| Assay ID | Title | Year | Journal | Article |
|---|
| AID454843 | Antiproliferative activity against human A2780 cells | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
| AID1649884 | Inhibition of HDAC8 (unknown origin) | 2019 | European journal of medicinal chemistry, Feb-15, Volume: 164 | Histone deacetylase 8 (HDAC8) and its inhibitors with selectivity to other isoforms: An overview. |
| AID454861 | Inhibition of human HDAC10 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
| AID454860 | Inhibition of human HDAC6 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
| AID454856 | Inhibition of human HDAC4 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
| AID454854 | Inhibition of human HDAC3 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
| AID454842 | Inhibition of HDAC in human HeLa cells extractt | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
| AID454844 | AUC (0 to infinity) in Sprague-Dawley rat at 2.5 mg/kg, iv administered in water at pH 4.4 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
| AID454846 | Volume of distribution at steady state in Sprague-Dawley rat at 2.5 mg/kg, iv administered in water at pH 4.4 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
| AID454847 | Half life in Sprague-Dawley rat at 2.5 mg/kg, iv administered in water at pH 4.4 measured 2 to 8 hrs post dose | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
| AID454858 | Inhibition of human HDAC7 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
| AID454841 | Thermodynamic solubility in phosphate-citrate buffer at pH 7.7 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
| AID454837 | Thermodynamic solubility in phosphate-citrate buffer at pH 4 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
| AID1649887 | Potency index, ratio of IC50 for SAHA to IC50 for test compound for HDAC8 (unknown origin) | 2019 | European journal of medicinal chemistry, Feb-15, Volume: 164 | Histone deacetylase 8 (HDAC8) and its inhibitors with selectivity to other isoforms: An overview. |
| AID454853 | Inhibition of human HDAC2 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
| AID454845 | Clearance in Sprague-Dawley rat at 2.5 mg/kg, iv administered in water at pH 4.4 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
| AID454852 | Inhibition of human HDAC1 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
| AID454849 | AUC (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, po administered in water at pH 4.5 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
| AID454857 | Inhibition of human HDAC5 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
| AID454855 | Inhibition of human HDAC8 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
| AID454850 | Oral bioavailability in Sprague-Dawley rat at 10 mg/kg administered in water at pH 4.5 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
| AID454862 | Inhibition of human HDAC11 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
| AID454859 | Inhibition of human HDAC9 | 2010 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 20, Issue:1
| Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |