Compounds > incb3619
Page last updated: 2024-11-12

incb3619

Description

INCB3619: ADAM inhibitor; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11625778
CHEMBL ID434567
SCHEMBL ID209111
MeSH IDM0501383

Synonyms (21)

Synonym
CHEMBL434567 ,
methyl (6s,7s)-7-[(hydroxyamino)carbonyl]-6-[(4-phenyl-3,6-dihydropyridin-1(2h)-yl)carbonyl]-5-azaspiro[2.5]octane-5-carboxylate
(6s,7s)-methyl 7-(hydroxycarbamoyl)-6-(4-phenyl-1,2,3,6-tetrahydropyridine-1-carbonyl)-5-azaspiro[2.5]octane-5-carboxylate
bdbm50203527
unii-q56ue7e40y
5-azaspiro(2.5)octane-5-carboxylic acid, 6-((3,6-dihydro-4-phenyl-1(2h)-pyridinyl)carbonyl)-7-((hydroxyamino)carbonyl)-, methyl ester, (6s,7s)-
incb 3619
incb-3619
791826-72-7
q56ue7e40y ,
5-azaspiro(2.5)octane-5-carboxylic acid, 6-((3,6-dihydro-4-phenyl-1(2h)-pyridinyl)carbonyl)-7-((hydroxyamino)carbonyl)-, methyl ester, (6s,7s)-
SCHEMBL209111
methyl (5s,6s)-5-(hydroxycarbamoyl)-6-(4-phenyl3,6-dihydro-2h-pyridine-1-carbonyl)-7-azaspiro[2.5]octane-7-carboxylate
incb3619
gtpl8679
Q27892968
iai-100
methyl (6s,7s)-7-(hydroxycarbamoyl)-6-(4-phenyl-3,6-dihydro-2h-pyridine-1-carbonyl)-5-azaspiro[2.5]octane-5-carboxylate
CS-0012124
AKOS040748575
HY-12636
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (14)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Disintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)IC50 (µMol)0.03120.00811.485210.0000AID1235676; AID1895847; AID277511; AID344625
Disintegrin and metalloproteinase domain-containing protein 17Sus scrofa (pig)IC50 (µMol)0.01400.00101.33658.0000AID1895848
Interstitial collagenaseHomo sapiens (human)IC50 (µMol)5.00000.00020.850210.0000AID277512; AID349373
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)IC50 (µMol)0.06800.00010.545310.0000AID277510
72 kDa type IV collagenaseHomo sapiens (human)IC50 (µMol)0.03700.00001.284810.0000AID277513; AID349374
Stromelysin-1Homo sapiens (human)IC50 (µMol)3.78000.00001.148410.0000AID277514; AID349375
MatrilysinHomo sapiens (human)IC50 (µMol)5.00000.00142.085910.0000AID349378
Matrix metalloproteinase-9Homo sapiens (human)IC50 (µMol)0.36600.00000.705310.0000AID277515; AID349379
Macrophage metalloelastaseHomo sapiens (human)IC50 (µMol)0.01700.00022.721710.0000AID349385
Matrix metalloproteinase-14Homo sapiens (human)IC50 (µMol)0.77200.00030.718210.0000AID1235677; AID349381
Disintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)IC50 (µMol)1.00001.00001.00001.0000AID344631
Disintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)IC50 (µMol)0.50700.00021.014010.0000AID1235688; AID349383
Disintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)IC50 (µMol)5.00000.00102.528410.0000AID344626
Disintegrin and metalloproteinase domain-containing protein 33Homo sapiens (human)IC50 (µMol)1.02601.02601.02601.0260AID344620
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (233)

Processvia Protein(s)Taxonomy
membrane protein ectodomain proteolysisDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
negative regulation of gene expressionDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
in utero embryonic developmentDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
protein phosphorylationDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
membrane protein ectodomain proteolysisDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
negative regulation of cell adhesionDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
Notch signaling pathwayDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
integrin-mediated signaling pathwayDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
cell-cell signalingDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
positive regulation of cell population proliferationDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
regulation of Notch signaling pathwayDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
positive regulation of T cell chemotaxisDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
protein processingDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
extracellular matrix disassemblyDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
positive regulation of cell growthDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
positive regulation of cell migrationDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
adherens junction organizationDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
response to tumor necrosis factorDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
epidermal growth factor receptor ligand maturationDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
monocyte activationDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
amyloid precursor protein catabolic processDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
pore complex assemblyDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
constitutive protein ectodomain proteolysisDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
cochlea developmentDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
regulation of neurotransmitter receptor localization to postsynaptic specialization membraneDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
postsynapse organizationDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
regulation of postsynapse organizationDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
protein catabolic process at postsynapseDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
regulation of vasculature developmentDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
proteolysisInterstitial collagenaseHomo sapiens (human)
protein metabolic processInterstitial collagenaseHomo sapiens (human)
extracellular matrix disassemblyInterstitial collagenaseHomo sapiens (human)
collagen catabolic processInterstitial collagenaseHomo sapiens (human)
positive regulation of protein-containing complex assemblyInterstitial collagenaseHomo sapiens (human)
cellular response to UV-AInterstitial collagenaseHomo sapiens (human)
extracellular matrix organizationInterstitial collagenaseHomo sapiens (human)
cell surface receptor signaling pathwayReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
positive regulation of protein phosphorylationReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
protein phosphorylationReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
signal transductionReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
enzyme-linked receptor protein signaling pathwayReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathwayReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
heart developmentReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
neuromuscular junction developmentReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
motor neuron axon guidanceReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
Schwann cell developmentReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
peptidyl-tyrosine phosphorylationReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
positive regulation of cell growthReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
regulation of microtubule-based processReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
immature T cell proliferation in thymusReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
negative regulation of immature T cell proliferation in thymusReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
positive regulation of Rho protein signal transductionReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
intracellular signal transductionReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
ERBB2-ERBB3 signaling pathwayReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
ERBB2-EGFR signaling pathwayReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
ERBB2-ERBB4 signaling pathwayReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
wound healingReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
myelinationReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
positive regulation of MAP kinase activityReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transductionReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
positive regulation of translationReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
regulation of angiogenesisReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
positive regulation of cell adhesionReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
positive regulation of transcription by RNA polymerase IReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
oligodendrocyte differentiationReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
positive regulation of epithelial cell proliferationReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
regulation of ERK1 and ERK2 cascadeReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
cellular response to growth factor stimulusReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
cellular response to epidermal growth factor stimulusReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
semaphorin-plexin signaling pathwayReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
positive regulation of protein targeting to membraneReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
neurotransmitter receptor localization to postsynaptic specialization membraneReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
neurogenesisReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
positive regulation of MAPK cascadeReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
negative regulation of apoptotic processReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
positive regulation of kinase activityReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
multicellular organism developmentReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
positive regulation of cell population proliferationReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
neuron differentiationReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
angiogenesis72 kDa type IV collagenaseHomo sapiens (human)
ovarian follicle development72 kDa type IV collagenaseHomo sapiens (human)
ovulation from ovarian follicle72 kDa type IV collagenaseHomo sapiens (human)
luteinization72 kDa type IV collagenaseHomo sapiens (human)
blood vessel maturation72 kDa type IV collagenaseHomo sapiens (human)
intramembranous ossification72 kDa type IV collagenaseHomo sapiens (human)
proteolysis72 kDa type IV collagenaseHomo sapiens (human)
negative regulation of cell adhesion72 kDa type IV collagenaseHomo sapiens (human)
heart development72 kDa type IV collagenaseHomo sapiens (human)
embryo implantation72 kDa type IV collagenaseHomo sapiens (human)
parturition72 kDa type IV collagenaseHomo sapiens (human)
response to xenobiotic stimulus72 kDa type IV collagenaseHomo sapiens (human)
response to mechanical stimulus72 kDa type IV collagenaseHomo sapiens (human)
peripheral nervous system axon regeneration72 kDa type IV collagenaseHomo sapiens (human)
response to activity72 kDa type IV collagenaseHomo sapiens (human)
protein metabolic process72 kDa type IV collagenaseHomo sapiens (human)
extracellular matrix disassembly72 kDa type IV collagenaseHomo sapiens (human)
protein catabolic process72 kDa type IV collagenaseHomo sapiens (human)
positive regulation of cell migration72 kDa type IV collagenaseHomo sapiens (human)
collagen catabolic process72 kDa type IV collagenaseHomo sapiens (human)
response to retinoic acid72 kDa type IV collagenaseHomo sapiens (human)
cellular response to reactive oxygen species72 kDa type IV collagenaseHomo sapiens (human)
response to nicotine72 kDa type IV collagenaseHomo sapiens (human)
endodermal cell differentiation72 kDa type IV collagenaseHomo sapiens (human)
response to hydrogen peroxide72 kDa type IV collagenaseHomo sapiens (human)
response to estrogen72 kDa type IV collagenaseHomo sapiens (human)
negative regulation of vasoconstriction72 kDa type IV collagenaseHomo sapiens (human)
ephrin receptor signaling pathway72 kDa type IV collagenaseHomo sapiens (human)
macrophage chemotaxis72 kDa type IV collagenaseHomo sapiens (human)
response to electrical stimulus72 kDa type IV collagenaseHomo sapiens (human)
response to hyperoxia72 kDa type IV collagenaseHomo sapiens (human)
face morphogenesis72 kDa type IV collagenaseHomo sapiens (human)
bone trabecula formation72 kDa type IV collagenaseHomo sapiens (human)
prostate gland epithelium morphogenesis72 kDa type IV collagenaseHomo sapiens (human)
cellular response to amino acid stimulus72 kDa type IV collagenaseHomo sapiens (human)
cellular response to interleukin-172 kDa type IV collagenaseHomo sapiens (human)
cellular response to estradiol stimulus72 kDa type IV collagenaseHomo sapiens (human)
cellular response to UV-A72 kDa type IV collagenaseHomo sapiens (human)
cellular response to fluid shear stress72 kDa type IV collagenaseHomo sapiens (human)
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway72 kDa type IV collagenaseHomo sapiens (human)
response to amyloid-beta72 kDa type IV collagenaseHomo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferation72 kDa type IV collagenaseHomo sapiens (human)
extracellular matrix organization72 kDa type IV collagenaseHomo sapiens (human)
response to hypoxia72 kDa type IV collagenaseHomo sapiens (human)
tissue remodeling72 kDa type IV collagenaseHomo sapiens (human)
proteolysisStromelysin-1Homo sapiens (human)
extracellular matrix disassemblyStromelysin-1Homo sapiens (human)
protein catabolic processStromelysin-1Homo sapiens (human)
regulation of cell migrationStromelysin-1Homo sapiens (human)
collagen catabolic processStromelysin-1Homo sapiens (human)
positive regulation of protein-containing complex assemblyStromelysin-1Homo sapiens (human)
cellular response to reactive oxygen speciesStromelysin-1Homo sapiens (human)
innate immune responseStromelysin-1Homo sapiens (human)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionStromelysin-1Homo sapiens (human)
cellular response to lipopolysaccharideStromelysin-1Homo sapiens (human)
cellular response to amino acid stimulusStromelysin-1Homo sapiens (human)
cellular response to UV-AStromelysin-1Homo sapiens (human)
cellular response to nitric oxideStromelysin-1Homo sapiens (human)
regulation of neuroinflammatory responseStromelysin-1Homo sapiens (human)
response to amyloid-betaStromelysin-1Homo sapiens (human)
negative regulation of reactive oxygen species metabolic processStromelysin-1Homo sapiens (human)
extracellular matrix organizationStromelysin-1Homo sapiens (human)
membrane protein ectodomain proteolysisMatrilysinHomo sapiens (human)
membrane protein intracellular domain proteolysisMatrilysinHomo sapiens (human)
antibacterial peptide secretionMatrilysinHomo sapiens (human)
antibacterial peptide biosynthetic processMatrilysinHomo sapiens (human)
proteolysisMatrilysinHomo sapiens (human)
response to xenobiotic stimulusMatrilysinHomo sapiens (human)
extracellular matrix disassemblyMatrilysinHomo sapiens (human)
positive regulation of cell migrationMatrilysinHomo sapiens (human)
collagen catabolic processMatrilysinHomo sapiens (human)
regulation of cell population proliferationMatrilysinHomo sapiens (human)
defense response to Gram-negative bacteriumMatrilysinHomo sapiens (human)
defense response to Gram-positive bacteriumMatrilysinHomo sapiens (human)
extracellular matrix organizationMatrilysinHomo sapiens (human)
skeletal system developmentMatrix metalloproteinase-9Homo sapiens (human)
positive regulation of protein phosphorylationMatrix metalloproteinase-9Homo sapiens (human)
proteolysisMatrix metalloproteinase-9Homo sapiens (human)
apoptotic processMatrix metalloproteinase-9Homo sapiens (human)
embryo implantationMatrix metalloproteinase-9Homo sapiens (human)
cell migrationMatrix metalloproteinase-9Homo sapiens (human)
extracellular matrix disassemblyMatrix metalloproteinase-9Homo sapiens (human)
macrophage differentiationMatrix metalloproteinase-9Homo sapiens (human)
collagen catabolic processMatrix metalloproteinase-9Homo sapiens (human)
cellular response to reactive oxygen speciesMatrix metalloproteinase-9Homo sapiens (human)
endodermal cell differentiationMatrix metalloproteinase-9Homo sapiens (human)
positive regulation of apoptotic processMatrix metalloproteinase-9Homo sapiens (human)
negative regulation of apoptotic processMatrix metalloproteinase-9Homo sapiens (human)
positive regulation of DNA bindingMatrix metalloproteinase-9Homo sapiens (human)
positive regulation of epidermal growth factor receptor signaling pathwayMatrix metalloproteinase-9Homo sapiens (human)
ephrin receptor signaling pathwayMatrix metalloproteinase-9Homo sapiens (human)
positive regulation of keratinocyte migrationMatrix metalloproteinase-9Homo sapiens (human)
cellular response to lipopolysaccharideMatrix metalloproteinase-9Homo sapiens (human)
cellular response to cadmium ionMatrix metalloproteinase-9Homo sapiens (human)
cellular response to UV-AMatrix metalloproteinase-9Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondriaMatrix metalloproteinase-9Homo sapiens (human)
regulation of neuroinflammatory responseMatrix metalloproteinase-9Homo sapiens (human)
positive regulation of receptor bindingMatrix metalloproteinase-9Homo sapiens (human)
response to amyloid-betaMatrix metalloproteinase-9Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferationMatrix metalloproteinase-9Homo sapiens (human)
negative regulation of epithelial cell differentiation involved in kidney developmentMatrix metalloproteinase-9Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathwayMatrix metalloproteinase-9Homo sapiens (human)
negative regulation of cation channel activityMatrix metalloproteinase-9Homo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayMatrix metalloproteinase-9Homo sapiens (human)
extracellular matrix organizationMatrix metalloproteinase-9Homo sapiens (human)
negative regulation of transcription by RNA polymerase IIMacrophage metalloelastaseHomo sapiens (human)
proteolysisMacrophage metalloelastaseHomo sapiens (human)
protein import into nucleusMacrophage metalloelastaseHomo sapiens (human)
extracellular matrix disassemblyMacrophage metalloelastaseHomo sapiens (human)
collagen catabolic processMacrophage metalloelastaseHomo sapiens (human)
positive regulation of interferon-alpha productionMacrophage metalloelastaseHomo sapiens (human)
wound healing, spreading of epidermal cellsMacrophage metalloelastaseHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIMacrophage metalloelastaseHomo sapiens (human)
lung alveolus developmentMacrophage metalloelastaseHomo sapiens (human)
regulation of defense response to virus by hostMacrophage metalloelastaseHomo sapiens (human)
positive regulation of epithelial cell proliferation involved in wound healingMacrophage metalloelastaseHomo sapiens (human)
elastin catabolic processMacrophage metalloelastaseHomo sapiens (human)
negative regulation of type I interferon-mediated signaling pathwayMacrophage metalloelastaseHomo sapiens (human)
positive regulation of type I interferon-mediated signaling pathwayMacrophage metalloelastaseHomo sapiens (human)
bronchiole developmentMacrophage metalloelastaseHomo sapiens (human)
cellular response to virusMacrophage metalloelastaseHomo sapiens (human)
response to amyloid-betaMacrophage metalloelastaseHomo sapiens (human)
negative regulation of endothelial cell-matrix adhesion via fibronectinMacrophage metalloelastaseHomo sapiens (human)
extracellular matrix organizationMacrophage metalloelastaseHomo sapiens (human)
angiogenesisMatrix metalloproteinase-14Homo sapiens (human)
ovarian follicle developmentMatrix metalloproteinase-14Homo sapiens (human)
response to hypoxiaMatrix metalloproteinase-14Homo sapiens (human)
endothelial cell proliferationMatrix metalloproteinase-14Homo sapiens (human)
endochondral ossificationMatrix metalloproteinase-14Homo sapiens (human)
proteolysisMatrix metalloproteinase-14Homo sapiens (human)
response to oxidative stressMatrix metalloproteinase-14Homo sapiens (human)
male gonad developmentMatrix metalloproteinase-14Homo sapiens (human)
response to mechanical stimulusMatrix metalloproteinase-14Homo sapiens (human)
positive regulation of myotube differentiationMatrix metalloproteinase-14Homo sapiens (human)
positive regulation of protein processingMatrix metalloproteinase-14Homo sapiens (human)
response to organic cyclic compoundMatrix metalloproteinase-14Homo sapiens (human)
protein processingMatrix metalloproteinase-14Homo sapiens (human)
extracellular matrix disassemblyMatrix metalloproteinase-14Homo sapiens (human)
protein catabolic processMatrix metalloproteinase-14Homo sapiens (human)
positive regulation of cell growthMatrix metalloproteinase-14Homo sapiens (human)
lung developmentMatrix metalloproteinase-14Homo sapiens (human)
positive regulation of cell migrationMatrix metalloproteinase-14Homo sapiens (human)
collagen catabolic processMatrix metalloproteinase-14Homo sapiens (human)
zymogen activationMatrix metalloproteinase-14Homo sapiens (human)
endodermal cell differentiationMatrix metalloproteinase-14Homo sapiens (human)
chondrocyte proliferationMatrix metalloproteinase-14Homo sapiens (human)
astrocyte cell migrationMatrix metalloproteinase-14Homo sapiens (human)
response to estrogenMatrix metalloproteinase-14Homo sapiens (human)
positive regulation of B cell differentiationMatrix metalloproteinase-14Homo sapiens (human)
negative regulation of Notch signaling pathwayMatrix metalloproteinase-14Homo sapiens (human)
embryonic cranial skeleton morphogenesisMatrix metalloproteinase-14Homo sapiens (human)
branching morphogenesis of an epithelial tubeMatrix metalloproteinase-14Homo sapiens (human)
tissue remodelingMatrix metalloproteinase-14Homo sapiens (human)
cell motilityMatrix metalloproteinase-14Homo sapiens (human)
negative regulation of focal adhesion assemblyMatrix metalloproteinase-14Homo sapiens (human)
head developmentMatrix metalloproteinase-14Homo sapiens (human)
craniofacial suture morphogenesisMatrix metalloproteinase-14Homo sapiens (human)
negative regulation of GDF15-GFRAL signaling pathwayMatrix metalloproteinase-14Homo sapiens (human)
regulation of protein localization to plasma membraneMatrix metalloproteinase-14Homo sapiens (human)
positive regulation of macrophage migrationMatrix metalloproteinase-14Homo sapiens (human)
response to odorantMatrix metalloproteinase-14Homo sapiens (human)
extracellular matrix organizationMatrix metalloproteinase-14Homo sapiens (human)
skeletal system developmentMatrix metalloproteinase-14Homo sapiens (human)
cell morphogenesisDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
angiogenesisDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
leukocyte migration involved in inflammatory responseDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
positive regulation of acute inflammatory responseDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
inflammatory responseDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
canonical NF-kappaB signal transductionDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
positive regulation of epithelial to mesenchymal transitionDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
positive regulation of protein processingDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
regulation of cell-cell adhesionDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
extracellular matrix disassemblyDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
signal releaseDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
positive regulation of T cell differentiation in thymusDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
positive regulation of MAPK cascadeDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
negative regulation of neuron apoptotic processDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
positive regulation of innate immune responseDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
positive regulation of bone resorptionDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
positive regulation of cell adhesionDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
lymphocyte chemotaxisDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
positive regulation of protein secretionDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
positive regulation of membrane protein ectodomain proteolysisDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
positive regulation of thymocyte apoptotic processDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
cellular response to hypoxiaDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
cell-cell adhesionDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
positive regulation of neutrophil extravasationDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
positive regulation of fibronectin-dependent thymocyte migrationDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
positive regulation of eosinophil migrationDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
positive regulation of cellular extravasationDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
proteolysisDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
positive regulation of epidermal growth factor receptor signaling pathwayDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
response to hypoxiaDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
neutrophil mediated immunityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
germinal center formationDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of leukocyte chemotaxisDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
proteolysisDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
membrane protein ectodomain proteolysisDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cell adhesionDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
Notch receptor processingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of cell population proliferationDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
response to xenobiotic stimulusDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of T cell chemotaxisDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
protein processingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
signal releaseDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
B cell differentiationDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of cell growthDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of cell migrationDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
response to lipopolysaccharideDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of chemokine productionDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of tumor necrosis factor productionDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
regulation of mast cell apoptotic processDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
T cell differentiation in thymusDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cell adhesion mediated by integrinDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
wound healing, spreading of epidermal cellsDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
amyloid precursor protein catabolic processDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of blood vessel endothelial cell migrationDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of cyclin-dependent protein serine/threonine kinase activityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of epidermal growth factor-activated receptor activityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of epidermal growth factor receptor signaling pathwayDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
spleen developmentDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cell motilityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
defense response to Gram-positive bacteriumDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cellular response to high density lipoprotein particle stimulusDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
commissural neuron axon guidanceDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
negative regulation of cold-induced thermogenesisDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of G1/S transition of mitotic cell cycleDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of tumor necrosis factor-mediated signaling pathwayDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of vascular endothelial cell proliferationDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
Notch signaling pathwayDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
positive regulation of MAP kinase activityDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
membrane protein ectodomain proteolysisDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
membrane protein intracellular domain proteolysisDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
membrane protein ectodomain proteolysisDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
cell adhesionDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
cell-matrix adhesionDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
integrin-mediated signaling pathwayDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
response to manganese ionDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
cell migrationDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
keratinocyte differentiationDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
positive regulation of cell migrationDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
cell adhesion mediated by integrinDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
positive regulation of cell adhesion mediated by integrinDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
cell-cell adhesion mediated by integrinDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
positive regulation of macrophage fusionDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
response to tumor necrosis factorDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
response to laminar fluid shear stressDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
monocyte activationDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
response to hydrogen peroxideDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
positive regulation of protein secretionDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
positive regulation of membrane protein ectodomain proteolysisDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
response to glucocorticoidDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
positive regulation of keratinocyte migrationDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
response to calcium ionDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
cellular response to lipopolysaccharideDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
response to antineoplastic agentDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
proteolysisDisintegrin and metalloproteinase domain-containing protein 33Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (43)

Processvia Protein(s)Taxonomy
endopeptidase activityDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
metalloendopeptidase activityDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
signaling receptor bindingDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
integrin bindingDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
protein bindingDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
metallopeptidase activityDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
SH3 domain bindingDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
protein kinase bindingDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
protein homodimerization activityDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
metal ion bindingDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
molecular adaptor activityDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
metallodipeptidase activityDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
metalloendopeptidase activity involved in amyloid precursor protein catabolic processDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
endopeptidase activityInterstitial collagenaseHomo sapiens (human)
metalloendopeptidase activityInterstitial collagenaseHomo sapiens (human)
serine-type endopeptidase activityInterstitial collagenaseHomo sapiens (human)
peptidase activityInterstitial collagenaseHomo sapiens (human)
zinc ion bindingInterstitial collagenaseHomo sapiens (human)
growth factor bindingReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
RNA polymerase I core bindingReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
protein tyrosine kinase activityReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activityReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
transmembrane signaling receptor activityReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
signaling receptor bindingReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
protein bindingReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
ATP bindingReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
coreceptor activityReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
receptor tyrosine kinase bindingReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
identical protein bindingReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
ErbB-3 class receptor bindingReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
protein heterodimerization activityReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
fibronectin binding72 kDa type IV collagenaseHomo sapiens (human)
endopeptidase activity72 kDa type IV collagenaseHomo sapiens (human)
metalloendopeptidase activity72 kDa type IV collagenaseHomo sapiens (human)
serine-type endopeptidase activity72 kDa type IV collagenaseHomo sapiens (human)
protein binding72 kDa type IV collagenaseHomo sapiens (human)
metallopeptidase activity72 kDa type IV collagenaseHomo sapiens (human)
zinc ion binding72 kDa type IV collagenaseHomo sapiens (human)
endopeptidase activityStromelysin-1Homo sapiens (human)
metalloendopeptidase activityStromelysin-1Homo sapiens (human)
serine-type endopeptidase activityStromelysin-1Homo sapiens (human)
protein bindingStromelysin-1Homo sapiens (human)
peptidase activityStromelysin-1Homo sapiens (human)
metallopeptidase activityStromelysin-1Homo sapiens (human)
zinc ion bindingStromelysin-1Homo sapiens (human)
endopeptidase activityMatrilysinHomo sapiens (human)
metalloendopeptidase activityMatrilysinHomo sapiens (human)
serine-type endopeptidase activityMatrilysinHomo sapiens (human)
protein bindingMatrilysinHomo sapiens (human)
metallopeptidase activityMatrilysinHomo sapiens (human)
zinc ion bindingMatrilysinHomo sapiens (human)
endopeptidase activityMatrix metalloproteinase-9Homo sapiens (human)
metalloendopeptidase activityMatrix metalloproteinase-9Homo sapiens (human)
serine-type endopeptidase activityMatrix metalloproteinase-9Homo sapiens (human)
protein bindingMatrix metalloproteinase-9Homo sapiens (human)
collagen bindingMatrix metalloproteinase-9Homo sapiens (human)
peptidase activityMatrix metalloproteinase-9Homo sapiens (human)
metallopeptidase activityMatrix metalloproteinase-9Homo sapiens (human)
zinc ion bindingMatrix metalloproteinase-9Homo sapiens (human)
identical protein bindingMatrix metalloproteinase-9Homo sapiens (human)
core promoter sequence-specific DNA bindingMacrophage metalloelastaseHomo sapiens (human)
endopeptidase activityMacrophage metalloelastaseHomo sapiens (human)
metalloendopeptidase activityMacrophage metalloelastaseHomo sapiens (human)
serine-type endopeptidase activityMacrophage metalloelastaseHomo sapiens (human)
calcium ion bindingMacrophage metalloelastaseHomo sapiens (human)
collagen bindingMacrophage metalloelastaseHomo sapiens (human)
zinc ion bindingMacrophage metalloelastaseHomo sapiens (human)
sequence-specific DNA bindingMacrophage metalloelastaseHomo sapiens (human)
endopeptidase activityMatrix metalloproteinase-14Homo sapiens (human)
metalloendopeptidase activityMatrix metalloproteinase-14Homo sapiens (human)
serine-type endopeptidase activityMatrix metalloproteinase-14Homo sapiens (human)
integrin bindingMatrix metalloproteinase-14Homo sapiens (human)
protein bindingMatrix metalloproteinase-14Homo sapiens (human)
zinc ion bindingMatrix metalloproteinase-14Homo sapiens (human)
metalloaminopeptidase activityMatrix metalloproteinase-14Homo sapiens (human)
serine-type endopeptidase activityDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
calcium ion bindingDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
protein bindingDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
metallopeptidase activityDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
zinc ion bindingDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
tumor necrosis factor receptor superfamily bindingDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
immunoglobulin receptor bindingDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
metalloendopeptidase activityDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
cell adhesion molecule bindingDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
endopeptidase activityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
metalloendopeptidase activityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
Notch bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
interleukin-6 receptor bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
integrin bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
protein bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
peptidase activityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
metallopeptidase activityDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
SH3 domain bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cytokine bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
PDZ domain bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
tumor necrosis factor bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
metal ion bindingDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
metalloendopeptidase activity involved in amyloid precursor protein catabolic processDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
metalloendopeptidase activityDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
protein kinase C bindingDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
integrin bindingDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
protein bindingDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
collagen bindingDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
metallopeptidase activityDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
SH3 domain bindingDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
laminin bindingDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
metal ion bindingDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
metalloendopeptidase activityDisintegrin and metalloproteinase domain-containing protein 33Homo sapiens (human)
zinc ion bindingDisintegrin and metalloproteinase domain-containing protein 33Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (63)

Processvia Protein(s)Taxonomy
Golgi membraneDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
nucleusDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
cytoplasmDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
endoplasmic reticulum lumenDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
Golgi apparatusDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
Golgi-associated vesicleDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
plasma membraneDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
adherens junctionDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
focal adhesionDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
cell surfaceDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
postsynaptic densityDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
membraneDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
clathrin-coated vesicleDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
axonDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
dendriteDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
specific granule membraneDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
intracellular membrane-bounded organelleDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
extracellular exosomeDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
tertiary granule membraneDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
perinuclear endoplasmic reticulumDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
synaptic membraneDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
tetraspanin-enriched microdomainDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
glutamatergic synapseDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
pore complexDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
synaptic membraneDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
plasma membraneDisintegrin and metalloproteinase domain-containing protein 10Homo sapiens (human)
extracellular regionInterstitial collagenaseHomo sapiens (human)
extracellular matrixInterstitial collagenaseHomo sapiens (human)
extracellular spaceInterstitial collagenaseHomo sapiens (human)
semaphorin receptor complexReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
nucleusReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
nucleoplasmReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
early endosomeReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
cytosolReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
plasma membraneReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
endosome membraneReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
membraneReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
basolateral plasma membraneReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
apical plasma membraneReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
neuromuscular junctionReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
ruffle membraneReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
presynaptic membraneReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
myelin sheathReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
perinuclear region of cytoplasmReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
ERBB3:ERBB2 complexReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
receptor complexReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
plasma membraneReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
basal plasma membraneReceptor tyrosine-protein kinase erbB-2Homo sapiens (human)
collagen-containing extracellular matrix72 kDa type IV collagenaseHomo sapiens (human)
extracellular region72 kDa type IV collagenaseHomo sapiens (human)
extracellular space72 kDa type IV collagenaseHomo sapiens (human)
nucleus72 kDa type IV collagenaseHomo sapiens (human)
mitochondrion72 kDa type IV collagenaseHomo sapiens (human)
plasma membrane72 kDa type IV collagenaseHomo sapiens (human)
sarcomere72 kDa type IV collagenaseHomo sapiens (human)
collagen-containing extracellular matrix72 kDa type IV collagenaseHomo sapiens (human)
extracellular space72 kDa type IV collagenaseHomo sapiens (human)
extracellular regionStromelysin-1Homo sapiens (human)
nucleusStromelysin-1Homo sapiens (human)
mitochondrionStromelysin-1Homo sapiens (human)
cytosolStromelysin-1Homo sapiens (human)
extracellular matrixStromelysin-1Homo sapiens (human)
extracellular spaceStromelysin-1Homo sapiens (human)
extracellular regionMatrilysinHomo sapiens (human)
extracellular matrixMatrilysinHomo sapiens (human)
extracellular exosomeMatrilysinHomo sapiens (human)
extracellular spaceMatrilysinHomo sapiens (human)
extracellular regionMatrix metalloproteinase-9Homo sapiens (human)
extracellular spaceMatrix metalloproteinase-9Homo sapiens (human)
collagen-containing extracellular matrixMatrix metalloproteinase-9Homo sapiens (human)
extracellular exosomeMatrix metalloproteinase-9Homo sapiens (human)
tertiary granule lumenMatrix metalloproteinase-9Homo sapiens (human)
ficolin-1-rich granule lumenMatrix metalloproteinase-9Homo sapiens (human)
extracellular spaceMatrix metalloproteinase-9Homo sapiens (human)
extracellular regionMacrophage metalloelastaseHomo sapiens (human)
extracellular spaceMacrophage metalloelastaseHomo sapiens (human)
nucleusMacrophage metalloelastaseHomo sapiens (human)
cytoplasmMacrophage metalloelastaseHomo sapiens (human)
extracellular matrixMacrophage metalloelastaseHomo sapiens (human)
extracellular spaceMacrophage metalloelastaseHomo sapiens (human)
cytoplasmMatrix metalloproteinase-14Homo sapiens (human)
plasma membraneMatrix metalloproteinase-14Homo sapiens (human)
extracellular spaceMatrix metalloproteinase-14Homo sapiens (human)
nucleusMatrix metalloproteinase-14Homo sapiens (human)
Golgi lumenMatrix metalloproteinase-14Homo sapiens (human)
cytosolMatrix metalloproteinase-14Homo sapiens (human)
plasma membraneMatrix metalloproteinase-14Homo sapiens (human)
focal adhesionMatrix metalloproteinase-14Homo sapiens (human)
extracellular matrixMatrix metalloproteinase-14Homo sapiens (human)
cytoplasmic vesicleMatrix metalloproteinase-14Homo sapiens (human)
melanosomeMatrix metalloproteinase-14Homo sapiens (human)
macropinosomeMatrix metalloproteinase-14Homo sapiens (human)
intermediate filament cytoskeletonMatrix metalloproteinase-14Homo sapiens (human)
extracellular spaceMatrix metalloproteinase-14Homo sapiens (human)
podosomeDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
cytoplasmDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
plasma membraneDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
cell surfaceDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
phagolysosomeDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
dense core granule membraneDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
specific granule membraneDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
specific granuleDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
tertiary granuleDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
tertiary granule membraneDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
ficolin-1-rich granule membraneDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
alpha9-beta1 integrin-ADAM8 complexDisintegrin and metalloproteinase domain-containing protein 8Homo sapiens (human)
cell-cell junctionDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
focal adhesionDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
ruffle membraneDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
Golgi membraneDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cytoplasmDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
endoplasmic reticulum lumenDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cytosolDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
plasma membraneDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
cell surfaceDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
actin cytoskeletonDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
membraneDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
apical plasma membraneDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
membrane raftDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
plasma membraneDisintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)
extracellular spaceDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
focal adhesionDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
external side of plasma membraneDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
cell surfaceDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
basolateral plasma membraneDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
extracellular exosomeDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
plasma membraneDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
extracellular spaceDisintegrin and metalloproteinase domain-containing protein 9Homo sapiens (human)
membraneDisintegrin and metalloproteinase domain-containing protein 33Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (32)

Assay IDTitleYearJournalArticle
AID277515Inhibition of MMP92007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
AID349373Inhibition of MMP12008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
AID277516Clearance in murine2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
AID277519Cmax in murine at 10 mg/kg, po2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
AID1895848Inhibition of porcine ADAM17 using (7-methoxycour-marin-4-yl)-acetyl-Pro-Leu-Ala-Gln-Ala-Val-(3-[2,4-dinitrophenyl]- L -2, 3-diaminopropionyl)-Arg-Ser-Ser-Ser-Arg-NH2 as a substrate2021European journal of medicinal chemistry, Dec-15, Volume: 226Zinc enzymes in medicinal chemistry.
AID277520Decrease of tumor volume in CD1 mouse xenografted with BT474 cells overexpressing HER2 at 30 mg/kg/day after 28 days2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
AID277521Decrease of HER2 ECD level in plasma of CD1 mouse xenografted with BT474 cells overexpressing HER2 at 30 mg/kg/day after 28 days2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
AID349374Inhibition of MMP22008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
AID277514Inhibition of MMP32007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
AID277513Inhibition of MMP22007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
AID277517Protein binding in murine plasma2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
AID344626Inhibition of ADAM92008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
AID349385Inhibition of MMP122008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
AID349383Inhibition of TACE2008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
AID349381Inhibition of MMP142008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
AID1235677Inhibition of human MT1-MMP2015Journal of medicinal chemistry, Aug-13, Volume: 58, Issue:15
SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.
AID344625Inhibition of ADAM102008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
AID1235688Inhibition of ADAM17 in human A549 cells assessed as potentiation of gefitinib-mediated inhibition of cell viability by measuring gefitinib IC50 at 10 uM after 96 hrs by CellTiter-Glo assay (Rvb = 8 microM)2015Journal of medicinal chemistry, Aug-13, Volume: 58, Issue:15
SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.
AID1895847Inhibition of human ADAM10 using (7-methoxycour-marin-4-yl)-acetyl-Pro-Leu-Ala-Gln-Ala-Val-(3-[2,4-dinitrophenyl]- L -2, 3-diaminopropionyl)-Arg-Ser-Ser-Ser-Arg-NH2 as a substrate2021European journal of medicinal chemistry, Dec-15, Volume: 226Zinc enzymes in medicinal chemistry.
AID277518AUC (0-24h) in murine at 10 mg/kg, po2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
AID349378Inhibition of MMP72008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
AID1235675Inhibition of porcine spleen ADAM172015Journal of medicinal chemistry, Aug-13, Volume: 58, Issue:15
SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.
AID344631Inhibition of ADAM82008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
AID344620Inhibition of ADAM332008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
AID277510Inhibition of Her2 sheddase activity in BT474 cell line2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
AID349379Inhibition of MMP92008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
AID277512Inhibition of MMP12007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
AID1235676Inhibition of human ADAM102015Journal of medicinal chemistry, Aug-13, Volume: 58, Issue:15
SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.
AID349375Inhibition of MMP32008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
AID277511Inhibition of ADAM102007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
AID1345418Human ADAM33 (M12: Astacin/Adamalysin)2008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
AID1345447Human ADAM8 (M12: Astacin/Adamalysin)2008Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (44.44)29.6817
2010's4 (44.44)24.3611
2020's1 (11.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (22.22%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (77.78%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
N-[4-(4-morpholinyl)butyl]-2-benzofurancarboxamide
CL82198: a selective inhibitor of MMP13		3.1410benzofurans
framycetin
Framycetin: A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed). framycetin : A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B.		3.4110aminoglycosideallergen;
antibacterial drug;
Escherichia coli metabolite
quinazolines
Quinazolines: A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring.. quinazoline : A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.. quinazolines : Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.		2.0310azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines
coformycin
[no description available]		3.4110coformycinsEC 3.5.4.4 (adenosine deaminase) inhibitor
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.0310taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
captopril
Captopril: A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.. captopril : A L-proline derivative in which L-proline is substituted on nitrogen with a (2S)-2-methyl-3-sulfanylpropanoyl group. It is used as an anti-hypertensive ACE inhibitor drug.		3.4110alkanethiol;
L-proline derivative;
N-acylpyrrolidine;
pyrrolidinemonocarboxylic acid		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
epigallocatechin gallate
epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.		3.4110flavans;
gallate ester;
polyphenol		antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite
marimastat
marimastat: a matrix metalloproteinase inhibitor active in patients with advanced carcinoma of the pancreas, prostate, or ovary. marimastat : A secondary carboxamide resulting from the foraml condensation of the carboxy group of (2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the alpha-amino group of N,3-dimethyl-L-valinamide.		2.1110hydroxamic acid;
secondary carboxamide		antineoplastic agent;
matrix metalloproteinase inhibitor
gefitinib
[no description available]		2.4620aromatic ether;
monochlorobenzenes;
monofluorobenzenes;
morpholines;
quinazolines;
secondary amino compound;
tertiary amino compound		antineoplastic agent;
epidermal growth factor receptor antagonist
9-(2-hydroxy-3-nonyl)adenine
(2S,3R)-EHNA : EHNA of absolute configuration 2S,3R.		3.4110EHNA
cilomilast
[no description available]		3.4110methoxybenzenes
pentostatin
Pentostatin: A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.. pentostatin : A member of the class of coformycins that is coformycin in which the hydroxy group at position 2' is replaced with a hydrogen. It is a drug used for the treatment of hairy cell leukaemia.		3.4110coformycinsantimetabolite;
antineoplastic agent;
Aspergillus metabolite;
bacterial metabolite;
EC 3.5.4.4 (adenosine deaminase) inhibitor
bms 214662
7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine: a farnesyltransferase inhibitor; structure in first source. BMS-214662 : A member of the class of benzodiazepines that is 2,3,4,5-tetrahydro-1H-1,4-benzodiazepine substituted by (1H-imidazol-5-yl)methyl, benzyl, (thiophen-2-yl)sulfonyl, and cyano groups at positions 1, 3R, 4 and 7, respectively. It is a potent inhibitor of farnesyltransferase (IC50 = 1.35nM) which was under clinical development for the treatment of solid tumors.		3.4110benzenes;
benzodiazepine;
imidazoles;
nitrile;
sulfonamide;
thiophenes		antineoplastic agent;
apoptosis inducer;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor
roflumilast
[no description available]		3.4110aromatic ether;
benzamides;
chloropyridine;
cyclopropanes;
organofluorine compound		anti-asthmatic drug;
phosphodiesterase IV inhibitor
lisinopril
Lisinopril: One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors), orally active, that has been used in the treatment of hypertension and congestive heart failure.		3.4110dipeptideEC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
ik 682
IK 682: inhibits TNF-alpha converting enzyme; structure in first source		4.1220hydroxamic acid;
pyrrolidin-2-ones;
quinolines
gsk 256066
[no description available]		3.4110
abt-770
ABT-770: structure in first source		3.1410
sb 3ct compound
SB 3CT compound: a matrix metalloproteinase-2 inhibitor; structure in first source		3.1410aromatic ether
arp-100
[no description available]		3.1410
bms-566394
BMS-566394: structure in first source		3.1410
piperidines
Piperidines: A family of hexahydropyridines.		3.3160
tasquinimod
tasquinimod: a lead second generation quinoline-3-carboxamide anti-angiogenic agent for the treatment of prostate cancer; structure in first source		3.4110
transforming growth factor alpha
Transforming Growth Factor alpha: An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form which binds to the EGF RECEPTOR.		2.1510
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Myelogenous Leukemia
[description not available]		02.0810
Cytomegalovirus
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.		02.0810
Leukemia, Myeloid, Acute
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.		02.0810
Carcinogenesis
The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.		02.1510
Cancer of Colon
[description not available]		02.1510
Colonic Neoplasms
Tumors or cancer of the COLON.		02.1510
Breast Cancer
[description not available]		02.0410
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0410
Benign Neoplasms, Brain
[description not available]		02.0710
Astrocytoma, Grade IV
[description not available]		02.0710
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.		02.0710
Glioblastoma
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.		02.0710
Carcinoma, Non-Small Cell Lung
[description not available]		02.0310
Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.		02.0310
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