| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
beta-alanine
[no description available] | 2.91 | 4 | 0 | amino acid zwitterion;
beta-amino acid | agonist;
fundamental metabolite;
human metabolite;
inhibitor;
neurotransmitter |
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group. | 1.99 | 1 | 0 | aromatic ether;
nitrile;
polyether;
tertiary amino compound | |
tirofiban
Tirofiban: Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in the treatment of ACUTE CORONARY SYNDROME.. tirofiban : A member of the class of piperidines that is L-tyrosine in which a hydrogen attached to the amino group is replaced by a butylsulfonyl group and in which the hydrogen attached to the phenolic hydroxy group is replaced by a 4-(piperidin-4-yl)butyl group. | 3.5 | 2 | 0 | L-tyrosine derivative;
piperidines;
sulfonamide | anticoagulant;
fibrin modulating drug;
platelet glycoprotein-IIb/IIIa receptor antagonist |
xemilofiban
xemilofiban: SC-54684A was administered as the hydrochloride salt; inhibits platelet glycoprotein GPIIB IIIA receptor; structure given in first source | 3.1 | 1 | 0 | | |
fradafiban
fradafiban: structure given in first source. fradafiban : A pyrrolidinone that is pyrrolidin-2-one which is substituted at positions 3 and 5 by carboxymethyl and hydroxymethyl groups, respectively, and in which the hydrogen of the resulting alcoholic hydroxy group is replaced by a 4'-carbamimidoylbiphenyl-4-yl group (the S,S-diastereoisomer). A figrinogen receptor antagonist. | 3.1 | 1 | 0 | carboxamidine;
monocarboxylic acid;
pyrrolidin-2-ones | platelet glycoprotein-IIb/IIIa receptor antagonist |
lotrafiban
[no description available] | 3.1 | 1 | 0 | | |
arginyl-glycyl-aspartic acid
arginyl-glycyl-aspartic acid: amino acid sequence of basic unit of widespread cellular recognition system | 2 | 1 | 0 | oligopeptide | |
fk 633
((4-(4-amidinophenoxy)butanoyl)aspartyl)valine: structure given in first source | 3.1 | 1 | 0 | | |
l 738167
L 738167: structure in first source | 3.79 | 3 | 0 | | |
sk&f 107260
SK&F 107260: structure given in first source | 3.1 | 1 | 0 | | |
gr 144053
GR 144053: structure given in first source | 3.1 | 1 | 0 | piperazines | |
roxifiban
roxifiban: structure in first source | 3.1 | 1 | 0 | | |
xv 459
XV 459: structure in first source | 3.1 | 1 | 0 | | |
l 734217
L 734217: fibrinogen receptor antagonist; structure given in first source | 4.01 | 4 | 0 | | |
orbofiban
orbofiban: structure in first source | 3.1 | 1 | 0 | | |
elarofiban
elarofiban: a GPIIb and GPIIIa receptor antagonist; structure in first source | 3.1 | 1 | 0 | | |
quinidine
Quinidine: An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.. quinidine : A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy. | 1.99 | 1 | 0 | cinchona alkaloid | alpha-adrenergic antagonist;
anti-arrhythmia drug;
antimalarial;
drug allergen;
EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor;
EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
muscarinic antagonist;
P450 inhibitor;
potassium channel blocker;
sodium channel blocker |
eptifibatide
[no description available] | 3.1 | 1 | 0 | homodetic cyclic peptide;
macrocycle;
organic disulfide | anticoagulant;
platelet aggregation inhibitor |
lamifiban
lamifiban: a nonpeptide glycoprotein IIb/IIIa antagonist; prevents platelet loss during experimental cardiopulmonary bypass | 3.1 | 1 | 0 | N-acylglycine | |
tak 029
TAK 029: structure in first source | 3.1 | 1 | 0 | | |
piperidines
Piperidines: A family of hexahydropyridines. | 2 | 1 | 0 | | |