Page last updated: 2024-12-11

cyclic(arg-gly-asp-d-phe-val)

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID9851104
CHEMBL ID411941
MeSH IDM0243203

Synonyms (17)

Synonym
NCGC00167283-01
cyclorgdfv
CHEMBL411941 ,
cyclo(arg-gly-asp-d-phe-val)
c(rgdfv)
[(2s,5r,8s,11s)-5-benzyl-11-(3-guanidino-propyl)-8-isopropyl-3,6,9,12,15-pentaoxo-1,4,7,10,13pentaaza-cyclopentadec-2-yl]-acetic acid
[5-benzyl-11-(3-guanidino-propyl)-8-isopropyl-3,6,9,12,15-pentaoxo-1,4,7,10,13pentaaza-cyclopentadec-2-yl]-acetic acid(cyclo (rgdfv))
bdbm50237601
c-[-arg-gly-asp-fv-]
c[arg-gly-asp-(r)-phe-val]
cyclo(-arg-gly-asp-d-phe-val)
2-[(2s,5r,8s,11s)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid
cyclo(-arg-gly-asp-d-phe-val-)
cyclo-(arg-gly-asp-d-phe-val)
cyclo[arg-gly-asp-d-phe-val]
CS-0062737
HY-P1613

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" In tumor-targeting experiments against the IGROV-1/Pt1 human ovarian carcinoma xenotransplanted in nude mice, compound 11 exhibited a superior activity compared with paclitaxel, despite the lower (about half) molar dosage used."( Synthesis and biological evaluation (in vitro and in vivo) of cyclic arginine-glycine-aspartate (RGD) peptidomimetic-paclitaxel conjugates targeting integrin αVβ3.
Arosio, D; Belvisi, L; Carenini, N; Castiglioni, V; Colombo, R; De Cesare, M; Gennari, C; Mingozzi, M; Perego, P; Piarulli, U; Scanziani, E; Zaffaroni, N, 2012
)
0.38
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (8)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
DNA polymerase kappa isoform 1Homo sapiens (human)Potency23.77810.031622.3146100.0000AID588579
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Integrin beta-3Homo sapiens (human)IC50 (µMol)6.99070.00010.632310.0000AID1349625; AID1349626; AID1433902; AID1576813; AID1686185; AID1686193; AID1686208; AID217315; AID256968; AID261127; AID265947; AID276738; AID328215; AID443823; AID443824; AID589567; AID709960; AID91595; AID93130
Integrin beta-1Homo sapiens (human)IC50 (µMol)34.70000.00010.72528.0000AID1156786; AID443825
Integrin alpha-V Homo sapiens (human)IC50 (µMol)1.02330.00010.625610.0000AID1349625; AID1349626; AID1433902; AID1576813; AID1686193; AID1686197; AID1686199; AID1686208; AID1686209; AID1686210; AID217315; AID256968; AID256969; AID261127; AID261128; AID265947; AID276738; AID328215; AID328216; AID443823; AID443824; AID589567; AID709959; AID709960
Integrin alpha-IIbHomo sapiens (human)IC50 (µMol)37.66670.00010.730910.0000AID1686185; AID91595; AID93130
Integrin alpha-5Homo sapiens (human)IC50 (µMol)34.70000.00011.40828.0000AID1156786; AID443825
Integrin beta-5Homo sapiens (human)IC50 (µMol)0.00630.00010.33725.4000AID1686197; AID1686209; AID256969; AID261128; AID328216; AID709959
Integrin beta-6Homo sapiens (human)IC50 (µMol)2.34800.47003.955510.0000AID1686199; AID1686210
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (161)

Processvia Protein(s)Taxonomy
negative regulation of low-density lipoprotein receptor activityIntegrin beta-3Homo sapiens (human)
positive regulation of protein phosphorylationIntegrin beta-3Homo sapiens (human)
positive regulation of endothelial cell proliferationIntegrin beta-3Homo sapiens (human)
positive regulation of cell-matrix adhesionIntegrin beta-3Homo sapiens (human)
cell-substrate junction assemblyIntegrin beta-3Homo sapiens (human)
cell adhesionIntegrin beta-3Homo sapiens (human)
cell-matrix adhesionIntegrin beta-3Homo sapiens (human)
integrin-mediated signaling pathwayIntegrin beta-3Homo sapiens (human)
embryo implantationIntegrin beta-3Homo sapiens (human)
blood coagulationIntegrin beta-3Homo sapiens (human)
positive regulation of endothelial cell migrationIntegrin beta-3Homo sapiens (human)
positive regulation of gene expressionIntegrin beta-3Homo sapiens (human)
negative regulation of macrophage derived foam cell differentiationIntegrin beta-3Homo sapiens (human)
positive regulation of fibroblast migrationIntegrin beta-3Homo sapiens (human)
negative regulation of lipid storageIntegrin beta-3Homo sapiens (human)
response to activityIntegrin beta-3Homo sapiens (human)
smooth muscle cell migrationIntegrin beta-3Homo sapiens (human)
positive regulation of smooth muscle cell migrationIntegrin beta-3Homo sapiens (human)
platelet activationIntegrin beta-3Homo sapiens (human)
positive regulation of vascular endothelial growth factor receptor signaling pathwayIntegrin beta-3Homo sapiens (human)
cell-substrate adhesionIntegrin beta-3Homo sapiens (human)
activation of protein kinase activityIntegrin beta-3Homo sapiens (human)
negative regulation of lipid transportIntegrin beta-3Homo sapiens (human)
regulation of protein localizationIntegrin beta-3Homo sapiens (human)
regulation of actin cytoskeleton organizationIntegrin beta-3Homo sapiens (human)
cell adhesion mediated by integrinIntegrin beta-3Homo sapiens (human)
positive regulation of cell adhesion mediated by integrinIntegrin beta-3Homo sapiens (human)
positive regulation of osteoblast proliferationIntegrin beta-3Homo sapiens (human)
heterotypic cell-cell adhesionIntegrin beta-3Homo sapiens (human)
substrate adhesion-dependent cell spreadingIntegrin beta-3Homo sapiens (human)
tube developmentIntegrin beta-3Homo sapiens (human)
wound healing, spreading of epidermal cellsIntegrin beta-3Homo sapiens (human)
cellular response to platelet-derived growth factor stimulusIntegrin beta-3Homo sapiens (human)
apolipoprotein A-I-mediated signaling pathwayIntegrin beta-3Homo sapiens (human)
wound healingIntegrin beta-3Homo sapiens (human)
apoptotic cell clearanceIntegrin beta-3Homo sapiens (human)
regulation of bone resorptionIntegrin beta-3Homo sapiens (human)
positive regulation of angiogenesisIntegrin beta-3Homo sapiens (human)
positive regulation of bone resorptionIntegrin beta-3Homo sapiens (human)
symbiont entry into host cellIntegrin beta-3Homo sapiens (human)
platelet-derived growth factor receptor signaling pathwayIntegrin beta-3Homo sapiens (human)
positive regulation of fibroblast proliferationIntegrin beta-3Homo sapiens (human)
mesodermal cell differentiationIntegrin beta-3Homo sapiens (human)
positive regulation of smooth muscle cell proliferationIntegrin beta-3Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationIntegrin beta-3Homo sapiens (human)
negative regulation of lipoprotein metabolic processIntegrin beta-3Homo sapiens (human)
negative chemotaxisIntegrin beta-3Homo sapiens (human)
regulation of release of sequestered calcium ion into cytosolIntegrin beta-3Homo sapiens (human)
regulation of serotonin uptakeIntegrin beta-3Homo sapiens (human)
angiogenesis involved in wound healingIntegrin beta-3Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeIntegrin beta-3Homo sapiens (human)
platelet aggregationIntegrin beta-3Homo sapiens (human)
cellular response to mechanical stimulusIntegrin beta-3Homo sapiens (human)
cellular response to xenobiotic stimulusIntegrin beta-3Homo sapiens (human)
positive regulation of glomerular mesangial cell proliferationIntegrin beta-3Homo sapiens (human)
blood coagulation, fibrin clot formationIntegrin beta-3Homo sapiens (human)
maintenance of postsynaptic specialization structureIntegrin beta-3Homo sapiens (human)
regulation of postsynaptic neurotransmitter receptor internalizationIntegrin beta-3Homo sapiens (human)
regulation of postsynaptic neurotransmitter receptor diffusion trappingIntegrin beta-3Homo sapiens (human)
positive regulation of substrate adhesion-dependent cell spreadingIntegrin beta-3Homo sapiens (human)
positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathwayIntegrin beta-3Homo sapiens (human)
regulation of trophoblast cell migrationIntegrin beta-3Homo sapiens (human)
regulation of extracellular matrix organizationIntegrin beta-3Homo sapiens (human)
cellular response to insulin-like growth factor stimulusIntegrin beta-3Homo sapiens (human)
negative regulation of endothelial cell apoptotic processIntegrin beta-3Homo sapiens (human)
positive regulation of T cell migrationIntegrin beta-3Homo sapiens (human)
cell migrationIntegrin beta-3Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayIntegrin beta-1Homo sapiens (human)
stress fiber assemblyIntegrin beta-1Homo sapiens (human)
calcium-independent cell-matrix adhesionIntegrin beta-1Homo sapiens (human)
positive regulation of apoptotic processIntegrin beta-1Homo sapiens (human)
positive regulation of glutamate uptake involved in transmission of nerve impulseIntegrin beta-1Homo sapiens (human)
regulation of inward rectifier potassium channel activityIntegrin beta-1Homo sapiens (human)
regulation of spontaneous synaptic transmissionIntegrin beta-1Homo sapiens (human)
reactive gliosisIntegrin beta-1Homo sapiens (human)
G1/S transition of mitotic cell cycleIntegrin beta-1Homo sapiens (human)
establishment of mitotic spindle orientationIntegrin beta-1Homo sapiens (human)
in utero embryonic developmentIntegrin beta-1Homo sapiens (human)
cell migration involved in sprouting angiogenesisIntegrin beta-1Homo sapiens (human)
positive regulation of neuroblast proliferationIntegrin beta-1Homo sapiens (human)
phagocytosisIntegrin beta-1Homo sapiens (human)
cellular defense responseIntegrin beta-1Homo sapiens (human)
cell adhesionIntegrin beta-1Homo sapiens (human)
homophilic cell adhesion via plasma membrane adhesion moleculesIntegrin beta-1Homo sapiens (human)
leukocyte cell-cell adhesionIntegrin beta-1Homo sapiens (human)
cell-matrix adhesionIntegrin beta-1Homo sapiens (human)
integrin-mediated signaling pathwayIntegrin beta-1Homo sapiens (human)
neuroblast proliferationIntegrin beta-1Homo sapiens (human)
muscle organ developmentIntegrin beta-1Homo sapiens (human)
myoblast fusionIntegrin beta-1Homo sapiens (human)
germ cell migrationIntegrin beta-1Homo sapiens (human)
visual learningIntegrin beta-1Homo sapiens (human)
regulation of collagen catabolic processIntegrin beta-1Homo sapiens (human)
positive regulation of fibroblast migrationIntegrin beta-1Homo sapiens (human)
cell migrationIntegrin beta-1Homo sapiens (human)
formation of radial glial scaffoldsIntegrin beta-1Homo sapiens (human)
CD40 signaling pathwayIntegrin beta-1Homo sapiens (human)
cell projection organizationIntegrin beta-1Homo sapiens (human)
lamellipodium assemblyIntegrin beta-1Homo sapiens (human)
B cell differentiationIntegrin beta-1Homo sapiens (human)
extracellular matrix organizationIntegrin beta-1Homo sapiens (human)
positive regulation of cell migrationIntegrin beta-1Homo sapiens (human)
cell-substrate adhesionIntegrin beta-1Homo sapiens (human)
receptor internalizationIntegrin beta-1Homo sapiens (human)
cell adhesion mediated by integrinIntegrin beta-1Homo sapiens (human)
cell-cell adhesion mediated by integrinIntegrin beta-1Homo sapiens (human)
heterotypic cell-cell adhesionIntegrin beta-1Homo sapiens (human)
negative regulation of Rho protein signal transductionIntegrin beta-1Homo sapiens (human)
wound healing, spreading of epidermal cellsIntegrin beta-1Homo sapiens (human)
maintenance of blood-brain barrierIntegrin beta-1Homo sapiens (human)
positive regulation of GTPase activityIntegrin beta-1Homo sapiens (human)
sarcomere organizationIntegrin beta-1Homo sapiens (human)
myoblast differentiationIntegrin beta-1Homo sapiens (human)
negative regulation of neuron differentiationIntegrin beta-1Homo sapiens (human)
positive regulation of fibroblast growth factor receptor signaling pathwayIntegrin beta-1Homo sapiens (human)
positive regulation of angiogenesisIntegrin beta-1Homo sapiens (human)
negative regulation of vasoconstrictionIntegrin beta-1Homo sapiens (human)
symbiont entry into host cellIntegrin beta-1Homo sapiens (human)
mesodermal cell differentiationIntegrin beta-1Homo sapiens (human)
myoblast fate specificationIntegrin beta-1Homo sapiens (human)
axon extensionIntegrin beta-1Homo sapiens (human)
dendrite morphogenesisIntegrin beta-1Homo sapiens (human)
leukocyte tethering or rollingIntegrin beta-1Homo sapiens (human)
regulation of cell cycleIntegrin beta-1Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionIntegrin beta-1Homo sapiens (human)
cardiac muscle cell differentiationIntegrin beta-1Homo sapiens (human)
cardiac muscle cell myoblast differentiationIntegrin beta-1Homo sapiens (human)
cardiac cell fate specificationIntegrin beta-1Homo sapiens (human)
cellular response to low-density lipoprotein particle stimulusIntegrin beta-1Homo sapiens (human)
basement membrane organizationIntegrin beta-1Homo sapiens (human)
positive regulation of wound healingIntegrin beta-1Homo sapiens (human)
positive regulation of vascular endothelial growth factor signaling pathwayIntegrin beta-1Homo sapiens (human)
positive regulation of protein localization to plasma membraneIntegrin beta-1Homo sapiens (human)
regulation of synapse pruningIntegrin beta-1Homo sapiens (human)
negative regulation of anoikisIntegrin beta-1Homo sapiens (human)
cell-cell adhesionIntegrin beta-1Homo sapiens (human)
negative regulation of low-density lipoprotein receptor activityIntegrin alpha-V Homo sapiens (human)
angiogenesisIntegrin alpha-V Homo sapiens (human)
vasculogenesisIntegrin alpha-V Homo sapiens (human)
cell adhesionIntegrin alpha-V Homo sapiens (human)
cell-matrix adhesionIntegrin alpha-V Homo sapiens (human)
positive regulation of cytosolic calcium ion concentrationIntegrin alpha-V Homo sapiens (human)
integrin-mediated signaling pathwayIntegrin alpha-V Homo sapiens (human)
positive regulation of cell population proliferationIntegrin alpha-V Homo sapiens (human)
negative regulation of macrophage derived foam cell differentiationIntegrin alpha-V Homo sapiens (human)
negative regulation of lipid storageIntegrin alpha-V Homo sapiens (human)
cell migrationIntegrin alpha-V Homo sapiens (human)
positive regulation of cell migrationIntegrin alpha-V Homo sapiens (human)
cell-substrate adhesionIntegrin alpha-V Homo sapiens (human)
negative regulation of lipid transportIntegrin alpha-V Homo sapiens (human)
cell adhesion mediated by integrinIntegrin alpha-V Homo sapiens (human)
positive regulation of osteoblast proliferationIntegrin alpha-V Homo sapiens (human)
heterotypic cell-cell adhesionIntegrin alpha-V Homo sapiens (human)
substrate adhesion-dependent cell spreadingIntegrin alpha-V Homo sapiens (human)
wound healing, spreading of epidermal cellsIntegrin alpha-V Homo sapiens (human)
endodermal cell differentiationIntegrin alpha-V Homo sapiens (human)
apolipoprotein A-I-mediated signaling pathwayIntegrin alpha-V Homo sapiens (human)
apoptotic cell clearanceIntegrin alpha-V Homo sapiens (human)
positive regulation of cell adhesionIntegrin alpha-V Homo sapiens (human)
symbiont entry into host cellIntegrin alpha-V Homo sapiens (human)
negative regulation of lipoprotein metabolic processIntegrin alpha-V Homo sapiens (human)
regulation of phagocytosisIntegrin alpha-V Homo sapiens (human)
negative chemotaxisIntegrin alpha-V Homo sapiens (human)
positive regulation of small GTPase mediated signal transductionIntegrin alpha-V Homo sapiens (human)
ERK1 and ERK2 cascadeIntegrin alpha-V Homo sapiens (human)
calcium ion transmembrane transportIntegrin alpha-V Homo sapiens (human)
transforming growth factor beta productionIntegrin alpha-V Homo sapiens (human)
entry into host cell by a symbiont-containing vacuoleIntegrin alpha-V Homo sapiens (human)
extrinsic apoptotic signaling pathway in absence of ligandIntegrin alpha-V Homo sapiens (human)
positive regulation of intracellular signal transductionIntegrin alpha-V Homo sapiens (human)
negative regulation of entry of bacterium into host cellIntegrin alpha-V Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathwayIntegrin alpha-V Homo sapiens (human)
cell-cell adhesionIntegrin alpha-V Homo sapiens (human)
positive regulation of leukocyte migrationIntegrin alpha-IIbHomo sapiens (human)
cell-matrix adhesionIntegrin alpha-IIbHomo sapiens (human)
integrin-mediated signaling pathwayIntegrin alpha-IIbHomo sapiens (human)
angiogenesisIntegrin alpha-IIbHomo sapiens (human)
cell-cell adhesionIntegrin alpha-IIbHomo sapiens (human)
cell adhesion mediated by integrinIntegrin alpha-IIbHomo sapiens (human)
angiogenesisIntegrin alpha-5Homo sapiens (human)
cell-substrate junction assemblyIntegrin alpha-5Homo sapiens (human)
cell adhesionIntegrin alpha-5Homo sapiens (human)
heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesIntegrin alpha-5Homo sapiens (human)
leukocyte cell-cell adhesionIntegrin alpha-5Homo sapiens (human)
cell-matrix adhesionIntegrin alpha-5Homo sapiens (human)
integrin-mediated signaling pathwayIntegrin alpha-5Homo sapiens (human)
female pregnancyIntegrin alpha-5Homo sapiens (human)
memoryIntegrin alpha-5Homo sapiens (human)
positive regulation of cell-substrate adhesionIntegrin alpha-5Homo sapiens (human)
CD40 signaling pathwayIntegrin alpha-5Homo sapiens (human)
positive regulation of cell migrationIntegrin alpha-5Homo sapiens (human)
positive regulation of vascular endothelial growth factor receptor signaling pathwayIntegrin alpha-5Homo sapiens (human)
cell-substrate adhesionIntegrin alpha-5Homo sapiens (human)
cell adhesion mediated by integrinIntegrin alpha-5Homo sapiens (human)
cell-cell adhesion mediated by integrinIntegrin alpha-5Homo sapiens (human)
heterotypic cell-cell adhesionIntegrin alpha-5Homo sapiens (human)
wound healing, spreading of epidermal cellsIntegrin alpha-5Homo sapiens (human)
endodermal cell differentiationIntegrin alpha-5Homo sapiens (human)
symbiont entry into host cellIntegrin alpha-5Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationIntegrin alpha-5Homo sapiens (human)
positive regulation of sprouting angiogenesisIntegrin alpha-5Homo sapiens (human)
negative regulation of anoikisIntegrin alpha-5Homo sapiens (human)
cell-cell adhesionIntegrin alpha-5Homo sapiens (human)
cell-matrix adhesionIntegrin beta-5Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayIntegrin beta-5Homo sapiens (human)
integrin-mediated signaling pathwayIntegrin beta-5Homo sapiens (human)
cell migrationIntegrin beta-5Homo sapiens (human)
wound healing, spreading of epidermal cellsIntegrin beta-5Homo sapiens (human)
endodermal cell differentiationIntegrin beta-5Homo sapiens (human)
stress fiber assemblyIntegrin beta-5Homo sapiens (human)
symbiont entry into host cellIntegrin beta-5Homo sapiens (human)
epithelial cell-cell adhesionIntegrin beta-5Homo sapiens (human)
cell adhesion mediated by integrinIntegrin beta-5Homo sapiens (human)
cell-cell adhesionIntegrin beta-5Homo sapiens (human)
cell morphogenesisIntegrin beta-6Homo sapiens (human)
inflammatory responseIntegrin beta-6Homo sapiens (human)
immune responseIntegrin beta-6Homo sapiens (human)
cell adhesionIntegrin beta-6Homo sapiens (human)
cell-matrix adhesionIntegrin beta-6Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayIntegrin beta-6Homo sapiens (human)
integrin-mediated signaling pathwayIntegrin beta-6Homo sapiens (human)
response to virusIntegrin beta-6Homo sapiens (human)
cell adhesion mediated by integrinIntegrin beta-6Homo sapiens (human)
wound healingIntegrin beta-6Homo sapiens (human)
surfactant homeostasisIntegrin beta-6Homo sapiens (human)
skin developmentIntegrin beta-6Homo sapiens (human)
symbiont entry into host cellIntegrin beta-6Homo sapiens (human)
lung alveolus developmentIntegrin beta-6Homo sapiens (human)
phospholipid homeostasisIntegrin beta-6Homo sapiens (human)
hard palate developmentIntegrin beta-6Homo sapiens (human)
bone developmentIntegrin beta-6Homo sapiens (human)
bronchiole developmentIntegrin beta-6Homo sapiens (human)
Langerhans cell differentiationIntegrin beta-6Homo sapiens (human)
enamel mineralizationIntegrin beta-6Homo sapiens (human)
cellular response to ionizing radiationIntegrin beta-6Homo sapiens (human)
transforming growth factor beta productionIntegrin beta-6Homo sapiens (human)
cell migrationIntegrin beta-6Homo sapiens (human)
cell-cell adhesionIntegrin beta-6Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (37)

Processvia Protein(s)Taxonomy
fibroblast growth factor bindingIntegrin beta-3Homo sapiens (human)
C-X3-C chemokine bindingIntegrin beta-3Homo sapiens (human)
insulin-like growth factor I bindingIntegrin beta-3Homo sapiens (human)
neuregulin bindingIntegrin beta-3Homo sapiens (human)
virus receptor activityIntegrin beta-3Homo sapiens (human)
fibronectin bindingIntegrin beta-3Homo sapiens (human)
protease bindingIntegrin beta-3Homo sapiens (human)
protein disulfide isomerase activityIntegrin beta-3Homo sapiens (human)
protein kinase C bindingIntegrin beta-3Homo sapiens (human)
platelet-derived growth factor receptor bindingIntegrin beta-3Homo sapiens (human)
integrin bindingIntegrin beta-3Homo sapiens (human)
protein bindingIntegrin beta-3Homo sapiens (human)
coreceptor activityIntegrin beta-3Homo sapiens (human)
enzyme bindingIntegrin beta-3Homo sapiens (human)
identical protein bindingIntegrin beta-3Homo sapiens (human)
vascular endothelial growth factor receptor 2 bindingIntegrin beta-3Homo sapiens (human)
metal ion bindingIntegrin beta-3Homo sapiens (human)
cell adhesion molecule bindingIntegrin beta-3Homo sapiens (human)
extracellular matrix bindingIntegrin beta-3Homo sapiens (human)
fibrinogen bindingIntegrin beta-3Homo sapiens (human)
C-X3-C chemokine bindingIntegrin beta-1Homo sapiens (human)
magnesium ion bindingIntegrin beta-1Homo sapiens (human)
virus receptor activityIntegrin beta-1Homo sapiens (human)
fibronectin bindingIntegrin beta-1Homo sapiens (human)
protease bindingIntegrin beta-1Homo sapiens (human)
actin bindingIntegrin beta-1Homo sapiens (human)
integrin bindingIntegrin beta-1Homo sapiens (human)
calcium ion bindingIntegrin beta-1Homo sapiens (human)
protein bindingIntegrin beta-1Homo sapiens (human)
coreceptor activityIntegrin beta-1Homo sapiens (human)
protein-containing complex bindingIntegrin beta-1Homo sapiens (human)
cadherin bindingIntegrin beta-1Homo sapiens (human)
protein heterodimerization activityIntegrin beta-1Homo sapiens (human)
cell adhesion molecule bindingIntegrin beta-1Homo sapiens (human)
collagen binding involved in cell-matrix adhesionIntegrin beta-1Homo sapiens (human)
integrin binding involved in cell-matrix adhesionIntegrin beta-1Homo sapiens (human)
protein tyrosine kinase bindingIntegrin beta-1Homo sapiens (human)
protein kinase bindingIntegrin beta-1Homo sapiens (human)
laminin bindingIntegrin beta-1Homo sapiens (human)
opsonin bindingIntegrin alpha-V Homo sapiens (human)
protein kinase C bindingIntegrin alpha-V Homo sapiens (human)
fibroblast growth factor bindingIntegrin alpha-V Homo sapiens (human)
C-X3-C chemokine bindingIntegrin alpha-V Homo sapiens (human)
insulin-like growth factor I bindingIntegrin alpha-V Homo sapiens (human)
neuregulin bindingIntegrin alpha-V Homo sapiens (human)
virus receptor activityIntegrin alpha-V Homo sapiens (human)
fibronectin bindingIntegrin alpha-V Homo sapiens (human)
protease bindingIntegrin alpha-V Homo sapiens (human)
integrin bindingIntegrin alpha-V Homo sapiens (human)
voltage-gated calcium channel activityIntegrin alpha-V Homo sapiens (human)
protein bindingIntegrin alpha-V Homo sapiens (human)
coreceptor activityIntegrin alpha-V Homo sapiens (human)
metal ion bindingIntegrin alpha-V Homo sapiens (human)
transforming growth factor beta bindingIntegrin alpha-V Homo sapiens (human)
extracellular matrix bindingIntegrin alpha-V Homo sapiens (human)
extracellular matrix protein bindingIntegrin alpha-V Homo sapiens (human)
protein bindingIntegrin alpha-IIbHomo sapiens (human)
identical protein bindingIntegrin alpha-IIbHomo sapiens (human)
metal ion bindingIntegrin alpha-IIbHomo sapiens (human)
extracellular matrix bindingIntegrin alpha-IIbHomo sapiens (human)
molecular adaptor activityIntegrin alpha-IIbHomo sapiens (human)
fibrinogen bindingIntegrin alpha-IIbHomo sapiens (human)
integrin bindingIntegrin alpha-IIbHomo sapiens (human)
virus receptor activityIntegrin alpha-5Homo sapiens (human)
epidermal growth factor receptor bindingIntegrin alpha-5Homo sapiens (human)
platelet-derived growth factor receptor bindingIntegrin alpha-5Homo sapiens (human)
calcium ion bindingIntegrin alpha-5Homo sapiens (human)
protein bindingIntegrin alpha-5Homo sapiens (human)
vascular endothelial growth factor receptor 2 bindingIntegrin alpha-5Homo sapiens (human)
integrin bindingIntegrin alpha-5Homo sapiens (human)
virus receptor activityIntegrin beta-5Homo sapiens (human)
protein bindingIntegrin beta-5Homo sapiens (human)
metal ion bindingIntegrin beta-5Homo sapiens (human)
integrin bindingIntegrin beta-5Homo sapiens (human)
virus receptor activityIntegrin beta-6Homo sapiens (human)
protein bindingIntegrin beta-6Homo sapiens (human)
metal ion bindingIntegrin beta-6Homo sapiens (human)
integrin bindingIntegrin beta-6Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (72)

Processvia Protein(s)Taxonomy
glutamatergic synapseIntegrin beta-3Homo sapiens (human)
nucleusIntegrin beta-3Homo sapiens (human)
nucleoplasmIntegrin beta-3Homo sapiens (human)
plasma membraneIntegrin beta-3Homo sapiens (human)
cell-cell junctionIntegrin beta-3Homo sapiens (human)
focal adhesionIntegrin beta-3Homo sapiens (human)
external side of plasma membraneIntegrin beta-3Homo sapiens (human)
cell surfaceIntegrin beta-3Homo sapiens (human)
apical plasma membraneIntegrin beta-3Homo sapiens (human)
platelet alpha granule membraneIntegrin beta-3Homo sapiens (human)
lamellipodium membraneIntegrin beta-3Homo sapiens (human)
filopodium membraneIntegrin beta-3Homo sapiens (human)
microvillus membraneIntegrin beta-3Homo sapiens (human)
ruffle membraneIntegrin beta-3Homo sapiens (human)
integrin alphav-beta3 complexIntegrin beta-3Homo sapiens (human)
melanosomeIntegrin beta-3Homo sapiens (human)
synapseIntegrin beta-3Homo sapiens (human)
postsynaptic membraneIntegrin beta-3Homo sapiens (human)
extracellular exosomeIntegrin beta-3Homo sapiens (human)
integrin alphaIIb-beta3 complexIntegrin beta-3Homo sapiens (human)
glycinergic synapseIntegrin beta-3Homo sapiens (human)
integrin complexIntegrin beta-3Homo sapiens (human)
protein-containing complexIntegrin beta-3Homo sapiens (human)
alphav-beta3 integrin-PKCalpha complexIntegrin beta-3Homo sapiens (human)
alphav-beta3 integrin-IGF-1-IGF1R complexIntegrin beta-3Homo sapiens (human)
alphav-beta3 integrin-HMGB1 complexIntegrin beta-3Homo sapiens (human)
receptor complexIntegrin beta-3Homo sapiens (human)
alphav-beta3 integrin-vitronectin complexIntegrin beta-3Homo sapiens (human)
alpha9-beta1 integrin-ADAM8 complexIntegrin beta-3Homo sapiens (human)
focal adhesionIntegrin beta-3Homo sapiens (human)
cell surfaceIntegrin beta-3Homo sapiens (human)
synapseIntegrin beta-3Homo sapiens (human)
focal adhesionIntegrin beta-1Homo sapiens (human)
ruffle membraneIntegrin beta-1Homo sapiens (human)
ruffleIntegrin beta-1Homo sapiens (human)
cytoplasmIntegrin beta-1Homo sapiens (human)
plasma membraneIntegrin beta-1Homo sapiens (human)
focal adhesionIntegrin beta-1Homo sapiens (human)
external side of plasma membraneIntegrin beta-1Homo sapiens (human)
cell surfaceIntegrin beta-1Homo sapiens (human)
endosome membraneIntegrin beta-1Homo sapiens (human)
intercalated discIntegrin beta-1Homo sapiens (human)
membraneIntegrin beta-1Homo sapiens (human)
lamellipodiumIntegrin beta-1Homo sapiens (human)
filopodiumIntegrin beta-1Homo sapiens (human)
neuromuscular junctionIntegrin beta-1Homo sapiens (human)
cleavage furrowIntegrin beta-1Homo sapiens (human)
ruffle membraneIntegrin beta-1Homo sapiens (human)
integrin alpha1-beta1 complexIntegrin beta-1Homo sapiens (human)
integrin alpha2-beta1 complexIntegrin beta-1Homo sapiens (human)
integrin alpha4-beta1 complexIntegrin beta-1Homo sapiens (human)
integrin alpha5-beta1 complexIntegrin beta-1Homo sapiens (human)
integrin alpha6-beta1 complexIntegrin beta-1Homo sapiens (human)
integrin alpha9-beta1 complexIntegrin beta-1Homo sapiens (human)
integrin alpha10-beta1 complexIntegrin beta-1Homo sapiens (human)
integrin alphav-beta1 complexIntegrin beta-1Homo sapiens (human)
myelin sheath abaxonal regionIntegrin beta-1Homo sapiens (human)
sarcolemmaIntegrin beta-1Homo sapiens (human)
melanosomeIntegrin beta-1Homo sapiens (human)
dendritic spineIntegrin beta-1Homo sapiens (human)
membrane raftIntegrin beta-1Homo sapiens (human)
perinuclear region of cytoplasmIntegrin beta-1Homo sapiens (human)
recycling endosomeIntegrin beta-1Homo sapiens (human)
extracellular exosomeIntegrin beta-1Homo sapiens (human)
synaptic membraneIntegrin beta-1Homo sapiens (human)
glial cell projectionIntegrin beta-1Homo sapiens (human)
Schaffer collateral - CA1 synapseIntegrin beta-1Homo sapiens (human)
cerebellar climbing fiber to Purkinje cell synapseIntegrin beta-1Homo sapiens (human)
integrin alpha3-beta1 complexIntegrin beta-1Homo sapiens (human)
integrin alpha7-beta1 complexIntegrin beta-1Homo sapiens (human)
integrin alpha8-beta1 complexIntegrin beta-1Homo sapiens (human)
integrin alpha11-beta1 complexIntegrin beta-1Homo sapiens (human)
receptor complexIntegrin beta-1Homo sapiens (human)
focal adhesionIntegrin beta-1Homo sapiens (human)
synapseIntegrin beta-1Homo sapiens (human)
integrin complexIntegrin beta-1Homo sapiens (human)
cell surfaceIntegrin beta-1Homo sapiens (human)
cytosolIntegrin alpha-V Homo sapiens (human)
plasma membraneIntegrin alpha-V Homo sapiens (human)
focal adhesionIntegrin alpha-V Homo sapiens (human)
cell surfaceIntegrin alpha-V Homo sapiens (human)
membraneIntegrin alpha-V Homo sapiens (human)
lamellipodium membraneIntegrin alpha-V Homo sapiens (human)
filopodium membraneIntegrin alpha-V Homo sapiens (human)
microvillus membraneIntegrin alpha-V Homo sapiens (human)
ruffle membraneIntegrin alpha-V Homo sapiens (human)
integrin alphav-beta1 complexIntegrin alpha-V Homo sapiens (human)
integrin alphav-beta3 complexIntegrin alpha-V Homo sapiens (human)
integrin alphav-beta5 complexIntegrin alpha-V Homo sapiens (human)
integrin alphav-beta6 complexIntegrin alpha-V Homo sapiens (human)
integrin alphav-beta8 complexIntegrin alpha-V Homo sapiens (human)
specific granule membraneIntegrin alpha-V Homo sapiens (human)
phagocytic vesicleIntegrin alpha-V Homo sapiens (human)
extracellular exosomeIntegrin alpha-V Homo sapiens (human)
integrin complexIntegrin alpha-V Homo sapiens (human)
alphav-beta3 integrin-PKCalpha complexIntegrin alpha-V Homo sapiens (human)
alphav-beta3 integrin-IGF-1-IGF1R complexIntegrin alpha-V Homo sapiens (human)
alphav-beta3 integrin-HMGB1 complexIntegrin alpha-V Homo sapiens (human)
external side of plasma membraneIntegrin alpha-V Homo sapiens (human)
plasma membraneIntegrin alpha-IIbHomo sapiens (human)
focal adhesionIntegrin alpha-IIbHomo sapiens (human)
cell surfaceIntegrin alpha-IIbHomo sapiens (human)
platelet alpha granule membraneIntegrin alpha-IIbHomo sapiens (human)
extracellular exosomeIntegrin alpha-IIbHomo sapiens (human)
integrin alphaIIb-beta3 complexIntegrin alpha-IIbHomo sapiens (human)
blood microparticleIntegrin alpha-IIbHomo sapiens (human)
integrin complexIntegrin alpha-IIbHomo sapiens (human)
external side of plasma membraneIntegrin alpha-IIbHomo sapiens (human)
cell-cell junctionIntegrin alpha-5Homo sapiens (human)
focal adhesionIntegrin alpha-5Homo sapiens (human)
ruffle membraneIntegrin alpha-5Homo sapiens (human)
ruffleIntegrin alpha-5Homo sapiens (human)
endoplasmic reticulumIntegrin alpha-5Homo sapiens (human)
Golgi apparatusIntegrin alpha-5Homo sapiens (human)
plasma membraneIntegrin alpha-5Homo sapiens (human)
focal adhesionIntegrin alpha-5Homo sapiens (human)
cell surfaceIntegrin alpha-5Homo sapiens (human)
cytoplasmic vesicleIntegrin alpha-5Homo sapiens (human)
integrin alpha5-beta1 complexIntegrin alpha-5Homo sapiens (human)
postsynaptic membraneIntegrin alpha-5Homo sapiens (human)
glutamatergic synapseIntegrin alpha-5Homo sapiens (human)
alphav-beta3 integrin-vitronectin complexIntegrin alpha-5Homo sapiens (human)
external side of plasma membraneIntegrin alpha-5Homo sapiens (human)
integrin complexIntegrin alpha-5Homo sapiens (human)
plasma membraneIntegrin beta-5Homo sapiens (human)
focal adhesionIntegrin beta-5Homo sapiens (human)
cell surfaceIntegrin beta-5Homo sapiens (human)
integrin alphav-beta5 complexIntegrin beta-5Homo sapiens (human)
phagocytic vesicleIntegrin beta-5Homo sapiens (human)
extracellular exosomeIntegrin beta-5Homo sapiens (human)
receptor complexIntegrin beta-5Homo sapiens (human)
focal adhesionIntegrin beta-5Homo sapiens (human)
integrin complexIntegrin beta-5Homo sapiens (human)
cell surfaceIntegrin beta-5Homo sapiens (human)
nucleoplasmIntegrin beta-6Homo sapiens (human)
centrosomeIntegrin beta-6Homo sapiens (human)
plasma membraneIntegrin beta-6Homo sapiens (human)
focal adhesionIntegrin beta-6Homo sapiens (human)
external side of plasma membraneIntegrin beta-6Homo sapiens (human)
cell junctionIntegrin beta-6Homo sapiens (human)
integrin alphav-beta6 complexIntegrin beta-6Homo sapiens (human)
integrin complexIntegrin beta-6Homo sapiens (human)
receptor complexIntegrin beta-6Homo sapiens (human)
focal adhesionIntegrin beta-6Homo sapiens (human)
cell surfaceIntegrin beta-6Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (133)

Assay IDTitleYearJournalArticle
AID265288Toxicity in po dosed Beagle dog2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID443824Inhibition of alphavbeta3 integrin-mediated cell adhesion in HUVEC on vitronectin coated plate after 30 mins2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Antiangiogenic effect of dual/selective alpha(5)beta(1)/alpha(v)beta(3) integrin antagonists designed on partially modified retro-inverso cyclotetrapeptide mimetics.
AID709958Selectivity ratio of IC50 for integrin alphaVbeta5 receptor to IC50 for integrin alphaVbeta3 receptor2012Journal of medicinal chemistry, Dec-13, Volume: 55, Issue:23
Synthesis and biological evaluation (in vitro and in vivo) of cyclic arginine-glycine-aspartate (RGD) peptidomimetic-paclitaxel conjugates targeting integrin αVβ3.
AID265273Binding affinity to opioid receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265246Inhibition of human recombinant cytochrome P450 2C192006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265947Inhibition of adhesion of K562 cells expressing alphaVbeta3 integrin receptor to vitronectin2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
Novel and selective alpha(v)beta3 receptor peptide antagonist: design, synthesis, and biological behavior.
AID265286Decrease in basal rectal temperature in stress-induced hyperthermic 129S6/SvEvTac mouse at 20 mg/kg, po2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265280Binding affinity to potassium channel by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265231Inhibition of hERG potassium channel in HEK293 cells by patch clamp assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265236Binding affinity to bovine 5HT1D receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265281Binding affinity to chloride channel by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID1686204Antagonist activity at alpha2bbeta3 in human HEL cells assessed as reduction in cell adhesion to fibrinogen pre-incubated for 30 mins before fibrinogen and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogenic2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID265234Binding affinity to 5HT1A receptor in rat cerebral cortex by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265221Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID1576814Inhibition of human vitronectin binding to human integrin alphavbeta3 receptor after 1 hr by ELISA2019Journal of medicinal chemistry, 08-22, Volume: 62, Issue:16
Cyclization of RGD Peptides by Suzuki-Miyaura Cross-Coupling.
AID265274Binding affinity to somatostatin receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265267Binding affinity to chemokine receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID589567Displacement of [125I]echistatin from human integrin alpha5beta3 expressed in human A549 cells by binding assay2011Bioorganic & medicinal chemistry letters, Apr-01, Volume: 21, Issue:7
Exploring new near-infrared fluorescent disulfide-based cyclic RGD peptide analogs for potential integrin-targeted optical imaging.
AID265279Binding affinity to sodium channel by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID91596Dissociation constant for human integrin alphaIIb-beta32001Journal of medicinal chemistry, Sep-13, Volume: 44, Issue:19
Determination of the binding specificity of an integral membrane protein by saturation transfer difference NMR: RGD peptide ligands binding to integrin alphaIIbbeta3.
AID1686187Toxicity in human SK-MEL-24 cells assessed as induction of cell necrosis and/or apoptosis incubated for 3 hrs by annexin V-PE and 7-AAD staining based by flow cytometry2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID217315Inhibition of alphaV-beta3 interaction with vitronectin1996Journal of medicinal chemistry, Oct-25, Volume: 39, Issue:22
Synthesis and solution conformation of cyclo[RGDRGD]: a cyclic peptide with selectivity for the alpha V beta 3 receptor.
AID265270Binding affinity to neurokinin receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID276738Inhibition of integrin alphavbeta3 mediated cell adhesion of human M21 cells to vitronectin2006Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22
Discovery of small molecule inhibitors of integrin alphavbeta3 through structure-based virtual screening.
AID1686197Antagonist activity at alphaVbeta5 in human MCF7 cells assessed as reduction in cell adhesion to fibrinogen pre-incubated for 30 mins before fibrinogen and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogenic2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID709959Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta5 receptor after 3 hrs by microplate reader analysis2012Journal of medicinal chemistry, Dec-13, Volume: 55, Issue:23
Synthesis and biological evaluation (in vitro and in vivo) of cyclic arginine-glycine-aspartate (RGD) peptidomimetic-paclitaxel conjugates targeting integrin αVβ3.
AID265269Binding affinity to muscarinic receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265226Displacement of [3H]RX 821002 from Adrenergic alpha-2a receptor in rat cerebral cortex cells at 1 uM2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID1686206Agonist activity at alphaLbeta2 in human Jurkat E6.1 cells assessed as increase in cell adhesion to ICAM1 pre-incubated for 30 mins before ICAM1 and further incubated for 30 mins by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogenic ass2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID265263Binding affinity to endothelin receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265245Inhibition of human recombinant cytochrome P450 2C92006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265222Half life in Sprague-Dawley rat at 3 mg/kg, po2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265219Elimination half life in human2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265266Binding affinity to cholecystokinin receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265257Binding affinity to beta adrenergic receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID1686211Inhibition of fibronectin binding to alpha4bbeta1 isolated from human Jurkat E6.1 cells incubated for 1 hr by scintillation-proximity assay based competitive solid-phase binding assay2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID265254Ratio of drug level in brain against serum in Sprague-Dawley rat at 3 mg/kg, po or 1 mg/kg, iv after 1 hr2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID1686209Inhibition of fibrinogen binding to alphaVbeta5 isolated form human mCf7 cells incubated for 1 hr by scintillation-proximity assay based competitive solid-phase binding assay2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID1686188Toxicity in human MCF7 cells assessed as induction of cell necrosis and/or apoptosis incubated for 3 hrs by annexin V-PE and 7-AAD staining based by flow cytometry2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID265251Half life in Beagle dog at 3 mg/kg, po2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID328215Displacement of [125I]echistatin from human placental integrin alphaVbeta3 receptor2008Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
Synthesis, SAR and in vitro evaluation of new cyclic Arg-Gly-Asp pseudopentapeptides containing a s-cis peptide bond as integrin alphavbeta3 and alphavbeta5 ligands.
AID265262Binding affinity to bradykinin receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID1686190Toxicity in human K562 cells assessed as induction of cell necrosis and/or apoptosis incubated for 3 hrs by annexin V-PE and 7-AAD staining based by flow cytometry2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID265249Displacement of [3H]prazosin from Adrenergic alpha-1 receptor in rat cerebral cortex cells at 10 uM2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265252Oral bioavailability in Beagle dog at 3 mg/kg, po and 1 mg/kg, iv2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265278Binding affinity to neuropeptide receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID1686207Antagonist activity at alphaLbeta2 in human Jurkat E6.1 cells assessed as reduction in cell adhesion to ICAM1 pre-incubated for 30 mins before ICAM1 and further incubated for 30 mins by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogenic2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID1686208Inhibition of fibronectin binding to human recombinant alphaVbeta3 expressed in HEK293 cells incubated for 1 hr by scintillation-proximity assay based competitive solid-phase binding assay2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID1686193Antagonist activity at alphaVbeta3 in human SK-MEL-24 cells assessed as reduction in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chro2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID265214Displacement of [3H]8-OH-DPAT from human 5HT1A receptor in HEK293 cells2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265290Transient increase in prolactin level in human serum at greater than 30 mg2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID1433902Displacement of biotinylated vitronectin from human integrin alphaVbeta3 measured after 3 hrs by solid-phase receptor binding assay2017Journal of medicinal chemistry, 01-12, Volume: 60, Issue:1
Synthesis of Novel c(AmpRGD)-Sunitinib Dual Conjugates as Molecular Tools Targeting the α
AID265228Binding affinity to 5HT2A receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265225Displacement of [3H]RX 821002 from Adrenergic alpha-2a receptor in rat cerebral cortex cells2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID1355340Allosteric activation of integrin alphaVbeta3 receptor in human MSR3 cell membranes assessed as increase in anti-beta3 LIBS integrin antibody AP5 binding at 500 uM incubated for 90 mins by flow cytometry2018Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
Succinimide-Based Conjugates Improve IsoDGR Cyclopeptide Affinity to α
AID265239Binding affinity to human 5HT4e receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265248Inhibition of human recombinant cytochrome P450 3A42006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID443823Inhibition of alphavbeta3 integrin-mediated cell adhesion in human SK-MEL-24 cells on fibronectin coated plate after 30 mins2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Antiangiogenic effect of dual/selective alpha(5)beta(1)/alpha(v)beta(3) integrin antagonists designed on partially modified retro-inverso cyclotetrapeptide mimetics.
AID265287Toxicity in po dosed Sprague-Dawley rat2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265224Displacement of [3H]prazosin from Adrenergic alpha-1 receptor in rat cerebral cortex cells at 1 uM2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID1686210Inhibition of fibronectin binding to alphaVbeta6 isolated form human HT-29 cells incubated for 1 hr by scintillation-proximity assay based competitive solid-phase binding assay2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID265259Binding affinity to histamine receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID392384Inhibition of VEGF-induced HUVEC proliferation after 48 hrs2009Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2
Synthesis and initial evaluation of novel, non-peptidic antagonists of the alpha(v)-integrins alpha(v)beta(3) and alpha(v)beta(5).
AID265215Displacement of [3H]prazosin from adrenergic alpha-1 receptor in rat cerebral cortex cells2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265255Protein binding in human serum at 10 uM2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID443825Inhibition of alpha5beta1 integrin-mediated cell adhesion in human K562 cells on fibronectin coated plate after 30 mins2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Antiangiogenic effect of dual/selective alpha(5)beta(1)/alpha(v)beta(3) integrin antagonists designed on partially modified retro-inverso cyclotetrapeptide mimetics.
AID265260Binding affinity to angiotensin2 receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID1576813Binding affinity to integrin alphavbeta3 receptor in human WM115 cells assessed as inhibition of cell adhesion to vitronectin after 0.5 hr by fluorescence assay2019Journal of medicinal chemistry, 08-22, Volume: 62, Issue:16
Cyclization of RGD Peptides by Suzuki-Miyaura Cross-Coupling.
AID265265Binding affinity to galanin receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265272Binding affinity to orphanin receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265284Binding affinity to guinea pig sigma receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265285Decrease in stress-induced hyperthermia in 129S6/SvEvTac mouse at 20 mg/kg, po2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265241Binding affinity to human 5HT6 receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265227Binding affinity to 5HT7 receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID1686205Antagonist activity at alpha4beta1 in human Jurkat E6.1 cells assessed as reduction in cell adhesion to VCAM1 pre-incubated for 30 mins before VCAM1 and further incubated for 30 mins by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogenic2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID1686189Toxicity in human HT-29 cells assessed as induction of cell necrosis and/or apoptosis incubated for 3 hrs by annexin V-PE and 7-AAD staining based by flow cytometry2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID265242Half life in human liver S9 fraction at 5 uM2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID709960Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta3 receptor after 3 hrs by microplate reader analysis2012Journal of medicinal chemistry, Dec-13, Volume: 55, Issue:23
Synthesis and biological evaluation (in vitro and in vivo) of cyclic arginine-glycine-aspartate (RGD) peptidomimetic-paclitaxel conjugates targeting integrin αVβ3.
AID1686200Agonist activity at alpha5beta1 in human K562 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogenic a2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID265283Binding affinity to dopamine transporter by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265247Inhibition of human recombinant cytochrome P450 2D62006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265276Binding affinity to vasoactive intestinal peptide receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265218Selectivity for D2 receptor over 5HT1A receptor2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265250Cmax in Sprague-Dawley rat at 3 mg/kg, po2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265264Binding affinity to GABA receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265237Binding affinity to human 5HT2C receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265277Binding affinity to vasopressin receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID1686185Inhibition of fibrinogen binding to alpha2bbeta3 isolated from human HEL cells incubated for 1 hr by scintillation-proximity assay based competitive solid-phase binding assay2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID265240Binding affinity to human 5HT5A receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID93130Inhibition of human platelet aggregation mediated by alpha llb/beta3 interaction with fibrinogen1996Journal of medicinal chemistry, Oct-25, Volume: 39, Issue:22
Synthesis and solution conformation of cyclo[RGDRGD]: a cyclic peptide with selectivity for the alpha V beta 3 receptor.
AID265216Selectivity for adrenergic alpha-1 receptor over 5HT1A receptor2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265261Binding affinity to benzodiazepine receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265223Oral bioavailability in Sprague-Dawley rat at 3 mg/kg, po and 1 mg/kg, iv2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID1686203Agonist activity at alpha2bbeta3 in human HEL cells assessed as increase in cell adhesion to fibrinogen pre-incubated for 30 mins before fibrinogen and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogenic ass2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID277076Inhibition of human alpha-v-beta-3 integrin receptor by ELISA2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Natural inhibitors targeting osteoclast-mediated bone resorption.
AID1686186Inhibition of fibronectin binding to alpha5beta1 isolated from human K562 cells incubated for 1 hr by scintillation-proximity assay based competitive solid-phase binding assay2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID1349626Inhibition of vitronectin binding to human integrin alphaVbeta3 measured after 4 hrs by ELISA2018ACS medicinal chemistry letters, Jan-11, Volume: 9, Issue:1
Synthesis of a Chloroalkene Dipeptide Isostere-Containing Peptidomimetic and Its Biological Application.
AID265233Inhibition of hERG potassium channel in HEK293 cells by patch clamp assay at 1 uM2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265253Cmax in Beagle dog at 3 mg/kg, po2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID1156786Antagonist activity at alpha5beta1 integrin in human K562 cells assessed as inhibition of fibronectin-mediated cell adhesion after 30 mins by fluorescence assay2014European journal of medicinal chemistry, Aug-18, Volume: 83Targeting integrins αvβ3 and α5β1 with new β-lactam derivatives.
AID328216Displacement of [125I]Echistatin from human placental integrin alpha-V-beta-5 receptor2008Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
Synthesis, SAR and in vitro evaluation of new cyclic Arg-Gly-Asp pseudopentapeptides containing a s-cis peptide bond as integrin alphavbeta3 and alphavbeta5 ligands.
AID265275Binding affinity to sigma receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265289Terminal half life in human2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265229Binding affinity to 5HT2B receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID1576815Inhibition of human fibronectin binding to human integrin alpha5beta1 incubated for 1 hr by ELISA2019Journal of medicinal chemistry, 08-22, Volume: 62, Issue:16
Cyclization of RGD Peptides by Suzuki-Miyaura Cross-Coupling.
AID1686201Antagonist activity at alpha5beta1 in human K562 cells assessed as reduction in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogen2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID726201Binding affinity to integrin in human WM-115 cells after 30 mins by immobilized vitronectin-based competitive cell adhesion assay2013Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
Conjugates of modified cryptophycins and RGD-peptides enter target cells by endocytosis.
AID261127Displacement of [125I]echistatin from AlphaV-beta-3 integrin receptor2006Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5
Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study of their conformational and biological behavior.
AID265282Binding affinity to norepinephrine transporter by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265238Binding affinity to mouse 5HT3 receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID1349625Inhibition of vitronectin binding to integrin alphaVbeta3 in HDF pretreated for 20 mins followed by vitronectin addition measured after 40 mins by crystal violet staining based assay2018ACS medicinal chemistry letters, Jan-11, Volume: 9, Issue:1
Synthesis of a Chloroalkene Dipeptide Isostere-Containing Peptidomimetic and Its Biological Application.
AID265271Binding affinity to neurotensin receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID91595Inhibition of integrin alphaIIb-beta3 binding2001Journal of medicinal chemistry, Sep-13, Volume: 44, Issue:19
Determination of the binding specificity of an integral membrane protein by saturation transfer difference NMR: RGD peptide ligands binding to integrin alphaIIbbeta3.
AID392386Apparent permeability across human Caco-2 cells2009Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2
Synthesis and initial evaluation of novel, non-peptidic antagonists of the alpha(v)-integrins alpha(v)beta(3) and alpha(v)beta(5).
AID1576816Inhibition of human fibronectin binding to human Integrin alpha2b beta3 receptor incubated for 1 hr by ELISA2019Journal of medicinal chemistry, 08-22, Volume: 62, Issue:16
Cyclization of RGD Peptides by Suzuki-Miyaura Cross-Coupling.
AID256968Displacement of [125I]-echistatin from alphavbeta3 integrin receptor2005Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders.
AID265230Binding affinity to 5HT transporter by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID256969Displacement of [125I]-echistatin from alpha-v-beta-5 integrin receptor2005Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders.
AID1686191Toxicity in human HEL cells assessed as induction of cell necrosis and/or apoptosis incubated for 3 hrs by annexin V-PE and 7-AAD staining based by flow cytometry2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID392385Inhibition of HUVEC migration after 4 hrs2009Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2
Synthesis and initial evaluation of novel, non-peptidic antagonists of the alpha(v)-integrins alpha(v)beta(3) and alpha(v)beta(5).
AID265220Activity against 5HT1A receptor relative to 5-HT by Gi-[35S]GTP-gamma-S binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID392383Inhibition of FGF-induced HUVEC proliferation after 48 hrs2009Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2
Synthesis and initial evaluation of novel, non-peptidic antagonists of the alpha(v)-integrins alpha(v)beta(3) and alpha(v)beta(5).
AID261128Displacement of [125I]echistatin from AlphaV-beta-5 integrin receptor2006Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5
Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study of their conformational and biological behavior.
AID1686202Agonist activity at alpha4beta1 in human Jurkat E6.1 cells assessed as increase in cell adhesion to VCAM1 pre-incubated for 30 mins before VCAM1 and further incubated for 30 mins by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogenic ass2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID1686199Antagonist activity at alphaVbeta6 in human HT-29 cells assessed as reduction in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromoge2016Journal of medicinal chemistry, 11-10, Volume: 59, Issue:21
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
AID265232Half life in human liver microsome at 5 uM2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265243Protein binding in human serum at 2 uM2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265217Binding affinity to D2 receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265244Inhibition of human recombinant cytochrome P450 1A22006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265256Binding affinity to adrenergic alpha receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265258Binding affinity to dopamine receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265235Binding affinity to 5HT1B receptor in rat cerebral cortex by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
AID265268Binding affinity to melanocortin receptor by radioligand binding assay2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (20)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (5.00)18.2507
2000's9 (45.00)29.6817
2010's10 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.38 (24.57)
Research Supply Index3.04 (2.92)
Research Growth Index5.42 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.38)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other20 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]