Compounds > abt-100
Page last updated: 2024-12-11

abt-100

Description

ABT-100: farnesyltransferase inhibitor; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6451154
CHEMBL ID4586794
SCHEMBL ID2731728
MeSH IDM0488416

Synonyms (19)

Synonym
a-409100
abt-100
abt100
4-[(2s)-2-(4-cyanophenyl)-2-hydroxy-2-(3-methylimidazol-4-yl)ethoxy]-3-[4-(trifluoromethoxy)phenyl]benzonitrile
qg74wr2hre ,
450839-40-4
abt 100
unii-qg74wr2hre
SCHEMBL2731728
DTXSID60196377
heuvrfnvtlgkmz-sanmltnesa-n
CS-0077432
HY-119257
MS-29364
CHEMBL4586794
(1,1'-biphenyl)-3-carbonitrile, 6-((2s)-2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1h-imidazol-5-yl)ethoxy)-4'-(trifluoromethoxy)-
6-((2s)-2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1h-imidazol-5-yl)ethoxy)-4'-(trifluoromethoxy)-1,1'-biphenyl-3-carbonitrile
6-((2s)-2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1h-imidazol-5-yl)ethoxy)-4'-(trifluoromethoxy)(1,1'-biphenyl)-3-carbonitrile
AKOS040732365

Research Excerpts

Bioavailability

ABT-100 is a highly selective, potent and orally bioavailable FTI. It shows 70% to 80% oral bioavailability in mice.

ExcerptReferenceRelevance
" ABT-100 shows 70% to 80% oral bioavailability in mice."( Antitumor activity of orally bioavailable farnesyltransferase inhibitor, ABT-100, is mediated by antiproliferative, proapoptotic, and antiangiogenic effects in xenograft models.
Bauch, J; Ferguson, D; Frost, D; Jarvis, K; Joseph, IB; Lin, NH; Marsh, K; O'Connor, J; Palma, JP; Refici, M; Rodriguez, LE; Rosenberg, S; Sham, HL; Sullivan, GM; Zhang, H, 2005)		1.47
" ABT-100 is a highly selective, potent and orally bioavailable FTI."( A highly potent and selective farnesyltransferase inhibitor ABT-100 in preclinical studies.
Anderson, MG; Cohen, J; Ferguson, D; Frost, D; Gu, WZ; Harlan, JE; Holzman, T; Jakob, CG; Jarvis, KP; Joseph, I; Kroeger, P; Ladror, US; Lin, NH; Marsh, K; Muchmore, SW; Ng, S; Rodriguez, LE; Rosenberg, SH; Sham, HL; Stoll, VS; Sullivan, GM; Walten, KA; Wang, L; Wang, YC; Zhang, H, 2005)		1.48

Dosage Studied

ExcerptRelevanceReference
" In a Wistar to Lewis rat heterotopic cardiac transplant model, ABT-100 was orally dosed alone or with a subtherapeutic course of cyclosporine (CsA)."( Potent farnesyltransferase inhibitor ABT-100 abrogates acute allograft rejection.
Imagawa, DK; Ji, P; Kusumoto, J; Kwok, J; Lee, M; Naasz, E; Ng, SC; Si, MS, 2005)		0.84
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (9)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Histamine H1 receptorHomo sapiens (human)Ki10.00000.00000.511010.0000AID1794426
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Ephrin type-A receptor 1Homo sapiens (human)Kd10.00000.00411.80009.8000AID1794066
Cyclin-dependent kinase 7Homo sapiens (human)Kd10.00000.00251.67837.7000AID1794010
Serine/threonine-protein kinase BRSK2Homo sapiens (human)Kd10.00000.00351.98638.9000AID1793985
Serine/threonine-protein kinase Nek7Homo sapiens (human)Kd10.00000.00303.67198.7000AID1794229
Aurora kinase BHomo sapiens (human)Kd10.00000.00201.061422.8520AID1793972
Homeodomain-interacting protein kinase 2Homo sapiens (human)Kd10.00000.00731.37395.0000AID1794125
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (129)

Processvia Protein(s)Taxonomy
positive regulation of cell-matrix adhesionEphrin type-A receptor 1Homo sapiens (human)
negative regulation of protein kinase activityEphrin type-A receptor 1Homo sapiens (human)
cell surface receptor signaling pathwayEphrin type-A receptor 1Homo sapiens (human)
positive regulation of cell population proliferationEphrin type-A receptor 1Homo sapiens (human)
peptidyl-tyrosine phosphorylationEphrin type-A receptor 1Homo sapiens (human)
positive regulation of cell migrationEphrin type-A receptor 1Homo sapiens (human)
negative regulation of cell migrationEphrin type-A receptor 1Homo sapiens (human)
substrate adhesion-dependent cell spreadingEphrin type-A receptor 1Homo sapiens (human)
regulation of GTPase activityEphrin type-A receptor 1Homo sapiens (human)
positive regulation of angiogenesisEphrin type-A receptor 1Homo sapiens (human)
protein autophosphorylationEphrin type-A receptor 1Homo sapiens (human)
positive regulation of stress fiber assemblyEphrin type-A receptor 1Homo sapiens (human)
activation of GTPase activityEphrin type-A receptor 1Homo sapiens (human)
positive regulation of kinase activityEphrin type-A receptor 1Homo sapiens (human)
multicellular organism developmentEphrin type-A receptor 1Homo sapiens (human)
angiogenesisEphrin type-A receptor 1Homo sapiens (human)
ephrin receptor signaling pathwayEphrin type-A receptor 1Homo sapiens (human)
inflammatory responseHistamine H1 receptorHomo sapiens (human)
G protein-coupled receptor signaling pathwayHistamine H1 receptorHomo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathwayHistamine H1 receptorHomo sapiens (human)
memoryHistamine H1 receptorHomo sapiens (human)
visual learningHistamine H1 receptorHomo sapiens (human)
regulation of vascular permeabilityHistamine H1 receptorHomo sapiens (human)
positive regulation of vasoconstrictionHistamine H1 receptorHomo sapiens (human)
regulation of synaptic plasticityHistamine H1 receptorHomo sapiens (human)
cellular response to histamineHistamine H1 receptorHomo sapiens (human)
G protein-coupled serotonin receptor signaling pathwayHistamine H1 receptorHomo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerHistamine H1 receptorHomo sapiens (human)
chemical synaptic transmissionHistamine H1 receptorHomo sapiens (human)
signal transductionBeta-adrenergic receptor kinase 2Homo sapiens (human)
G protein-coupled receptor signaling pathwayBeta-adrenergic receptor kinase 2Homo sapiens (human)
receptor internalizationBeta-adrenergic receptor kinase 2Homo sapiens (human)
protein phosphorylationBeta-adrenergic receptor kinase 2Homo sapiens (human)
desensitization of G protein-coupled receptor signaling pathwayBeta-adrenergic receptor kinase 2Homo sapiens (human)
DNA repairCyclin-dependent kinase 7Homo sapiens (human)
transcription by RNA polymerase IICyclin-dependent kinase 7Homo sapiens (human)
transcription initiation at RNA polymerase II promoterCyclin-dependent kinase 7Homo sapiens (human)
snRNA transcription by RNA polymerase IICyclin-dependent kinase 7Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICyclin-dependent kinase 7Homo sapiens (human)
protein stabilizationCyclin-dependent kinase 7Homo sapiens (human)
cell divisionCyclin-dependent kinase 7Homo sapiens (human)
regulation of cell cycleCyclin-dependent kinase 7Homo sapiens (human)
regulation of G1/S transition of mitotic cell cycleCyclin-dependent kinase 7Homo sapiens (human)
protein phosphorylationCyclin-dependent kinase 7Homo sapiens (human)
peptidyl-serine phosphorylationCalcium/calmodulin-dependent protein kinase type 1BHomo sapiens (human)
G2/M transition of mitotic cell cycleSerine/threonine-protein kinase BRSK2Homo sapiens (human)
protein phosphorylationSerine/threonine-protein kinase BRSK2Homo sapiens (human)
exocytosisSerine/threonine-protein kinase BRSK2Homo sapiens (human)
axonogenesisSerine/threonine-protein kinase BRSK2Homo sapiens (human)
regulation of neuron projection developmentSerine/threonine-protein kinase BRSK2Homo sapiens (human)
establishment of cell polaritySerine/threonine-protein kinase BRSK2Homo sapiens (human)
actin cytoskeleton organizationSerine/threonine-protein kinase BRSK2Homo sapiens (human)
neuron differentiationSerine/threonine-protein kinase BRSK2Homo sapiens (human)
ERAD pathwaySerine/threonine-protein kinase BRSK2Homo sapiens (human)
regulation of ATP-dependent activitySerine/threonine-protein kinase BRSK2Homo sapiens (human)
regulation of axonogenesisSerine/threonine-protein kinase BRSK2Homo sapiens (human)
cell divisionSerine/threonine-protein kinase BRSK2Homo sapiens (human)
regulation of insulin secretion involved in cellular response to glucose stimulusSerine/threonine-protein kinase BRSK2Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressSerine/threonine-protein kinase BRSK2Homo sapiens (human)
microtubule cytoskeleton organization involved in establishment of planar polaritySerine/threonine-protein kinase BRSK2Homo sapiens (human)
regulation of retrograde protein transport, ER to cytosolSerine/threonine-protein kinase BRSK2Homo sapiens (human)
regulation of synaptic vesicle clusteringSerine/threonine-protein kinase BRSK2Homo sapiens (human)
protein phosphorylationSerine/threonine-protein kinase Nek7Homo sapiens (human)
regulation of mitotic cell cycleSerine/threonine-protein kinase Nek7Homo sapiens (human)
positive regulation of telomere maintenance via telomeraseSerine/threonine-protein kinase Nek7Homo sapiens (human)
cellular response to potassium ionSerine/threonine-protein kinase Nek7Homo sapiens (human)
spindle assemblySerine/threonine-protein kinase Nek7Homo sapiens (human)
positive regulation of telomerase activitySerine/threonine-protein kinase Nek7Homo sapiens (human)
positive regulation of NLRP3 inflammasome complex assemblySerine/threonine-protein kinase Nek7Homo sapiens (human)
positive regulation of telomere cappingSerine/threonine-protein kinase Nek7Homo sapiens (human)
peptidyl-serine phosphorylationSerine/threonine-protein kinase Nek7Homo sapiens (human)
negative regulation of transcription by RNA polymerase IIAurora kinase BHomo sapiens (human)
mitotic cell cycleAurora kinase BHomo sapiens (human)
mitotic cytokinesisAurora kinase BHomo sapiens (human)
negative regulation of B cell apoptotic processAurora kinase BHomo sapiens (human)
protein phosphorylationAurora kinase BHomo sapiens (human)
spindle organizationAurora kinase BHomo sapiens (human)
attachment of spindle microtubules to kinetochoreAurora kinase BHomo sapiens (human)
abscissionAurora kinase BHomo sapiens (human)
negative regulation of protein bindingAurora kinase BHomo sapiens (human)
positive regulation of telomere maintenance via telomeraseAurora kinase BHomo sapiens (human)
negative regulation of cytokinesisAurora kinase BHomo sapiens (human)
positive regulation of cytokinesisAurora kinase BHomo sapiens (human)
protein localization to kinetochoreAurora kinase BHomo sapiens (human)
cellular response to UVAurora kinase BHomo sapiens (human)
cleavage furrow formationAurora kinase BHomo sapiens (human)
post-translational protein modificationAurora kinase BHomo sapiens (human)
cell cycle G2/M phase transitionAurora kinase BHomo sapiens (human)
mitotic cytokinesis checkpoint signalingAurora kinase BHomo sapiens (human)
negative regulation of innate immune responseAurora kinase BHomo sapiens (human)
protein autophosphorylationAurora kinase BHomo sapiens (human)
mitotic spindle midzone assemblyAurora kinase BHomo sapiens (human)
positive regulation of telomerase activityAurora kinase BHomo sapiens (human)
regulation of chromosome segregationAurora kinase BHomo sapiens (human)
positive regulation of mitotic sister chromatid segregationAurora kinase BHomo sapiens (human)
positive regulation of mitotic cell cycle spindle assembly checkpointAurora kinase BHomo sapiens (human)
mitotic spindle assemblyAurora kinase BHomo sapiens (human)
negative regulation of cGAS/STING signaling pathwayAurora kinase BHomo sapiens (human)
regulation of signal transduction by p53 class mediatorAurora kinase BHomo sapiens (human)
positive regulation of mitotic sister chromatid separationAurora kinase BHomo sapiens (human)
positive regulation of attachment of mitotic spindle microtubules to kinetochoreAurora kinase BHomo sapiens (human)
positive regulation of mitotic cytokinesisAurora kinase BHomo sapiens (human)
positive regulation of telomere cappingAurora kinase BHomo sapiens (human)
positive regulation of lateral attachment of mitotic spindle microtubules to kinetochoreAurora kinase BHomo sapiens (human)
mitotic spindle organizationAurora kinase BHomo sapiens (human)
regulation of cytokinesisAurora kinase BHomo sapiens (human)
negative regulation of transcription by RNA polymerase IIHomeodomain-interacting protein kinase 2Homo sapiens (human)
eye developmentHomeodomain-interacting protein kinase 2Homo sapiens (human)
positive regulation of protein phosphorylationHomeodomain-interacting protein kinase 2Homo sapiens (human)
respiratory system processHomeodomain-interacting protein kinase 2Homo sapiens (human)
protein phosphorylationHomeodomain-interacting protein kinase 2Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayHomeodomain-interacting protein kinase 2Homo sapiens (human)
adult walking behaviorHomeodomain-interacting protein kinase 2Homo sapiens (human)
cell population proliferationHomeodomain-interacting protein kinase 2Homo sapiens (human)
positive regulation of cell population proliferationHomeodomain-interacting protein kinase 2Homo sapiens (human)
anterior/posterior pattern specificationHomeodomain-interacting protein kinase 2Homo sapiens (human)
gene expressionHomeodomain-interacting protein kinase 2Homo sapiens (human)
retina layer formationHomeodomain-interacting protein kinase 2Homo sapiens (human)
peptidyl-serine phosphorylationHomeodomain-interacting protein kinase 2Homo sapiens (human)
peptidyl-threonine phosphorylationHomeodomain-interacting protein kinase 2Homo sapiens (human)
neuron differentiationHomeodomain-interacting protein kinase 2Homo sapiens (human)
erythrocyte differentiationHomeodomain-interacting protein kinase 2Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediatorHomeodomain-interacting protein kinase 2Homo sapiens (human)
positive regulation of transforming growth factor beta receptor signaling pathwayHomeodomain-interacting protein kinase 2Homo sapiens (human)
negative regulation of BMP signaling pathwayHomeodomain-interacting protein kinase 2Homo sapiens (human)
PML body organizationHomeodomain-interacting protein kinase 2Homo sapiens (human)
thyroid gland developmentHomeodomain-interacting protein kinase 2Homo sapiens (human)
positive regulation of protein bindingHomeodomain-interacting protein kinase 2Homo sapiens (human)
epigenetic regulation of gene expressionHomeodomain-interacting protein kinase 2Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorHomeodomain-interacting protein kinase 2Homo sapiens (human)
negative regulation of neuron apoptotic processHomeodomain-interacting protein kinase 2Homo sapiens (human)
positive regulation of angiogenesisHomeodomain-interacting protein kinase 2Homo sapiens (human)
positive regulation of transcription by RNA polymerase IIHomeodomain-interacting protein kinase 2Homo sapiens (human)
positive regulation of JNK cascadeHomeodomain-interacting protein kinase 2Homo sapiens (human)
embryonic camera-type eye morphogenesisHomeodomain-interacting protein kinase 2Homo sapiens (human)
voluntary musculoskeletal movementHomeodomain-interacting protein kinase 2Homo sapiens (human)
positive regulation of DNA-binding transcription factor activityHomeodomain-interacting protein kinase 2Homo sapiens (human)
neuron apoptotic processHomeodomain-interacting protein kinase 2Homo sapiens (human)
regulation of cell cycleHomeodomain-interacting protein kinase 2Homo sapiens (human)
embryonic retina morphogenesis in camera-type eyeHomeodomain-interacting protein kinase 2Homo sapiens (human)
lens induction in camera-type eyeHomeodomain-interacting protein kinase 2Homo sapiens (human)
SMAD protein signal transductionHomeodomain-interacting protein kinase 2Homo sapiens (human)
lung morphogenesisHomeodomain-interacting protein kinase 2Homo sapiens (human)
iris morphogenesisHomeodomain-interacting protein kinase 2Homo sapiens (human)
cellular response to hypoxiaHomeodomain-interacting protein kinase 2Homo sapiens (human)
intrinsic apoptotic signaling pathwayHomeodomain-interacting protein kinase 2Homo sapiens (human)
regulation of signal transduction by p53 class mediatorHomeodomain-interacting protein kinase 2Homo sapiens (human)
negative regulation of ubiquitin-dependent protein catabolic processHomeodomain-interacting protein kinase 2Homo sapiens (human)
smoothened signaling pathwayHomeodomain-interacting protein kinase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (35)

Processvia Protein(s)Taxonomy
fibronectin bindingEphrin type-A receptor 1Homo sapiens (human)
protein kinase activityEphrin type-A receptor 1Homo sapiens (human)
transmembrane-ephrin receptor activityEphrin type-A receptor 1Homo sapiens (human)
ATP bindingEphrin type-A receptor 1Homo sapiens (human)
protein kinase bindingEphrin type-A receptor 1Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activityEphrin type-A receptor 1Homo sapiens (human)
histamine receptor activityHistamine H1 receptorHomo sapiens (human)
G protein-coupled serotonin receptor activityHistamine H1 receptorHomo sapiens (human)
neurotransmitter receptor activityHistamine H1 receptorHomo sapiens (human)
protein kinase activityBeta-adrenergic receptor kinase 2Homo sapiens (human)
protein bindingBeta-adrenergic receptor kinase 2Homo sapiens (human)
ATP bindingBeta-adrenergic receptor kinase 2Homo sapiens (human)
beta-adrenergic receptor kinase activityBeta-adrenergic receptor kinase 2Homo sapiens (human)
G protein-coupled receptor bindingBeta-adrenergic receptor kinase 2Homo sapiens (human)
G protein-coupled receptor kinase activityBeta-adrenergic receptor kinase 2Homo sapiens (human)
protein kinase activityCyclin-dependent kinase 7Homo sapiens (human)
protein serine/threonine kinase activityCyclin-dependent kinase 7Homo sapiens (human)
protein bindingCyclin-dependent kinase 7Homo sapiens (human)
ATP bindingCyclin-dependent kinase 7Homo sapiens (human)
ATP-dependent activity, acting on DNACyclin-dependent kinase 7Homo sapiens (human)
RNA polymerase II CTD heptapeptide repeat kinase activityCyclin-dependent kinase 7Homo sapiens (human)
protein serine kinase activityCyclin-dependent kinase 7Homo sapiens (human)
cyclin-dependent protein serine/threonine kinase activityCyclin-dependent kinase 7Homo sapiens (human)
ATP bindingCalcium/calmodulin-dependent protein kinase type 1BHomo sapiens (human)
protein serine kinase activityCalcium/calmodulin-dependent protein kinase type 1BHomo sapiens (human)
calmodulin bindingCalcium/calmodulin-dependent protein kinase type 1BHomo sapiens (human)
calmodulin-dependent protein kinase activityCalcium/calmodulin-dependent protein kinase type 1BHomo sapiens (human)
magnesium ion bindingSerine/threonine-protein kinase BRSK2Homo sapiens (human)
protein serine/threonine kinase activitySerine/threonine-protein kinase BRSK2Homo sapiens (human)
protein bindingSerine/threonine-protein kinase BRSK2Homo sapiens (human)
ATP bindingSerine/threonine-protein kinase BRSK2Homo sapiens (human)
protein kinase bindingSerine/threonine-protein kinase BRSK2Homo sapiens (human)
tau protein bindingSerine/threonine-protein kinase BRSK2Homo sapiens (human)
tau-protein kinase activitySerine/threonine-protein kinase BRSK2Homo sapiens (human)
ATPase bindingSerine/threonine-protein kinase BRSK2Homo sapiens (human)
ATPase regulator activitySerine/threonine-protein kinase BRSK2Homo sapiens (human)
protein serine kinase activitySerine/threonine-protein kinase BRSK2Homo sapiens (human)
protein serine/threonine kinase activitySerine/threonine-protein kinase Nek7Homo sapiens (human)
protein bindingSerine/threonine-protein kinase Nek7Homo sapiens (human)
ATP bindingSerine/threonine-protein kinase Nek7Homo sapiens (human)
metal ion bindingSerine/threonine-protein kinase Nek7Homo sapiens (human)
protein serine kinase activitySerine/threonine-protein kinase Nek7Homo sapiens (human)
molecular function activator activitySerine/threonine-protein kinase Nek7Homo sapiens (human)
protein serine/threonine kinase activityAurora kinase BHomo sapiens (human)
protein serine/threonine kinase activityAurora kinase BHomo sapiens (human)
protein serine/threonine/tyrosine kinase activityAurora kinase BHomo sapiens (human)
protein bindingAurora kinase BHomo sapiens (human)
ATP bindingAurora kinase BHomo sapiens (human)
kinase bindingAurora kinase BHomo sapiens (human)
protein serine kinase activityAurora kinase BHomo sapiens (human)
transcription coactivator activityHomeodomain-interacting protein kinase 2Homo sapiens (human)
transcription corepressor activityHomeodomain-interacting protein kinase 2Homo sapiens (human)
protein kinase activityHomeodomain-interacting protein kinase 2Homo sapiens (human)
protein serine/threonine kinase activityHomeodomain-interacting protein kinase 2Homo sapiens (human)
protein bindingHomeodomain-interacting protein kinase 2Homo sapiens (human)
ATP bindingHomeodomain-interacting protein kinase 2Homo sapiens (human)
SMAD bindingHomeodomain-interacting protein kinase 2Homo sapiens (human)
virion bindingHomeodomain-interacting protein kinase 2Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingHomeodomain-interacting protein kinase 2Homo sapiens (human)
protein serine kinase activityHomeodomain-interacting protein kinase 2Homo sapiens (human)
protein tyrosine kinase activityHomeodomain-interacting protein kinase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (42)

Processvia Protein(s)Taxonomy
plasma membraneEphrin type-A receptor 1Homo sapiens (human)
receptor complexEphrin type-A receptor 1Homo sapiens (human)
plasma membraneEphrin type-A receptor 1Homo sapiens (human)
cytosolHistamine H1 receptorHomo sapiens (human)
plasma membraneHistamine H1 receptorHomo sapiens (human)
synapseHistamine H1 receptorHomo sapiens (human)
dendriteHistamine H1 receptorHomo sapiens (human)
plasma membraneHistamine H1 receptorHomo sapiens (human)
cytosolBeta-adrenergic receptor kinase 2Homo sapiens (human)
plasma membraneBeta-adrenergic receptor kinase 2Homo sapiens (human)
cell projectionBeta-adrenergic receptor kinase 2Homo sapiens (human)
presynapseBeta-adrenergic receptor kinase 2Homo sapiens (human)
postsynapseBeta-adrenergic receptor kinase 2Homo sapiens (human)
cyclin-dependent protein kinase holoenzyme complexCyclin-dependent kinase 7Homo sapiens (human)
fibrillar centerCyclin-dependent kinase 7Homo sapiens (human)
male germ cell nucleusCyclin-dependent kinase 7Homo sapiens (human)
nucleusCyclin-dependent kinase 7Homo sapiens (human)
nucleoplasmCyclin-dependent kinase 7Homo sapiens (human)
cytosolCyclin-dependent kinase 7Homo sapiens (human)
plasma membraneCyclin-dependent kinase 7Homo sapiens (human)
perinuclear region of cytoplasmCyclin-dependent kinase 7Homo sapiens (human)
transcription factor TFIIH core complexCyclin-dependent kinase 7Homo sapiens (human)
transcription factor TFIIH holo complexCyclin-dependent kinase 7Homo sapiens (human)
CAK-ERCC2 complexCyclin-dependent kinase 7Homo sapiens (human)
transcription factor TFIIK complexCyclin-dependent kinase 7Homo sapiens (human)
cytoplasmCyclin-dependent kinase 7Homo sapiens (human)
nucleusCyclin-dependent kinase 7Homo sapiens (human)
nucleusCalcium/calmodulin-dependent protein kinase type 1BHomo sapiens (human)
cytoplasmCalcium/calmodulin-dependent protein kinase type 1BHomo sapiens (human)
intracellular anatomical structureCalcium/calmodulin-dependent protein kinase type 1BHomo sapiens (human)
cytoplasmSerine/threonine-protein kinase BRSK2Homo sapiens (human)
endoplasmic reticulumSerine/threonine-protein kinase BRSK2Homo sapiens (human)
centrosomeSerine/threonine-protein kinase BRSK2Homo sapiens (human)
perinuclear region of cytoplasmSerine/threonine-protein kinase BRSK2Homo sapiens (human)
distal axonSerine/threonine-protein kinase BRSK2Homo sapiens (human)
centrosomeSerine/threonine-protein kinase BRSK2Homo sapiens (human)
microtubule organizing centerSerine/threonine-protein kinase Nek7Homo sapiens (human)
spindle poleSerine/threonine-protein kinase Nek7Homo sapiens (human)
nucleoplasmSerine/threonine-protein kinase Nek7Homo sapiens (human)
cytoplasmSerine/threonine-protein kinase Nek7Homo sapiens (human)
centrosomeSerine/threonine-protein kinase Nek7Homo sapiens (human)
microtubuleSerine/threonine-protein kinase Nek7Homo sapiens (human)
nucleusSerine/threonine-protein kinase Nek7Homo sapiens (human)
kinetochoreAurora kinase BHomo sapiens (human)
condensed chromosome, centromeric regionAurora kinase BHomo sapiens (human)
nucleusAurora kinase BHomo sapiens (human)
nucleoplasmAurora kinase BHomo sapiens (human)
spindleAurora kinase BHomo sapiens (human)
cytosolAurora kinase BHomo sapiens (human)
chromocenterAurora kinase BHomo sapiens (human)
microtubule cytoskeletonAurora kinase BHomo sapiens (human)
midbodyAurora kinase BHomo sapiens (human)
chromosome passenger complexAurora kinase BHomo sapiens (human)
mitotic spindle poleAurora kinase BHomo sapiens (human)
mitotic spindle midzoneAurora kinase BHomo sapiens (human)
kinetochoreAurora kinase BHomo sapiens (human)
spindle pole centrosomeAurora kinase BHomo sapiens (human)
spindle microtubuleAurora kinase BHomo sapiens (human)
spindle midzoneAurora kinase BHomo sapiens (human)
PML bodyHomeodomain-interacting protein kinase 2Homo sapiens (human)
nucleusHomeodomain-interacting protein kinase 2Homo sapiens (human)
nucleoplasmHomeodomain-interacting protein kinase 2Homo sapiens (human)
cytoplasmHomeodomain-interacting protein kinase 2Homo sapiens (human)
cytoplasmic stress granuleHomeodomain-interacting protein kinase 2Homo sapiens (human)
nuclear bodyHomeodomain-interacting protein kinase 2Homo sapiens (human)
RNA polymerase II transcription regulator complexHomeodomain-interacting protein kinase 2Homo sapiens (human)
nucleusHomeodomain-interacting protein kinase 2Homo sapiens (human)
cytoplasmHomeodomain-interacting protein kinase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (75.00)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 41.83

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index41.83 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.26 (4.65)
Search Engine Demand Index55.70 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (41.83)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
diethylnitrosamine
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.. N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.		2.0210nitrosaminecarcinogenic agent;
hepatotoxic agent;
mutagen
interleukin-8
Interleukin-8: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.		2.0210
ConditionIndicatedRelationship StrengthStudiesTrials
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.4420
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.7330
Hutchinson Gilford Progeria Syndrome
[description not available]		02.7430
Progeria
An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature graying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.		02.7430
Angiogenesis, Pathologic
[description not available]		02.0210
Hepatocellular Carcinoma
[description not available]		02.0210
Cancer of Liver
[description not available]		02.0210
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.0210
Liver Neoplasms
Tumors or cancer of the LIVER.		02.0210
Acute Disease
Disease having a short and relatively severe course.		02.0210
Benign Neoplasms
[description not available]		02.0210
Corneal Angiogenesis
[description not available]		02.0210
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.0210
Corneal Neovascularization
New blood vessels originating from the corneal blood vessels and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.		02.0210
Rib Fractures
Fractures of any of the RIBS.		02.0310
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