| Assay ID | Title | Year | Journal | Article |
|---|
| AID63356 | Tested for antagonist binding affinity by measuring displacement of [3H]spiperone from Human Dopamine receptor D3 expressed in CHO K-1 cells | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15
| Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). |
| AID1725413 | Displacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cells at 100 uM after 60 mins by microbeta counting based assay relative to control | 2020 | ACS medicinal chemistry letters, Oct-08, Volume: 11, Issue:10
| Exception That Proves the Rule: Investigation of Privileged Stereochemistry in Designing Dopamine D |
| AID1725414 | Displacement of [3H]-DAMGO from human MOR expressed in HEK293 cells after 60 mins by microbeta counting based assay | 2020 | ACS medicinal chemistry letters, Oct-08, Volume: 11, Issue:10
| Exception That Proves the Rule: Investigation of Privileged Stereochemistry in Designing Dopamine D |
| AID63675 | Tested for antagonist binding affinity by measuring displacement of [3H]spiperone from Human Dopamine receptor D4 expressed in CHO K-1 cells; ND means Not Determined | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15
| Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). |
| AID184105 | Inhibition of gamma-butyrolactone-stimulated DOPA synthesis in the corpus striatum of rats (30 mg/kg administered intraperitoneally) | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
| Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. |
| AID173505 | Inhibition of dopamine neuronal firing activity in the rat substantia nigra DA neutrons (2.2 mg/kg administered intraperitoneally) | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
| Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. |
| AID130894 | Inhibition of locomotor activity (LMA) in mice by the compound administered intraperitoneally. | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
| Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. |
| AID64487 | Tested for antagonist binding affinity by measuring displacement of [3H]spiperone from Human Dopamine receptor D2L expressed in CHO K-1 cells | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15
| Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). |
| AID64484 | Tested for agonist binding affinity by measuring displacement of [3H]NPA from Human Dopamine receptor D2L expressed in CHO K-1 cells; ND means Not Determined | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15
| Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). |
| AID1725411 | Displacement of [3H]-(R)-(+)-7-OH-DPAT from human D3 receptor expressed in HEK293 cells after 90 mins by microbeta counting based assay | 2020 | ACS medicinal chemistry letters, Oct-08, Volume: 11, Issue:10
| Exception That Proves the Rule: Investigation of Privileged Stereochemistry in Designing Dopamine D |
| AID1725412 | Displacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cells after 60 mins by microbeta counting based assay | 2020 | ACS medicinal chemistry letters, Oct-08, Volume: 11, Issue:10
| Exception That Proves the Rule: Investigation of Privileged Stereochemistry in Designing Dopamine D |
| AID64278 | Concentration inhibiting specific binding of [3H]haloperidol to Dopamine receptor D2 from rat striatal brain. | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
| Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. |
| AID1725410 | Displacement of [3H]-(R)-(+)-7-OH-DPAT from human D2L receptor expressed in HEK293 cells after 90 mins by microbeta counting based assay | 2020 | ACS medicinal chemistry letters, Oct-08, Volume: 11, Issue:10
| Exception That Proves the Rule: Investigation of Privileged Stereochemistry in Designing Dopamine D |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1345833 | Human D3 receptor (Dopamine receptors) | 1995 | The Journal of pharmacology and experimental therapeutics, Dec, Volume: 275, Issue:3
| Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907. |
| AID1345788 | Human D2 receptor (Dopamine receptors) | 1995 | Neuroreport, Jan-26, Volume: 6, Issue:2
| A functional test identifies dopamine agonists selective for D3 versus D2 receptors. |
| AID1345788 | Human D2 receptor (Dopamine receptors) | 1995 | The Journal of pharmacology and experimental therapeutics, Dec, Volume: 275, Issue:3
| Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907. |
| AID1345833 | Human D3 receptor (Dopamine receptors) | 1995 | Neuroreport, Jan-26, Volume: 6, Issue:2
| A functional test identifies dopamine agonists selective for D3 versus D2 receptors. |
| AID1345833 | Human D3 receptor (Dopamine receptors) | 1995 | Life sciences, , Volume: 57, Issue:15
| Characterization of binding of [3H]PD 128907, a selective dopamine D3 receptor agonist ligand, to CHO-K1 cells. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347045 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347050 | Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347049 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588378 | qHTS for Inhibitors of ATXN expression: Validation | | | |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID588349 | qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay | | | |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504836 | Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation | 2002 | The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID64278 | Concentration inhibiting specific binding of [3H]haloperidol to Dopamine receptor D2 from rat striatal brain. | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
| Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. |
| AID1765926 | Selectivity ratio of Ki for human D2 receptor transfected in HEK293 cell membrane to Ki for human D3 receptor transfected in HEK293 cell membrane | 2021 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 48 | Design, synthesis and preliminary bioactivity evaluation of bitopic benzopyranomorpholine analogues as selective dopamine D3 receptor ligands as anti-drug addiction therapeutic agents. |
| AID130894 | Inhibition of locomotor activity (LMA) in mice by the compound administered intraperitoneally. | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
| Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. |
| AID184105 | Inhibition of gamma-butyrolactone-stimulated DOPA synthesis in the corpus striatum of rats (30 mg/kg administered intraperitoneally) | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
| Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. |
| AID5297 | Tested for binding affinity by measuring displacement of [3H]ketanserin from rat serotonin 5-hydroxytryptamine 2 receptor in rat cortex; NA means Not Active | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15
| Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). |
| AID64487 | Tested for antagonist binding affinity by measuring displacement of [3H]spiperone from Human Dopamine receptor D2L expressed in CHO K-1 cells | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15
| Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). |
| AID1563552 | Displacement of [3H]-(R)-(+)-7-OH-DPAT from recombinant human D2L receptor expressed in HEK293 cell membranes measured after 90 mins by microbeta scintillation counting analysis | 2019 | Journal of medicinal chemistry, 07-11, Volume: 62, Issue:13
| The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D |
| AID63356 | Tested for antagonist binding affinity by measuring displacement of [3H]spiperone from Human Dopamine receptor D3 expressed in CHO K-1 cells | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15
| Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). |
| AID64475 | Human Dopamine receptor D2L affinities to determine agonist activity, using [3H]N-0437 as radioligand | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15
| Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). |
| AID54451 | Potency to displace the specific in vitro binding of [3H]N-0437 to calf striatal membrane | 1988 | Journal of medicinal chemistry, Nov, Volume: 31, Issue:11
| Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation. |
| AID1725414 | Displacement of [3H]-DAMGO from human MOR expressed in HEK293 cells after 60 mins by microbeta counting based assay | 2020 | ACS medicinal chemistry letters, Oct-08, Volume: 11, Issue:10
| Exception That Proves the Rule: Investigation of Privileged Stereochemistry in Designing Dopamine D |
| AID1563556 | Selectivity ratio of Ki for displacement of [3H]-(R)-(+)-7-OH-DPAT from recombinant human D4.4 receptor expressed in HEK293 cell membranes to Ki for displacement of [3H]-(R)-(+)-7-OH-DPAT from recombinant human D3 receptor expressed in HEK293 cell membran | 2019 | Journal of medicinal chemistry, 07-11, Volume: 62, Issue:13
| The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D |
| AID239943 | Inhibition constant against [3H]-spiperone binding to human Dopamine receptor D3 expressed in CHO cells | 2005 | Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7
| CoMFA and CoMSIA investigations revealing novel insights into the binding modes of dopamine D3 receptor agonists. |
| AID173505 | Inhibition of dopamine neuronal firing activity in the rat substantia nigra DA neutrons (2.2 mg/kg administered intraperitoneally) | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
| Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. |
| AID168912 | Potency to displace the specific in vitro binding of [3H]DP-5,6-ADTN to rat striatal membrane | 1988 | Journal of medicinal chemistry, Nov, Volume: 31, Issue:11
| Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation. |
| AID64485 | Tested for agonist binding affinity by measuring displacement of [3H]NPA from Human Dopamine receptor D2L expressed in CHO K-1 cells; ND means Not determined | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15
| Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). |
| AID65465 | Agonist activity by measuring the [3H]-thymidine uptake against Dopamine receptor D3 from rat | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15
| Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). |
| AID64637 | Agonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D2L from rat | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15
| Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). |
| AID1725412 | Displacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cells after 60 mins by microbeta counting based assay | 2020 | ACS medicinal chemistry letters, Oct-08, Volume: 11, Issue:10
| Exception That Proves the Rule: Investigation of Privileged Stereochemistry in Designing Dopamine D |
| AID173641 | In Vivo effect on concentration of HVA in rat striatum at dose of 10 umol/kg administered intraperitoneally | 1988 | Journal of medicinal chemistry, Nov, Volume: 31, Issue:11
| Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation. |
| AID231116 | Ratio of binding affinities of human Dopamine D2A and D3 receptors | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15
| Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). |
| AID1725411 | Displacement of [3H]-(R)-(+)-7-OH-DPAT from human D3 receptor expressed in HEK293 cells after 90 mins by microbeta counting based assay | 2020 | ACS medicinal chemistry letters, Oct-08, Volume: 11, Issue:10
| Exception That Proves the Rule: Investigation of Privileged Stereochemistry in Designing Dopamine D |
| AID177910 | Inhibition of gamma-butyrolactone-stimulated DOPA synthesis in the corpus striatum of rats (dose administered subcutaneously) | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
| Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. |
| AID1725410 | Displacement of [3H]-(R)-(+)-7-OH-DPAT from human D2L receptor expressed in HEK293 cells after 90 mins by microbeta counting based assay | 2020 | ACS medicinal chemistry letters, Oct-08, Volume: 11, Issue:10
| Exception That Proves the Rule: Investigation of Privileged Stereochemistry in Designing Dopamine D |
| AID64642 | Intrinsic activity (IA) by the mitogenesis assay | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15
| Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). |
| AID19222 | Partition coefficient in octanol-buffer at a pH 7.4 | 1988 | Journal of medicinal chemistry, Nov, Volume: 31, Issue:11
| Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation. |
| AID173771 | Inhibition of gamma-butyrolactone-stimulated DOPA synthesis in the corpus striatum of rats | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
| Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. |
| AID1563555 | Selectivity ratio of Ki for displacement of [3H]-(R)-(+)-7-OH-DPAT from recombinant human D2L receptor expressed in HEK293 cell membranes to Ki for displacement of [3H]-(R)-(+)-7-OH-DPAT from recombinant human D3 receptor expressed in HEK293 cell membrane | 2019 | Journal of medicinal chemistry, 07-11, Volume: 62, Issue:13
| The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D |
| AID26626 | Ionization constant in presence of nitrogen | 1988 | Journal of medicinal chemistry, Nov, Volume: 31, Issue:11
| Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation. |
| AID173668 | In vivo effect on concentration of DOPAC in rat striatum at dose of 10 umol/kg administered intraperitoneally | 1988 | Journal of medicinal chemistry, Nov, Volume: 31, Issue:11
| Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation. |
| AID63674 | Tested for antagonist binding affinity by measuring displacement of [3H]spiperone from Human Dopamine receptor D4 expressed in CHO K-1 cells | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15
| Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). |
| AID64636 | Antagonist activity by measuring the inhibition of quinpirole stimulated [3H]- thymidine uptake against Dopamine receptor D2L; NA means Not Active | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15
| Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). |
| AID65594 | Intrinsic activity (IA) by the mitogenesis assay | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15
| Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). |
| AID63675 | Tested for antagonist binding affinity by measuring displacement of [3H]spiperone from Human Dopamine receptor D4 expressed in CHO K-1 cells; ND means Not Determined | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15
| Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). |
| AID1725413 | Displacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cells at 100 uM after 60 mins by microbeta counting based assay relative to control | 2020 | ACS medicinal chemistry letters, Oct-08, Volume: 11, Issue:10
| Exception That Proves the Rule: Investigation of Privileged Stereochemistry in Designing Dopamine D |
| AID26837 | Ionization constant in presence of hydroxyl | 1988 | Journal of medicinal chemistry, Nov, Volume: 31, Issue:11
| Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation. |
| AID130895 | Inhibition of locomotor activity (LMA) in mice generated from four doses of 5-12 animals per dose (dose administered po) | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
| Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. |
| AID1765925 | Displacement of [3H]spiperone from human D3 receptor transfected in HEK293 cell membrane measured after 50 mins by competitive radioligand binding analysis | 2021 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 48 | Design, synthesis and preliminary bioactivity evaluation of bitopic benzopyranomorpholine analogues as selective dopamine D3 receptor ligands as anti-drug addiction therapeutic agents. |
| AID176597 | In Vivo effect of agonist on the induction of stereotypy (continuous sniffing behavior in rat) at 10 umol/kg; Inactive | 1988 | Journal of medicinal chemistry, Nov, Volume: 31, Issue:11
| Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation. |
| AID130896 | Inhibition of locomotor activity (LMA) in mice generated from four doses of 5-12 animals per dose (dose administered subcutaneously) | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
| Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. |
| AID65462 | Antagonist activity by measuring the inhibition of quinpirole stimulated [3H]- thymidine uptake against Dopamine receptor D3; the compound is active | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15
| Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). |
| AID4341 | Tested for binding affinity by measuring displacement of [3H]8-OH-DPAT from rat serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus | 2000 | Journal of medicinal chemistry, Jul-27, Volume: 43, Issue:15
| Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). |
| AID1765924 | Displacement of [3H]spiperone from human D2 receptor transfected in HEK293 cell membrane measured after 50 mins by competitive radioligand binding analysis | 2021 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 48 | Design, synthesis and preliminary bioactivity evaluation of bitopic benzopyranomorpholine analogues as selective dopamine D3 receptor ligands as anti-drug addiction therapeutic agents. |
| AID176637 | Reversal of reserpine-induced depression in rat (dose administered subcutaneously) | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
| Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. |
| AID61398 | Affinity for [3H]N-propylnorapomorphine (NPA) Dopamine receptor D2 | 1990 | Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
| Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. |
| AID1563553 | Displacement of [3H]-(R)-(+)-7-OH-DPAT from recombinant human D3 receptor expressed in HEK293 cell membranes measured after 90 mins by microbeta scintillation counting analysis | 2019 | Journal of medicinal chemistry, 07-11, Volume: 62, Issue:13
| The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D |
| AID1563554 | Displacement of [3H]-(R)-(+)-7-OH-DPAT from recombinant human D4.4 receptor expressed in HEK293 cell membranes measured after 90 mins by microbeta scintillation counting analysis | 2019 | Journal of medicinal chemistry, 07-11, Volume: 62, Issue:13
| The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D |
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |