Compounds > halisulfate 1
Page last updated: 2024-11-13

halisulfate 1

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Description

halisulfate 1: an isocitrate lyase inhibitor sesterterpene sulfate from sponge, Hippospongia sp.; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID23662099
CHEMBL ID387584
CHEBI ID69280
SCHEMBL ID3537034
MeSH IDM0513396

Synonyms (7)

Synonym
chebi:69280 ,
halisulfate 1
CHEMBL387584 ,
halisulfate 1, (rel)-
SCHEMBL3537034
Q27137619
sodium;[(e,2r,3r)-1-[(1s,4as,8as)-2,5,5,8a-tetramethyl-1,4,4a,6,7,8-hexahydronaphthalen-1-yl]-9-(2,5-dihydroxyphenyl)-3,7-dimethylnon-7-en-2-yl] sulfate
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
organic molecular entityAny molecular entity that contains carbon.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (13)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Sodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)IC50 (µMol)3.00000.00480.78076.0000AID614150
Sodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)IC50 (µMol)3.00000.00480.81346.0000AID614150
Sodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)IC50 (µMol)3.00000.00480.81346.0000AID614150
Sodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)IC50 (µMol)3.00000.00480.81346.0000AID614150
Polyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)IC50 (µMol)0.90000.04002.099810.0000AID354432
Sodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)IC50 (µMol)3.00000.00480.81346.0000AID614150
Sodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)IC50 (µMol)3.00000.00480.81346.0000AID614150
Sodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)IC50 (µMol)3.00000.00480.81346.0000AID614150
Mu-type opioid receptorCavia porcellus (domestic guinea pig)IC50 (µMol)12.60000.00020.660310.0000AID290415
Sodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)IC50 (µMol)3.00000.00480.81346.0000AID614150
Isocitrate lyaseCandida albicansIC50 (µMol)44.60006.00007.50009.0000AID389382; AID614149
Class A sortase SrtA Staphylococcus aureusIC50 (µMol)36.00000.30002.86005.9000AID614148
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (120)

Processvia Protein(s)Taxonomy
regulation of the force of heart contractionSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
regulation of sodium ion transportSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
osmosensory signaling pathwaySodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
regulation of blood pressureSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
response to xenobiotic stimulusSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
establishment or maintenance of transmembrane electrochemical gradientSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
negative regulation of glucocorticoid biosynthetic processSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
negative regulation of heart contractionSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
positive regulation of heart contractionSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
positive regulation of striated muscle contractionSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
relaxation of cardiac muscleSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
cellular response to steroid hormone stimulusSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
cardiac muscle cell action potential involved in contractionSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
membrane repolarizationSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
membrane repolarization during cardiac muscle cell action potentialSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
cell communication by electrical coupling involved in cardiac conductionSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
proton transmembrane transportSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
response to glycosideSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
intracellular calcium ion homeostasisSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
cell adhesionSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
establishment or maintenance of transmembrane electrochemical gradientSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
regulation of gene expressionSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
regulation of cardiac muscle contraction by calcium ion signalingSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
positive regulation of ATP-dependent activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
sodium ion transmembrane transportSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
protein transport into plasma membrane raftSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
innate immune responseSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
ATP metabolic processSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
protein stabilizationSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
relaxation of cardiac muscleSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
cardiac muscle contractionSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
protein localization to plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
membrane repolarizationSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
membrane repolarization during cardiac muscle cell action potentialSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
cell communication by electrical coupling involved in cardiac conductionSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
monoatomic cation transmembrane transportSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
positive regulation of potassium ion transmembrane transporter activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
proton transmembrane transportSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
positive regulation of sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
positive regulation of calcium:sodium antiporter activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
positive regulation of potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
positive regulation of P-type sodium:potassium-exchanging transporter activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
establishment or maintenance of transmembrane electrochemical gradientSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
regulation of resting membrane potentialSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
cellular response to steroid hormone stimulusSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
cell communication by electrical coupling involved in cardiac conductionSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
response to glycosideSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
cellular response to amyloid-betaSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
neuron projection maintenanceSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
proton transmembrane transportSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
retina homeostasisSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
lateral ventricle developmentSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
third ventricle developmentSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
neuronal-glial interaction involved in hindbrain glial-mediated radial cell migrationSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
photoreceptor cell maintenanceSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
motor behaviorSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
plasma membrane bounded cell projection organizationSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
positive regulation of neuron projection developmentSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
cell-substrate adhesionSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
positive regulation of ATP-dependent activitySodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
protein stabilizationSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
membrane repolarizationSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
cell communication by electrical coupling involved in cardiac conductionSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
transport across blood-brain barrierSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
positive regulation of potassium ion transmembrane transporter activitySodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
positive regulation of sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
positive regulation of potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
negative regulation of glial cell migrationSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
ossificationPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
negative regulation of adaptive immune responsePolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
lipid metabolic processPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
phosphatidylethanolamine biosynthetic processPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
inflammatory responsePolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
positive regulation of cell-substrate adhesionPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
arachidonic acid metabolic processPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
lipoxygenase pathwayPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
fatty acid oxidationPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
bone mineralizationPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
positive regulation of actin filament polymerizationPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
response to endoplasmic reticulum stressPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
regulation of peroxisome proliferator activated receptor signaling pathwayPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
cellular response to interleukin-13Polyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
wound healingPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
long-chain fatty acid biosynthetic processPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
apoptotic cell clearancePolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
linoleic acid metabolic processPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
regulation of inflammatory responsePolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
hepoxilin biosynthetic processPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascadePolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
cellular response to calcium ionPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
regulation of engulfment of apoptotic cellPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
lipoxin A4 biosynthetic processPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
lipid oxidationPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
behavioral fear responseSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of the force of heart contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of respiratory gaseous exchange by nervous system processSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of muscle contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
amygdala developmentSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
olfactory cortex developmentSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
locomotionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
negative regulation of heart contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
positive regulation of heart contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
negative regulation of cytosolic calcium ion concentrationSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
neurotransmitter uptakeSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
potassium ion transportSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
sodium ion transportSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of smooth muscle contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of striated muscle contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of blood pressureSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
adult locomotory behaviorSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
visual learningSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
establishment or maintenance of transmembrane electrochemical gradientSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
response to auditory stimulusSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
neuronal action potential propagationSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of vasoconstrictionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
L-ascorbic acid metabolic processSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
response to nicotineSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
locomotory exploration behaviorSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
sodium ion transmembrane transportSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
response to potassium ionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
negative regulation of striated muscle contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
ATP metabolic processSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of glutamate uptake involved in transmission of nerve impulseSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of synaptic transmission, glutamatergicSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
relaxation of cardiac muscleSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
cardiac muscle contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
cellular response to mechanical stimulusSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
cellular response to steroid hormone stimulusSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
potassium ion transmembrane transportSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
regulation of cardiac muscle cell contractionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
membrane repolarizationSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
membrane depolarization during cardiac muscle cell action potentialSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
cell communication by electrical coupling involved in cardiac conductionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
monoatomic cation transmembrane transportSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
transport across blood-brain barrierSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
negative regulation of calcium ion transmembrane transportSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
negative regulation of calcium:sodium antiporter activitySodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
response to glycosideSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
proton transmembrane transportSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
positive regulation of ATP-dependent activitySodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
sodium ion transmembrane transportSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
protein stabilizationSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
potassium ion transmembrane transportSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
protein localization to plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
membrane repolarizationSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
positive regulation of potassium ion transmembrane transporter activitySodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
positive regulation of sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
positive regulation of potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
establishment or maintenance of transmembrane electrochemical gradientSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
transmembrane transportSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
proton transmembrane transportSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
positive regulation of P-type sodium:potassium-exchanging transporter activitySodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
regulation of sodium ion transmembrane transporter activitySodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
monoatomic ion transportSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
potassium ion transportSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
sodium ion transportSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
cell surface receptor signaling pathwaySodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
spermatogenesisSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
fertilizationSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
establishment or maintenance of transmembrane electrochemical gradientSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
flagellated sperm motilitySodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
regulation of cellular pHSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
sodium ion transmembrane transportSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
regulation of membrane potentialSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
establishment of localization in cellSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
potassium ion transmembrane transportSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
transport across blood-brain barrierSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
proton transmembrane transportSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
sodium ion export across plasma membraneSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
potassium ion import across plasma membraneSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
intracellular potassium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
intracellular sodium ion homeostasisSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (27)

Processvia Protein(s)Taxonomy
P-type sodium:potassium-exchanging transporter activitySodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
protein bindingSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
ATP bindingSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
phosphatase activitySodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
ATP hydrolysis activitySodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
potassium ion bindingSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
sodium ion bindingSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
transmembrane transporter bindingSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
protein heterodimerization activitySodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
protein-folding chaperone bindingSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
steroid hormone bindingSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
ATPase activator activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
P-type sodium:potassium-exchanging transporter activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
protein bindingSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
protein kinase bindingSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
MHC class II protein complex bindingSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
protein-macromolecule adaptor activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
protein heterodimerization activitySodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
ATPase bindingSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
amyloid-beta bindingSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
P-type sodium:potassium-exchanging transporter activitySodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
protein bindingSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
ATP bindingSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
ATP hydrolysis activitySodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
metal ion bindingSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
protein-folding chaperone bindingSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
steroid hormone bindingSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
ATPase activator activitySodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
protein bindingSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
protein-macromolecule adaptor activitySodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
protein heterodimerization activitySodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
ATPase bindingSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
arachidonate 12(S)-lipoxygenase activityPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
iron ion bindingPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
protein bindingPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
phosphatidylinositol-4,5-bisphosphate bindingPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
linoleate 13S-lipoxygenase activityPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
arachidonate 15-lipoxygenase activityPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
P-type sodium:potassium-exchanging transporter activitySodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
steroid bindingSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
protein bindingSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
ATP bindingSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
phosphatase activitySodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
ATP hydrolysis activitySodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
ATPase-coupled monoatomic cation transmembrane transporter activitySodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
potassium ion bindingSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
sodium ion bindingSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
protein heterodimerization activitySodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
protein-folding chaperone bindingSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
steroid hormone bindingSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
ATPase activator activitySodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
protein bindingSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
protein-macromolecule adaptor activitySodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
ATPase bindingSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
ATPase activator activitySodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
protein-macromolecule adaptor activitySodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
sodium channel regulator activitySodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
P-type sodium:potassium-exchanging transporter activitySodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
protein bindingSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
ATP bindingSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
ATP hydrolysis activitySodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
ATPase-coupled monoatomic cation transmembrane transporter activitySodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
kinase bindingSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
metal ion bindingSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (44)

Processvia Protein(s)Taxonomy
endoplasmic reticulumSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
Golgi apparatusSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
postsynaptic densitySodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
basolateral plasma membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
apical plasma membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
lateral plasma membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
T-tubuleSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
axonSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
organelle membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
sperm flagellumSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
sarcolemmaSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
melanosomeSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
membrane raftSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
photoreceptor inner segment membraneSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
extracellular exosomeSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
extracellular vesicleSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
protein-containing complexSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
sarcolemmaSodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
intercalated discSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
basolateral plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
apical plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
lateral plasma membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
T-tubuleSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
organelle membraneSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
sperm flagellumSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
sarcolemmaSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
extracellular exosomeSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
extracellular vesicleSodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)
photoreceptor inner segmentSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
endoplasmic reticulumSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
Golgi apparatusSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
axonSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
organelle membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
neuronal cell body membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
neuronal cell bodySodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
synapseSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
photoreceptor inner segment membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
neuron to neuron synapseSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
extracellular vesicleSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)
photoreceptor inner segmentSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
cytoplasmSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
external side of plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
apical plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
lateral plasma membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
cell projection membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
cell body membraneSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
cell peripherySodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
astrocyte projectionSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
astrocyte end-footSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
neuron to neuron synapseSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)
lipid dropletPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
cytosolPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
plasma membranePolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
cytoplasmic side of plasma membranePolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
membranePolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
plasma membranePolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
cytosolPolyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)
cytoplasmSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
endosomeSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
endoplasmic reticulumSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
caveolaSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
cell surfaceSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
intercalated discSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
membraneSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
T-tubuleSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
organelle membraneSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
cell projectionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
neuronal cell bodySodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
dendritic spineSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
extracellular vesicleSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
cell projectionSodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
basolateral plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
apical plasma membraneSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
sperm flagellumSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
melanosomeSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
extracellular exosomeSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
extracellular exosomeSodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
membrane raftSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
sperm midpieceSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
photoreceptor cell ciliumSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
rod photoreceptor outer segmentSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
sodium:potassium-exchanging ATPase complexSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
plasma membraneSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
cell projectionSodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (33)

Assay IDTitleYearJournalArticle
AID614150Inhibition of human Na(+)/K(+) ATPase assessed as reduction in ouabain-sensitive and K(+)-dependent cleavage of fluorescent pseudosubstrate 3-O-methylfluorescein phosphate by fluorometric method2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Sesterterpenes from the tropical sponge Coscinoderma sp.
AID354431Inhibition of soybean 15-lipoxygenase2003Journal of natural products, Feb, Volume: 66, Issue:2
Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.
AID389387Antibacterial activity against Proteus vulgaris ATCC 38512008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
Inhibition of Candida albicans isocitrate lyase activity by sesterterpene sulfates from the tropical sponge Dysidea sp.
AID354433Inhibition of His-tagged human platelet 12-lipoxygenase2003Journal of natural products, Feb, Volume: 66, Issue:2
Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.
AID389383Antifungal activity against candida albicans ATCC 102312008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
Inhibition of Candida albicans isocitrate lyase activity by sesterterpene sulfates from the tropical sponge Dysidea sp.
AID354432Inhibition of His-tagged human reticulocyte 15-lipoxygenase2003Journal of natural products, Feb, Volume: 66, Issue:2
Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.
AID354434Ratio of IC50 for human 12-lipoxygenase to IC50 for human 15-lipoxygenase2003Journal of natural products, Feb, Volume: 66, Issue:2
Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.
AID614156Antimicrobial activity against Escherichia coli ATCC 352702011Journal of natural products, Aug-26, Volume: 74, Issue:8
Sesterterpenes from the tropical sponge Coscinoderma sp.
AID389385Antibacterial activity against Bacillus subtilis ATCC 66332008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
Inhibition of Candida albicans isocitrate lyase activity by sesterterpene sulfates from the tropical sponge Dysidea sp.
AID614157Antimicrobial activity against Aspergillus fumigatus HIC 60942011Journal of natural products, Aug-26, Volume: 74, Issue:8
Sesterterpenes from the tropical sponge Coscinoderma sp.
AID614159Antimicrobial activity against Trichophyton mentagrophytes IFO 409962011Journal of natural products, Aug-26, Volume: 74, Issue:8
Sesterterpenes from the tropical sponge Coscinoderma sp.
AID614154Antimicrobial activity against Salmonella Typhimurium ATCC 140282011Journal of natural products, Aug-26, Volume: 74, Issue:8
Sesterterpenes from the tropical sponge Coscinoderma sp.
AID389382Inhibition of candida albicans isocitrate lyase2008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
Inhibition of Candida albicans isocitrate lyase activity by sesterterpene sulfates from the tropical sponge Dysidea sp.
AID389388Antibacterial activity against Salmonella Typhimurium ATCC 140282008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
Inhibition of Candida albicans isocitrate lyase activity by sesterterpene sulfates from the tropical sponge Dysidea sp.
AID389384Antibacterial activity against Staphylococcus aureus ATCC 65382008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
Inhibition of Candida albicans isocitrate lyase activity by sesterterpene sulfates from the tropical sponge Dysidea sp.
AID354436Ratio of IC50 for soybean 15-lipoxygenase to IC50 for human 15-lipoxygenase2003Journal of natural products, Feb, Volume: 66, Issue:2
Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.
AID614151Antimicrobial activity against Staphylococcus aureus ATCC 6538p2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Sesterterpenes from the tropical sponge Coscinoderma sp.
AID290419Reduction of appressorium formation in wild type Magnaporthe grisea Guy 11 after 14 hrs2007Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9
Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp.
AID290416Inhibition of Magnaporthe grisea Guy 11 malate synthase2007Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9
Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp.
AID614148Inhibition of recombinant Staphylococcus aureus ATCC 6538p sortase lacking the N-terminal membrane anchor domain expressed in Escherichia coli cells TOP10 using Dabcyl-QALPETGEE-Edans substrate measured after 1 hr by fluorescence S13 spectrophotometry2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Sesterterpenes from the tropical sponge Coscinoderma sp.
AID614158Antimicrobial activity against Trichophyton rubrum IFO 91852011Journal of natural products, Aug-26, Volume: 74, Issue:8
Sesterterpenes from the tropical sponge Coscinoderma sp.
AID354435Ratio of IC50 for human 12-lipoxygenase to IC50 for soybean 15-lipoxygenase2003Journal of natural products, Feb, Volume: 66, Issue:2
Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.
AID290417Growth inhibition of Magnaporthe grisea Guy 11 in presence of glucose after 6 days2007Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9
Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp.
AID614152Antimicrobial activity against Bacillus subtilis ATCC 66332011Journal of natural products, Aug-26, Volume: 74, Issue:8
Sesterterpenes from the tropical sponge Coscinoderma sp.
AID614160Antimicrobial activity against Candida albicans ATCC 102312011Journal of natural products, Aug-26, Volume: 74, Issue:8
Sesterterpenes from the tropical sponge Coscinoderma sp.
AID389389Antibacterial activity against Escherichia coli ATCC 117752008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
Inhibition of Candida albicans isocitrate lyase activity by sesterterpene sulfates from the tropical sponge Dysidea sp.
AID290415Inhibition of Magnaporthe grisea Guy 11 isocitrate lyase2007Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9
Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp.
AID614153Antimicrobial activity against Micrococcus luteus IFO 127082011Journal of natural products, Aug-26, Volume: 74, Issue:8
Sesterterpenes from the tropical sponge Coscinoderma sp.
AID290418Growth inhibition of Magnaporthe grisea Guy 11 in presence of sodium acetate after 6 days2007Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9
Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp.
AID614149Inhibition of Candida albicans isocitrate lyase2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Sesterterpenes from the tropical sponge Coscinoderma sp.
AID389386Antibacterial activity against Micrococcus luteus IFC127082008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
Inhibition of Candida albicans isocitrate lyase activity by sesterterpene sulfates from the tropical sponge Dysidea sp.
AID614155Antimicrobial activity against Proteus vulgaris ATCC 38512011Journal of natural products, Aug-26, Volume: 74, Issue:8
Sesterterpenes from the tropical sponge Coscinoderma sp.
AID614147Cytotoxicity against human K562 cells2011Journal of natural products, Aug-26, Volume: 74, Issue:8
Sesterterpenes from the tropical sponge Coscinoderma sp.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (80.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
3-nitropropionic acid
3-nitropropionic acid: succinate dehydrogenase inactivator; biosynthesized by FABACEAE plants from ASPARAGINE. 3-nitropropanoic acid : A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.		2.4620C-nitro compoundantimycobacterial drug;
EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor;
mycotoxin;
neurotoxin
masoprocol
nordihydroguaretic acid: antioxidant compound found in the creosote bush (Larrea tridentata)		2.0110catechols;
lignan;
tetrol		antioxidant;
ferroptosis inhibitor;
geroprotector;
plant metabolite
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		2.4620beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
puupehenone
[no description available]		2.0110
ouabain
Ouabain: A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.. cardiac glycoside : Steroid lactones containing sugar residues that act on the contractile force of the cardiac muscles.. ouabain : A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus.		2.061011alpha-hydroxy steroid;
14beta-hydroxy steroid;
5beta-hydroxy steroid;
alpha-L-rhamnoside;
cardenolide glycoside;
steroid hormone		anti-arrhythmia drug;
cardiotonic drug;
EC 2.3.3.1 [citrate (Si)-synthase] inhibitor;
EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
ion transport inhibitor;
plant metabolite
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		2.4620antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
jaspaquinol
jaspaquinol: structure in first source		2.0110
ConditionIndicatedRelationship StrengthStudiesTrials