Compounds > cp-640186
Page last updated: 2024-09-27

cp-640186

Description

CP-640186: a potent inhibitor of mammalian Acetyl-coenzyme A carboxylases & can reduce body weight and improve insulin sensitivity in test animals; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID449097
CHEMBL ID208943
CHEBI ID45293
SCHEMBL ID976549
MeSH IDM0484542

Synonyms (41)

Synonym
(3r)-1'-(9-anthrylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidine
RCP ,
1W2X ,
CHEBI:45293 ,
(3r)-1'-(anthracen-9-ylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidine
{(3r)-1'-(anthracen-9-ylcarbonyl)[1,4'-bipiperidin]-3-yl}(morpholin-4-yl)methanone
(3r)-1''-(9-anthrylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4''-bipiperidine
(3r)-1''-(anthracen-9-ylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4''-bipiperidine
bdbm50189617
{(3r)-1''-(anthracen-9-ylcarbonyl)[1,4''-bipiperidin]-3-yl}(morpholin-4-yl)methanone
[(3r)-1-[1-(anthracene-9-carbonyl)piperidin-4-yl]piperidin-3-yl]-morpholin-4-ylmethanone
cp-640186
CHEMBL208943 ,
S6753
HY-15259
cp-640186 hydrochloride
unii-04l1e4j3zt
morpholine, 4-(((3r)-1'-(9-anthracenylcarbonyl)(1,4'-bipiperidin)-3-yl)carbonyl)-
(anthracen-9-yl)((3r)-3-((morpholin-4-yl)carbonyl)(1,4')bipiperidinyl-1'-yl)methanone
methanone, ((3r)-1'-(9-anthracenylcarbonyl)(1,4'-bipiperidin)-3-yl)-4-morpholinyl-
04l1e4j3zt ,
591778-68-6
(3r)-anthracen-9-yl-[3-(morpholine-4-carbonyl)-[1,4']bipiperidinyl-1'-yl]-methanone
LDQKDRLEMKIYMC-XMMPIXPASA-N ,
630111-13-6
(r)-anthracen-9-yl(3-(morpholine-4-carbonyl)-[1,4'-bipiperidin]-1'-yl)methanone
SCHEMBL976549
cp640186
AC-31461
cp 640186
AKOS027254693
mfcd25976696
NCGC00371124-02
Q27120595
cp 640,186
compound 1 [pmid: 16973360]
gtpl12243
EX-A2042
MS-29027
EN300-18161237
(3r)-1'-(anthracene-9-carbonyl)-3-(morpholine-4-carbonyl)-1,4'-bipiperidine

Drug Classes (4)

ClassDescription
anthracenesCompounds containing an anthracene skeleton.
morpholinesAny compound containing morpholine as part of its structure.
bipiperidines
N-acylpiperidine
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (6)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency21.31740.01237.983543.2770AID1645841
cytochrome P450 2D6Homo sapiens (human)Potency21.31740.00108.379861.1304AID1645840
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Acetyl-CoA carboxylase 2Homo sapiens (human)IC50 (µMol)0.07870.03400.07870.1940AID267164; AID267166; AID276641; AID469048; AID469052; AID546595; AID626469
Acetyl-CoA carboxylase 1 Rattus norvegicus (Norway rat)IC50 (µMol)0.17880.05300.17880.5900AID267165; AID370975; AID469058; AID476840; AID546598; AID613002
Acetyl-CoA carboxylase 1Homo sapiens (human)IC50 (µMol)0.47530.11601.26466.0000AID267163; AID276640; AID469048; AID469051; AID546596; AID626468
Acetyl-CoA carboxylase Rattus norvegicus (Norway rat)IC50 (µMol)0.09530.05500.09530.1700AID370976; AID469059; AID613001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (26)

Processvia Protein(s)Taxonomy
acetyl-CoA metabolic processAcetyl-CoA carboxylase 2Homo sapiens (human)
pentose-phosphate shuntAcetyl-CoA carboxylase 2Homo sapiens (human)
response to nutrientAcetyl-CoA carboxylase 2Homo sapiens (human)
response to xenobiotic stimulusAcetyl-CoA carboxylase 2Homo sapiens (human)
negative regulation of gene expressionAcetyl-CoA carboxylase 2Homo sapiens (human)
positive regulation of lipid storageAcetyl-CoA carboxylase 2Homo sapiens (human)
regulation of glucose metabolic processAcetyl-CoA carboxylase 2Homo sapiens (human)
response to organic cyclic compoundAcetyl-CoA carboxylase 2Homo sapiens (human)
fatty acid oxidationAcetyl-CoA carboxylase 2Homo sapiens (human)
negative regulation of fatty acid beta-oxidationAcetyl-CoA carboxylase 2Homo sapiens (human)
glucose importAcetyl-CoA carboxylase 2Homo sapiens (human)
lactic acid secretionAcetyl-CoA carboxylase 2Homo sapiens (human)
protein homotetramerizationAcetyl-CoA carboxylase 2Homo sapiens (human)
positive regulation of heart growthAcetyl-CoA carboxylase 2Homo sapiens (human)
tricarboxylic acid metabolic processAcetyl-CoA carboxylase 2Homo sapiens (human)
intracellular aspartate homeostasisAcetyl-CoA carboxylase 2Homo sapiens (human)
intracellular glutamate homeostasisAcetyl-CoA carboxylase 2Homo sapiens (human)
energy homeostasisAcetyl-CoA carboxylase 2Homo sapiens (human)
regulation of cardiac muscle hypertrophy in response to stressAcetyl-CoA carboxylase 2Homo sapiens (human)
malonyl-CoA biosynthetic processAcetyl-CoA carboxylase 2Homo sapiens (human)
fatty acid biosynthetic processAcetyl-CoA carboxylase 2Homo sapiens (human)
tissue homeostasisAcetyl-CoA carboxylase 1Homo sapiens (human)
acetyl-CoA metabolic processAcetyl-CoA carboxylase 1Homo sapiens (human)
fatty acid biosynthetic processAcetyl-CoA carboxylase 1Homo sapiens (human)
protein metabolic processAcetyl-CoA carboxylase 1Homo sapiens (human)
fatty-acyl-CoA biosynthetic processAcetyl-CoA carboxylase 1Homo sapiens (human)
protein homotetramerizationAcetyl-CoA carboxylase 1Homo sapiens (human)
lipid homeostasisAcetyl-CoA carboxylase 1Homo sapiens (human)
cellular response to prostaglandin E stimulusAcetyl-CoA carboxylase 1Homo sapiens (human)
malonyl-CoA biosynthetic processAcetyl-CoA carboxylase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (6)

Processvia Protein(s)Taxonomy
acetyl-CoA carboxylase activityAcetyl-CoA carboxylase 2Homo sapiens (human)
protein bindingAcetyl-CoA carboxylase 2Homo sapiens (human)
ATP bindingAcetyl-CoA carboxylase 2Homo sapiens (human)
biotin bindingAcetyl-CoA carboxylase 2Homo sapiens (human)
identical protein bindingAcetyl-CoA carboxylase 2Homo sapiens (human)
metal ion bindingAcetyl-CoA carboxylase 2Homo sapiens (human)
acetyl-CoA carboxylase activityAcetyl-CoA carboxylase 1Homo sapiens (human)
protein bindingAcetyl-CoA carboxylase 1Homo sapiens (human)
ATP bindingAcetyl-CoA carboxylase 1Homo sapiens (human)
identical protein bindingAcetyl-CoA carboxylase 1Homo sapiens (human)
metal ion bindingAcetyl-CoA carboxylase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (7)

Processvia Protein(s)Taxonomy
nucleusAcetyl-CoA carboxylase 2Homo sapiens (human)
mitochondrionAcetyl-CoA carboxylase 2Homo sapiens (human)
mitochondrial outer membraneAcetyl-CoA carboxylase 2Homo sapiens (human)
cytosolAcetyl-CoA carboxylase 2Homo sapiens (human)
mitochondrial fatty acid beta-oxidation multienzyme complexAcetyl-CoA carboxylase 2Homo sapiens (human)
mitochondrionAcetyl-CoA carboxylase 2Homo sapiens (human)
fibrillar centerAcetyl-CoA carboxylase 1Homo sapiens (human)
cytosolAcetyl-CoA carboxylase 1Homo sapiens (human)
actin cytoskeletonAcetyl-CoA carboxylase 1Homo sapiens (human)
mitochondrionAcetyl-CoA carboxylase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (38)

Assay IDTitleYearJournalArticle
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID469059Inhibition of rat ACC22009Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.
AID267164Inhibition of human recombinant ACC2 expressed in baculovirus/sf9 system2006Journal of medicinal chemistry, Jun-29, Volume: 49, Issue:13
Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors.
AID613001Inhibition of ACC2 in obese Zucker rat assessed as reduction in hepatic malonyl-coA level preincubated for 15 mins measured after 1.5 hrs using Malachite green reagent method2011Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10
Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.
AID469052Inhibition of human recombinant ACC22009Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.
AID626469Inhibition of human ACC22011Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors.
AID370976Inhibition of rat acetyl-CoA carboxylase 22009Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3
Synthesis of spiro[chroman-2,4'-piperidin]-4-one derivatives as acetyl-CoA carboxylase inhibitors.
AID469049Induction of fatty acid oxidation in human HepG2 cells after 48 hrs2009Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.
AID469048Inhibition of human recombinant ACC1/22009Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.
AID267165Inhibitory activity against rat ACC12006Journal of medicinal chemistry, Jun-29, Volume: 49, Issue:13
Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors.
AID370970Inhibition of acetyl-CoA carboxylase in rat skeletal muscle by HPLC at 10 uM2009Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3
Synthesis of spiro[chroman-2,4'-piperidin]-4-one derivatives as acetyl-CoA carboxylase inhibitors.
AID276640Inhibition of human recombinant ACC12006Bioorganic & medicinal chemistry letters, Dec-01, Volume: 16, Issue:23
Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity.
AID469054Metabolic stability in rat liver microsome assessed as drug remaining at 5 uM after 15 mins2009Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.
AID613003Antiobesity activity in obese Zucker rat assessed as reduction in hepatic malonyl-coA level, iv administered 2 hrs2011Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10
Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.
AID370969Inhibition of acetyl-CoA carboxylase in rat skeletal muscle by HPLC2009Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3
Synthesis of spiro[chroman-2,4'-piperidin]-4-one derivatives as acetyl-CoA carboxylase inhibitors.
AID469051Inhibition of human recombinant ACC12009Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.
AID546598Inhibition of N-terminal His-tagged rat recombinant ACC1 expressed in high five insect cells by ATP consumption assay2010Journal of medicinal chemistry, Dec-23, Volume: 53, Issue:24
Identification and synthesis of novel inhibitors of acetyl-CoA carboxylase with in vitro and in vivo efficacy on fat oxidation.
AID469053Metabolic stability in human liver microsome assessed as drug remaining at 5 uM after 15 mins2009Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.
AID267166Inhibitory activity against rat ACC22006Journal of medicinal chemistry, Jun-29, Volume: 49, Issue:13
Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors.
AID370975Inhibition of rat acetyl-CoA carboxylase 12009Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3
Synthesis of spiro[chroman-2,4'-piperidin]-4-one derivatives as acetyl-CoA carboxylase inhibitors.
AID276642Selectivity for human ACC2 over human ACC12006Bioorganic & medicinal chemistry letters, Dec-01, Volume: 16, Issue:23
Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity.
AID276641Inhibition of human recombinant ACC22006Bioorganic & medicinal chemistry letters, Dec-01, Volume: 16, Issue:23
Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity.
AID546595Inhibition of N-terminal His-tagged human recombinant ACC2 expressed in high five insect cells by ATP consumption assay2010Journal of medicinal chemistry, Dec-23, Volume: 53, Issue:24
Identification and synthesis of novel inhibitors of acetyl-CoA carboxylase with in vitro and in vivo efficacy on fat oxidation.
AID469056Tmax in Sprague-Dawley rat at 10 mg/kg, po2009Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.
AID476840Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter2010Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7
Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.
AID546596Inhibition of N-terminal His-tagged human recombinant ACC1 expressed in high five insect cells by ATP consumption assay2010Journal of medicinal chemistry, Dec-23, Volume: 53, Issue:24
Identification and synthesis of novel inhibitors of acetyl-CoA carboxylase with in vitro and in vivo efficacy on fat oxidation.
AID267163Inhibition of human recombinant ACC1 expressed in HEK293 cells2006Journal of medicinal chemistry, Jun-29, Volume: 49, Issue:13
Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors.
AID626468Inhibition of human ACC12011Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors.
AID613002Inhibition of obese Zucker rat ACC1 assessed as reduction in hepatic malonyl-coA level preincubated for 15 mins measured after 1.5 hrs using Malachite green reagent method2011Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10
Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.
AID469058Inhibition of rat ACC12009Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.
AID546597Inhibition of N-terminal His-tagged rat recombinant ACC2 expressed in high five insect cells by ATP consumption assay2010Journal of medicinal chemistry, Dec-23, Volume: 53, Issue:24
Identification and synthesis of novel inhibitors of acetyl-CoA carboxylase with in vitro and in vivo efficacy on fat oxidation.
AID469055Cmax in Sprague-Dawley rat at 10 mg/kg, po2009Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.
AID469057AUC in Sprague-Dawley rat at 10 mg/kg, po2009Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.
AID469050Inhibition of fatty acid synthesis in human HepG2 cells after 48 hrs2009Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (33.33)29.6817
2010's7 (46.67)24.3611
2020's3 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
aminoimidazole carboxamide[no description available]medium10aminoimidazole;
monocarboxylic acid amide		mouse metabolite
piperidines[no description available]medium40
aica ribonucleotide[no description available]medium101-(phosphoribosyl)imidazolecarboxamide;
aminoimidazole		cardiovascular drug;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
oleic acid[no description available]medium10octadec-9-enoic acidantioxidant;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite;
solvent
soraphen a[no description available]medium10cyclic hemiketal;
ether;
macrolide;
olefinic compound		bacterial metabolite;
EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor;
teratogenic agent
anthralin[no description available]low00anthracenesantipsoriatic
maprotiline[no description available]low00anthracenes
anthracene[no description available]low00acene;
anthracenes;
ortho-fused tricyclic hydrocarbon
9-nitroanthracene[no description available]low00anthracenes
isobarbaloin[no description available]low00anthracenes;
C-glycosyl compound;
cyclic ketone;
phenols		laxative;
metabolite
9,10-diphenylanthracene[no description available]low00anthracenesfluorochrome;
photosensitizing agent
trausabun[no description available]low00anthracenes
benzoctamine[no description available]low00anthracenes
bisantrene[no description available]low00anthracenes;
hydrazone;
imidazolidines		antineoplastic agent
maprotiline hydrochloride[no description available]low00anthracenes
9,10-bis(phenylethynyl)anthracene[no description available]low00anthracenes;
arylacetylene;
benzenes		fluorochrome
triptycene[no description available]low00anthracenes
rhein-9-anthrone[no description available]low00anthracenes
desmethylmaprotiline[no description available]low00anthracenes
aloe emodin anthrone[no description available]low00anthracenes
1-Anilino-9,10-dioxo-2-anthroic acid[no description available]low00anthracenes
xe 991, anthracenone[no description available]low00anthracenes
LSM-34582[no description available]low00anthracenes
brd 7389[no description available]low00anthracenes
1-(9-anthracenylmethyl)-3-piperidinol[no description available]low00anthracenes
10,10-bis((2-fluoro-4-pyridinyl)methyl)-9(10h)-anthracenone[no description available]low00anthracenes
alloin[no description available]low00anthracenes;
C-glycosyl compound;
cyclic ketone;
phenols		laxative;
metabolite
dimorpholamine[no description available]low00morpholines;
ureas
1-phenyl-2-palmitoylamino-3-morpholino-1-propanol[no description available]low00benzyl alcohols;
fatty amide;
morpholines;
secondary alcohol;
tertiary amino compound
doxapram[no description available]low00morpholines;
pyrrolidin-2-ones		central nervous system stimulant
hemicholinium 3[no description available]low00morpholines
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one[no description available]low00chromones;
morpholines;
organochlorine compound		autophagy inhibitor;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
geroprotector
minaprine[no description available]low00morpholines;
pyridazines;
secondary amine		antidepressant;
antiparkinson drug;
cholinergic drug;
dopamine uptake inhibitor;
serotonin uptake inhibitor
moclobemide[no description available]low00benzamides;
monochlorobenzenes;
morpholines		antidepressant;
environmental contaminant;
xenobiotic
molsidomine[no description available]low00ethyl ester;
morpholines;
oxadiazole;
zwitterion		antioxidant;
apoptosis inhibitor;
cardioprotective agent;
nitric oxide donor;
vasodilator agent
phenmetrazine[no description available]low00morpholinesmetabolite;
sympathomimetic agent
pramoxine[no description available]low00aromatic ether;
morpholines		local anaesthetic
linsidomine[no description available]low00morpholines
morpholine[no description available]low00morpholines;
saturated organic heteromonocyclic parent		NMR chemical shift reference compound
trimetozine[no description available]low00morpholines
trifenmorph[no description available]low00morpholines
fenbutrazate[no description available]low00morpholines
tridemorph[no description available]low00morpholines;
tertiary amino compound		antifungal agrochemical
moricizine[no description available]low00carbamate ester;
morpholines;
phenothiazines		anti-arrhythmia drug
morazone[no description available]low00morpholines
delmopinol[no description available]low00morpholines
3-morpholinopropylamine[no description available]low00morpholines;
primary amino compound
morzid[no description available]low00morpholines
methoxy-morpholinyl-doxorubicin[no description available]low00anthracycline antibiotic;
morpholines;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone
morphazinamide[no description available]low00morpholines;
pyrazines;
secondary carboxamide
morpholinopropane sulfonic acid[no description available]low00MOPS;
morpholines;
organosulfonic acid
1-cyclohexyl-3-(2-(4-morpholinyl)ethyl)carbodiimide[no description available]low00carbodiimide;
morpholines		cross-linking reagent
dextromoramide[no description available]low00morpholines;
N-acylpyrrolidine		opioid analgesic
landiolol[no description available]low00morpholines
mosapride[no description available]low00aromatic ether;
benzamides;
monochlorobenzenes;
monofluorobenzenes;
morpholines;
secondary carboxamide;
substituted aniline;
tertiary amino compound
gefitinib[no description available]low00aromatic ether;
monochlorobenzenes;
monofluorobenzenes;
morpholines;
quinazolines;
secondary amino compound;
tertiary amino compound		antineoplastic agent;
epidermal growth factor receptor antagonist
pre 084[no description available]low00morpholines
xamoterol[no description available]low00morpholines
canertinib[no description available]low00monochlorobenzenes;
morpholines;
organofluorine compound;
quinazolines		antineoplastic agent;
tyrosine kinase inhibitor
birb 796[no description available]low00aromatic ether;
morpholines;
naphthalenes;
pyrazoles;
ureas		EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
immunomodulator
Landiolol hydrochloride[no description available]low00morpholines
2-(4-morpholinoanilino)-6-cyclohexylaminopurine[no description available]low00morpholines;
purines;
secondary amino compound;
tertiary amino compound		adenosine A3 receptor antagonist;
antineoplastic agent;
Aurora kinase inhibitor;
cell dedifferentiation agent
4-2-Aminoethyl-morpholine[no description available]low00morpholines
rocuronium[no description available]low003alpha-hydroxy steroid;
acetate ester;
androstane;
morpholines;
quaternary ammonium ion;
tertiary amino compound		drug allergen;
muscle relaxant;
neuromuscular agent
linezolid[no description available]low00acetamides;
morpholines;
organofluorine compound;
oxazolidinone		antibacterial drug;
protein synthesis inhibitor
4-Morpholinyl(4-pentylcyclohexyl)methanone[no description available]low00morpholines
2-[5-[4-(dimethylamino)phenyl]-2-tetrazolyl]-N-[2-(4-morpholinyl)phenyl]acetamide[no description available]low00morpholines
2-[[5-(4-fluorophenyl)-1-methyl-2-imidazolyl]thio]-N-[2-(4-morpholinyl)phenyl]acetamide[no description available]low00morpholines
2-(2,4-dioxo-3-thiazolidinyl)-N-[4-(4-morpholinyl)phenyl]acetamide[no description available]low00morpholines
N-(2-methylphenyl)-2-[5-[4-(4-morpholinyl)phenyl]-2-tetrazolyl]acetamide[no description available]low00morpholines
5-[4-morpholinyl(oxo)methyl]-2-pyranone[no description available]low00morpholines
5-(1,3-benzodioxol-5-ylmethylamino)-2-(4-morpholinyl)benzoic acid methyl ester[no description available]low00morpholines
N-[4-(4-morpholinyl)phenyl]-2-thiophenesulfonamide[no description available]low00morpholines
4-(4-morpholinyl)-N-(pyridin-4-ylmethyl)aniline[no description available]low00morpholines
[4-amino-3-(4-methylphenyl)-2-sulfanylidene-5-thiazolyl]-(4-morpholinyl)methanone[no description available]low00morpholines
2-(1,3-dimethyl-2,6-dioxo-9-purinyl)-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]acetamide[no description available]low00morpholines
DND-167 dye[no description available]low00morpholinesfluorochrome
1-(2,1,3-benzothiadiazol-5-yl)-3-[4-(4-morpholinyl)phenyl]urea[no description available]low00morpholines
2-(4-methylphenyl)-N-[4-(4-morpholinyl)phenyl]-4-quinazolinamine[no description available]low00morpholines
2-(3-methylphenyl)-N-[4-(4-morpholinyl)phenyl]-4-quinazolinamine[no description available]low00morpholines
1-[2,3-bis(2-furanyl)-6-quinoxalinyl]-3-[4-(4-morpholinyl)phenyl]thiourea[no description available]low00morpholines
1-[5-(5-chloro-2-methylphenyl)-2-furanyl]-N-[4-(4-morpholinyl)phenyl]methanimine[no description available]low00morpholines
N-[4-(4-morpholinyl)phenyl]carbamic acid butyl ester[no description available]low00morpholines
2-(2,4-dioxo-1H-pyrimidin-6-yl)-N-[2-(4-morpholinyl)ethyl]acetamide[no description available]low00morpholines;
pyrimidone;
secondary carboxamide;
tertiary amino compound
1-(4-butylphenyl)-3-(4-morpholinyl)thiourea[no description available]low00morpholines
5-[[2-methoxy-4-(4-morpholinyl)phenyl]methylidene]-1,3-diazinane-2,4,6-trione[no description available]low00morpholines
N-[2,2-dichloro-1-(3-fluoro-4-methylphenyl)ethenyl]-4-morpholinecarboxamide[no description available]low00morpholines
2-(methylthio)-3-pyridinecarboxylic acid [2-[2-(4-morpholinyl)-5-(trifluoromethyl)anilino]-2-oxoethyl] ester[no description available]low00morpholines
2-[(2-hydroxy-1-naphthalenyl)methyl-methylamino]-N-[4-(4-morpholinyl)phenyl]acetamide[no description available]low00morpholines
N-(2,5-diethoxy-4-morpholinophenyl)acetamide[no description available]low00morpholines
Benzo[b]thiophen-2-yl(morpholino)methanone[no description available]low00morpholines
5-(4-morpholinoanilino)-5-oxo-3-phenylpentanoic acid[no description available]low00morpholines
N-(2-morpholinophenyl)-N'-phenylurea[no description available]low00morpholines
N,N'-di[4-(2,6-dimethylmorpholino)phenyl]thiourea[no description available]low00morpholines
3,5,7-trimethyl-N-[4-morpholinyl(sulfanylidene)methyl]-1-adamantanecarboxamide[no description available]low00morpholines
N-[2-(3-methylphenoxy)ethyl]-5-(4-morpholinyl)-2-nitroaniline[no description available]low00morpholines
N-[2-(4-methoxyphenoxy)ethyl]-5-(4-morpholinyl)-2-nitroaniline[no description available]low00morpholines
[3-[(2-chlorophenoxy)methyl]phenyl]-(2,6-dimethyl-4-morpholinyl)methanone[no description available]low00morpholines
2,6-dimethyl-4-thiophen-2-ylsulfonylmorpholine[no description available]low00morpholines
1-[4-(dimethylamino)phenyl]-3-[4-(4-morpholinyl)anilino]pyrrolidine-2,5-dione[no description available]low00morpholines
1-(2,4-dimethoxyphenyl)-3-[4-(4-morpholinyl)anilino]pyrrolidine-2,5-dione[no description available]low00morpholines
N-[3-chloro-4-(4-morpholinyl)phenyl]-1,1-dioxo-1,2-benzothiazol-3-amine[no description available]low00morpholines
7-[(2,6-dimethyl-4-morpholinyl)methyl]-5-thiazolo[3,2-a]pyrimidinone[no description available]low00morpholines;
thiazolopyrimidine
3-(4-chlorophenyl)sulfonyl-N-[2,5-diethoxy-4-(4-morpholinyl)phenyl]propanamide[no description available]low00morpholines
3-(methanesulfonamido)benzoic acid [1-[4-(4-morpholinyl)anilino]-1-oxopropan-2-yl] ester[no description available]low00morpholines
2-(4-chloro-2-methylphenoxy)-N-[2-(4-morpholinyl)phenyl]propanamide[no description available]low00morpholines
3-amino-5-morpholinomethyl-2-oxazolidinone[no description available]low00morpholines;
oxazolidinone		marine xenobiotic metabolite;
xenobiotic metabolite
5-ethyl-2-[[[3-(4-morpholinyl)-4-nitrophenyl]-oxomethyl]amino]-3-thiophenecarboxylic acid ethyl ester[no description available]low00morpholines
1-methyl-N-[4-(4-morpholinyl)phenyl]-2-quinolinimine[no description available]low00morpholines
4-morpholinecarboxylic acid [3-(6-amino-5-cyano-3-propan-2-yl-2,4-dihydropyrano[2,3-c]pyrazol-4-yl)phenyl] ester[no description available]low00morpholines;
pyranopyrazole
4-morpholinecarboxylic acid [3-(6-amino-5-cyano-3-ethyl-2,4-dihydropyrano[2,3-c]pyrazol-4-yl)phenyl] ester[no description available]low00morpholines;
pyranopyrazole
(4-amino-3-ethyl-2-sulfanylidene-5-thiazolyl)-(4-morpholinyl)methanone[no description available]low00morpholines
LSM-19878[no description available]low00morpholines
2-(4-morpholinyl)-5-(1-piperidinylsulfonyl)benzoic acid [2-[2-(4-fluorophenyl)ethylamino]-2-oxoethyl] ester[no description available]low00morpholines
4-(4-morpholinyl)-3-nitro-N-(2-thiazolyl)benzamide[no description available]low00morpholines
2-(1-adamantyl)-N-[2,5-diethoxy-4-(4-morpholinyl)phenyl]acetamide[no description available]low00morpholines
2-[2,5-diethoxy-4-(4-morpholinyl)anilino]-1-(4-methyl-1-piperidinyl)-1-propanone[no description available]low00morpholines
[4-[bis(4-morpholinyl)phosphoryl]-1-methyl-2-pyrrolyl]-bis(4-morpholinyl)-sulfanylidenephosphorane[no description available]low00morpholines
5-benzoyl-6-methyl-4-[4-(4-morpholinyl)phenyl]-3,4-dihydro-1H-pyrimidin-2-one[no description available]low00morpholines
purmorphamine[no description available]low00aromatic ether;
morpholines;
purines;
secondary amino compound		osteogenesis regulator;
SMO receptor agonist
(3r)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone[no description available]low00morpholines;
naphthyl ketone;
organic heterotricyclic compound;
synthetic cannabinoid		analgesic;
apoptosis inhibitor;
neuroprotective agent
DPI2[no description available]low00benzenes;
morpholines;
secondary carboxamide;
tertiary amino compound;
thiazolidinone		ferroptosis inducer
N-(3-methylphenyl)-4-[4-(4-morpholinyl)-3-nitrophenyl]-1-phthalazinamine[no description available]low00morpholines
rivaroxaban[no description available]low00aromatic amide;
lactam;
monocarboxylic acid amide;
morpholines;
organochlorine compound;
oxazolidinone;
thiophenes		anticoagulant;
EC 3.4.21.6 (coagulation factor Xa) inhibitor
pi103[no description available]low00aromatic amine;
morpholines;
organic heterotricyclic compound;
phenols;
tertiary amino compound		antineoplastic agent;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
mTOR inhibitor
zm 447439[no description available]low00aromatic ether;
benzamides;
morpholines;
polyether;
quinazolines;
secondary amino compound;
tertiary amino compound		antineoplastic agent;
apoptosis inducer;
Aurora kinase inhibitor
tae226[no description available]low00morpholines
flumorph[no description available]low00aromatic ether;
enamide;
morpholines;
organofluorine compound;
tertiary carboxamide
epoxomicin[no description available]low00morpholines;
tripeptide		proteasome inhibitor
MI-63[no description available]low00azaspiro compound;
monochlorobenzenes;
monofluorobenzenes;
morpholines;
oxindoles;
pyrrolidines;
secondary carboxamide		apoptosis inducer
chir 090[no description available]low00acetylenic compound;
benzamides;
hydroxamic acid;
L-threonine derivative;
morpholines		antimicrobial agent;
EC 3.5.1.108 (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor;
lipopolysaccharide biosynthesis inhibitor
carfilzomib[no description available]low00epoxide;
morpholines;
tetrapeptide		antineoplastic agent;
proteasome inhibitor
zstk474[no description available]low00benzimidazoles;
morpholines;
organofluorine compound;
triamino-1,3,5-triazine		antineoplastic agent;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
1-(4-bromophenyl)-3-[[[4-(4-morpholinyl)-3-nitrophenyl]-oxomethyl]amino]thiourea[no description available]low00morpholines
4-[(2-heptan-3-yl-1,3-dioxolan-4-yl)methyl]-4-methylmorpholin-4-ium[no description available]low00morpholines
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[4-(4-morpholinyl)phenyl]-3-imidazo[1,2-a]pyrazinamine[no description available]low00morpholines
buparlisib[no description available]low00aminopyridine;
aminopyrimidine;
morpholines;
organofluorine compound		antineoplastic agent;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
ku 0063794[no description available]low00benzyl alcohols;
monomethoxybenzene;
morpholines;
pyridopyrimidine;
tertiary amino compound		antineoplastic agent;
mTOR inhibitor
gdc 0941[no description available]low00indazoles;
morpholines;
piperazines;
sulfonamide;
thienopyrimidine		EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
lde225[no description available]low00aminopyridine;
aromatic ether;
benzamides;
biphenyls;
morpholines;
organofluorine compound;
tertiary amino compound		antineoplastic agent;
Hedgehog signaling pathway inhibitor;
SMO receptor antagonist
quizartinib[no description available]low00benzoimidazothiazole;
isoxazoles;
morpholines;
phenylureas		antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
necroptosis inhibitor
navitoclax[no description available]low00aryl sulfide;
monochlorobenzenes;
morpholines;
N-sulfonylcarboxamide;
organofluorine compound;
piperazines;
secondary amino compound;
sulfone;
tertiary amino compound		antineoplastic agent;
apoptosis inducer;
B-cell lymphoma 2 inhibitor
n-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide[no description available]low00aminopyrimidine;
benzamides;
morpholines;
nitrile;
secondary amino compound;
tertiary amino compound		anti-anaemic agent;
antineoplastic agent;
apoptosis inducer;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor
cobicistat[no description available]low001,3-thiazoles;
carbamate ester;
monocarboxylic acid amide;
morpholines;
ureas		P450 inhibitor
(5-(2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol[no description available]low00benzyl alcohols;
morpholines;
pyridopyrimidine;
tertiary amino compound		antineoplastic agent;
apoptosis inducer;
mTOR inhibitor
alectinib[no description available]low00aromatic ketone;
morpholines;
nitrile;
organic heterotetracyclic compound;
piperidines		antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
3-fluorophenmetrazine[no description available]low00morpholines
HG-10-102-01[no description available]low00aminopyrimidine;
aromatic ether;
monocarboxylic acid amide;
morpholines;
organochlorine compound;
secondary amino compound		EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
MLI-2[no description available]low00aromatic ether;
cyclopropanes;
indazoles;
morpholines;
pyrimidines;
tertiary amino compound		EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
aprepitant[no description available]low00(trifluoromethyl)benzenes;
cyclic acetal;
morpholines;
triazoles		antidepressant;
antiemetic;
neurokinin-1 receptor antagonist;
peripheral nervous system drug;
substance P receptor antagonist
fosaprepitant[no description available]low00(trifluoromethyl)benzenes;
cyclic acetal;
morpholines;
phosphoramide;
triazoles		antiemetic;
neurokinin-1 receptor antagonist;
prodrug
2-[ethyl-[(4-oxo-1H-quinazolin-2-yl)methyl]amino]-N-[4-(4-morpholinyl)phenyl]acetamide[no description available]low00morpholines
ver 52296[no description available]low00aromatic amide;
isoxazoles;
monocarboxylic acid amide;
morpholines;
resorcinols		angiogenesis inhibitor;
antineoplastic agent;
Hsp90 inhibitor
2-hydroxy-3-(5-((morpholin-4-yl)methyl)pyridin-2-yl)-1h-indole-5-carbonitrile[no description available]low00hydroxyindoles;
morpholines;
nitrile;
pyridines;
tertiary amino compound		antineoplastic agent;
apoptosis inducer;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
tau aggregation inhibitor
pipamperone[no description available]low00aromatic ketone;
bipiperidines;
monocarboxylic acid amide;
organofluorine compound;
tertiary amino compound		dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
1-(1,3-benzodioxol-5-ylcarbonyl)piperidine[no description available]low00N-acylpiperidine
loratadine[no description available]low00benzocycloheptapyridine;
ethyl ester;
N-acylpiperidine;
organochlorine compound;
tertiary carboxamide		anti-allergic agent;
cholinergic antagonist;
geroprotector;
H1-receptor antagonist
irinotecan[no description available]low00carbamate ester;
delta-lactone;
N-acylpiperidine;
pyranoindolizinoquinoline;
ring assembly;
tertiary alcohol;
tertiary amino compound		antineoplastic agent;
apoptosis inducer;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
prodrug
n-benzoylpiperidine[no description available]low00benzamides;
N-acylpiperidine
bdp 12[no description available]low00N-acylpiperidine
ammodendrine[no description available]low00acetamides;
N-acylpiperidine;
piperidine alkaloid		plant metabolite;
teratogenic agent
1-adamantyl(piperidino)methanone[no description available]low00N-acylpiperidine
piperine[no description available]low00benzodioxoles;
N-acylpiperidine;
piperidine alkaloid;
tertiary carboxamide		food component;
human blood serum metabolite;
NF-kappaB inhibitor;
plant metabolite
[3-[3-(5-methyl-2-furanyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-phenylmethanone[no description available]low00benzamides;
N-acylpiperidine
(2,4-difluorophenyl)-[3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]methanone[no description available]low00benzamides;
N-acylpiperidine
4,6-dimethyl-2-[[2-oxo-2-(1-piperidinyl)ethyl]thio]-3-pyridinecarbonitrile[no description available]low00N-acylpiperidine
[5-(4-nitrophenyl)-2-furanyl]-(1-piperidinyl)methanone[no description available]low00N-acylpiperidine
2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]thio]-1-(1-piperidinyl)ethanone[no description available]low00N-acylpiperidine
1-[(Phenylthio)acetyl]piperidine[no description available]low00N-acylpiperidine
N-(4-methoxyphenyl)-1-[oxo(thiophen-2-yl)methyl]-4-piperidinecarboxamide[no description available]low00N-acylpiperidine
[2-methoxy-4-(methylthio)phenyl]-[4-(phenylmethyl)-1-piperidinyl]methanone[no description available]low00benzamides;
N-acylpiperidine
[4-[(2-bromophenoxy)methyl]phenyl]-(1-piperidinyl)methanone[no description available]low00benzamides;
N-acylpiperidine
(2,6-difluorophenyl)-[4-(5-fluoro-2-methyl-1-benzimidazolyl)-1-piperidinyl]methanone[no description available]low00benzamides;
N-acylpiperidine
(4-chlorophenyl)-[4-[[(2,4-dichlorophenyl)thio]methyl]-4-hydroxy-1-piperidinyl]methanone[no description available]low00benzamides;
N-acylpiperidine
4-(4-chlorophenoxy)-1-(1-piperidinyl)-1-butanone[no description available]low00N-acylpiperidine
1-piperidinyl-(5-thiophen-2-yl-3-isoxazolyl)methanone[no description available]low00N-acylpiperidine
4-[2-(2,6-dimethyl-1-piperidinyl)-2-oxoethyl]-1-methyl-5-pyrrolo[3,2-b]pyrrolecarboxylic acid ethyl ester[no description available]low00N-acylpiperidine
3-(1,3-benzodioxol-5-ylmethyl)-7-[1,4-dioxa-8-azaspiro[4.5]decan-8-yl(oxo)methyl]-2-sulfanylidene-1H-quinazolin-4-one[no description available]low00N-acylpiperidine
1-[[4-[(4-fluorophenyl)methyl]-5-thieno[3,2-b]pyrrolyl]-oxomethyl]-N-(2-furanylmethyl)-4-piperidinecarboxamide[no description available]low00N-acylpiperidine
N-[3-(cyclohexylthio)propyl]-1-[(4-methyl-5-thieno[3,2-b]pyrrolyl)-oxomethyl]-3-piperidinecarboxamide[no description available]low00N-acylpiperidine
1-[(4-chlorophenyl)-oxomethyl]-N-[4-(1-piperidinylsulfonyl)phenyl]-3-piperidinecarboxamide[no description available]low00benzamides;
N-acylpiperidine
4-(3,5-dimethyl-1-piperidinyl)-N-[5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl]-4-oxobutanamide[no description available]low00N-acylpiperidine
[5-(2-furanyl)-3-isoxazolyl]-(4-methyl-1-piperidinyl)methanone[no description available]low00N-acylpiperidine
2-(4-methylphenoxy)-N-[2-[oxo(1-piperidinyl)methyl]phenyl]acetamide[no description available]low00benzamides;
N-acylpiperidine
[1-[(3,5-dimethyl-4-isoxazolyl)sulfonyl]-4-piperidinyl]-[4-(1-piperidinyl)-1-piperidinyl]methanone[no description available]low00N-acylpiperidine
[5-(2-methoxyphenyl)-3-isoxazolyl]-(1-piperidinyl)methanone[no description available]low00N-acylpiperidine
[2-methoxy-5-[[4-(4-methylphenyl)-1-phthalazinyl]amino]phenyl]-(1-piperidinyl)methanone[no description available]low00benzamides;
N-acylpiperidine
[4-(phenylmethyl)-2,3-dihydro-1,4-benzothiazin-6-yl]-(1-piperidinyl)methanone[no description available]low00N-acylpiperidine
fk 866[no description available]low00benzamides;
N-acylpiperidine
1-tert-butyl-5-[2-oxo-2-(1-piperidinyl)ethyl]-4-pyrazolo[3,4-d]pyrimidinone[no description available]low00N-acylpiperidine
2-[[6-(2-furanyl)-3-pyridazinyl]thio]-1-(1-piperidinyl)ethanone[no description available]low00N-acylpiperidine
[4-[[4-(1-benzothiophen-2-yl)-2-pyrimidinyl]amino]phenyl]-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone[no description available]low00benzamides;
N-acylpiperidine
lonafarnib[no description available]low00benzocycloheptapyridine;
heteroarylpiperidine;
N-acylpiperidine;
organobromine compound;
organochlorine compound;
ureas
sd 0006[no description available]low00monochlorobenzenes;
N-acylpiperidine;
primary alcohol;
pyrazoles;
pyrimidines
tofacitinib[no description available]low00N-acylpiperidine;
nitrile;
pyrrolopyrimidine;
tertiary amino compound		antirheumatic drug;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor
coumaperine[no description available]low00N-acylpiperidine
2-(2-methoxyanilino)-8-[(3-methyl-1-piperidinyl)-oxomethyl]-[1,3,4]thiadiazolo[2,3-b]quinazolin-5-one[no description available]low00N-acylpiperidine
N-cyclopropyl-1-[1-[[5-(2-methylpropyl)-1H-pyrazol-3-yl]-oxomethyl]-4-piperidinyl]-4-piperidinecarboxamide[no description available]low00N-acylpiperidine
dafadine C[no description available]low00aromatic amide;
aromatic ether;
difluorobenzene;
isoxazoles;
N-acylpiperidine;
pyridines		P450 inhibitor
dafadine B[no description available]low00aromatic amide;
aromatic ether;
isoxazoles;
monochlorobenzenes;
monofluorobenzenes;
N-acylpiperidine;
pyridines		P450 inhibitor
[1-[1-[[5-(2-methylpropyl)-1H-pyrazol-3-yl]-oxomethyl]-4-piperidinyl]-4-piperidinyl]-(4-morpholinyl)methanone[no description available]low00N-acylpiperidine
4-(1-((5-((2,6-dimethylphenoxy)methyl)-3-isoxazolyl)carbonyl)-4-piperidinyl)pyridine[no description available]low00aromatic amide;
aromatic ether;
isoxazoles;
N-acylpiperidine;
pyridines		geroprotector;
P450 inhibitor
[5-[(3,4-difluorophenoxy)methyl]-3-isoxazolyl]-(3-propoxy-1-piperidinyl)methanone[no description available]low00N-acylpiperidine
dafadine D[no description available]low00aromatic amide;
aromatic ether;
isoxazoles;
N-acylpiperidine;
organofluorine compound;
pyridines		P450 inhibitor
dafadine O[no description available]low00aromatic amide;
aromatic ether;
isoxazoles;
N-acylpiperidine;
pyridines;
ring assembly		P450 inhibitor
pci 32765[no description available]low00acrylamides;
aromatic amine;
aromatic ether;
N-acylpiperidine;
pyrazolopyrimidine;
tertiary carboxamide		antineoplastic agent;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor
poziotinib[no description available]low00acrylamides;
aromatic ether;
dichlorobenzene;
diether;
monofluorobenzenes;
N-acylpiperidine;
quinazolines;
secondary amino compound;
substituted aniline		antineoplastic agent;
apoptosis inducer;
epidermal growth factor receptor antagonist
lrrk2-in1[no description available]low00aromatic amine;
aromatic ether;
N-acylpiperidine;
N-alkylpiperazine;
pyrimidobenzodiazepine;
secondary amino compound;
tertiary amino compound		antineoplastic agent;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
pf 956980[no description available]low00N-acylpiperidine;
N-acylpyrrolidine;
pyrrolopyrimidine;
tertiary amino compound		EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor
N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide[no description available]low00benzamides;
N-acylpiperidine
oxathiapiprolin[no description available]low001,3-thiazoles;
isoxazoline;
N-acylpiperidine;
organofluorine compound;
pyrazoles;
tertiary carboxamide
entecavir[no description available]low00benzamides;
N-acylpiperidine
ap20187[no description available]low00aromatic ether;
carboxylic ester;
N-acylpiperidine;
tertiary amino compound		ligand
THZ531[no description available]low00aminopyrimidine;
enamide;
indoles;
N-acylpiperidine;
organochlorine compound;
secondary amino compound;
secondary carboxamide		antineoplastic agent;
apoptosis inducer;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
N-[6-amino-2-[[2-(4-methyl-1-piperidinyl)-2-oxoethyl]thio]-4-oxo-1H-pyrimidin-5-yl]benzamide[no description available]low00N-acylpiperidine
ConditionIndicatedRelationship StrengthStudiesTrials
Congenital Zika Syndrome0low10
Congenital Zika Virus Infection0low10
Diabetes Mellitus, Adult-Onset0low10
Diabetes Mellitus, Ketosis-Resistant0low10
Diabetes Mellitus, Maturity-Onset0low10
Diabetes Mellitus, Non Insulin Dependent0low10
Diabetes Mellitus, Non-Insulin-Dependent0low10
Diabetes Mellitus, Noninsulin Dependent0low10
Diabetes Mellitus, Noninsulin-Dependent0low10
Diabetes Mellitus, Slow-Onset0low10
Diabetes Mellitus, Stable0low10
Diabetes Mellitus, Type 20low10
Diabetes Mellitus, Type II0low10
Disease Models, Animal0low10
Fever, Zika0low10
Maturity-Onset Diabetes0low10
Maturity-Onset Diabetes Mellitus0low10
MODY0low10
NIDDM0low10
Noninsulin-Dependent Diabetes Mellitus0low10
Obesity0low10
Type 2 Diabetes0low10
Type 2 Diabetes Mellitus0low10
Zika Fever0low10
Zika Virus Disease0low10
Zika Virus Infection0low10
ZikV Infection0low10

Research Highlights

Long-term Use (1)

ArticleYear
Identification and synthesis of novel inhibitors of acetyl-CoA carboxylase with in vitro and in vivo efficacy on fat oxidation.
Journal of medicinal chemistry, Dec-23, Volume: 53, Issue: 24		2010
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (2)

ArticleYear
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology, Volume: 96, Issue: 5		2019
Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.
Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue: 10		2011
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]