D-64406: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 5330535 |
| CHEMBL ID | 7735 |
| CHEBI ID | 92486 |
| SCHEMBL ID | 4456469 |
| MeSH ID | M0436129 |
| Synonym |
|---|
| (5-hydroxy-1h-2-indolyl)(1h-2-indolyl)-methanone |
| bdbm6581 |
| 2-(1h-indol-2-ylcarbonyl)-1h-indol-5-ol |
| chembl7735 , |
| bis(1h-2-indolyl)methanone 39 |
| HSCI1_000198 |
| pdgf receptor tyrosine kinase inhibitor i |
| d-64406 |
| (5-hydroxy-1h-indol-2-yl)-(1h-indol-2-yl)methanone |
| NCGC00185731-01 |
| methanone, (5-hydroxy-1h-indol-2-yl)-1h-indol-2-yl- |
| 249762-62-7 |
| BRD-K27665173-001-01-3 |
| SCHEMBL4456469 |
| DTXSID20416205 |
| CHEBI:92486 |
| (5-hydroxy-1h-indol-2-yl)(1h-indol-2-yl)methanone |
| Q27164220 |
| pdgfr tyrosine kinase inhibitor i |
| kcv65fk2nq , |
| (5-hydroxy-1h-indol-2-yl)-1h-indol-2-ylmethanone |
| 1h-indol-2-yl-(5-oxidanyl-1h-indol-2-yl)methanone |
| unii-kcv65fk2nq |
| PD178095 |
| Class | Description |
|---|---|
| indolyl carboxylic acid | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 6.5397 | 0.0041 | 10.8903 | 31.5287 | AID686934; AID720565 |
| TDP1 protein | Homo sapiens (human) | Potency | 19.1180 | 0.0008 | 11.3822 | 44.6684 | AID686978; AID686979 |
| Smad3 | Homo sapiens (human) | Potency | 35.4813 | 0.0052 | 7.8098 | 29.0929 | AID588855 |
| 67.9K protein | Vaccinia virus | Potency | 13.8914 | 0.0001 | 8.4406 | 100.0000 | AID720579; AID720580 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 (µMol) | 30.0000 | 0.0000 | 0.5369 | 10.0000 | AID70045 |
| Platelet-derived growth factor receptor beta | Mus musculus (house mouse) | IC50 (µMol) | 0.2000 | 0.0018 | 0.7552 | 9.5000 | AID265203 |
| Platelet-derived growth factor receptor beta | Homo sapiens (human) | IC50 (µMol) | 0.7483 | 0.0006 | 0.8007 | 8.5000 | AID161091; AID161414; AID161415; AID161416; AID1795917; AID226346 |
| Fibroblast growth factor receptor 1 | Homo sapiens (human) | IC50 (µMol) | 10.0000 | 0.0002 | 0.9420 | 10.0000 | AID73460 |
| Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (human) | IC50 (µMol) | 30.0000 | 0.0002 | 0.5335 | 10.0000 | AID205489 |
| Platelet-derived growth factor receptor alpha | Homo sapiens (human) | IC50 (µMol) | 0.6000 | 0.0001 | 0.4912 | 10.0000 | AID161091; AID161251 |
| Platelet-derived growth factor receptor alpha | Mus musculus (house mouse) | IC50 (µMol) | 0.2000 | 0.0018 | 0.8572 | 9.5000 | AID265203 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 (µMol) | 0.5700 | 0.0001 | 0.3275 | 9.5480 | AID265202 |
| Protein kinase C epsilon type | Homo sapiens (human) | IC50 (µMol) | 30.0000 | 0.0001 | 0.8029 | 10.0000 | AID163839 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1882144 | Inhibition of PDGF-BB-stimulated PDGFR autophosphorylation in mouse Swiss-3T3 cells treated for 2 hrs followed by PDGF-BB stimulation measured after 10 mins by immunoblot analysis | 2022 | Bioorganic & medicinal chemistry, 01-01, Volume: 53 | How the structural properties of the indole derivatives are important in kinase targeted drug design?: A case study on tyrosine kinase inhibitors. |
| AID73460 | Inhibition of Fibroblast growth factor receptor 1 autophosphorylation in PAE cells | 2002 | Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5 | Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. |
| AID70045 | Inhibition of Epidermal growth factor receptor autophosphorylation in A431 cells | 2002 | Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5 | Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. |
| AID161414 | Inhibition of Platelet-derived growth factor receptor beta autophosphorylation in PAE cells | 2002 | Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5 | Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. |
| AID161091 | Antitumor activity measured by the inhibition of platelet-derived growth factor receptor autophosphorylation in intact Swiss 3T3 cells | 2002 | Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5 | Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. |
| AID265203 | Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts | 2006 | Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11 | Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. |
| AID161415 | Inhibition of Platelet-derived growth factor receptor beta kinase activity in Sf9-expressed GST-fusion protein | 2002 | Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5 | Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. |
| AID265202 | Inhibition of endogenous FLT3 in EOL1 cells | 2006 | Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11 | Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. |
| AID205489 | Inhibition of Src protein tyrosine kinase | 2002 | Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5 | Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. |
| AID165145 | Inhibition of Protein kinase C isoforms epsilon and iota in vitro phosphorylation | 2002 | Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5 | Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. |
| AID161416 | Inhibition of purified Platelet-derived growth factor receptor beta kinase activity | 2002 | Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5 | Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. |
| AID72432 | Inhibition of G-protein coupled receptor kinase 2 (GRK2) in vitro phosphorylation (Not tested) | 2002 | Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5 | Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. |
| AID161251 | Inhibition of Platelet-derived growth factor receptor alpha autophosphorylation in PAE cells | 2002 | Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5 | Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. |
| AID226346 | Inhibition of proliferation of inducible PDGF-B expressing sis-NIH3T3 cells | 2002 | Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5 | Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. |
| AID163839 | Inhibition of His-tagged Protein kinase C epsilon over-expressed in COS7 cells | 2002 | Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5 | Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. |
| AID1795917 | Receptor Autophosphorylation Inhibition Assay from Article 10.1021/jm010988n: \\Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase.\\ | 2002 | Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5 | Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.56) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (20.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 4 (80.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||