| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
aspirin
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5). acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity. | 3.39 | 1 | 1 | benzoic acids;
phenyl acetates;
salicylates | anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent |
isoxazoles
Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent. | 5.89 | 13 | 2 | isoxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene | |
tirofiban
Tirofiban: Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in the treatment of ACUTE CORONARY SYNDROME.. tirofiban : A member of the class of piperidines that is L-tyrosine in which a hydrogen attached to the amino group is replaced by a butylsulfonyl group and in which the hydrogen attached to the phenolic hydroxy group is replaced by a 4-(piperidin-4-yl)butyl group. | 3.1 | 1 | 0 | L-tyrosine derivative;
piperidines;
sulfonamide | anticoagulant;
fibrin modulating drug;
platelet glycoprotein-IIb/IIIa receptor antagonist |
xemilofiban
xemilofiban: SC-54684A was administered as the hydrochloride salt; inhibits platelet glycoprotein GPIIB IIIA receptor; structure given in first source | 3.1 | 1 | 0 | | |
fradafiban
fradafiban: structure given in first source. fradafiban : A pyrrolidinone that is pyrrolidin-2-one which is substituted at positions 3 and 5 by carboxymethyl and hydroxymethyl groups, respectively, and in which the hydrogen of the resulting alcoholic hydroxy group is replaced by a 4'-carbamimidoylbiphenyl-4-yl group (the S,S-diastereoisomer). A figrinogen receptor antagonist. | 3.1 | 1 | 0 | carboxamidine;
monocarboxylic acid;
pyrrolidin-2-ones | platelet glycoprotein-IIb/IIIa receptor antagonist |
lotrafiban
[no description available] | 3.1 | 1 | 0 | | |
fibrinogen
Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.. D-iditol : The D-enantiomer of iditol. | 2.4 | 2 | 0 | iditol | fungal metabolite |
fk 633
((4-(4-amidinophenoxy)butanoyl)aspartyl)valine: structure given in first source | 3.1 | 1 | 0 | | |
l 738167
L 738167: structure in first source | 3.1 | 1 | 0 | | |
sk&f 107260
SK&F 107260: structure given in first source | 3.1 | 1 | 0 | | |
roxifiban acetate
roxifiban acetate: structure in first source | 2.69 | 3 | 0 | | |
gr 144053
GR 144053: structure given in first source | 3.1 | 1 | 0 | piperazines | |
roxifiban
roxifiban: structure in first source | 6.3 | 6 | 2 | | |
l 767679
L 767679: structure in first source | 3.1 | 1 | 0 | | |
l 734217
L 734217: fibrinogen receptor antagonist; structure given in first source | 3.1 | 1 | 0 | | |
orbofiban
orbofiban: structure in first source | 3.1 | 1 | 0 | | |
elarofiban
elarofiban: a GPIIb and GPIIIa receptor antagonist; structure in first source | 3.1 | 1 | 0 | | |
eptifibatide
[no description available] | 3.1 | 1 | 0 | homodetic cyclic peptide;
macrocycle;
organic disulfide | anticoagulant;
platelet aggregation inhibitor |
lamifiban
lamifiban: a nonpeptide glycoprotein IIb/IIIa antagonist; prevents platelet loss during experimental cardiopulmonary bypass | 3.1 | 1 | 0 | N-acylglycine | |
tak 029
TAK 029: structure in first source | 3.1 | 1 | 0 | | |
dmp 728
DMP 728: structure in first source; RN given refers to the monomethane sulfate | 1.99 | 1 | 0 | | |
cardiovascular agents
Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume. | 2 | 1 | 0 | | |