| ID Source | ID |
|---|---|
| PubMed CID | 417052 |
| CHEMBL ID | 338115 |
| CHEBI ID | 92962 |
| SCHEMBL ID | 3877767 |
| MeSH ID | M0130327 |
| Synonym |
|---|
| 6-methoxyharmalane |
| 6-methoxyharmalan |
| 6-methoxy-1-methyl-4,9-dihydro-3h-pyrido(3,4-b)indole monohydrochloride |
| 3h-pyrido(3,4-b)indole, 4,9-dihydro-6-methoxy-1-methyl-, monohydrochloride |
| 1-methyl-6-methoxy-dihydro-beta-carboline |
| 10-methoxyharmalan |
| MLS002153914 |
| smr001233263 |
| BRD-K54906270-001-03-5 |
| PRESTWICK_324 |
| methoxy-6-harmalan |
| 3589-73-9 |
| NCGC00016633-01 |
| cas-3589-73-9 |
| BPBIO1_000642 |
| PRESTWICK2_000621 |
| PRESTWICK3_000621 |
| OPREA1_335320 |
| BSPBIO_000582 |
| PRESTWICK0_000621 |
| SPBIO_002801 |
| PRESTWICK1_000621 |
| NCGC00016633-02 |
| 6-methoxyharmalan, crystalline |
| bdbm50132104 |
| 6-methoxy-1-methyl-4,9-dihydro-3h-beta-carboline |
| CHEMBL338115 , |
| 6-methoxy-harmalan |
| 6-methoxy-1-methyl-3,4-dihydro-2h-pyrido[3,4-b]indole |
| HMS1569N04 |
| HMS2096N04 |
| unii-43f45vjv8c |
| 43f45vjv8c , |
| A823026 |
| HMS2233C16 |
| FT-0634918 |
| 1-methyl-6-methoxy-dihydro-.beta.-carboline |
| 1-methyl-6-methoxy-3,4-dihydro-2-carboline |
| 10-methoxyharmalan [mi] |
| 4,9-dihydro-6-methoxy-1-methyl-3h-pyrido(3,4-b)indole |
| 3,4-dihydromethoxyharman |
| HMS3370E16 |
| SCHEMBL3877767 |
| 3h-pyrido(3,4-b)indole, 4,9-dihydro-6-methoxy-1-methyl- |
| 6-methoxy-1-methyl-3,4-dihydro-.beta.-carboline |
| 6-methoxy-1-methyl-4,9-dihydro-3h-pyrido(3,4-b)indole |
| 3h-pyrido(3,4-b)indole, 4,9-dihydro-6-methoxy-1-methyl-, monohydrochloride (salt/mix) |
| 6-methoxy-1-methyl-4,9-dihydro-3h-pyrido(3,4-b)indole monohydrochloride (salt/mix) |
| HMBHRMFLDKKSCT-UHFFFAOYSA-N |
| SR-01000841225-2 |
| sr-01000841225 |
| CHEBI:92962 |
| AS-65610 |
| Q27164697 |
| PIRYBCJVLMHZOK-UHFFFAOYSA-N |
| 6-methoxy-1-methyl-3h,4h,9h-pyrido[3,4-b]indole |
| 6-methoxy-1-methyl-4,9-dihydro-3h-pyrido[3,4-b]indole |
| Q27258644 |
| noname_1047 |
| DTXSID10901872 |
| DTXSID80957306 |
| AKOS037646003 |
| ethyl3-(naphthalen-8-yl)-3-oxopropanoate |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 17.7828 | 0.0040 | 23.8416 | 100.0000 | AID485290 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 3.5481 | 0.0447 | 17.8581 | 100.0000 | AID485294 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 35.4813 | 0.6310 | 35.7641 | 100.0000 | AID504339 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 12.5893 | 0.1778 | 14.3909 | 39.8107 | AID2147 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 10.0000 | 0.1259 | 19.1169 | 125.8920 | AID2549 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 12.5893 | 0.0020 | 14.6779 | 39.8107 | AID1476 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 6.3096 | 0.0126 | 10.6917 | 88.5700 | AID887 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 14.1254 | 0.0316 | 37.5844 | 354.8130 | AID504865 |
| TDP1 protein | Homo sapiens (human) | Potency | 0.4109 | 0.0008 | 11.3822 | 44.6684 | AID686978 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 44.6684 | 0.7079 | 36.9043 | 89.1251 | AID504333 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 18.5482 | 0.0355 | 20.9770 | 89.1251 | AID504332 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 0.6310 | 0.0020 | 7.5337 | 39.8107 | AID891 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 14.5810 | 0.0041 | 9.9848 | 25.9290 | AID504444 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 56.2341 | 5.8048 | 36.1306 | 65.1308 | AID540263 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 50.1187 | 0.1337 | 25.4129 | 89.1251 | AID588795 |
| snurportin-1 | Homo sapiens (human) | Potency | 56.2341 | 5.8048 | 36.1306 | 65.1308 | AID540263 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 44.6684 | 0.4256 | 12.0591 | 28.1838 | AID504891 |
| geminin | Homo sapiens (human) | Potency | 8.9125 | 0.0046 | 11.3741 | 33.4983 | AID624297 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 5.0119 | 0.0316 | 10.2792 | 39.8107 | AID884; AID885 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 15.8489 | 0.0003 | 11.4484 | 31.6228 | AID900 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1.0000 | 12.2248 | 31.6228 | AID885 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 3E | Homo sapiens (human) | Ki | 10.0000 | 0.0010 | 0.8835 | 9.9000 | AID5996 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.0002 | 0.6561 | 10.0000 | AID39935 |
| 5-hydroxytryptamine receptor 3B | Homo sapiens (human) | Ki | 10.0000 | 0.0010 | 0.8711 | 9.9000 | AID5996 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 (µMol) | 4.0000 | 0.0003 | 2.1774 | 10.0000 | AID1725119 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 10.0000 | 0.0000 | 0.6902 | 10.0000 | AID142899 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 10.0000 | 0.0000 | 0.7951 | 9.1201 | AID142899 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 10.0000 | 0.0001 | 0.5326 | 10.0000 | AID3824 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 10.0000 | 0.0000 | 0.7292 | 6.9183 | AID142899 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 10.0000 | 0.0000 | 0.5972 | 9.1201 | AID142899 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 10.0000 | 0.0000 | 0.6518 | 10.0000 | AID63034 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 5.6000 | 0.0001 | 0.6017 | 10.0000 | AID5536 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.0002 | 0.6561 | 10.0000 | AID39935 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.0002 | 0.6561 | 10.0000 | AID39935 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.0002 | 0.5614 | 10.0000 | AID39935 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.0002 | 0.6352 | 10.0000 | AID39935 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.0002 | 0.6217 | 10.0000 | AID39935 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 10.0000 | 0.0000 | 0.5405 | 7.7600 | AID142899 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 10.0000 | 0.0001 | 0.8363 | 10.0000 | AID63034 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 10.0000 | 0.0000 | 0.4362 | 10.0000 | AID63034 |
| D(1B) dopamine receptor | Homo sapiens (human) | Ki | 10.0000 | 0.0003 | 0.4017 | 7.9000 | AID63034 |
| Metabotropic glutamate receptor 1 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.0079 | 0.3145 | 0.9000 | AID108345 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.0002 | 0.6758 | 10.0000 | AID39935 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.0002 | 0.6469 | 10.0000 | AID39935 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 4.1000 | 0.0003 | 1.4656 | 10.0000 | AID145367 |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | Ki | 10.0000 | 0.0001 | 0.8087 | 10.0000 | AID4616 |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | Ki | 10.0000 | 0.0001 | 0.5485 | 9.2100 | AID4247 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.9240 | 0.0001 | 0.9549 | 10.0000 | AID5615 |
| Neuromedin-B receptor | Homo sapiens (human) | Ki | 10.0000 | 0.0002 | 0.0008 | 0.0020 | AID4247 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.0002 | 0.6561 | 10.0000 | AID39935 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.0002 | 0.6561 | 10.0000 | AID39935 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.0002 | 0.6712 | 10.0000 | AID39935 |
| Metabotropic glutamate receptor 2 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.0031 | 0.1265 | 0.4760 | AID108345 |
| Metabotropic glutamate receptor 3 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.0030 | 0.1340 | 0.4760 | AID108345 |
| Metabotropic glutamate receptor 4 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.1600 | 1.7800 | 3.4000 | AID108345 |
| Metabotropic glutamate receptor 5 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.0005 | 0.1964 | 3.7600 | AID108345 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 10.0000 | 0.0000 | 0.7048 | 8.1930 | AID204092 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | Ki | 2.9600 | 0.0003 | 0.3806 | 10.0000 | AID6591 |
| Metabotropic glutamate receptor 7 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.1100 | 0.1100 | 0.1100 | AID108345 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 10.0000 | 0.0000 | 0.6020 | 10.0000 | AID63034 |
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | Ki | 10.0000 | 0.0000 | 0.7411 | 9.9000 | AID5996 |
| 5-hydroxytryptamine receptor 5A | Homo sapiens (human) | Ki | 10.0000 | 0.0008 | 0.9433 | 5.1600 | AID6482; AID6500 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 1.9300 | 0.0002 | 0.5229 | 10.0000 | AID6517 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.0002 | 0.5577 | 10.0000 | AID39935 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.0002 | 0.6403 | 10.0000 | AID39935 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.0002 | 0.5708 | 10.0000 | AID39935 |
| Metabotropic glutamate receptor 8 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1.9000 | 2.6500 | 3.4000 | AID108345 |
| Prostaglandin G/H synthase 2 | Mus musculus (house mouse) | IC50 (µMol) | 2.0000 | 0.0005 | 0.4008 | 6.2000 | AID1725120; AID1725121; AID1725122 |
| 5-hydroxytryptamine receptor 3D | Homo sapiens (human) | Ki | 10.0000 | 0.0010 | 0.8835 | 9.9000 | AID5996 |
| 5-hydroxytryptamine receptor 3C | Homo sapiens (human) | Ki | 10.0000 | 0.0010 | 0.8835 | 9.9000 | AID5996 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.0002 | 0.6561 | 10.0000 | AID39935 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 0.0002 | 0.6561 | 10.0000 | AID39935 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 4.1000 | 0.0001 | 0.8667 | 10.0000 | AID145367 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1725122 | Inhibition of mouse COX2 using 2-arachidonylglycerol as substrate preincubated for 3 mins followed by substrate addition and measured for 30 sec by LC/MS analysis | 2020 | ACS medicinal chemistry letters, Oct-08, Volume: 11, Issue:10 | Harmaline Analogs as Substrate-Selective Cyclooxygenase-2 Inhibitors. |
| AID1725120 | Inhibition of mouse COX2 using [1-14C]AA as substrate preincubated for 20 mins followed by substrate addition and measured for 30 sec by thin layer chromatography analysis | 2020 | ACS medicinal chemistry letters, Oct-08, Volume: 11, Issue:10 | Harmaline Analogs as Substrate-Selective Cyclooxygenase-2 Inhibitors. |
| AID333916 | Genotoxicity in CHO cells assessed as chromosomal aberrations at 10 ppm after 90 mins in dark | |||
| AID333915 | Genotoxicity in CHO cells assessed as chromosomal aberrations at 10 ppm after 60 mins in dark followed by 5 W/m'2 UV irradiation for 30 mins | |||
| AID1725119 | Inhibition of ovine COX1 using [1-14C]AA as substrate preincubated for 20 mins followed by substrate addition and measured for 30 sec by thin layer chromatography analysis | 2020 | ACS medicinal chemistry letters, Oct-08, Volume: 11, Issue:10 | Harmaline Analogs as Substrate-Selective Cyclooxygenase-2 Inhibitors. |
| AID6517 | Binding affinity towards human 5-hydroxytryptamine 6 receptor | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID204092 | Binding affinity towards Serotonin transporter | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID63034 | Binding affinity towards Dopamine receptor | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID142899 | Binding affinity towards Muscarinic acetylcholine receptor | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID333921 | Genotoxicity in CHO cells assessed as chromosomal aberrations at 1.25 ppm after 60 mins in dark followed by 5 W/m'2 UV irradiation for 30 mins | |||
| AID39935 | Binding affinity towards GABA-A benzodiazepine receptor | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID223228 | Binding affinity towards Imidazoline I1 receptor; ND=Not determined | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID333906 | Genotoxicity in CHO cells assessed as chromosomal aberrations at 2.5 ppm after 60 mins in dark followed by 5 W/m'2 UV irradiation for 30 mins | |||
| AID36401 | Binding affinity towards Alpha-2C adrenergic receptor; ND=Not determined | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID108345 | Binding affinity towards Glutamate (rPCP) receptor | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID333949 | Genotoxicity in CHO cells assessed as chromosomal aberrations at 0.07 ppm after 60 mins in dark followed by 5 W/m'2 UV irradiation for 30 mins | |||
| AID6591 | Binding affinity towards 5-hydroxytryptamine 7 receptor | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID145367 | Binding affinity towards NET | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID333923 | Genotoxicity in CHO cells assessed as mitotic inhibition at 0.31 ppm after 60 mins in dark followed by 5 W/m'2 UV irradiation for 30 mins | |||
| AID6500 | Binding affinity towards 5-hydroxytryptamine 5A receptor using lysergic acid diethylamide (LSD) as radioligand | 2003 | Journal of medicinal chemistry, Aug-28, Volume: 46, Issue:18 | Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors. |
| AID6482 | Binding affinity towards 5-HT5A receptor | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID333920 | Genotoxicity in CHO cells assessed as chromosomal aberrations at 0.15 ppm after 60 mins in dark followed by 5 W/m'2 UV irradiation for 30 mins | |||
| AID1725121 | Inhibition of mouse COX2 using arachidonic acid as substrate preincubated for 3 mins followed by substrate addition and measured for 30 sec by LC/MS analysis | 2020 | ACS medicinal chemistry letters, Oct-08, Volume: 11, Issue:10 | Harmaline Analogs as Substrate-Selective Cyclooxygenase-2 Inhibitors. |
| AID4247 | Binding affinity towards 5-hydroxytryptamine 1B receptor | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID36595 | Binding affinity towards Alpha-1A adrenergic receptor; ND=Not determined | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID35940 | Binding affinity towards Alpha-2A adrenergic receptor; ND=Not determined | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID5536 | Binding affinity towards 5-hydroxytryptamine 2A receptor | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID333918 | Genotoxicity in CHO cells assessed as mitotic inhibition at 0.62 ppm after 60 mins in dark followed by 5 W/m'2 UV irradiation for 30 mins | |||
| AID4616 | Binding affinity towards 5-hydroxytryptamine 1D receptor | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID36223 | Binding affinity towards Alpha-2B adrenergic receptor; ND=Not determined | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID333904 | Genotoxicity in CHO cells assessed as mitotic inhibition at 5 ppm after 60 mins in dark followed by 5 W/m'2 UV irradiation for 30 mins | |||
| AID64344 | Binding affinity towards DAT (bovine) | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID5996 | Binding affinity towards 5-HT3 receptor | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID41508 | Binding affinity towards Beta-2A adrenergic receptor; ND=Not determined | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID3824 | Binding affinity towards 5-hydroxytryptamine 1A receptor | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID40568 | Binding affinity towards Beta-1A adrenergic receptor; ND=Not determined | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID37208 | Binding affinity towards Alpha-1B adrenergic receptor; ND=Not determined | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID223243 | Binding affinity towards Imidazoline I2 receptor; ND=Not determined | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID5615 | Binding affinity towards 5-hydroxytryptamine 2C receptor | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24 | Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.49) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 13 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||