Compounds > l 161240
Page last updated: 2024-12-11

l 161240

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

L 161240: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9839581
CHEMBL ID107313
SCHEMBL ID15237961
MeSH IDM0267193
PubMed CID137699305
MeSH IDM0267193

Synonyms (14)

Synonym
(r)-2-(3,4-dimethoxy-5-propylphenyl)-n-hydroxy-4,5-dihydrooxazole-4-carboxamide
bdbm50074960
(r)-2-(3,4-dimethoxy-5-propyl-phenyl)-4,5-dihydro-oxazole-4-carboxylic acid hydroxyamide
CHEMBL107313 ,
l-161240
(4r)-2-(3,4-dimethoxy-5-propylphenyl)-n-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
SCHEMBL15237961
(4r)-2-(3,4-dimethoxy-5-propyl-phenyl)-n-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Q27462705
183298-68-2
PD160463
AKOS040752342
l 161240
PD118333
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
UDP-3-O-acyl-N-acetylglucosamine deacetylase Rhizobium leguminosarum bv. trifolii WSM1325Ki0.11000.00070.02930.1100AID330341
UDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12IC50 (µMol)0.03000.00300.03040.0580AID214943
UDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12Ki0.03010.00010.08800.6500AID330337; AID330338; AID568324; AID652927; AID766725
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (4)

Processvia Protein(s)Taxonomy
lipid A biosynthetic processUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
phosphate-containing compound metabolic processUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
lipid A biosynthetic processUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
organophosphate metabolic processUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
carbohydrate derivative metabolic processUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (7)

Processvia Protein(s)Taxonomy
iron ion bindingUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
zinc ion bindingUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activityUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
hydrolase activityUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
deacetylase activityUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
metal ion bindingUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
UDP-3-O-acyl-N-acetylglucosamine deacetylase activityUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
cytoplasmUDP-3-O-acyl-N-acetylglucosamine deacetylaseEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID1875128Antibacterial activity against Escherichia coli MB28842022Journal of medicinal chemistry, 09-08, Volume: 65, Issue:17
Structure-Kinetic Relationship Studies for the Development of Long Residence Time LpxC Inhibitors.
AID766725Inhibition of Escherichia coli LpxC enzyme2013Journal of medicinal chemistry, Sep-12, Volume: 56, Issue:17
Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors.
AID330337Inhibition of Escherichia coli LpxC2007Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding.
AID652927Inhibition of Escherichia coli LpxC2012Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7
Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC.
AID568324Inhibition of Escherichia coli LpxC2011Bioorganic & medicinal chemistry letters, Feb-15, Volume: 21, Issue:4
Design and synthesis of potent Gram-negative specific LpxC inhibitors.
AID330338Inhibition of Escherichia coli LpxC Q202W/G210S mutant2007Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding.
AID163925Antibacterial activity against Pseudomonas was determined; NA=not active1999Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis.
AID69769Antibacterial activity against Escherichia coli mutant (envA1) was determined; Ranges from 0.008-0.0161999Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis.
AID214943Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using direct deacetylase assay (DEACET) in Escherichia coli strain JB 11041999Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis.
AID330341Inhibition of Rhizobium leguminosarum LpxC W206Q/S214G mutant2007Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding.
AID205200Antibacterial activity against Serratia was determined; NA=not active1999Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis.
AID69772Antibacterial activity against Escherichia coli was determined; Ranges from 1-31999Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis.
AID214942Inhibition of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase using coupled radiochemical assay (WAVE) in Escherichia coli strain JB 1104; NA= not available1999Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis.
AID330339Inhibition of Rhizobium leguminosarum LpxC2007Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding.
AID330340Inhibition of Rhizobium leguminosarum LpxC S214G mutant2007Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (20.00)18.2507
2000's2 (20.00)29.6817
2010's5 (50.00)24.3611
2020's1 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.05

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.05 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.99 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.05)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		2.0610aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
chloramphenicol
Amphenicol: Chloramphenicol and its derivatives.		2.0610C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		2.0610beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
zithromax
Azithromycin: A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.. azithromycin : A macrolide antibiotic useful for the treatment of bacterial infections.		2.0610macrolide antibioticantibacterial drug;
environmental contaminant;
xenobiotic
tu-514
[no description available]		2.4720
bb-78485
BB-78485: structure in first source		2.4620
chir 090
CHIR 090: structure in first source. CHIR-090 : An L-threonine derivative obtained by formal condensation of the carboxy group of 4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzoic acid with the amino group of N-hydroxy-L-threoninamide.		3.1850acetylenic compound;
benzamides;
hydroxamic acid;
L-threonine derivative;
morpholines		antimicrobial agent;
EC 3.5.1.108 (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor;
lipopolysaccharide biosynthesis inhibitor
tetracycline
Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.		2.0610
hydrogen
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.		2.0510elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
phenylalanine
Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.		2.0310amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid		algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
histidine
Histidine: An essential amino acid that is required for the production of HISTAMINE.. L-histidine : The L-enantiomer of the amino acid histidine.. histidine : An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.		2.0310amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.		3.12501,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
bb-78485
BB-78485: structure in first source		2.110
lipid a
Lipid A: Lipid A is the biologically active component of lipopolysaccharides. It shows strong endotoxic activity and exhibits immunogenic properties.. lipid A : The glycolipid moiety of bacterial lipopolysaccharide (R can be either hydrogen or a fatty acyl group).		2.6930dodecanoate ester;
lipid A;
tetradecanoate ester		Escherichia coli metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
E coli Infections
[description not available]		01.9910
Escherichia coli Infections
Infections with bacteria of the species ESCHERICHIA COLI.		01.9910