| Assay ID | Title | Year | Journal | Article |
|---|
| AID225110 | Antagonism of Pergolide-Induced Circling Behavior in rats with unilateral 6-OHDA Lesions after 2 hr of sc injection | 1996 | Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
| Serotonin 5-HT2 receptor, dopamine D2 receptor, and alpha 1 adrenoceptor antagonists. Conformationally flexible analogues of the atypical antipsychotic sertindole. |
| AID225301 | Effective dose was measured to inhibit 50% of quipazine induced head twitches in rat after 24 hr r of subcutaneous administration; Not tested | 1996 | Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
| Serotonin 5-HT2 receptor, dopamine D2 receptor, and alpha 1 adrenoceptor antagonists. Conformationally flexible analogues of the atypical antipsychotic sertindole. |
| AID61406 | Binding affinity to dopamine receptor D2 using a [3H]-spiperone binding assay in rat cortical membranes | 1996 | Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
| Serotonin 5-HT2 receptor, dopamine D2 receptor, and alpha 1 adrenoceptor antagonists. Conformationally flexible analogues of the atypical antipsychotic sertindole. |
| AID225299 | Effective dose was measured to inhibit 50% of quipazine induced head twitches in rat after 24 hr r of peroral administration; Not tested | 1996 | Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
| Serotonin 5-HT2 receptor, dopamine D2 receptor, and alpha 1 adrenoceptor antagonists. Conformationally flexible analogues of the atypical antipsychotic sertindole. |
| AID65100 | Binding affinity to rat Dopamine receptor D2 expressed in CHO cells was determined using [125 I ] iodosulpride as radioligand | 1996 | Journal of medicinal chemistry, Jul-05, Volume: 39, Issue:14
| Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds. |
| AID5477 | Binding affinity to serotonin 5-hydroxytryptamine 2A receptors using a radioligand [3H]ketanserin binding assay in rat cortical membranes | 1996 | Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
| Serotonin 5-HT2 receptor, dopamine D2 receptor, and alpha 1 adrenoceptor antagonists. Conformationally flexible analogues of the atypical antipsychotic sertindole. |
| AID65609 | Binding affinity to rat Dopamine receptor D3 expressed in CHO cells was determined using [125 I] iodosulpride as radioligand | 1996 | Journal of medicinal chemistry, Jul-05, Volume: 39, Issue:14
| Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds. |
| AID36029 | Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes | 1996 | Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
| Serotonin 5-HT2 receptor, dopamine D2 receptor, and alpha 1 adrenoceptor antagonists. Conformationally flexible analogues of the atypical antipsychotic sertindole. |
| AID1664667 | Displacement of [3H]-N-Methylspiperone from human dopamine D4 receptor expressed in stable HEK cells incubated for 90 mins by microbeta counting method | 2020 | Bioorganic & medicinal chemistry, 08-01, Volume: 28, Issue:15
| Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HT |
| AID65945 | Binding Affinity to Human Dopamine receptor D4 expressed in CHO cells was determined using [3H]- nemonapride as radioligand | 1996 | Journal of medicinal chemistry, Jul-05, Volume: 39, Issue:14
| Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds. |
| AID1598364 | Antagonist activity at recombinant human D4 receptor expressed in CHOK1 cells assessed as inhibition of lisuride-induced beta arrestin2 recruitment preincubated for 30 mins followed by lisuride-stimulation and measured after 90 mins by coelenterazine-base | | | |
| AID1763013 | Displacement of [3H]DTG from sigma2 receptor(unknown origin) | 2021 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 42 | New tetrahydroisoquinoline-based D |
| AID176196 | Effective dose to induce catalepsy in 50% of the rats (95% confidence limits included in parentheses) | 1981 | Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
| Synthesis and neuroleptic activity of benzamides. Cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide and related compounds. |
| AID176655 | Subcutaneous dose to inhibit apomorphine-induced stereotyped behavior in 50% of rats | 1981 | Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
| Synthesis and neuroleptic activity of benzamides. Cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide and related compounds. |
| AID112819 | Compound was tested for inhibition of Apomorphine induced climbing in Mice on subcutaneous administration | 1996 | Journal of medicinal chemistry, Jul-05, Volume: 39, Issue:14
| Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds. |
| AID1763012 | Displacement of [3H]-methylspiperone from dopamine D4 receptor (unknown origin) | 2021 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 42 | New tetrahydroisoquinoline-based D |
| AID180915 | The inhibitory effect on the continuous avoidance was expressed as the dose to increase the number of electroshocks by 60% of the rats | 1981 | Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
| Synthesis and neuroleptic activity of benzamides. Cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide and related compounds. |
| AID1664666 | Displacement of [3H]-N-Methylspiperone from dopamine D3 receptor (unknown origin) incubated for 90 mins by microbeta counting method | 2020 | Bioorganic & medicinal chemistry, 08-01, Volume: 28, Issue:15
| Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HT |
| AID232561 | Ratio of ED50 for inhibition of catalepsy induction to stereotypy induction | 1981 | Journal of medicinal chemistry, Oct, Volume: 24, Issue:10
| Synthesis and neuroleptic activity of benzamides. Cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide and related compounds. |
| AID1763011 | Displacement of [3H]-methylspiperone from dopamine D3 receptor (unknown origin) | 2021 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 42 | New tetrahydroisoquinoline-based D |
| AID1763010 | Displacement of [3H]N-methylspiperone from dopamine D2 receptor (unknown origin) | 2021 | Bioorganic & medicinal chemistry letters, 06-15, Volume: 42 | New tetrahydroisoquinoline-based D |
| AID225304 | Effective dose was measured to inhibit 50% of quipazine induced head twitches in rat after 2 hr of subcutaneous administration; Not tested | 1996 | Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
| Serotonin 5-HT2 receptor, dopamine D2 receptor, and alpha 1 adrenoceptor antagonists. Conformationally flexible analogues of the atypical antipsychotic sertindole. |
| AID1345814 | Human D4 receptor (Dopamine receptors) | 1993 | Synapse (New York, N.Y.), Aug, Volume: 14, Issue:4
| Low density of dopamine D4 receptors in Parkinson's, schizophrenia, and control brain striata. |
| AID1345833 | Human D3 receptor (Dopamine receptors) | 1994 | European journal of pharmacology, Jan-01, Volume: 266, Issue:1
| Characterization of the human dopamine D3 receptor expressed in transfected cell lines. |
| AID1345833 | Human D3 receptor (Dopamine receptors) | 1994 | The Journal of pharmacology and experimental therapeutics, Jan, Volume: 268, Issue:1
| Pharmacological and functional characterization of D2, D3 and D4 dopamine receptors in fibroblast and dopaminergic cell lines. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |