Compounds > 3,4,5,6-tetrahydroxyxanthone
Page last updated: 2024-08-02 13:38:22

3,4,5,6-tetrahydroxyxanthone

Description

Cross-References

ID SourceID
PubMed CID10015450
CHEMBL ID477921
SCHEMBL ID1444851
MeSH IDM0508168

Synonyms (7)

Synonym
3,4,5,6-tetrahydroxyxanthen-9-one
bdbm50292546
3,4,5,6-tetrahydroxyxanthone
CHEMBL477921 ,
SCHEMBL1444851
3,4,5,6-tetrahydroxy-9h-xanthen-9-one
99420-08-3

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Angiotensin-converting enzyme Homo sapiens (human)IC50238.5000AID335366
Angiotensin-converting enzyme Homo sapiens (human)Ki126.0000AID335370
7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)IC5057.0000AID1542231

Bioassays (7)

Assay IDTitleYearJournalArticle
AID335367Inhibition of ACE at 100 uM1992Journal of natural products, May, Volume: 55, Issue:5
ISSN: 0163-3864		Inhibition of angiotensin-I-converting enzyme by tetrahydroxyxanthones isolated from Tripterospermum lanceolatum.
AID335366Inhibition of ACE1992Journal of natural products, May, Volume: 55, Issue:5
ISSN: 0163-3864		Inhibition of angiotensin-I-converting enzyme by tetrahydroxyxanthones isolated from Tripterospermum lanceolatum.
AID335369Inhibition of ACE at 400 uM1992Journal of natural products, May, Volume: 55, Issue:5
ISSN: 0163-3864		Inhibition of angiotensin-I-converting enzyme by tetrahydroxyxanthones isolated from Tripterospermum lanceolatum.
AID1520339Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay2019European journal of medicinal chemistry, Mar-15, Volume: 166ISSN: 1768-3254All that glitters is not gold: Panning cytotoxic natural products and derivatives with a fused tricyclic backbone by the estimation of their leadlikeness for cancer treatment.
AID335368Inhibition of ACE at 200 uM1992Journal of natural products, May, Volume: 55, Issue:5
ISSN: 0163-3864		Inhibition of angiotensin-I-converting enzyme by tetrahydroxyxanthones isolated from Tripterospermum lanceolatum.
AID335370Inhibition of ACE by Lineweaver-Burke plot1992Journal of natural products, May, Volume: 55, Issue:5
ISSN: 0163-3864		Inhibition of angiotensin-I-converting enzyme by tetrahydroxyxanthones isolated from Tripterospermum lanceolatum.
AID1542231Inhibition of recombinant C-terminal 6xHis-tagged MTH1 (3 to 156 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using dGTP as substrate measured after 30 mins by malachite green dye based inorganic phosphatase coupled absorbance 2019European journal of medicinal chemistry, Apr-01, Volume: 167ISSN: 1768-3254Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening.

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's3 (33.33)29.6817
2010's5 (55.56)24.3611
2020's0 (0.00)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (11.11%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (88.89%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
quinacrine
1
acridines;
aromatic ether;
organochlorine compound;
tertiary amino compound		antimalarial;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor		201920195.0low000010
mitoxantrone
1
dihydroxyanthraquinoneanalgesic;
antineoplastic agent		201920195.0low000010
phenazine
1
azaarene;
heteranthrene;
mancude organic heterotricyclic parent;
phenazines;
polycyclic heteroarene		201920195.0low000010
captopril
1
alkanethiol;
L-proline derivative;
N-acylpyrrolidine;
pyrrolidinemonocarboxylic acid		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor		1992199232.0low001000
1,10-phenanthroline-5,6-dione
1
201920195.0low000010
sugiol
1
abietane diterpenoid;
carbotricyclic compound;
cyclic terpene ketone;
meroterpenoid;
phenols		antineoplastic agent;
antioxidant;
antiviral agent;
plant metabolite;
radical scavenger		201920195.0low000010
dactylariol
1
201920195.0high000010
8-deoxygartanin
1
xanthones201920195.0medium000010
N-ethylharmine
1
aromatic ether;
beta-carbolines;
semisynthetic derivative		anti-HIV agent201920195.0high000010
7-hydroxy-2-methoxy-1,4-phenanthrenedione
1
201920195.0medium000010
6,7-dehydroroyleanone
1
201920195.0medium000010
gartanin
1
polyphenol;
xanthones		antineoplastic agent;
plant metabolite		201920195.0medium000010
gentisein
1
polyphenol;
xanthones		plant metabolite201920195.0low000010
mangiferin
1
C-glycosyl compound;
xanthones		anti-inflammatory agent;
antioxidant;
hypoglycemic agent;
plant metabolite		201920195.0low000010
mangostin
2
aromatic ether;
phenols;
xanthones		antimicrobial agent;
antineoplastic agent;
antioxidant;
plant metabolite		201920195.0low000020
norathyriol
2
polyphenol;
xanthones		antineoplastic agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
plant metabolite		1992201918.5low001010
gamma-mangostin
1
phenols;
xanthones		antineoplastic agent;
plant metabolite;
protein kinase inhibitor		201920195.0low000010
1,3,5,6-tetrahydroxyxanthone
2
1992201918.5high001010
1,3-dihydroxy-xanthone
1
201920195.0low000010
1,6-dihydroxyxanthone
1
201920195.0medium000010
1,3,7-trihydroxy-2-(3-methylbut-2-enyl)-xanthone
1
201920195.0medium000010
beta-Mangostin
1
xanthones201920195.0medium000010
marcanine a
1
201920195.0medium000010
dicerandrol a
1
201920195.0high000010
3-isomangostin
1
xanthones201920195.0medium000010
dehydroabietinol
1
abietane diterpenoid;
carbotricyclic compound		201920195.0medium000010
garcinone c
1
xanthones201920195.0medium000010
ent-crizotinib
1
3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine201920195.0medium000010
deoxyguanosine triphosphate
1
deoxyguanosine phosphate;
guanyl deoxyribonucleotide;
purine 2'-deoxyribonucleoside 5'-triphosphate		Arabidopsis thaliana metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite		201920195.0low000010
4-deoxybostrycin
1
201920195.0medium000010
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
n(g),n(g')-dimethyl-l-arginine
1
alpha-amino acid2011201113.0low000010
nitroglycerin
1
nitroglycerolexplosive;
muscle relaxant;
nitric oxide donor;
prodrug;
tocolytic agent;
vasodilator agent;
xenobiotic		2006200618.0low000100
arginine
2
arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical		2009201114.0low000110
xanthone
1
xanthonesinsecticide2014201410.0low000010
malondialdehyde
1
dialdehydebiomarker2009200915.0low000100
n,n-dimethylarginine
1
dimethylarginine;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid		EC 1.14.13.39 (nitric oxide synthase) inhibitor2011201113.0low000010
ouabain
1
11alpha-hydroxy steroid;
14beta-hydroxy steroid;
5beta-hydroxy steroid;
alpha-L-rhamnoside;
cardenolide glycoside;
steroid hormone		anti-arrhythmia drug;
cardiotonic drug;
EC 2.3.3.1 [citrate (Si)-synthase] inhibitor;
EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
ion transport inhibitor;
plant metabolite		201820186.0low000010
t0901317
1
2008200816.0low000100
genistein
1
7-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor		2014201410.0low000010
mangiferin
1
C-glycosyl compound;
xanthones		anti-inflammatory agent;
antioxidant;
hypoglycemic agent;
plant metabolite		2014201410.0low000010
lysophosphatidylcholines
1
1-O-acyl-sn-glycero-3-phosphocholine2011201113.0low000010
dimethylarginine
1
2009200915.0low000100
epidermal growth factor
1
201820186.0low000010
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Atherogenesis0
1
2009200915.0medium000100
Atherosclerosis0
1
2009200915.0medium000100
Breast Cancer0
1
201820186.0medium000010
Breast Neoplasms0
1
201820186.0medium000010
Disease Models, Animal0
1
2008200816.0medium000100
Dyslipidemia0
1
2008200816.0medium000100
Dyslipidemias0
1
2008200816.0medium000100
Invasiveness, Neoplasm0
1
201820186.0medium000010