6-(3,5-difluoroanilino)-9-ethyl-2-purinecarbonitrile profile

ID Source	ID
PubMed CID	44143088
CHEMBL ID	567341
CHEBI ID	92430

Synonym
6-[(3,5-difluorophenyl)amino]-9-ethyl-9h-purine-2-carbonitrile
NCGC00181918-01
NCGC00181918-02
ml092
smr001395197
MLS002471782
CHEMBL567341 ,
bdbm50303420
6-(3,5-difluorophenylamino)-9-ethyl-9h-purine-2-carbonitrile
HMS2203P24
HMS3332L09
CHEBI:92430
1199523-24-4
mmv676881
Q27164166
6-(3,5-difluoroanilino)-9-ethyl-2-purinecarbonitrile
cruzain-in-1
CS-0002855
HY-10836
BS-14613
BCP29960
ml092;ml 092;ml-092
ml092 cruzain-in-1
cruzain-in-1ml092
cruzain-in-1;ml-092
D80998
S0722
6-(3,5-difluoroanilino)-9-ethylpurine-2-carbonitrile
sr-01000860687
SR-01000860687-2
AKOS037515628
ZXB52324
EN300-7501911
DTXSID201347893
Z2941522289
6-((3,5-difluorophenyl)amino)-9-ethyl-9h-purine-2-carbonitrile

Class	Description
6-aminopurines	Any compound having 6-aminopurine (adenine) as part of its structure.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (21)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, PAPAIN	Carica papaya (papaya)	Potency	0.3000	0.3000	12.5348	31.6228	AID2161
Chain A, Cruzipain	Trypanosoma cruzi	Potency	0.0100	0.0020	14.6779	39.8107	AID2158
ATAD5 protein, partial	Homo sapiens (human)	Potency	11.5774	0.0041	10.8903	31.5287	AID504467
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	18.3564	0.0041	9.9848	25.9290	AID504444
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	Homo sapiens (human)	Potency	35.4813	3.5481	19.5427	44.6684	AID743266
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Cathepsin L2	Homo sapiens (human)	IC50 (µMol)	0.2399	0.0750	2.2141	10.0000	AID444709
Papain	Carica papaya (papaya)	IC50 (µMol)	0.0447	0.0020	1.5045	10.0000	AID444710
Procathepsin L	Homo sapiens (human)	IC50 (µMol)	0.1175	0.0002	1.6661	9.5100	AID444707
Cathepsin B	Homo sapiens (human)	IC50 (µMol)	10.7152	0.0002	1.8453	10.0000	AID444703
Pro-cathepsin H	Homo sapiens (human)	IC50 (µMol)	0.1259	0.1259	2.7404	10.0000	AID444705
Cathepsin S	Homo sapiens (human)	IC50 (µMol)	0.0159	0.0002	1.3191	10.0000	AID444708
Cruzipain	Trypanosoma cruzi	IC50 (µMol)	0.0051	0.0002	2.0450	8.0000	AID444616; AID444617
Cathepsin K	Homo sapiens (human)	IC50 (µMol)	0.0234	0.0001	0.8482	10.0000	AID444706
Caspase-4	Homo sapiens (human)	IC50 (µMol)	33.1131	0.3000	2.2641	8.8000	AID444694
Matrix metalloproteinase-14	Homo sapiens (human)	IC50 (µMol)	72.4436	0.0003	0.7182	10.0000	AID444727
Dipeptidyl peptidase 1	Homo sapiens (human)	IC50 (µMol)	0.0347	0.0347	3.1515	10.0000	AID444704
Beta-secretase 1	Homo sapiens (human)	IC50 (µMol)	63.0957	0.0006	1.6194	10.0000	AID444686
Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)	IC50 (µMol)	74.1310	0.0002	1.0140	10.0000	AID444728
Cathepsin Z	Homo sapiens (human)	IC50 (µMol)	0.9333	0.3162	3.7498	10.0000	AID444711
Kallikrein-4	Homo sapiens (human)	IC50 (µMol)	14.4544	9.7724	9.8862	10.0000	AID444745
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (156)

Process	via Protein(s)	Taxonomy
apoptotic process	Cathepsin L2	Homo sapiens (human)
antigen processing and presentation of exogenous peptide antigen via MHC class II	Cathepsin L2	Homo sapiens (human)
extracellular matrix disassembly	Cathepsin L2	Homo sapiens (human)
immune response	Cathepsin L2	Homo sapiens (human)
positive regulation of apoptotic signaling pathway	Cathepsin L2	Homo sapiens (human)
positive regulation of peptidase activity	Cathepsin L2	Homo sapiens (human)
proteolysis involved in protein catabolic process	Cathepsin L2	Homo sapiens (human)
adaptive immune response	Procathepsin L	Homo sapiens (human)
proteolysis	Procathepsin L	Homo sapiens (human)
protein autoprocessing	Procathepsin L	Homo sapiens (human)
fusion of virus membrane with host plasma membrane	Procathepsin L	Homo sapiens (human)
receptor-mediated endocytosis of virus by host cell	Procathepsin L	Homo sapiens (human)
antigen processing and presentation	Procathepsin L	Homo sapiens (human)
antigen processing and presentation of exogenous peptide antigen via MHC class II	Procathepsin L	Homo sapiens (human)
collagen catabolic process	Procathepsin L	Homo sapiens (human)
zymogen activation	Procathepsin L	Homo sapiens (human)
enkephalin processing	Procathepsin L	Homo sapiens (human)
fusion of virus membrane with host endosome membrane	Procathepsin L	Homo sapiens (human)
CD4-positive, alpha-beta T cell lineage commitment	Procathepsin L	Homo sapiens (human)
symbiont entry into host cell	Procathepsin L	Homo sapiens (human)
antigen processing and presentation of peptide antigen	Procathepsin L	Homo sapiens (human)
proteolysis involved in protein catabolic process	Procathepsin L	Homo sapiens (human)
elastin catabolic process	Procathepsin L	Homo sapiens (human)
macrophage apoptotic process	Procathepsin L	Homo sapiens (human)
cellular response to thyroid hormone stimulus	Procathepsin L	Homo sapiens (human)
positive regulation of apoptotic signaling pathway	Procathepsin L	Homo sapiens (human)
positive regulation of peptidase activity	Procathepsin L	Homo sapiens (human)
immune response	Procathepsin L	Homo sapiens (human)
proteolysis	Cathepsin B	Homo sapiens (human)
thyroid hormone generation	Cathepsin B	Homo sapiens (human)
collagen catabolic process	Cathepsin B	Homo sapiens (human)
epithelial cell differentiation	Cathepsin B	Homo sapiens (human)
regulation of apoptotic process	Cathepsin B	Homo sapiens (human)
decidualization	Cathepsin B	Homo sapiens (human)
symbiont entry into host cell	Cathepsin B	Homo sapiens (human)
proteolysis involved in protein catabolic process	Cathepsin B	Homo sapiens (human)
cellular response to thyroid hormone stimulus	Cathepsin B	Homo sapiens (human)
metanephros development	Pro-cathepsin H	Homo sapiens (human)
T cell mediated cytotoxicity	Pro-cathepsin H	Homo sapiens (human)
adaptive immune response	Pro-cathepsin H	Homo sapiens (human)
immune response-regulating signaling pathway	Pro-cathepsin H	Homo sapiens (human)
proteolysis	Pro-cathepsin H	Homo sapiens (human)
apoptotic process	Pro-cathepsin H	Homo sapiens (human)
positive regulation of cell population proliferation	Pro-cathepsin H	Homo sapiens (human)
positive regulation of gene expression	Pro-cathepsin H	Homo sapiens (human)
positive regulation of epithelial cell migration	Pro-cathepsin H	Homo sapiens (human)
neuropeptide catabolic process	Pro-cathepsin H	Homo sapiens (human)
bradykinin catabolic process	Pro-cathepsin H	Homo sapiens (human)
positive regulation of peptidase activity	Pro-cathepsin H	Homo sapiens (human)
antigen processing and presentation	Pro-cathepsin H	Homo sapiens (human)
positive regulation of cell migration	Pro-cathepsin H	Homo sapiens (human)
zymogen activation	Pro-cathepsin H	Homo sapiens (human)
protein destabilization	Pro-cathepsin H	Homo sapiens (human)
response to retinoic acid	Pro-cathepsin H	Homo sapiens (human)
membrane protein proteolysis	Pro-cathepsin H	Homo sapiens (human)
negative regulation of apoptotic process	Pro-cathepsin H	Homo sapiens (human)
surfactant homeostasis	Pro-cathepsin H	Homo sapiens (human)
positive regulation of angiogenesis	Pro-cathepsin H	Homo sapiens (human)
dichotomous subdivision of terminal units involved in lung branching	Pro-cathepsin H	Homo sapiens (human)
ERK1 and ERK2 cascade	Pro-cathepsin H	Homo sapiens (human)
cellular response to thyroid hormone stimulus	Pro-cathepsin H	Homo sapiens (human)
positive regulation of apoptotic signaling pathway	Pro-cathepsin H	Homo sapiens (human)
proteolysis involved in protein catabolic process	Pro-cathepsin H	Homo sapiens (human)
immune response	Pro-cathepsin H	Homo sapiens (human)
toll-like receptor signaling pathway	Cathepsin S	Homo sapiens (human)
adaptive immune response	Cathepsin S	Homo sapiens (human)
proteolysis	Cathepsin S	Homo sapiens (human)
apoptotic process	Cathepsin S	Homo sapiens (human)
response to acidic pH	Cathepsin S	Homo sapiens (human)
protein processing	Cathepsin S	Homo sapiens (human)
antigen processing and presentation	Cathepsin S	Homo sapiens (human)
antigen processing and presentation of exogenous peptide antigen via MHC class II	Cathepsin S	Homo sapiens (human)
extracellular matrix disassembly	Cathepsin S	Homo sapiens (human)
collagen catabolic process	Cathepsin S	Homo sapiens (human)
basement membrane disassembly	Cathepsin S	Homo sapiens (human)
antigen processing and presentation of peptide antigen	Cathepsin S	Homo sapiens (human)
proteolysis involved in protein catabolic process	Cathepsin S	Homo sapiens (human)
cellular response to thyroid hormone stimulus	Cathepsin S	Homo sapiens (human)
positive regulation of cation channel activity	Cathepsin S	Homo sapiens (human)
positive regulation of peptidase activity	Cathepsin S	Homo sapiens (human)
immune response	Cathepsin S	Homo sapiens (human)
positive regulation of apoptotic signaling pathway	Cathepsin S	Homo sapiens (human)
collagen catabolic process	Cathepsin K	Homo sapiens (human)
mitophagy	Cathepsin K	Homo sapiens (human)
intramembranous ossification	Cathepsin K	Homo sapiens (human)
proteolysis	Cathepsin K	Homo sapiens (human)
thyroid hormone generation	Cathepsin K	Homo sapiens (human)
apoptotic process	Cathepsin K	Homo sapiens (human)
response to organic cyclic compound	Cathepsin K	Homo sapiens (human)
extracellular matrix disassembly	Cathepsin K	Homo sapiens (human)
collagen catabolic process	Cathepsin K	Homo sapiens (human)
response to insulin	Cathepsin K	Homo sapiens (human)
cellular response to zinc ion starvation	Cathepsin K	Homo sapiens (human)
bone resorption	Cathepsin K	Homo sapiens (human)
response to ethanol	Cathepsin K	Homo sapiens (human)
proteolysis involved in protein catabolic process	Cathepsin K	Homo sapiens (human)
negative regulation of cartilage development	Cathepsin K	Homo sapiens (human)
cellular response to tumor necrosis factor	Cathepsin K	Homo sapiens (human)
cellular response to transforming growth factor beta stimulus	Cathepsin K	Homo sapiens (human)
mononuclear cell differentiation	Cathepsin K	Homo sapiens (human)
positive regulation of apoptotic signaling pathway	Cathepsin K	Homo sapiens (human)
positive regulation of peptidase activity	Cathepsin K	Homo sapiens (human)
immune response	Cathepsin K	Homo sapiens (human)
proteolysis	Caspase-4	Homo sapiens (human)
inflammatory response	Caspase-4	Homo sapiens (human)
protein autoprocessing	Caspase-4	Homo sapiens (human)
defense response to bacterium	Caspase-4	Homo sapiens (human)
innate immune response	Caspase-4	Homo sapiens (human)
regulation of inflammatory response	Caspase-4	Homo sapiens (human)
positive regulation of inflammatory response	Caspase-4	Homo sapiens (human)
defense response to Gram-positive bacterium	Caspase-4	Homo sapiens (human)
protein maturation	Caspase-4	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Caspase-4	Homo sapiens (human)
pyroptosis	Caspase-4	Homo sapiens (human)
intrinsic apoptotic signaling pathway	Caspase-4	Homo sapiens (human)
non-canonical inflammasome complex assembly	Caspase-4	Homo sapiens (human)
positive regulation of tumor necrosis factor-mediated signaling pathway	Caspase-4	Homo sapiens (human)
cellular response to amyloid-beta	Caspase-4	Homo sapiens (human)
positive regulation of interleukin-18-mediated signaling pathway	Caspase-4	Homo sapiens (human)
apoptotic process	Caspase-4	Homo sapiens (human)
positive regulation of neuron apoptotic process	Caspase-4	Homo sapiens (human)
angiogenesis	Matrix metalloproteinase-14	Homo sapiens (human)
ovarian follicle development	Matrix metalloproteinase-14	Homo sapiens (human)
response to hypoxia	Matrix metalloproteinase-14	Homo sapiens (human)
endothelial cell proliferation	Matrix metalloproteinase-14	Homo sapiens (human)
endochondral ossification	Matrix metalloproteinase-14	Homo sapiens (human)
proteolysis	Matrix metalloproteinase-14	Homo sapiens (human)
response to oxidative stress	Matrix metalloproteinase-14	Homo sapiens (human)
male gonad development	Matrix metalloproteinase-14	Homo sapiens (human)
response to mechanical stimulus	Matrix metalloproteinase-14	Homo sapiens (human)
positive regulation of myotube differentiation	Matrix metalloproteinase-14	Homo sapiens (human)
positive regulation of protein processing	Matrix metalloproteinase-14	Homo sapiens (human)
response to organic cyclic compound	Matrix metalloproteinase-14	Homo sapiens (human)
protein processing	Matrix metalloproteinase-14	Homo sapiens (human)
extracellular matrix disassembly	Matrix metalloproteinase-14	Homo sapiens (human)
protein catabolic process	Matrix metalloproteinase-14	Homo sapiens (human)
positive regulation of cell growth	Matrix metalloproteinase-14	Homo sapiens (human)
lung development	Matrix metalloproteinase-14	Homo sapiens (human)
positive regulation of cell migration	Matrix metalloproteinase-14	Homo sapiens (human)
collagen catabolic process	Matrix metalloproteinase-14	Homo sapiens (human)
zymogen activation	Matrix metalloproteinase-14	Homo sapiens (human)
endodermal cell differentiation	Matrix metalloproteinase-14	Homo sapiens (human)
chondrocyte proliferation	Matrix metalloproteinase-14	Homo sapiens (human)
astrocyte cell migration	Matrix metalloproteinase-14	Homo sapiens (human)
response to estrogen	Matrix metalloproteinase-14	Homo sapiens (human)
positive regulation of B cell differentiation	Matrix metalloproteinase-14	Homo sapiens (human)
negative regulation of Notch signaling pathway	Matrix metalloproteinase-14	Homo sapiens (human)
embryonic cranial skeleton morphogenesis	Matrix metalloproteinase-14	Homo sapiens (human)
branching morphogenesis of an epithelial tube	Matrix metalloproteinase-14	Homo sapiens (human)
tissue remodeling	Matrix metalloproteinase-14	Homo sapiens (human)
cell motility	Matrix metalloproteinase-14	Homo sapiens (human)
negative regulation of focal adhesion assembly	Matrix metalloproteinase-14	Homo sapiens (human)
head development	Matrix metalloproteinase-14	Homo sapiens (human)
craniofacial suture morphogenesis	Matrix metalloproteinase-14	Homo sapiens (human)
negative regulation of GDF15-GFRAL signaling pathway	Matrix metalloproteinase-14	Homo sapiens (human)
regulation of protein localization to plasma membrane	Matrix metalloproteinase-14	Homo sapiens (human)
positive regulation of macrophage migration	Matrix metalloproteinase-14	Homo sapiens (human)
response to odorant	Matrix metalloproteinase-14	Homo sapiens (human)
extracellular matrix organization	Matrix metalloproteinase-14	Homo sapiens (human)
skeletal system development	Matrix metalloproteinase-14	Homo sapiens (human)
T cell mediated cytotoxicity	Dipeptidyl peptidase 1	Homo sapiens (human)
proteolysis	Dipeptidyl peptidase 1	Homo sapiens (human)
apoptotic process	Dipeptidyl peptidase 1	Homo sapiens (human)
immune response	Dipeptidyl peptidase 1	Homo sapiens (human)
response to organic substance	Dipeptidyl peptidase 1	Homo sapiens (human)
negative regulation of myelination	Dipeptidyl peptidase 1	Homo sapiens (human)
positive regulation of proteolysis involved in protein catabolic process	Dipeptidyl peptidase 1	Homo sapiens (human)
positive regulation of microglial cell activation	Dipeptidyl peptidase 1	Homo sapiens (human)
positive regulation of apoptotic signaling pathway	Dipeptidyl peptidase 1	Homo sapiens (human)
proteolysis involved in protein catabolic process	Dipeptidyl peptidase 1	Homo sapiens (human)
proteolysis	Beta-secretase 1	Homo sapiens (human)
membrane protein ectodomain proteolysis	Beta-secretase 1	Homo sapiens (human)
response to lead ion	Beta-secretase 1	Homo sapiens (human)
protein processing	Beta-secretase 1	Homo sapiens (human)
amyloid-beta formation	Beta-secretase 1	Homo sapiens (human)
amyloid precursor protein catabolic process	Beta-secretase 1	Homo sapiens (human)
positive regulation of neuron apoptotic process	Beta-secretase 1	Homo sapiens (human)
amyloid-beta metabolic process	Beta-secretase 1	Homo sapiens (human)
detection of mechanical stimulus involved in sensory perception of pain	Beta-secretase 1	Homo sapiens (human)
prepulse inhibition	Beta-secretase 1	Homo sapiens (human)
cellular response to copper ion	Beta-secretase 1	Homo sapiens (human)
cellular response to manganese ion	Beta-secretase 1	Homo sapiens (human)
presynaptic modulation of chemical synaptic transmission	Beta-secretase 1	Homo sapiens (human)
signaling receptor ligand precursor processing	Beta-secretase 1	Homo sapiens (human)
cellular response to amyloid-beta	Beta-secretase 1	Homo sapiens (human)
amyloid fibril formation	Beta-secretase 1	Homo sapiens (human)
positive regulation of epidermal growth factor receptor signaling pathway	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
response to hypoxia	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
neutrophil mediated immunity	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
germinal center formation	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
positive regulation of leukocyte chemotaxis	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
proteolysis	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
membrane protein ectodomain proteolysis	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
cell adhesion	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
Notch receptor processing	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
positive regulation of cell population proliferation	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
response to xenobiotic stimulus	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
positive regulation of T cell chemotaxis	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
protein processing	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
signal release	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
B cell differentiation	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
positive regulation of cell growth	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
positive regulation of cell migration	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathway	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
response to lipopolysaccharide	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
positive regulation of chemokine production	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
positive regulation of tumor necrosis factor production	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
regulation of mast cell apoptotic process	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
T cell differentiation in thymus	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
cell adhesion mediated by integrin	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
wound healing, spreading of epidermal cells	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
amyloid precursor protein catabolic process	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
positive regulation of blood vessel endothelial cell migration	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
positive regulation of cyclin-dependent protein serine/threonine kinase activity	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
positive regulation of epidermal growth factor-activated receptor activity	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
positive regulation of epidermal growth factor receptor signaling pathway	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
spleen development	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
cell motility	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
defense response to Gram-positive bacterium	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
cellular response to high density lipoprotein particle stimulus	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
commissural neuron axon guidance	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
negative regulation of cold-induced thermogenesis	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
positive regulation of G1/S transition of mitotic cell cycle	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
positive regulation of tumor necrosis factor-mediated signaling pathway	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
positive regulation of vascular endothelial cell proliferation	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
Notch signaling pathway	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
angiotensin maturation	Cathepsin Z	Homo sapiens (human)
proteolysis	Cathepsin Z	Homo sapiens (human)
negative regulation of plasminogen activation	Cathepsin Z	Homo sapiens (human)
epithelial tube branching involved in lung morphogenesis	Cathepsin Z	Homo sapiens (human)
proteolysis involved in protein catabolic process	Cathepsin Z	Homo sapiens (human)
proteolysis	Kallikrein-4	Homo sapiens (human)
biomineral tissue development	Kallikrein-4	Homo sapiens (human)
amelogenesis	Kallikrein-4	Homo sapiens (human)
extracellular matrix disassembly	Kallikrein-4	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (46)

Process	via Protein(s)	Taxonomy
cysteine-type endopeptidase activity	Cathepsin L2	Homo sapiens (human)
serine-type endopeptidase activity	Cathepsin L2	Homo sapiens (human)
protein binding	Cathepsin L2	Homo sapiens (human)
cysteine-type peptidase activity	Cathepsin L2	Homo sapiens (human)
cysteine-type endopeptidase activator activity involved in apoptotic process	Cathepsin L2	Homo sapiens (human)
fibronectin binding	Procathepsin L	Homo sapiens (human)
cysteine-type endopeptidase activity	Procathepsin L	Homo sapiens (human)
protein binding	Procathepsin L	Homo sapiens (human)
collagen binding	Procathepsin L	Homo sapiens (human)
cysteine-type peptidase activity	Procathepsin L	Homo sapiens (human)
histone binding	Procathepsin L	Homo sapiens (human)
proteoglycan binding	Procathepsin L	Homo sapiens (human)
serpin family protein binding	Procathepsin L	Homo sapiens (human)
cysteine-type endopeptidase activator activity involved in apoptotic process	Procathepsin L	Homo sapiens (human)
cysteine-type endopeptidase activity	Cathepsin B	Homo sapiens (human)
protein binding	Cathepsin B	Homo sapiens (human)
collagen binding	Cathepsin B	Homo sapiens (human)
peptidase activity	Cathepsin B	Homo sapiens (human)
cysteine-type peptidase activity	Cathepsin B	Homo sapiens (human)
proteoglycan binding	Cathepsin B	Homo sapiens (human)
endopeptidase activity	Pro-cathepsin H	Homo sapiens (human)
aminopeptidase activity	Pro-cathepsin H	Homo sapiens (human)
cysteine-type endopeptidase activity	Pro-cathepsin H	Homo sapiens (human)
serine-type endopeptidase activity	Pro-cathepsin H	Homo sapiens (human)
protein binding	Pro-cathepsin H	Homo sapiens (human)
peptidase activity	Pro-cathepsin H	Homo sapiens (human)
cysteine-type peptidase activity	Pro-cathepsin H	Homo sapiens (human)
cysteine-type endopeptidase activator activity involved in apoptotic process	Pro-cathepsin H	Homo sapiens (human)
HLA-A specific activating MHC class I receptor activity	Pro-cathepsin H	Homo sapiens (human)
thyroid hormone binding	Pro-cathepsin H	Homo sapiens (human)
fibronectin binding	Cathepsin S	Homo sapiens (human)
cysteine-type endopeptidase activity	Cathepsin S	Homo sapiens (human)
serine-type endopeptidase activity	Cathepsin S	Homo sapiens (human)
collagen binding	Cathepsin S	Homo sapiens (human)
laminin binding	Cathepsin S	Homo sapiens (human)
proteoglycan binding	Cathepsin S	Homo sapiens (human)
cysteine-type endopeptidase activator activity involved in apoptotic process	Cathepsin S	Homo sapiens (human)
fibronectin binding	Cathepsin K	Homo sapiens (human)
cysteine-type endopeptidase activity	Cathepsin K	Homo sapiens (human)
serine-type endopeptidase activity	Cathepsin K	Homo sapiens (human)
protein binding	Cathepsin K	Homo sapiens (human)
collagen binding	Cathepsin K	Homo sapiens (human)
cysteine-type peptidase activity	Cathepsin K	Homo sapiens (human)
proteoglycan binding	Cathepsin K	Homo sapiens (human)
cysteine-type endopeptidase activator activity involved in apoptotic process	Cathepsin K	Homo sapiens (human)
lipopolysaccharide binding	Caspase-4	Homo sapiens (human)
cysteine-type endopeptidase activity	Caspase-4	Homo sapiens (human)
protein binding	Caspase-4	Homo sapiens (human)
lipid binding	Caspase-4	Homo sapiens (human)
CARD domain binding	Caspase-4	Homo sapiens (human)
cysteine-type endopeptidase activity involved in apoptotic process	Caspase-4	Homo sapiens (human)
endopeptidase activity	Matrix metalloproteinase-14	Homo sapiens (human)
metalloendopeptidase activity	Matrix metalloproteinase-14	Homo sapiens (human)
serine-type endopeptidase activity	Matrix metalloproteinase-14	Homo sapiens (human)
integrin binding	Matrix metalloproteinase-14	Homo sapiens (human)
protein binding	Matrix metalloproteinase-14	Homo sapiens (human)
zinc ion binding	Matrix metalloproteinase-14	Homo sapiens (human)
metalloaminopeptidase activity	Matrix metalloproteinase-14	Homo sapiens (human)
serine-type endopeptidase activity	Dipeptidyl peptidase 1	Homo sapiens (human)
protein binding	Dipeptidyl peptidase 1	Homo sapiens (human)
cysteine-type peptidase activity	Dipeptidyl peptidase 1	Homo sapiens (human)
dipeptidyl-peptidase activity	Dipeptidyl peptidase 1	Homo sapiens (human)
peptidase activator activity involved in apoptotic process	Dipeptidyl peptidase 1	Homo sapiens (human)
phosphatase binding	Dipeptidyl peptidase 1	Homo sapiens (human)
chloride ion binding	Dipeptidyl peptidase 1	Homo sapiens (human)
identical protein binding	Dipeptidyl peptidase 1	Homo sapiens (human)
protein-folding chaperone binding	Dipeptidyl peptidase 1	Homo sapiens (human)
cysteine-type endopeptidase activity	Dipeptidyl peptidase 1	Homo sapiens (human)
amyloid-beta binding	Beta-secretase 1	Homo sapiens (human)
endopeptidase activity	Beta-secretase 1	Homo sapiens (human)
aspartic-type endopeptidase activity	Beta-secretase 1	Homo sapiens (human)
protein binding	Beta-secretase 1	Homo sapiens (human)
peptidase activity	Beta-secretase 1	Homo sapiens (human)
beta-aspartyl-peptidase activity	Beta-secretase 1	Homo sapiens (human)
enzyme binding	Beta-secretase 1	Homo sapiens (human)
protein serine/threonine kinase binding	Beta-secretase 1	Homo sapiens (human)
endopeptidase activity	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
metalloendopeptidase activity	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
Notch binding	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
interleukin-6 receptor binding	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
integrin binding	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
protein binding	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
peptidase activity	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
metallopeptidase activity	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
SH3 domain binding	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
cytokine binding	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
PDZ domain binding	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
tumor necrosis factor binding	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
metal ion binding	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
metalloendopeptidase activity involved in amyloid precursor protein catabolic process	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
carboxypeptidase activity	Cathepsin Z	Homo sapiens (human)
protein binding	Cathepsin Z	Homo sapiens (human)
cysteine-type peptidase activity	Cathepsin Z	Homo sapiens (human)
cysteine-type endopeptidase activity	Cathepsin Z	Homo sapiens (human)
serine-type endopeptidase activity	Kallikrein-4	Homo sapiens (human)
protein binding	Kallikrein-4	Homo sapiens (human)
serine-type peptidase activity	Kallikrein-4	Homo sapiens (human)
metal ion binding	Kallikrein-4	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (68)

Process	via Protein(s)	Taxonomy
extracellular region	Cathepsin L2	Homo sapiens (human)
lysosomal lumen	Cathepsin L2	Homo sapiens (human)
extracellular space	Cathepsin L2	Homo sapiens (human)
lysosome	Cathepsin L2	Homo sapiens (human)
extracellular region	Procathepsin L	Homo sapiens (human)
extracellular space	Procathepsin L	Homo sapiens (human)
nucleus	Procathepsin L	Homo sapiens (human)
lysosome	Procathepsin L	Homo sapiens (human)
multivesicular body	Procathepsin L	Homo sapiens (human)
Golgi apparatus	Procathepsin L	Homo sapiens (human)
plasma membrane	Procathepsin L	Homo sapiens (human)
apical plasma membrane	Procathepsin L	Homo sapiens (human)
endolysosome lumen	Procathepsin L	Homo sapiens (human)
chromaffin granule	Procathepsin L	Homo sapiens (human)
lysosomal lumen	Procathepsin L	Homo sapiens (human)
intracellular membrane-bounded organelle	Procathepsin L	Homo sapiens (human)
collagen-containing extracellular matrix	Procathepsin L	Homo sapiens (human)
extracellular exosome	Procathepsin L	Homo sapiens (human)
endocytic vesicle lumen	Procathepsin L	Homo sapiens (human)
extracellular space	Procathepsin L	Homo sapiens (human)
lysosome	Procathepsin L	Homo sapiens (human)
collagen-containing extracellular matrix	Cathepsin B	Homo sapiens (human)
extracellular region	Cathepsin B	Homo sapiens (human)
extracellular space	Cathepsin B	Homo sapiens (human)
lysosome	Cathepsin B	Homo sapiens (human)
external side of plasma membrane	Cathepsin B	Homo sapiens (human)
apical plasma membrane	Cathepsin B	Homo sapiens (human)
endolysosome lumen	Cathepsin B	Homo sapiens (human)
melanosome	Cathepsin B	Homo sapiens (human)
perinuclear region of cytoplasm	Cathepsin B	Homo sapiens (human)
collagen-containing extracellular matrix	Cathepsin B	Homo sapiens (human)
extracellular exosome	Cathepsin B	Homo sapiens (human)
peptidase inhibitor complex	Cathepsin B	Homo sapiens (human)
ficolin-1-rich granule lumen	Cathepsin B	Homo sapiens (human)
extracellular space	Cathepsin B	Homo sapiens (human)
lysosome	Cathepsin B	Homo sapiens (human)
extracellular region	Pro-cathepsin H	Homo sapiens (human)
extracellular space	Pro-cathepsin H	Homo sapiens (human)
lysosome	Pro-cathepsin H	Homo sapiens (human)
cytosol	Pro-cathepsin H	Homo sapiens (human)
secretory granule lumen	Pro-cathepsin H	Homo sapiens (human)
cytoplasmic ribonucleoprotein granule	Pro-cathepsin H	Homo sapiens (human)
intracellular membrane-bounded organelle	Pro-cathepsin H	Homo sapiens (human)
collagen-containing extracellular matrix	Pro-cathepsin H	Homo sapiens (human)
extracellular exosome	Pro-cathepsin H	Homo sapiens (human)
alveolar lamellar body	Pro-cathepsin H	Homo sapiens (human)
multivesicular body lumen	Pro-cathepsin H	Homo sapiens (human)
tertiary granule lumen	Pro-cathepsin H	Homo sapiens (human)
ficolin-1-rich granule lumen	Pro-cathepsin H	Homo sapiens (human)
extracellular space	Pro-cathepsin H	Homo sapiens (human)
lysosome	Pro-cathepsin H	Homo sapiens (human)
extracellular region	Cathepsin S	Homo sapiens (human)
extracellular space	Cathepsin S	Homo sapiens (human)
lysosome	Cathepsin S	Homo sapiens (human)
late endosome	Cathepsin S	Homo sapiens (human)
endolysosome lumen	Cathepsin S	Homo sapiens (human)
lysosomal lumen	Cathepsin S	Homo sapiens (human)
intracellular membrane-bounded organelle	Cathepsin S	Homo sapiens (human)
phagocytic vesicle	Cathepsin S	Homo sapiens (human)
collagen-containing extracellular matrix	Cathepsin S	Homo sapiens (human)
tertiary granule lumen	Cathepsin S	Homo sapiens (human)
ficolin-1-rich granule lumen	Cathepsin S	Homo sapiens (human)
extracellular space	Cathepsin S	Homo sapiens (human)
lysosome	Cathepsin S	Homo sapiens (human)
extracellular region	Cathepsin K	Homo sapiens (human)
extracellular space	Cathepsin K	Homo sapiens (human)
nucleoplasm	Cathepsin K	Homo sapiens (human)
lysosome	Cathepsin K	Homo sapiens (human)
external side of plasma membrane	Cathepsin K	Homo sapiens (human)
apical plasma membrane	Cathepsin K	Homo sapiens (human)
endolysosome lumen	Cathepsin K	Homo sapiens (human)
lysosomal lumen	Cathepsin K	Homo sapiens (human)
intracellular membrane-bounded organelle	Cathepsin K	Homo sapiens (human)
extracellular space	Cathepsin K	Homo sapiens (human)
lysosome	Cathepsin K	Homo sapiens (human)
cytosol	Caspase-4	Homo sapiens (human)
extracellular region	Caspase-4	Homo sapiens (human)
mitochondrion	Caspase-4	Homo sapiens (human)
endoplasmic reticulum	Caspase-4	Homo sapiens (human)
endoplasmic reticulum membrane	Caspase-4	Homo sapiens (human)
cytosol	Caspase-4	Homo sapiens (human)
plasma membrane	Caspase-4	Homo sapiens (human)
protein-containing complex	Caspase-4	Homo sapiens (human)
non-canonical inflammasome complex	Caspase-4	Homo sapiens (human)
cytoplasm	Caspase-4	Homo sapiens (human)
NLRP1 inflammasome complex	Caspase-4	Homo sapiens (human)
cytoplasm	Matrix metalloproteinase-14	Homo sapiens (human)
plasma membrane	Matrix metalloproteinase-14	Homo sapiens (human)
extracellular space	Matrix metalloproteinase-14	Homo sapiens (human)
nucleus	Matrix metalloproteinase-14	Homo sapiens (human)
Golgi lumen	Matrix metalloproteinase-14	Homo sapiens (human)
cytosol	Matrix metalloproteinase-14	Homo sapiens (human)
plasma membrane	Matrix metalloproteinase-14	Homo sapiens (human)
focal adhesion	Matrix metalloproteinase-14	Homo sapiens (human)
extracellular matrix	Matrix metalloproteinase-14	Homo sapiens (human)
cytoplasmic vesicle	Matrix metalloproteinase-14	Homo sapiens (human)
melanosome	Matrix metalloproteinase-14	Homo sapiens (human)
macropinosome	Matrix metalloproteinase-14	Homo sapiens (human)
intermediate filament cytoskeleton	Matrix metalloproteinase-14	Homo sapiens (human)
extracellular space	Matrix metalloproteinase-14	Homo sapiens (human)
extracellular region	Dipeptidyl peptidase 1	Homo sapiens (human)
extracellular space	Dipeptidyl peptidase 1	Homo sapiens (human)
nucleoplasm	Dipeptidyl peptidase 1	Homo sapiens (human)
lysosome	Dipeptidyl peptidase 1	Homo sapiens (human)
endoplasmic reticulum lumen	Dipeptidyl peptidase 1	Homo sapiens (human)
centrosome	Dipeptidyl peptidase 1	Homo sapiens (human)
membrane	Dipeptidyl peptidase 1	Homo sapiens (human)
COPII-coated ER to Golgi transport vesicle	Dipeptidyl peptidase 1	Homo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartment membrane	Dipeptidyl peptidase 1	Homo sapiens (human)
azurophil granule lumen	Dipeptidyl peptidase 1	Homo sapiens (human)
intracellular membrane-bounded organelle	Dipeptidyl peptidase 1	Homo sapiens (human)
collagen-containing extracellular matrix	Dipeptidyl peptidase 1	Homo sapiens (human)
extracellular exosome	Dipeptidyl peptidase 1	Homo sapiens (human)
lysosome	Dipeptidyl peptidase 1	Homo sapiens (human)
extracellular space	Dipeptidyl peptidase 1	Homo sapiens (human)
lysosome	Beta-secretase 1	Homo sapiens (human)
endosome	Beta-secretase 1	Homo sapiens (human)
early endosome	Beta-secretase 1	Homo sapiens (human)
late endosome	Beta-secretase 1	Homo sapiens (human)
multivesicular body	Beta-secretase 1	Homo sapiens (human)
endoplasmic reticulum lumen	Beta-secretase 1	Homo sapiens (human)
Golgi apparatus	Beta-secretase 1	Homo sapiens (human)
trans-Golgi network	Beta-secretase 1	Homo sapiens (human)
plasma membrane	Beta-secretase 1	Homo sapiens (human)
synaptic vesicle	Beta-secretase 1	Homo sapiens (human)
cell surface	Beta-secretase 1	Homo sapiens (human)
endosome membrane	Beta-secretase 1	Homo sapiens (human)
membrane	Beta-secretase 1	Homo sapiens (human)
axon	Beta-secretase 1	Homo sapiens (human)
dendrite	Beta-secretase 1	Homo sapiens (human)
neuronal cell body	Beta-secretase 1	Homo sapiens (human)
membrane raft	Beta-secretase 1	Homo sapiens (human)
recycling endosome	Beta-secretase 1	Homo sapiens (human)
Golgi-associated vesicle lumen	Beta-secretase 1	Homo sapiens (human)
hippocampal mossy fiber to CA3 synapse	Beta-secretase 1	Homo sapiens (human)
endosome	Beta-secretase 1	Homo sapiens (human)
plasma membrane	Beta-secretase 1	Homo sapiens (human)
trans-Golgi network	Beta-secretase 1	Homo sapiens (human)
cell-cell junction	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
focal adhesion	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
ruffle membrane	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
Golgi membrane	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
cytoplasm	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
endoplasmic reticulum lumen	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
cytosol	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
plasma membrane	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
cell surface	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
actin cytoskeleton	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
membrane	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
apical plasma membrane	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
membrane raft	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
plasma membrane	Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)
extracellular region	Cathepsin Z	Homo sapiens (human)
extracellular space	Cathepsin Z	Homo sapiens (human)
lysosome	Cathepsin Z	Homo sapiens (human)
endoplasmic reticulum	Cathepsin Z	Homo sapiens (human)
endoplasmic reticulum lumen	Cathepsin Z	Homo sapiens (human)
plasma membrane	Cathepsin Z	Homo sapiens (human)
cell cortex	Cathepsin Z	Homo sapiens (human)
COPII-coated ER to Golgi transport vesicle	Cathepsin Z	Homo sapiens (human)
cytoplasmic vesicle	Cathepsin Z	Homo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartment membrane	Cathepsin Z	Homo sapiens (human)
specific granule lumen	Cathepsin Z	Homo sapiens (human)
intracellular membrane-bounded organelle	Cathepsin Z	Homo sapiens (human)
collagen-containing extracellular matrix	Cathepsin Z	Homo sapiens (human)
extracellular exosome	Cathepsin Z	Homo sapiens (human)
ficolin-1-rich granule lumen	Cathepsin Z	Homo sapiens (human)
lysosome	Cathepsin Z	Homo sapiens (human)
extracellular space	Cathepsin Z	Homo sapiens (human)
extracellular region	Kallikrein-4	Homo sapiens (human)
secretory granule	Kallikrein-4	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (38)

Assay ID	Title	Year	Journal	Article
AID444745	Inhibition of human Kallikrein 4	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444727	Inhibition of human MMP14	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444705	Inhibition of human Cathepsin H	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444708	Inhibition of human Cathepsin S	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444617	Inhibition of recombinant Trypanosoma cruzi cruzain after 5 mins by spectrofluorimetric analysis	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444759	Toxicity in dog	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444685	Antitrypanosomal activity against Trypanosoma cruzi Y trypomastigotes infected in mouse J774 cells at 10 uM after 27 days medium replaced every 48 hrs	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444711	Inhibition of human Cathepsin X/Z	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444620	Inhibition of recombinant Trypanosoma brucei cathepsin B after 5 mins by spectrofluorimetric analysis	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444689	Inhibition of human Proteinase A	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444704	Inhibition of human Cathepsin C	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444686	Inhibition of human BACE1	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444619	Inhibition of recombinant Trypanosoma brucei rhodesain after 5 mins by spectrofluorimetric analysis	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444709	Inhibition of human Cathepsin V	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444750	Inhibition of human Proteinase K	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444707	Inhibition of human Cathepsin L	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444694	Inhibition of human Caspase 4	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444621	Antitrypanosomal activity against Trypanosoma brucei brucei 221 infected in human macrophage after 48 hrs	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444728	Inhibition of human TACE	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444710	Inhibition of papaya papain	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444703	Inhibition of human Cathepsin B	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444616	Inhibition of Trypanosoma cruzi cruzain after 15 mins	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444758	Toxicity in rat	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444757	Toxicity in mouse	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444706	Inhibition of human Cathepsin K/O2	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (16.67)	29.6817
2010's	4 (66.67)	24.3611
2020's	1 (16.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes
4-(3,5-difluoroanilino)-6-(2,2-difluoroethylamino)-1,3,5-triazine-2-carbonitrile [no description available]	2.05	1	diamino-1,3,5-triazine
6-(3-chloroanilino)-9-cyclopentyl-2-purinecarbonitrile [no description available]	2.05	1	6-aminopurines
6-(3,5-difluoroanilino)-9-(2,2-difluoroethyl)-2-purinecarbonitrile [no description available]	2.05	1	6-aminopurines
6-(3-chloroanilino)-9-ethyl-2-purinecarbonitrile [no description available]	2.05	1	6-aminopurines
9-(3,5-difluorophenyl)-6-(ethylamino)-2-purinecarbonitrile [no description available]	2.05	1	imidazoles

Condition	Indicated	Relationship Strength	Studies	Trials
Innate Inflammatory Response [description not available]	0	2.05	1	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	0	2.05	1	0

6-(3,5-difluoroanilino)-9-ethyl-2-purinecarbonitrile

Cross-References

Synonyms (36)

Drug Classes (1)

Protein Targets (21)

Potency Measurements

Inhibition Measurements

Biological Processes (156)

Molecular Functions (46)

Ceullar Components (68)

Bioassays (38)

Research

Studies (6)

Market Indicators

Research Demand Index: 12.41

Study Types

6-(3,5-difluoroanilino)-9-ethyl-2-purinecarbonitrile

Cross-References

Synonyms (36)

Drug Classes (1)

Protein Targets (21)

Potency Measurements

Inhibition Measurements

Biological Processes (156)

Molecular Functions (46)

Ceullar Components (68)

Bioassays (38)

Research

Studies (6)

Market Indicators

Research Demand Index: 12.41

Study Types

Related Drugs (5)

Related Conditions (2)