muscarinic toxin 2: muscarinic agonists from Dendroaspis angusticeps; amino acid sequence given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
alpha-D-mannoside : Any mannoside in which the anomeric centre has alpha-configuration. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
alpha-D-mannose : D-Mannopyranose having alpha-configuration at the anomeric centre. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 185698 |
| CHEMBL ID | 365590 |
| CHEBI ID | 28729 |
| CHEBI ID | 27535 |
| SCHEMBL ID | 76882 |
| MeSH ID | M0186996 |
| Synonym |
|---|
| CHEMBL365590 , |
| alpha-d-man |
| CHEBI:28729 , |
| d(+)-mannose |
| alpha-d-mannose |
| C00936 |
| alpha-d-mannoside |
| alpha-d-mannopyranose |
| 1RDL |
| 1RIN |
| 7296-15-3 |
| WQZGKKKJIJFFOK-PQMKYFCFSA-N |
| manalpha1, |
| (2s,3s,4s,5s,6r)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol |
| 101357-35-1 |
| 137498-12-5 |
| (+-)-mannose |
| w3f28j9g0w , |
| unii-w3f28j9g0w |
| alpha-mannose |
| 101357-07-7 |
| 135317-04-3 |
| muscarinic toxin 2 |
| EPITOPE ID:130701 |
| .alpha.-d-mannose |
| .alpha.-d-mannopyranose |
| .alpha.-mannose |
| SCHEMBL76882 |
| 3h-mannose |
| alpha-d-mannopyranoside |
| CHEBI:27535 |
| alpha-d-mannosides , |
| alpha-d-mannopyranosides |
| hydroboracite |
| alpha-d-mannose; d-mannose; mannose |
| (2s,3s,4s,5s,6r)-6-(hydroxymethyl)tetrahydro-2h-pyran-2,3,4,5-tetraol |
| 12046-12-7 |
| Q27103868 |
| DTXSID001015858 |
| bdbm50467903 |
| calcium sulfide (cas), solid soln. with strontium sulfide, bismuth and europium-doped |
| Role | Description |
|---|---|
| epitope | The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| D-mannopyranose | D-Mannose in its six-membered ring form. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain 1, Mannose-binding Protein-c | Rattus rattus (black rat) | Ki | 5,700.0000 | 5,700.0000 | 5,700.0000 | 5,700.0000 | AID977610 |
| Chain 1, Mannose-binding Protein-c | Rattus rattus (black rat) | Ki | 5,700.0000 | 5,700.0000 | 5,700.0000 | 5,700.0000 | AID977610 |
| Chain 1, Mannose-binding Protein-c | Rattus rattus (black rat) | Ki | 5,700.0000 | 5,700.0000 | 5,700.0000 | 5,700.0000 | AID977610 |
| Chain 1, Mannose-binding Protein-c | Rattus rattus (black rat) | Ki | 5,700.0000 | 5,700.0000 | 5,700.0000 | 5,700.0000 | AID977610 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, Pea Lectin | Pisum sativum (garden pea) | Kd | 700.0000 | 700.0000 | 700.0000 | 700.0000 | AID977611 |
| Chain B, Pea Lectin | Pisum sativum (garden pea) | Kd | 700.0000 | 700.0000 | 700.0000 | 700.0000 | AID977611 |
| Type 1 fimbrin D-mannose specific adhesin | Escherichia coli K-12 | Kd | 2.3000 | 2.2000 | 2.2500 | 2.3000 | AID1885011 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID756905 | Antiadhesive activity against type-1 piliated adherent-invasive Escherichia coli LF82 assessed as decrease in residual bacterial adhesion to colonic tissue isolated from FVB/N transgenic mouse expressing human CEACAM6 at 10 umol after 1 hr relative to con | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13 | Thiazolylaminomannosides as potent antiadhesives of type 1 piliated Escherichia coli isolated from Crohn's disease patients. |
| AID756902 | Antiadhesive activity against type-1 piliated adherent-invasive Escherichia coli LF82 assessed as inhibition of bacterial adhesion to colonic tissue isolated from FVB/N transgenic mouse expressing human CEACAM6 after 1 hr | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13 | Thiazolylaminomannosides as potent antiadhesives of type 1 piliated Escherichia coli isolated from Crohn's disease patients. |
| AID756909 | Antiadhesive activity against type-1 piliated adherent-invasive Escherichia coli LF82 assessed as residual bacterial adhesion to human T84 cells overexpressing CEACAM6 at 1000 uM incubated for 1 hr prior to infection measured after 3 hrs relative to contr | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13 | Thiazolylaminomannosides as potent antiadhesives of type 1 piliated Escherichia coli isolated from Crohn's disease patients. |
| AID756910 | Antiadhesive activity against type-1 piliated adherent-invasive Escherichia coli LF82 assessed as inhibition of bacterial adhesion to human T84 cells overexpressing CEACAM6 incubated for 1 hr prior to infection measured after 3 hrs | 2013 | Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13 | Thiazolylaminomannosides as potent antiadhesives of type 1 piliated Escherichia coli isolated from Crohn's disease patients. |
| AID1422774 | Inhibition of binding of trimannoside containing horseradish peroxidase to DC-SIGN carbohydrate binding domain (unknown origin) expressed in Escherichia coli preincubated for 1 hr followed by TMB substrate addition measured after 30 mins by ELISA | 2018 | Bioorganic & medicinal chemistry, 10-15, Volume: 26, Issue:19 | Genetically-encoded fragment-based discovery of glycopeptide ligands for DC-SIGN. |
| AID1885011 | Binding affinity to Escherichia coli FimH assessed as dissociation constant by SPR analysis | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13 | Small Carbohydrate Derivatives as Potent Antibiofilm Agents. |
| AID1811208 | Inhibition of DC-SIGN extracellular domain (unknown origin) binding to HIV gp120 by surface plasmon resonance analysis | 2021 | Journal of medicinal chemistry, 10-14, Volume: 64, Issue:19 | Low-Valent Calix[4]arene Glycoconjugates Based on Hydroxamic Acid Bearing Linkers as Potent Inhibitors in a Model of Ebola Virus Cis-Infection and HCMV-gB-Recombinant Glycoprotein Interaction with MDDC Cells by Blocking DC-SIGN. |
| AID1811 | Experimentally measured binding affinity data derived from PDB | 1996 | The Journal of biological chemistry, Jan-12, Volume: 271, Issue:2 | Structural analysis of monosaccharide recognition by rat liver mannose-binding protein. |
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 1996 | The Journal of biological chemistry, Jan-12, Volume: 271, Issue:2 | Structural analysis of monosaccharide recognition by rat liver mannose-binding protein. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 1993 | The Journal of biological chemistry, May-15, Volume: 268, Issue:14 | X-ray crystal structure of a pea lectin-trimannoside complex at 2.6 A resolution. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (57.89) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.61) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 2 (10.53%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 17 (89.47%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||