (11.11)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.02

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.02 (24.57)
Research Supply Index	2.30 (2.92)
Research Growth Index	4.32 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.02)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
oxyquinoline Oxyquinoline: An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.. quinolin-8-ol : A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.	2.05	1	monohydroxyquinoline	antibacterial agent; antifungal agrochemical; antiseptic drug; iron chelator
dichlorophen Dichlorophen: Nontoxic laxative vermicide effective for taenia infestation. It tends to produce colic and nausea. It is also used as a veterinary fungicide, anthelmintic, and antiprotozoan. (From Merck, 11th ed.)	2.05	1	bridged diphenyl fungicide; diarylmethane
benzophenone benzophenone : The simplest member of the class of benzophenones, being formaldehyde in which both hydrogens are replaced by phenyl groups.	2.05	1	benzophenones	photosensitizing agent; plant metabolite
4-aminodiphenylamine 4-aminodiphenylamine: RN given refers to parent cpd. p-aminodiphenylamine : An aromatic amine that is the 4-amino derivative of diphenylamine.	2.05	1	aromatic amine; secondary amino compound	allergen
9-fluorenone fluoren-9-one : The simplest member of the class fluoren-9-ones that is 9H-fluorene bearing an oxo substituent at position 9.	2.05	1	fluoren-9-ones	fungal xenobiotic metabolite
1,4-naphthohydroquinone naphthohydroquinone : A hydroxynaphthalene that is naphthalene-1,4-diol and its C-substituted derivatives.	2.05	1	naphthalenediol; naphthohydroquinone
phenthiazamine phenthiazamine: RN given refers to parent cpd	2.49	2
fluoren-9-ol fluoren-9-ol : A member of the class of hydroxyfluorenes that is 9H-fluorene substituted by a hydroxy group at position 9 (the non-aromatic carbon).	2.05	1	hydroxyfluorenes; secondary alcohol	animal metabolite
4-hydroxycarbazole 4-hydroxycarbazole: structure in first source	2.05	1
indoximod [no description available]	2.05	1
5-amino-8-hydroxyquinoline 5-amino-8-hydroxyquinoline: structure in first source	2.05	1
1-methyltryptophan 1-methyltryptophan: an immunomodulator. 1-methyltryptophan : A tryptophan derivative that is tryptophan carrying a single methyl substituent at position 1 on the indole.	2.05	1	indolyl carboxylic acid
4-(4-fluorophenyl)-3H-thiazole-2-thione [no description available]	2.15	1	organofluorine compound

Condition	Relationship Strength	Studies
Innate Inflammatory Response [description not available]	2.05	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.05	1
Encephalitis, Polio [description not available]	2.06	1
Poliomyelitis An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)	2.06	1

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