Page last updated: 2024-12-08
ustiloxin a
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
ustiloxin A: a modified peptide from the fungus Ustilaginoidea virens or false smut ball; structurally similar to phomopsin A; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 164454 |
| CHEMBL ID | 212074 |
| MeSH ID | M0231113 |
Synonyms (6)
| Synonym |
|---|
| 143557-93-1 |
| ustiloxin a |
| CHEMBL212074 |
| glycine, 2-((4-amino-4-carboxy-2-hydroxybutyl)sulfinyl)-threo-beta,5-dihydroxy-n-methyl-l-tyrosyl-l-valyl-3-hydroxy-l-isoleucyl-, cyclic (15-3)-ether, (2s-(1(s*),2r*,4r*))- |
| (2s,4s)-2-amino-5-[[(3r,4s,7s,10s,11r)-4-(carboxymethylcarbamoyl)-3-ethyl-11,15-dihydroxy-3-methyl-10-(methylamino)-6,9-dioxo-7-propan-2-yl-2-oxa-5,8-diazabicyclo[10.3.1]hexadeca-1(15),12(16),13-trien-13-yl]sulfinyl]-4-hydroxypentanoic acid |
| glycine, (|ar)-2-[(r)-[(2s,4s)-4-amino-4-carboxy-2-hydroxybutyl]sulfinyl]-|a,5-dihydroxy-n-methyl-l-tyrosyl-l-valyl-3-hydroxy-l-isoleucyl-, cyclic (15 inverted exclamation marku3)-ether |
Research Excerpts
Overview
Ustiloxin A is a modified peptide derived from false smut balls on rice panicles, caused by the fungus Ustilaginoidea virens. structurally, it resembles phomopsin A.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Ustiloxin A is a cyclopeptide mycotoxin originally isolated from rice false smut balls (FSBs) that formed in rice spikelets infected by the fungal pathogen Ustilaginoidea virens. " | ( Acute exposure to ustiloxin A affects growth and development of early life zebrafish, Danio rerio. Dang, Y; Hu, Z; Liu, C; Liu, H; Zhou, L, 2019) | 2.29 |
| "Ustiloxin A is a modified peptide derived from false smut balls on rice panicles, caused by the fungus Ustilaginoidea virens; structurally, it resembles phomopsin A. " | ( Interaction of ustiloxin A with bovine brain tubulin. Banerjee, M; Iwasaki, S; Koiso, Y; Li, Y; Ludueńa, RF; Prasad, V; Roach, MC, 1994) | 2.08 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Protein Targets (15)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Tubulin beta-4A chain | Homo sapiens (human) | IC50 (µMol) | 1.1000 | 0.0005 | 1.9680 | 10.0000 | AID270819 |
| Tubulin beta chain | Homo sapiens (human) | IC50 (µMol) | 1.1000 | 0.0005 | 2.0529 | 10.0000 | AID270819 |
| Tubulin alpha-3C chain | Homo sapiens (human) | IC50 (µMol) | 1.1000 | 0.0005 | 1.9555 | 10.0000 | AID270819 |
| Tubulin alpha-1B chain | Homo sapiens (human) | IC50 (µMol) | 1.1000 | 0.0005 | 1.9555 | 10.0000 | AID270819 |
| Tubulin alpha-4A chain | Homo sapiens (human) | IC50 (µMol) | 1.1000 | 0.0005 | 1.9555 | 10.0000 | AID270819 |
| Tubulin beta-4B chain | Homo sapiens (human) | IC50 (µMol) | 1.1000 | 0.0005 | 1.9680 | 10.0000 | AID270819 |
| Tubulin beta-3 chain | Homo sapiens (human) | IC50 (µMol) | 1.1000 | 0.0005 | 1.8945 | 10.0000 | AID270819 |
| Tubulin beta-2A chain | Homo sapiens (human) | IC50 (µMol) | 1.1000 | 0.0005 | 1.9680 | 10.0000 | AID270819 |
| Tubulin beta-8 chain | Homo sapiens (human) | IC50 (µMol) | 1.1000 | 0.0005 | 1.9680 | 10.0000 | AID270819 |
| Tubulin alpha-3E chain | Homo sapiens (human) | IC50 (µMol) | 1.1000 | 0.0005 | 1.9555 | 10.0000 | AID270819 |
| Tubulin alpha-1A chain | Homo sapiens (human) | IC50 (µMol) | 1.1000 | 0.0005 | 1.9555 | 10.0000 | AID270819 |
| Tubulin alpha-1C chain | Homo sapiens (human) | IC50 (µMol) | 1.1000 | 0.0005 | 1.9555 | 10.0000 | AID270819 |
| Tubulin beta-6 chain | Homo sapiens (human) | IC50 (µMol) | 1.1000 | 0.0005 | 1.9680 | 10.0000 | AID270819 |
| Tubulin beta-2B chain | Homo sapiens (human) | IC50 (µMol) | 1.1000 | 0.0005 | 1.9680 | 10.0000 | AID270819 |
| Tubulin beta-1 chain | Homo sapiens (human) | IC50 (µMol) | 1.1000 | 0.0005 | 1.9870 | 10.0000 | AID270819 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Biological Processes (51)
Molecular Functions (21)
Ceullar Components (36)
Bioassays (2)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID270819 | Inhibition of tubulin polymerization | 2006 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 16, Issue:18 | Total synthesis and biological evaluation of ustiloxin natural products and two analogs. |
| AID270820 | Cytotoxicity against human CA46 cell line | 2006 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 16, Issue:18 | Total synthesis and biological evaluation of ustiloxin natural products and two analogs. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (25)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 4 (16.00) | 29.6817 |
| 2010's | 11 (44.00) | 24.3611 |
| 2020's | 4 (16.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 11.70
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.70) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 25 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||