| Assay ID | Title | Year | Journal | Article |
|---|
| AID319292 | Growth inhibition of human K562 cells after 24 hrs | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
| Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation. |
| AID1140409 | Inhibition of GGDPS in human RPMI-8226 cells assessed as disruption of Rap1a geranylgeranylation at <10 uM after 48 hrs by western blot analysis | 2014 | Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9
| Geranyl and neryl triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase. |
| AID669079 | Inhibition of human recombinant N-terminal His6 tagged GGPPS expressed in Escherichia coli BL21 using FPP and [14C]IPP as substrate incubated for 10 mins prior to substrate addition by scintillation counting | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
| Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells. |
| AID319295 | Inhibition of Rap1a protein modification in human K562 cells by Western blot relative to lovastatin | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
| Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation. |
| AID669076 | Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [3H]IPP and GPP as substrate measured after 20 mins by liquid scintillation counting | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
| Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells. |
| AID1140424 | Inhibition of GGDPS in human RPMI-8226 cells assessed as disruption of monoclonal protein trafficking by measuring accumulation of intracellular lambda light chain at 10 uM after 48 hrs by ELISA | 2014 | Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9
| Geranyl and neryl triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase. |
| AID1584449 | Antiproliferative activity against human RPMI8226 cells after 72 hrs by MTT assay | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors. |
| AID326571 | Inhibition of GST-tagged human recombinant GGDPS expressed in BL21 gold bacteria | 2008 | Bioorganic & medicinal chemistry, Jan-01, Volume: 16, Issue:1
| Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors. |
| AID391371 | Inhibition of human recombinant geranylgeranyl diphosphate synthase | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. |
| AID1140419 | Inhibition of recombinant GGDPS (unknown origin) assessed as decrease in radiolabeld GGPP level using FPP and [14C]IPP as substrate treated with enzyme for 10 mins prior to substrate challenge for 30 mins by liquid scintillation counting analysis | 2014 | Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9
| Geranyl and neryl triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase. |
| AID1584450 | Inhibition of human N-terminal His6-tagged GGPPS Y246D mutant expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 mins by scintillation counting | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors. |
| AID319289 | Inhibition of human recombinant GGDPS expressed in BL21 gold bacteria at 10 uM relative to control | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
| Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation. |
| AID326572 | Inhibition of human GGDPS-mediated Rap1a geranylgeranylation in human K562 cells after 24 hrs by Western blot | 2008 | Bioorganic & medicinal chemistry, Jan-01, Volume: 16, Issue:1
| Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors. |
| AID319294 | Inhibition of human recombinant GGDPS expressed in BL21 gold bacteria | 2008 | Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7
| Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation. |
| AID739024 | Inhibition of human FPPS | 2013 | Bioorganic & medicinal chemistry, Apr-15, Volume: 21, Issue:8
| Discovery of thienopyrimidine-based inhibitors of the human farnesyl pyrophosphate synthase--parallel synthesis of analogs via a trimethylsilyl ylidene intermediate. |
| AID1140406 | Inhibition of GGDPS in human RPMI-8226 cells assessed as disruption of Rap1a geranylgeranylation at 10 uM after 48 hrs by western blot analysis | 2014 | Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9
| Geranyl and neryl triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase. |
| AID1584444 | Inhibition of human FPPS using [14C]-IPP and FPP as substrates after 10 mins by scintillation counting | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors. |
| AID669074 | Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 mins prior to substrate addition measured after 10 mins by scintillation counting | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
| Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells. |
| AID1584443 | Inhibition of human N-terminal His6-tagged GGPPS expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 mins by scintillation counting | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors. |
| AID1140408 | Inhibition of FDPS in human RPMI-8226 cells assessed as disruption of Ras farnesylation after 48 hrs by western blot analysis | 2014 | Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9
| Geranyl and neryl triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase. |
| AID1140407 | Inhibition of GGDPS in human RPMI-8226 cells assessed as disruption of Rab6 geranylgeranylation at 10 uM after 48 hrs by western blot analysis | 2014 | Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9
| Geranyl and neryl triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase. |
| AID1346874 | Human geranylgeranyl diphosphate synthase (Lanosterol biosynthesis pathway) | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. |
| AID1346874 | Human geranylgeranyl diphosphate synthase (Lanosterol biosynthesis pathway) | 2007 | Biochemical and biophysical research communications, Feb-23, Volume: 353, Issue:4
| Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase. |
| AID1798541 | GGPP Synthase Inhibition Assay from Article 10.1021/jm800325y: \\Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.\\ | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |