Compounds > 2-nitrosotoluene
Page last updated: 2024-12-05

2-nitrosotoluene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID11909
CHEMBL ID3184586
SCHEMBL ID836649
MeSH IDM0108342

Synonyms (37)

Synonym
1-methyl-2-nitroso-benzene
ccris 480
brn 1927295
nsc 66507
2-methylnitrosobenzene
einecs 210-261-4
nsc677512
nsc-677512
o-nitrosotoluene
nsc66507
1-methyl-2-nitrosobenzene
toluene, o-nitroso-
611-23-4
o-methylnitrosobenzene
2-methyl-1-nitrosobenzene
2-nitrosotoluene
benzene, 1-methyl-2-nitroso-
nsc-66507
2-nitrosotoluene, 97%
NCGC00248875-01
tox21_200917
NCGC00258471-01
cas-611-23-4
dtxsid3021065 ,
dtxcid901065
4-05-00-00844 (beilstein handbook reference)
unii-h2p2o30zss
h2p2o30zss ,
AKOS015889069
SCHEMBL836649
1‐methyl‐2‐nitrosobenzene (substrate 3)
bdbm108226
ortho-nitrosotoluene
nitrosotoluene
CHEMBL3184586
Q27279561
AS-83108
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
RAR-related orphan receptor gammaMus musculus (house mouse)Potency6.26880.006038.004119,952.5996AID1159521
AR proteinHomo sapiens (human)Potency63.24720.000221.22318,912.5098AID743035
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency55.87070.001022.650876.6163AID1224838
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency23.56050.000627.21521,122.0200AID743219
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (7)

Processvia Protein(s)Taxonomy
ubiquinone biosynthetic process1-deoxy-D-xylulose-5-phosphate synthaseEscherichia coli K-12
isoprenoid biosynthetic process1-deoxy-D-xylulose-5-phosphate synthaseEscherichia coli K-12
pyridoxine biosynthetic process1-deoxy-D-xylulose-5-phosphate synthaseEscherichia coli K-12
thiamine biosynthetic process1-deoxy-D-xylulose-5-phosphate synthaseEscherichia coli K-12
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway1-deoxy-D-xylulose-5-phosphate synthaseEscherichia coli K-12
isoprenoid biosynthetic process1-deoxy-D-xylulose-5-phosphate synthaseEscherichia coli K-12
thiamine biosynthetic process1-deoxy-D-xylulose-5-phosphate synthaseEscherichia coli K-12
terpenoid biosynthetic process1-deoxy-D-xylulose-5-phosphate synthaseEscherichia coli K-12
1-deoxy-D-xylulose 5-phosphate biosynthetic process1-deoxy-D-xylulose-5-phosphate synthaseEscherichia coli K-12
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway1-deoxy-D-xylulose-5-phosphate synthaseEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (7)

Processvia Protein(s)Taxonomy
magnesium ion binding1-deoxy-D-xylulose-5-phosphate synthaseEscherichia coli K-12
1-deoxy-D-xylulose-5-phosphate synthase activity1-deoxy-D-xylulose-5-phosphate synthaseEscherichia coli K-12
transferase activity1-deoxy-D-xylulose-5-phosphate synthaseEscherichia coli K-12
transketolase or transaldolase activity1-deoxy-D-xylulose-5-phosphate synthaseEscherichia coli K-12
thiamine pyrophosphate binding1-deoxy-D-xylulose-5-phosphate synthaseEscherichia coli K-12
protein homodimerization activity1-deoxy-D-xylulose-5-phosphate synthaseEscherichia coli K-12
metal ion binding1-deoxy-D-xylulose-5-phosphate synthaseEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
cytosol1-deoxy-D-xylulose-5-phosphate synthaseEscherichia coli K-12
cytosol1-deoxy-D-xylulose-5-phosphate synthaseEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1800220DXP Synthase Inhibition Assay from Article 10.1002/cbic.201300187: \\DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design.\\2013Chembiochem : a European journal of chemical biology, Jul-22, Volume: 14, Issue:11
DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (40.00)18.7374
1990's1 (20.00)18.2507
2000's1 (20.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.47 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.42 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
formamide
formimidic acid : A carboximidic acid that is formic acid in which the carbonyl oxygen is replaced by an imino group.. primary carboxamide : A carboxamide resulting from the formal condensation of a carboxylic acid with ammonia; formula RC(=O)NH2.		2.0210carboximidic acid;
formamides;
monocarboxylic acid amide;
one-carbon compound		solvent
hydroxylamine
amino alcohol : An alcohol containing an amino functional group in addition to the alcohol-defining hydroxy group.		2.0210hydroxylaminesalgal metabolite;
bacterial xenobiotic metabolite;
EC 1.1.3.13 (alcohol oxidase) inhibitor;
EC 4.2.1.22 (cystathionine beta-synthase) inhibitor;
EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor;
nitric oxide donor;
nucleophilic reagent
2-toluidine
2-toluidine: RN given refers to parent cpd. o-toluidine : An aminotoluene in which the amino substituent is ortho to the methyl group.		2.3820aminotoluenecarcinogenic agent
1-nitroso-2-naphthol
[no description available]		2.0810naphthols
4-nitrosodimethylaniline
4-nitrosodimethylaniline: structure; RN given refers to parent cpd. N,N-dimethyl-4-nitrosoaniline : A member of the class of dimethylanilines that is N,N-dimethylaniline having a nitroso group at the 4-position.		2.0810dimethylaniline;
nitroso compound;
tertiary amino compound
nitrosobenzene
[no description available]		2.420benzenes;
nitroso compound		xenobiotic metabolite
cyclopropylamine
cyclopropylamine: RN given refers to parent cpd. cyclopropylamine : A primary aliphatic amine that consists of cyclopropane bearing a single amino substituent.		2.0210primary aliphatic aminemouse metabolite
nad
NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.		210organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
heme
Heme: The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.. ferroheme : Any iron(II)--porphyrin coordination complex.. ferroheme b : Heme b in which the iron has oxidation state +2.. heme : A heme is any tetrapyrrolic chelate of iron.		2.0210
deoxyguanosine
[no description available]		210purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
8-hydroxy-2'-deoxyguanosine
8-Hydroxy-2'-Deoxyguanosine: Common oxidized form of deoxyguanosine in which C-8 position of guanine base has a carbonyl group.. 8-hydroxy-2'-deoxyguanosine : Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.		210guanosinesbiomarker
ConditionIndicatedRelationship StrengthStudiesTrials
Bladder Cancer
[description not available]		01.9610
Urinary Bladder Neoplasms
Tumors or cancer of the URINARY BLADDER.		01.9610