Page last updated: 2024-10-15
2-amino-6-hydroxy-8-mercaptopurine
Cross-References
ID Source | ID |
---|---|
PubMed CID | 135423614 |
CHEMBL ID | 178006 |
SCHEMBL ID | 94822 |
MeSH ID | M0511211 |
Synonyms (49)
Synonym |
---|
OPREA1_703445 |
B55 , |
2-amino-8-sulfanyl-1,9-dihydro-6h-purin-6-one |
nsc29188 |
nsc-29188 |
6324-72-7 |
NCGC00161968-01 |
SR-01000634975-1 |
HMS1667K04 |
bdbm50108009 |
2-amino-8-mercapto-1h-purin-6(9h)-one |
2-amino-8-mercapto-1,9-dihydro-purin-6-one |
FT-0661842 |
CHEMBL178006 , |
2-amino-1,7,8,9-tetrahydro-2-thioxo-6h-purin-6-one |
einecs 228-686-9 |
nsc 29188 |
2-amino-6-hydroxy-8-thiopurine |
28128-40-7 |
AKOS006229987 |
CCG-45192 |
2-amino-6-hydroxy-8-mercaptopurine |
FT-0611207 |
SCHEMBL94822 |
JHEKNTQSGTVPAO-UHFFFAOYSA-N |
8-mercaptoguanine |
2-amino-8-mercapto-7h-purin-6-ol |
AKOS024306764 |
W-203352 |
DTXSID50212631 |
mfcd00075623 |
AKOS027320780 |
2-amino-6-oxy-8-thiopurine |
bdbm50181897 |
2-amino-8-mercapto-1,9-dihydro-6h-purin-6-one |
6h-purin-6-one,2-amino-1,7,8,9-tetrahydro-8-thioxo- |
2-amino-8-thioxo-8,9-dihydro-1h-purin-6(7h)-one |
2-amino-8-thioxo-3,7,8,9-tetrahydro-6h-purin-6-one |
oxirane,2-[[2,2,2-trifluoro-1-(2,3,5,6-tetrafluorophenyl)-1-(trifluoromethyl)ethoxy]methyl]- |
2-amino-8-mercapto-1h-purin-6(7h)-one |
2-amino-8-mercapto-9h-purin-6-ol |
E78564 |
Q27458232 |
BS-51664 |
2-amino-8-sulfanyl-3,7-dihydropurin-6-one |
2-amino-8-sulfanylidene-7,9-dihydro-1h-purin-6-one |
EN300-2596716 |
2-amino-8-sulfanyl-7h-purin-6-ol |
Z1198147829 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Protein Targets (6)
Potency Measurements
Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 31.6228 | 0.6310 | 35.7641 | 100.0000 | AID504339 |
chromobox protein homolog 1 | Homo sapiens (human) | Potency | 14.1254 | 0.0060 | 26.1688 | 89.1251 | AID540317 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Inhibition Measurements
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Activation Measurements
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | Escherichia coli K-12 | Kd | 130.0000 | 7.5000 | 7.5000 | 7.5000 | AID1129829; AID1308277 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Biological Processes (4)
Process | via Protein(s) | Taxonomy |
---|---|---|
response to xenobiotic stimulus | Dihydropteroate synthase | Escherichia coli K-12 |
folic acid biosynthetic process | Dihydropteroate synthase | Escherichia coli K-12 |
folic acid-containing compound biosynthetic process | Dihydropteroate synthase | Escherichia coli K-12 |
tetrahydrofolate biosynthetic process | Dihydropteroate synthase | Escherichia coli K-12 |
folic acid biosynthetic process | Dihydropteroate synthase | Escherichia coli K-12 |
folic acid-containing compound biosynthetic process | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | Escherichia coli K-12 |
tetrahydrofolate biosynthetic process | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | Escherichia coli K-12 |
folic acid biosynthetic process | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | Escherichia coli K-12 |
[Information is prepared from geneontology information from the June-17-2024 release] |
Molecular Functions (7)
Process | via Protein(s) | Taxonomy |
---|---|---|
dihydropteroate synthase activity | Dihydropteroate synthase | Escherichia coli K-12 |
transferase activity | Dihydropteroate synthase | Escherichia coli K-12 |
metal ion binding | Dihydropteroate synthase | Escherichia coli K-12 |
magnesium ion binding | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | Escherichia coli K-12 |
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | Escherichia coli K-12 |
ATP binding | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | Escherichia coli K-12 |
kinase activity | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | Escherichia coli K-12 |
[Information is prepared from geneontology information from the June-17-2024 release] |
Ceullar Components (2)
Process | via Protein(s) | Taxonomy |
---|---|---|
cytoplasm | Dihydropteroate synthase | Escherichia coli K-12 |
cytosol | Dihydropteroate synthase | Escherichia coli K-12 |
cytosol | Dihydropteroate synthase | Escherichia coli K-12 |
[Information is prepared from geneontology information from the June-17-2024 release] |
Bioassays (16)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID1129829 | Binding affinity to GST-tagged Escherichia coli HPPK expressed in Escherichia coli by SPR assay based alternative equilibrium affinity method in presence of AMP-CPP | 2014 | Bioorganic & medicinal chemistry, Apr-01, Volume: 22, Issue:7 | The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. |
AID66419 | Inhibitory concentration against Enzymatic A chain of ricin (RTA) using Artemia salina ribosomes | 2002 | Journal of medicinal chemistry, Jan-03, Volume: 45, Issue:1 | Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition. |
AID1129827 | Inhibition of GST-tagged Escherichia coli HPPK expressed in Escherichia coli using 6-hydroxymethyl-7,8-dihydropterin hydrochloride as substrate at 250 uM after 20 mins by luminescence assay | 2014 | Bioorganic & medicinal chemistry, Apr-01, Volume: 22, Issue:7 | The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. |
AID1308277 | Binding affinity to biotinylated Escherichia coli HPPK expressed in Escherichia coli BL21 (DE3) in presence of 1 mM ATP by SPR assay | 2016 | Journal of medicinal chemistry, 06-09, Volume: 59, Issue:11 | Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli. |
AID444560 | Inhibition of Bacillus anthracis DHPS expressed in Escherichia coli BL21 (DE3) after 30 mins | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Structural studies of pterin-based inhibitors of dihydropteroate synthase. |
AID1170152 | Binding affinity to Escherichia coli DHPS by surface plasmon resonance analysis | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22 | Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus. |
AID444558 | Inhibition of Bacillus anthracis DHPS expressed in Escherichia coli BL21 (DE3) at 250 uM after 30 mins | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Structural studies of pterin-based inhibitors of dihydropteroate synthase. |
AID1170150 | Binding affinity to Staphylococcus aureus recombinant HPPK by surface plasmon resonance analysis in presence of ATP | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22 | Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus. |
AID1170149 | Binding affinity to Staphylococcus aureus HPPK by isothermal calorimetry | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22 | Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus. |
AID1170151 | Binding affinity to Staphylococcus aureus recombinant HPPK by surface plasmon resonance analysis | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22 | Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus. |
AID1170148 | Inhibition of Staphylococcus aureus HPPK after 20 mins by luciferase reporter gene assay | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22 | Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus. |
AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6 | A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | |||
AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (11)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (18.18) | 29.6817 |
2010's | 8 (72.73) | 24.3611 |
2020's | 1 (9.09) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 11 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |