acetyl isogambogic acid: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 6857789 |
| CHEMBL ID | 3039433 |
| MeSH ID | M0517917 |
| Synonym |
|---|
| SDCCGMLS-0066892.P001 |
| SPECTRUM300549 |
| acetyl isogambogic acid |
| chembl3039433 , |
| bdbm50442907 |
| CCG-214257 |
| (e)-4-[(2s,17s)-12-acetyloxy-8,21,21-trimethyl-5-(3-methylbut-2-enyl)-8-(4-methylpent-3-enyl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.02,15.02,19.04,13.06,11]docosa-4,6(11),9,12,15-pentaen-19-yl]-2-methylbut-2-enoic acid |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 2 | Homo sapiens (human) | IC50 (µMol) | 17.3200 | 5.4000 | 6.1000 | 6.8000 | AID1794863 |
| Ubiquitin carboxyl-terminal hydrolase isozyme L1 | Homo sapiens (human) | IC50 (µMol) | 17.3200 | 3.0000 | 5.0667 | 6.8000 | AID1794863 |
| Ubiquitin carboxyl-terminal hydrolase isozyme L3 | Homo sapiens (human) | IC50 (µMol) | 17.3200 | 0.0500 | 3.9083 | 10.0000 | AID1794863 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | IC50 (µMol) | 5.3703 | 0.1047 | 2.7195 | 7.0795 | AID977603 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Ki | 4.1700 | 0.0800 | 2.4688 | 9.8000 | AID977604 |
| Ubiquitin carboxyl-terminal hydrolase 15 | Homo sapiens (human) | IC50 (µMol) | 17.3200 | 5.4000 | 6.1000 | 6.8000 | AID1794863 |
| Ubiquitin carboxyl-terminal hydrolase isozyme L5 | Homo sapiens (human) | IC50 (µMol) | 17.3200 | 5.4000 | 6.1000 | 6.8000 | AID1794863 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 (µMol) | 4.0738 | 0.0500 | 2.3797 | 9.7000 | AID977600 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Ki | 2.2400 | 0.0440 | 1.3630 | 5.0000 | AID977601 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID1794863 | Fluorometric Ub-AMC Hydrolysis Assay from Article 10.1021/acschembio.7b00543: \\Cell Lysate-Based AlphaLISA Deubiquitinase Assay Platform for Identification of Small Molecule Inhibitors.\\ | 2017 | ACS chemical biology, 09-15, Volume: 12, Issue:9 | Cell Lysate-Based AlphaLISA Deubiquitinase Assay Platform for Identification of Small Molecule Inhibitors. |
| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11 | 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| AID977604 | Ki values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID977600 | pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID977602 | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID977603 | pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID977599 | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID977601 | Ki values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.28) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (20.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 4 (80.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||