Compounds > guttiferone k
Page last updated: 2024-11-12

guttiferone k

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

guttiferone K: antiproliferative compound of Rheedia calcicola from the Madagascar rain forest; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Calcicolagenus[no description available]MalpighiaceaeA plant family of the order Polygalales, subclass Rosidae class, Magnoliopsida that are mostly shrubs and small trees. Many of the members contain indole alkaloids.[MeSH]
Rheediagenus[no description available]ClusiaceaeThe mangosteen plant family (sometimes classified as Guttiferae; also known as Hypericaceae) of the order THEALES, subclass Dilleniidae, class Magnoliopsida. It includes trees and shrubs with resinous, sticky sap, usually with broad-ended, oblong, leathery leaves with a strong, central vein, flowers with many stamens.[MeSH]
Rheedia calcicolaspecies[no description available]ClusiaceaeThe mangosteen plant family (sometimes classified as Guttiferae; also known as Hypericaceae) of the order THEALES, subclass Dilleniidae, class Magnoliopsida. It includes trees and shrubs with resinous, sticky sap, usually with broad-ended, oblong, leathery leaves with a strong, central vein, flowers with many stamens.[MeSH]

Cross-References

ID SourceID
PubMed CID16216670
CHEMBL ID388529
MeSH IDM0509850

Synonyms (3)

Synonym
guttiferone k
CHEMBL388529
(1r,3e,5s,6s,7r)-3-[(3,4-dihydroxyphenyl)-hydroxymethylidene]-6-methyl-1,5,7-tris(3-methylbut-2-enyl)-6-(4-methylpent-3-enyl)bicyclo[3.3.1]nonane-2,4,9-trione
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
DNA polymerase lambdaHomo sapiens (human)IC50 (µMol)5.40005.20005.30005.4000AID1323393
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Signal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)Kd20.60000.70000.70000.7000AID1070486
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (67)

Processvia Protein(s)Taxonomy
hematopoietic progenitor cell differentiationDNA topoisomerase 2-alphaHomo sapiens (human)
DNA topological changeDNA topoisomerase 2-alphaHomo sapiens (human)
DNA ligationDNA topoisomerase 2-alphaHomo sapiens (human)
DNA damage responseDNA topoisomerase 2-alphaHomo sapiens (human)
chromosome segregationDNA topoisomerase 2-alphaHomo sapiens (human)
female meiotic nuclear divisionDNA topoisomerase 2-alphaHomo sapiens (human)
apoptotic chromosome condensationDNA topoisomerase 2-alphaHomo sapiens (human)
embryonic cleavageDNA topoisomerase 2-alphaHomo sapiens (human)
regulation of circadian rhythmDNA topoisomerase 2-alphaHomo sapiens (human)
positive regulation of apoptotic processDNA topoisomerase 2-alphaHomo sapiens (human)
positive regulation of single stranded viral RNA replication via double stranded DNA intermediateDNA topoisomerase 2-alphaHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIDNA topoisomerase 2-alphaHomo sapiens (human)
rhythmic processDNA topoisomerase 2-alphaHomo sapiens (human)
negative regulation of DNA duplex unwindingDNA topoisomerase 2-alphaHomo sapiens (human)
resolution of meiotic recombination intermediatesDNA topoisomerase 2-alphaHomo sapiens (human)
sister chromatid segregationDNA topoisomerase 2-alphaHomo sapiens (human)
endothelial cell migrationSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
negative regulation of transcription by RNA polymerase IISignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
negative regulation of endothelial cell proliferationSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
positive regulation of mesenchymal cell proliferationSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
positive regulation of defense response to virus by hostSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
regulation of transcription by RNA polymerase IISignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
cell surface receptor signaling pathway via JAK-STATSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
response to nutrientSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
blood circulationSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
response to xenobiotic stimulusSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
response to mechanical stimulusSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
macrophage derived foam cell differentiationSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
negative regulation of angiogenesisSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
positive regulation of interferon-alpha productionSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
cellular response to insulin stimulusSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
tumor necrosis factor-mediated signaling pathwaySignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
response to cytokineSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
response to type II interferonSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
response to interferon-betaSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
cellular response to interferon-betaSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
interleukin-9-mediated signaling pathwaySignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
response to hydrogen peroxideSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
regulation of apoptotic processSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
negative regulation of canonical NF-kappaB signal transductionSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
response to peptide hormoneSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
positive regulation of erythrocyte differentiationSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
positive regulation of DNA-templated transcriptionSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
positive regulation of transcription by RNA polymerase IISignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
negative regulation by virus of viral protein levels in host cellSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
positive regulation of smooth muscle cell proliferationSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
response to cAMPSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
defense response to virusSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
positive regulation of nitric-oxide synthase biosynthetic processSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
type II interferon-mediated signaling pathwaySignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
type I interferon-mediated signaling pathwaySignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
renal tubule developmentSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
interleukin-27-mediated signaling pathwaySignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
cellular response to type II interferonSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
cellular response to organic cyclic compoundSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
metanephric mesenchymal cell proliferation involved in metanephros developmentSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
metanephric mesenchymal cell differentiationSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
negative regulation of metanephric nephron tubule epithelial cell differentiationSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
regulation of cell population proliferationSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
defense responseSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
double-strand break repair via homologous recombinationDNA polymerase lambdaHomo sapiens (human)
DNA replicationDNA polymerase lambdaHomo sapiens (human)
base-excision repair, gap-fillingDNA polymerase lambdaHomo sapiens (human)
nucleotide-excision repairDNA polymerase lambdaHomo sapiens (human)
double-strand break repair via nonhomologous end joiningDNA polymerase lambdaHomo sapiens (human)
somatic hypermutation of immunoglobulin genesDNA polymerase lambdaHomo sapiens (human)
DNA biosynthetic processDNA polymerase lambdaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (35)

Processvia Protein(s)Taxonomy
magnesium ion bindingDNA topoisomerase 2-alphaHomo sapiens (human)
DNA bindingDNA topoisomerase 2-alphaHomo sapiens (human)
chromatin bindingDNA topoisomerase 2-alphaHomo sapiens (human)
RNA bindingDNA topoisomerase 2-alphaHomo sapiens (human)
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activityDNA topoisomerase 2-alphaHomo sapiens (human)
protein kinase C bindingDNA topoisomerase 2-alphaHomo sapiens (human)
protein bindingDNA topoisomerase 2-alphaHomo sapiens (human)
ATP bindingDNA topoisomerase 2-alphaHomo sapiens (human)
ATP-dependent activity, acting on DNADNA topoisomerase 2-alphaHomo sapiens (human)
DNA binding, bendingDNA topoisomerase 2-alphaHomo sapiens (human)
protein homodimerization activityDNA topoisomerase 2-alphaHomo sapiens (human)
ubiquitin bindingDNA topoisomerase 2-alphaHomo sapiens (human)
protein heterodimerization activityDNA topoisomerase 2-alphaHomo sapiens (human)
RNA polymerase II transcription regulatory region sequence-specific DNA bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
RNA polymerase II core promoter sequence-specific DNA bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
transcription corepressor bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
transcription coactivator bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
double-stranded DNA bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
DNA-binding transcription factor activitySignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
tumor necrosis factor receptor bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
protein bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
nuclear receptor bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
enzyme bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
CCR5 chemokine receptor bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
histone acetyltransferase bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
histone bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
identical protein bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
protein homodimerization activitySignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
ubiquitin-like protein ligase bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
cadherin bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
protein phosphatase 2A bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
promoter-specific chromatin bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
DNA bindingDNA polymerase lambdaHomo sapiens (human)
DNA-directed DNA polymerase activityDNA polymerase lambdaHomo sapiens (human)
protein bindingDNA polymerase lambdaHomo sapiens (human)
metal ion bindingDNA polymerase lambdaHomo sapiens (human)
5'-deoxyribose-5-phosphate lyase activityDNA polymerase lambdaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (20)

Processvia Protein(s)Taxonomy
nucleolusDNA topoisomerase 2-alphaHomo sapiens (human)
nuclear chromosomeDNA topoisomerase 2-alphaHomo sapiens (human)
centrioleDNA topoisomerase 2-alphaHomo sapiens (human)
chromosome, centromeric regionDNA topoisomerase 2-alphaHomo sapiens (human)
condensed chromosomeDNA topoisomerase 2-alphaHomo sapiens (human)
male germ cell nucleusDNA topoisomerase 2-alphaHomo sapiens (human)
nucleusDNA topoisomerase 2-alphaHomo sapiens (human)
nucleoplasmDNA topoisomerase 2-alphaHomo sapiens (human)
nucleolusDNA topoisomerase 2-alphaHomo sapiens (human)
cytoplasmDNA topoisomerase 2-alphaHomo sapiens (human)
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complexDNA topoisomerase 2-alphaHomo sapiens (human)
protein-containing complexDNA topoisomerase 2-alphaHomo sapiens (human)
ribonucleoprotein complexDNA topoisomerase 2-alphaHomo sapiens (human)
nucleusDNA topoisomerase 2-alphaHomo sapiens (human)
nucleusSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
nucleusSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
nucleusSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
nucleoplasmSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
nucleolusSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
cytoplasmSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
cytosolSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
axonSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
dendriteSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
perinuclear region of cytoplasmSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
ISGF3 complexSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
RNA polymerase II transcription regulator complexSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
chromatinSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
protein-containing complexSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
cytoplasmSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
site of double-strand breakDNA polymerase lambdaHomo sapiens (human)
nucleusDNA polymerase lambdaHomo sapiens (human)
nucleoplasmDNA polymerase lambdaHomo sapiens (human)
nucleusDNA polymerase lambdaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (27)

Assay IDTitleYearJournalArticle
AID465637Cytotoxicity against human CCD-18Co cells at 5 uM after 24 hrs by MTT assay2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Cytotoxic acylphloroglucinol derivatives from the twigs of Garcinia cowa.
AID1540977Inhibition of human topoisomerase 2beta-mediated DNA cleavage at 12.5 to 200 uM using supercoiled pSG483 as substrate after 30 mins by ethidium bromide staining based gel electrophoresis method2019Journal of natural products, 10-25, Volume: 82, Issue:10
Garcinol and Related Polyisoprenylated Benzophenones as Topoisomerase II Inhibitors: Biochemical and Molecular Modeling Studies.
AID1540986Mixed-type inhibition of topoisomerase 2alpha ATPase activity (unknown origin) assessed as apparent Km at 10 uM using salmon sperm DNA as substrate measured every 30 secs for 90 mins in presence of ATP by pyruvate kinase/lactate dehydrogenase enzyme coupl2019Journal of natural products, 10-25, Volume: 82, Issue:10
Garcinol and Related Polyisoprenylated Benzophenones as Topoisomerase II Inhibitors: Biochemical and Molecular Modeling Studies.
AID1540981Mixed-type inhibition of topoisomerase 2alpha ATPase activity (unknown origin) assessed as apparent Vmax per mg protein at 10 uM using salmon sperm DNA as substrate measured every 30 secs for 90 mins in presence of ATP by pyruvate kinase/lactate dehydroge2019Journal of natural products, 10-25, Volume: 82, Issue:10
Garcinol and Related Polyisoprenylated Benzophenones as Topoisomerase II Inhibitors: Biochemical and Molecular Modeling Studies.
AID1323394Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay2016Journal of natural products, 07-22, Volume: 79, Issue:7
Polyprenylated Benzoylphloroglucinols with DNA Polymerase Inhibitory Activity from the Fruits of Garcinia schomburgkiana.
AID1540982Mixed-type inhibition of topoisomerase 2alpha ATPase activity (unknown origin) assessed as apparent Vmax per mg protein at 25 uM using salmon sperm DNA as substrate measured every 30 secs for 90 mins in presence of ATP by pyruvate kinase/lactate dehydroge2019Journal of natural products, 10-25, Volume: 82, Issue:10
Garcinol and Related Polyisoprenylated Benzophenones as Topoisomerase II Inhibitors: Biochemical and Molecular Modeling Studies.
AID1070482Inhibition of STAT1 in human MDA-MD-231 cells assessed as suppression of INFgamma-induced SOCS-1 expression at 25 to 40 uM by Northern blotting technique2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Direct interaction of garcinol and related polyisoprenylated benzophenones of Garcinia cambogia fruits with the transcription factor STAT-1 as a likely mechanism of their inhibitory effect on cytokine signaling pathways.
AID1540989Mixed-type inhibition of topoisomerase 2alpha ATPase activity (unknown origin) assessed as apparent Km at 5 uM using salmon sperm DNA as substrate measured every 30 secs for 90 mins in presence of ATP by pyruvate kinase/lactate dehydrogenase enzyme couple2019Journal of natural products, 10-25, Volume: 82, Issue:10
Garcinol and Related Polyisoprenylated Benzophenones as Topoisomerase II Inhibitors: Biochemical and Molecular Modeling Studies.
AID1323393Inhibition of recombinant human His-tagged DNA polymerase lambda assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as template/primer preincubated for 10 mins followed by template/primer addition measured after 60 mins2016Journal of natural products, 07-22, Volume: 79, Issue:7
Polyprenylated Benzoylphloroglucinols with DNA Polymerase Inhibitory Activity from the Fruits of Garcinia schomburgkiana.
AID465635Cytotoxicity against human HCT116 cells at 5 uM after 24 hrs by MTT assay2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Cytotoxic acylphloroglucinol derivatives from the twigs of Garcinia cowa.
AID1070477Inhibition of INFgamma-induced STAT1 activation in rat INS-1E cells assessed as reduction of STAT1-DNA binding activity at 10 uM preincubated for 30 mins followed by cytokine challenge measured after 60 mins by electrophoretic mobility shift assay2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Direct interaction of garcinol and related polyisoprenylated benzophenones of Garcinia cambogia fruits with the transcription factor STAT-1 as a likely mechanism of their inhibitory effect on cytokine signaling pathways.
AID1540987Mixed-type inhibition of topoisomerase 2alpha ATPase activity (unknown origin) assessed as apparent Km at 25 uM using salmon sperm DNA as substrate measured every 30 secs for 90 mins in presence of ATP by pyruvate kinase/lactate dehydrogenase enzyme coupl2019Journal of natural products, 10-25, Volume: 82, Issue:10
Garcinol and Related Polyisoprenylated Benzophenones as Topoisomerase II Inhibitors: Biochemical and Molecular Modeling Studies.
AID1540973Inhibition of human topoisomerase 2beta-mediated relaxation of supercoiled pSG483 DNA at 12.5 to 200 uM after 30 mins by ethidium bromide staining based agarose gel electrophoresis method2019Journal of natural products, 10-25, Volume: 82, Issue:10
Garcinol and Related Polyisoprenylated Benzophenones as Topoisomerase II Inhibitors: Biochemical and Molecular Modeling Studies.
AID465634Cytotoxicity against human CCD-18Co cells at 5 uM after 48 hrs by MTT assay2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Cytotoxic acylphloroglucinol derivatives from the twigs of Garcinia cowa.
AID1070478Inhibition of TNFalpha-induced NFkappaB activation in rat INS-1E cells assessed as reduction of NFkappaB-DNA binding activity at 25 uM preincubated for 30 mins followed by cytokine challenge measured after 60 mins by electrophoretic mobility shift assay2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Direct interaction of garcinol and related polyisoprenylated benzophenones of Garcinia cambogia fruits with the transcription factor STAT-1 as a likely mechanism of their inhibitory effect on cytokine signaling pathways.
AID1070479Inhibition of TNFalpha-induced NFkappaB activation in human MDA-MB-231 cells assessed as reduction of NFkappaB-DNA binding activity at 50 uM preincubated for 30 mins followed by cytokine challenge measured after 60 mins by electrophoretic mobility shift a2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Direct interaction of garcinol and related polyisoprenylated benzophenones of Garcinia cambogia fruits with the transcription factor STAT-1 as a likely mechanism of their inhibitory effect on cytokine signaling pathways.
AID465636Cytotoxicity against human HT-29 cells after 24 hrs by MTT assay2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Cytotoxic acylphloroglucinol derivatives from the twigs of Garcinia cowa.
AID1070486Binding affinity to STAT1 (unknown origin) by surface plasmon resonance assay2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Direct interaction of garcinol and related polyisoprenylated benzophenones of Garcinia cambogia fruits with the transcription factor STAT-1 as a likely mechanism of their inhibitory effect on cytokine signaling pathways.
AID1070485Inhibition of INFgamma-induced STAT1 activation in human MDA-MD-231 cells assessed as reduction of STAT1-DNA binding activity preincubated for 30 mins followed by cytokine challenge measured after 60 mins by electrophoretic mobility shift assay2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Direct interaction of garcinol and related polyisoprenylated benzophenones of Garcinia cambogia fruits with the transcription factor STAT-1 as a likely mechanism of their inhibitory effect on cytokine signaling pathways.
AID465633Cytotoxicity against human HT-29 cells at 5 uM after 24 hrs by MTT assay2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Cytotoxic acylphloroglucinol derivatives from the twigs of Garcinia cowa.
AID1070481Inhibition of INFgamma-induced STAT1 activation in rat INS-1E cells assessed as reduction of STAT1-DNA binding activity at 25 uM preincubated for 30 mins followed by cytokine challenge measured after 60 mins by electrophoretic mobility shift assay2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Direct interaction of garcinol and related polyisoprenylated benzophenones of Garcinia cambogia fruits with the transcription factor STAT-1 as a likely mechanism of their inhibitory effect on cytokine signaling pathways.
AID1323392Inhibition of calf thymus DNA polymerase alpha assessed as reduction in [3H]dTTP incorporation using poly(dA)/oligo(dT)18 as template/primer preincubated for 10 mins followed by template/primer addition measured after 60 mins2016Journal of natural products, 07-22, Volume: 79, Issue:7
Polyprenylated Benzoylphloroglucinols with DNA Polymerase Inhibitory Activity from the Fruits of Garcinia schomburgkiana.
AID1540972Inhibition of human topoisomerase 2alpha-mediated relaxation of supercoiled pSG483 DNA at 12.5 to 200 uM after 30 mins by ethidium bromide staining based agarose gel electrophoresis method2019Journal of natural products, 10-25, Volume: 82, Issue:10
Garcinol and Related Polyisoprenylated Benzophenones as Topoisomerase II Inhibitors: Biochemical and Molecular Modeling Studies.
AID1540984Mixed-type inhibition of topoisomerase 2alpha ATPase activity (unknown origin) assessed as apparent Vmax per mg protein at 5 uM using salmon sperm DNA as substrate measured every 30 secs for 90 mins in presence of ATP by pyruvate kinase/lactate dehydrogen2019Journal of natural products, 10-25, Volume: 82, Issue:10
Garcinol and Related Polyisoprenylated Benzophenones as Topoisomerase II Inhibitors: Biochemical and Molecular Modeling Studies.
AID283784Antiproliferative activity against human A2780 cells2007Journal of natural products, Apr, Volume: 70, Issue:4
Guttiferones K and L, antiproliferative compounds of Rheedia calcicola from the Madagascar rain forest.
AID1070483Inhibition of INFgamma-induced STAT1 activation in human MDA-MD-231 cells assessed as reduction of STAT1-DNA binding activity at 50 uM preincubated for 30 mins followed by cytokine challenge measured after 60 mins by electrophoretic mobility shift assay2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Direct interaction of garcinol and related polyisoprenylated benzophenones of Garcinia cambogia fruits with the transcription factor STAT-1 as a likely mechanism of their inhibitory effect on cytokine signaling pathways.
AID1540976Inhibition of human topoisomerase 2alpha-mediated DNA cleavage at 12.5 to 200 uM using supercoiled pSG483 as substrate after 30 mins by ethidium bromide staining based gel electrophoresis method2019Journal of natural products, 10-25, Volume: 82, Issue:10
Garcinol and Related Polyisoprenylated Benzophenones as Topoisomerase II Inhibitors: Biochemical and Molecular Modeling Studies.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (25.00)29.6817
2010's9 (75.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.17

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.17 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.73 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.17)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.0810nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
hydroxychloroquine
Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970). hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.		2.1110aminoquinoline;
organochlorine compound;
primary alcohol;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
dermatologic drug
pyrazolanthrone
pyrazolanthrone: JNK (c-Jun N-terminal kinase) inhibitor; structure in first source. anthra[1,9-cd]pyrazol-6(2H)-one : A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.		2.0810anthrapyrazole;
aromatic ketone;
cyclic ketone		antineoplastic agent;
c-Jun N-terminal kinase inhibitor;
geroprotector
2',3'-dideoxythymidine triphosphate
ddTTP : A pyrimidine 2',3'-dideoxyribonucleoside 5'-triphosphate having thymine as the nucleobase.		2.1310pyrimidine 2',3'-dideoxyribonucleoside 5'-triphosphate;
thymidine phosphate
epigallocatechin gallate
epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.		2.110flavans;
gallate ester;
polyphenol		antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite
peroxynitrous acid
Peroxynitrous Acid: A potent oxidant synthesized by the cell during its normal metabolism. Peroxynitrite is formed from the reaction of two free radicals, NITRIC OXIDE and the superoxide anion (SUPEROXIDES).		2.0510nitrogen oxoacid
aphidicolin
Aphidicolin: An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.. aphidicolin : A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positions 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication.		2.1310tetracyclic diterpenoidantimicrobial agent;
antimitotic;
antineoplastic agent;
antiviral drug;
apoptosis inducer;
Aspergillus metabolite;
DNA synthesis inhibitor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
fungal metabolite
garcinol
garcinol: from stem bark of Garcinia huillensis; has chemotherapeutic activity against gram-positive & gram-negative cocci, mycobacteria & fungi		7.7530
guttiferone e
guttiferone E: isolated from the fruits of Garcinia pyrifera collected in Malaysia; structure in first source		2.2110
oblongifolin c
oblongifolin C: has antineoplastic activity; isolated from Garcinia yunnanensis; structure in first source		7.7930
cambogin
isogarcinol: has immunosuppresant activity; isolated from Garcinia mangostana; structure in first source		2.0510
cyclin d1
Cyclin D1: Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials
Carcinogenesis
The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.		02.1310
Cancer of Prostate
[description not available]		02.1310
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.1310
Hepatocellular Carcinoma
[description not available]		07.1310
Cancer of Liver
[description not available]		02.1310
Metastase
[description not available]		02.1310
Invasiveness, Neoplasm
[description not available]		02.1310
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.1310
Liver Neoplasms
Tumors or cancer of the LIVER.		02.1310
Neoplasm Metastasis
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.		02.1310
Cancer of Colon
[description not available]		02.0810
Colonic Neoplasms
Tumors or cancer of the COLON.		02.0810