2-ethylbenzimidazole profile

2-Ethylbenzimidazole is a heterocyclic compound with potential pharmaceutical applications. It has been studied for its anti-inflammatory, antimicrobial, and antioxidant properties. Its synthesis typically involves the condensation of o-phenylenediamine with propionic acid or its derivatives. Research efforts focus on its ability to modulate various biological pathways and its potential therapeutic applications.'

ID Source	ID
PubMed CID	15807
CHEMBL ID	351569
SCHEMBL ID	157456
MeSH ID	M0066399

Synonym
EN300-16422
BB 0240432
2-ethyl-1h-benzimidazole
smr000137092
MLS000532151
nsc-38878
nsc38878
nsc-28961
nsc28961
1848-84-6
2-ethylbenzimidazole
wln: t56 bm dnj c2
1h-benzimidazole, 2-ethyl-
benzimidazole, 2-ethyl-
ENAMINE_005373
nsc 38878
brn 0116484
ai3-51842
einecs 217-433-8
nsc 28961
STK501711
inchi=1/c9h10n2/c1-2-9-10-7-5-3-4-6-8(7)11-9/h3-6h,2h2,1h3,(h,10,11
AKOS000275562
HMS1409E05
CHEMBL351569 ,
2-ethyl-benzimidazole
NCGC00245718-01
HMS2484F04
2-ethyl-1h-benzoimidazole
2-ethyl-1h-benzo[d]imidazole
5-23-06-00436 (beilstein handbook reference)
2-ethyl-1h-1,3-benzodiazole
2-ethylbenzimidazole;2-ethyl-1h-benzo[d]imidazole
bdbm50404858
FT-0600265
AM20030215
SCHEMBL157456
2-ethyl benzimidazole
2-ethyl-1h-benzimidazole #
Q-101089
Z55692907
DTXSID60171664
F0853-0447
mfcd00022684
2-ethylbenzoimidazole
SY015992
CS-0030568
AS-12145
2-ethyl-1h-benzimidazole;1h-benzimidazole, 2-ethyl-
BCP27456
T91 ,
E1358
2-ethyl-1h-1,3-benzimidazole

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	7.3078	0.0041	9.9848	25.9290	AID504444
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	100.0000	0.0501	27.0736	89.1251	AID588590
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Homo sapiens (human)	IC50 (µMol)	1,400.0000	7.8000	8.2570	8.7140	AID682939
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Homo sapiens (human)	Ki	800.0000	0.0500	1.4929	2.0000	AID682940
Cytochrome P450 2B1	Rattus norvegicus (Norway rat)	IC50 (µMol)	673.0415	7.4000	7.8000	8.2000	AID38392; AID38394
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
citrulline metabolic process	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Homo sapiens (human)
regulation of systemic arterial blood pressure	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Homo sapiens (human)
arginine catabolic process	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Homo sapiens (human)
nitric oxide mediated signal transduction	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Homo sapiens (human)
negative regulation of cell population proliferation	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Homo sapiens (human)
negative regulation of vascular permeability	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Homo sapiens (human)
positive regulation of nitric oxide biosynthetic process	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Homo sapiens (human)
positive regulation of angiogenesis	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Homo sapiens (human)
nitric oxide metabolic process	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Homo sapiens (human)
negative regulation of cellular response to hypoxia	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Homo sapiens (human)
arginine metabolic process	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
catalytic activity	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Homo sapiens (human)
dimethylargininase activity	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Homo sapiens (human)
metal ion binding	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Homo sapiens (human)
amino acid binding	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
cytosol	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Homo sapiens (human)
extracellular exosome	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (42)

Assay ID	Title	Year	Journal	Article
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1186327	Cytotoxicity against mock-infected human MT4 cells after 96 hrs by MTT assay	2014	Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17	Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents.
AID1186335	Antiviral activity against Coxsackievirus B5 infected in african green monkey Vero 76 cells assessed as reduction in plaque number after 3 days by plaque reduction assay	2014	Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17	Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents.
AID26812	Partition coefficient (logP)	1982	Journal of medicinal chemistry, Jun, Volume: 25, Issue:6	Inhibitors of hepatic mixed-function oxidases. 4. Effects of benzimidazole and related compounds on aryl hydrocarbon hydroxylase activity from phenobarbitone and 3-methylcholanthrene induced rats.
AID1186340	Antiviral activity against HSV1 infected in african green monkey Vero 76 cells assessed as reduction in plaque number after 3 days by plaque reduction assay	2014	Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17	Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents.
AID1186339	Antiviral activity against Vaccinia Virus infected in african green monkey Vero 76 cells assessed as reduction in plaque number after 3 days by plaque reduction assay	2014	Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17	Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents.
AID1186333	Antiviral activity against Reovirus type-1 infected in BHK21 cells assessed as inhibition of virus-induced cytopathogenicity after 3 to 4 days by MTT assay	2014	Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17	Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents.
AID682935	Inhibition of human recombinant His6-tagged DDAH1 expressed in Escherichia coli BL21(DE3) using Nomega,Nomega-dimethyl-L-arginine as substrate at 400 uM after 1 to 2 hrs by colorimetric ureido derivitization assay	2012	Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18	Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase.
AID1186331	Cytotoxicity against mock-infected BHK21 cells after 48 to 96 hrs by MTT assay	2014	Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17	Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents.
AID682938	Reversible inhibition of human recombinant His6-tagged DDAH1 expressed in Escherichia coli BL21(DE3) using 1 mM Nomega,Nomega-dimethyl-L-arginine as substrate incubated up to 120 mins prior to substrate addition measured after 120 mins by colorimetric ure	2012	Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18	Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase.
AID38392	Inhibition of Aminopyrine N-demethylase in Phenobarbitone-treated rats	1982	Journal of medicinal chemistry, Jun, Volume: 25, Issue:6	Inhibitors of hepatic mixed-function oxidases. 4. Effects of benzimidazole and related compounds on aryl hydrocarbon hydroxylase activity from phenobarbitone and 3-methylcholanthrene induced rats.
AID1186329	Cytotoxicity against mock-infected MDBK cells after 48 to 96 hrs by MTT assay	2014	Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17	Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents.
AID682934	Inhibition of human recombinant His6-tagged DDAH1 expressed in Escherichia coli BL21(DE3) using S-methyl-L-thiocitrulline as substrate at 100 uM by CPM-based fluorescence spectrophotometry	2012	Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18	Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase.
AID1186330	Antiviral activity against Bovine viral diarrhea virus infected in MDBK cells assessed as inhibition of virus-induced cytopathogenicity after 3 to 4 days by MTT assay	2014	Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17	Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents.
AID1186328	Antiviral activity against HIV1 infected in human MT4 cells assessed as inhibition of virus-induced cytopathogenicity after 4 days by MTT assay	2014	Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17	Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents.
AID1186332	Antiviral activity against Yellow fever virus infected in BHK21 cells assessed as inhibition of virus-induced cytopathogenicity after 3 to 4 days by MTT assay	2014	Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17	Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents.
AID682937	Inhibition of human recombinant His6-tagged DDAH1 expressed in Escherichia coli BL21(DE3) using Nomega,Nomega-dimethyl-L-arginine as substrate at 400 uM incubated for 10 to 20 mins prior to substrate addition measured after 1 to 2 hrs by colorimetric urei	2012	Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18	Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase.
AID1186336	Antiviral activity against Poliovirus type 1 Sabin strain infected in african green monkey Vero 76 cells assessed as reduction in plaque number after 2 days by plaque reduction assay	2014	Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17	Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents.
AID38394	Inhibitory potency to aminopyrine N-demethylase activity (P450) in hepatic microsomes from phenobarbitone-induced rats.	1982	Journal of medicinal chemistry, Aug, Volume: 25, Issue:8	Inhibition of rat hepatic microsomal aminopyrine N-demethylase activity by benzimidazole derivatives. Quantitative structure-activity relationships.
AID39088	Inhibition of Aryl hydrocarbon hydroxylase in phenobarbitone-treated rats	1982	Journal of medicinal chemistry, Jun, Volume: 25, Issue:6	Inhibitors of hepatic mixed-function oxidases. 4. Effects of benzimidazole and related compounds on aryl hydrocarbon hydroxylase activity from phenobarbitone and 3-methylcholanthrene induced rats.
AID682933	Inhibition of Pseudomonas aeruginosa His6-tagged DDAH expressed in Escherichia coli BL21(DE3) using S-methyl-Lthiocitrulline as substrate at 100 uM measured every 20 secs for 10 mins by fluorescence spectrophotometry	2012	Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18	Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase.
AID39090	Inhibition of Aryl hydrocarbon hydroxylase in phenobarbitone-treated rats	1982	Journal of medicinal chemistry, Jun, Volume: 25, Issue:6	Inhibitors of hepatic mixed-function oxidases. 4. Effects of benzimidazole and related compounds on aryl hydrocarbon hydroxylase activity from phenobarbitone and 3-methylcholanthrene induced rats.
AID682941	Inhibition of Pseudomonas aeruginosa His6-tagged DDAH expressed in Escherichia coli BL21(DE3) using S-methyl-Lthiocitrulline as substrate up to 1 mM measured every 20 secs for 10 mins by fluorescence spectrophotometry	2012	Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18	Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase.
AID1186334	Cytotoxicity against mock-infected african green monkey Vero 76 cells after 48 to 96 hrs by MTT assay	2014	Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17	Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents.
AID1186337	Antiviral activity against Respiratory syncytial virus infected in african green monkey Vero 76 cells assessed as reduction in plaque number after 5 days by plaque reduction assay	2014	Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17	Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents.
AID24235	Partition coefficient (logP)	1982	Journal of medicinal chemistry, Aug, Volume: 25, Issue:8	Inhibition of rat hepatic microsomal aminopyrine N-demethylase activity by benzimidazole derivatives. Quantitative structure-activity relationships.
AID1186338	Antiviral activity against Vesicular stomatitis virus infected in african green monkey Vero 76 cells assessed as reduction in plaque number after 2 days by plaque reduction assay	2014	Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17	Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents.
AID682939	Inhibition of human recombinant His6-tagged DDAH1 expressed in Escherichia coli BL21(DE3) using Nomega,Nomega-dimethyl-L-arginine as substrate after 80 mins by colorimetric ureido derivitization assay	2012	Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18	Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase.
AID682940	Competitive inhibition of human recombinant His6-tagged DDAH1 expressed in Escherichia coli BL21(DE3) using Nomega,Nomega-dimethyl-L-arginine as substrate after 80 mins by double-reciprocal plot analysis	2012	Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18	Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase.
AID588519	A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities	2011	Antiviral research, Sep, Volume: 91, Issue:3	High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	4 (33.33)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (8.33)	29.6817
2010's	6 (50.00)	24.3611
2020's	1 (8.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
5,6-dimethylbenzimidazole 5,6-dimethylbenzimidazole: RN given refers to parent cpd. 5,6-dimethylbenzimidazole : A dimethylbenzimidazole carrying methyl substituents at positions 5 and 6.	2.36	2	dimethylbenzimidazole	Escherichia coli metabolite; human metabolite
diuron Diuron: A pre-emergent herbicide.. diuron : A member of the class of 3-(3,4-substituted-phenyl)-1,1-dimethylureas that is urea in which both of the hydrogens attached to one nitrogen are substituted by methyl groups, and one of the hydrogens attached to the other nitrogen is substituted by a 3,4-dichlorophenyl group.	1.96	1	3-(3,4-substituted-phenyl)-1,1-dimethylurea; dichlorobenzene	environmental contaminant; mitochondrial respiratory-chain inhibitor; photosystem-II inhibitor; urea herbicide; xenobiotic
2-hydroxybenzylbenzimidazole 2-hydroxybenzylbenzimidazole: RN given refers to cpd without isomeric designation	1.96	1
benzimidazole 1H-benzimidazole : The 1H-tautomer of benzimidazole.	2.36	2	benzimidazole; polycyclic heteroarene
azauridine Azauridine: A triazine nucleoside used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.	2.1	1	N-glycosyl-1,2,4-triazine	antimetabolite; antineoplastic agent; drug metabolite
5-methylbenzimidazole 5-methylbenzimidazole: structure in first source. 5-methyl-1H-benzimidazole : A member of the class of imidazoles that is 1H-benzimidazole in which the hydrogen at position 5 is substituted by a methyl group.	2.36	2	imidazoles
2-methylbenzimidazole [no description available]	2.36	2	benzimidazoles
bendazole bendazole: also an NSAID; Russian drug; RN given refers to parent cpd; structure	1.96	1	benzimidazoles
2-phenylbenzimidazole 2-phenylbenzimidazole: structure in first source	1.96	1
2,6-dichloroindophenol 2,6-Dichloroindophenol: A dye used as a reagent in the determination of vitamin C.. 2,6-dichloroindophenol : A quinone imine that is indophenol substituted by chloro groups at positions 2 and 6.. N-3,5-dichloro-4-hydroxyphenyl-1,4-benzoquinone imine : 1,4-benzoquinone imine having a 3,5-dichloro-4-hydroxyphenyl substituent attached to the nitrogen atom.	1.96	1	dichlorobenzene; quinone imine
2-Butyl-1H-benzimidazole [no description available]	1.96	1	benzimidazoles
2-tert-butylbenzimidazole 2-tert-butylbenzimidazole: structure in first source	1.96	1
ribavirin Rebetron: Rebetron is tradename	2.1	1	1-ribosyltriazole; aromatic amide; monocarboxylic acid amide; primary carboxamide	anticoronaviral agent; antiinfective agent; antimetabolite; antiviral agent; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
efavirenz efavirenz: HIV-1 reverse transcriptase inhibitor. efavirenz : 1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection.	2.1	1	acetylenic compound; benzoxazine; cyclopropanes; organochlorine compound; organofluorine compound	antiviral drug; HIV-1 reverse transcriptase inhibitor
proadifen hydrochloride [no description available]	1.96	1
1,7-phenanthroline [no description available]	1.96	1	phenanthroline
4(5)-phenylimidazole 4(5)-phenylimidazole: tautomeric cpd; cytochrome P450 14alpha-sterol demethylase, CYP51 antagonist	1.96	1
2-(2'-pyridyl)benzimidazole 2-(2'-pyridyl)benzimidazole: structure in first source	1.96	1
5,6-dichlorobenzimidazole 5,6-dichlorobenzimidazole: inhibits transcript elongation	1.96	1
mycophenolic acid Mycophenolic Acid: Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.. mycophenolate : A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of mycophenolic acid.. mycophenolic acid : A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.	2.1	1	2-benzofurans; gamma-lactone; monocarboxylic acid; phenols	anticoronaviral agent; antimicrobial agent; antineoplastic agent; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; environmental contaminant; immunosuppressive agent; mycotoxin; Penicillium metabolite; xenobiotic
1-benzyl-2-phenylbenzimidazole 1-benzyl-2-phenylbenzimidazole: has antineoplastic activity; structure in first source	2.1	1
vitamin k semiquinone radical vitamin K semiquinone radical: found in active preparations of vitamin K-dependent carboxylase. vitamin K : Any member of a group of fat-soluble 2-methyl-1,4-napthoquinones that exhibit biological activity against vitamin K deficiency. Vitamin K is required for the synthesis of prothrombin and certain other blood coagulation factors.	1.96	1
acyclovir Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.	2.1	1	2-aminopurines; oxopurine	antimetabolite; antiviral drug

Condition	Relationship Strength	Studies
Innate Inflammatory Response [description not available]	2.05	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.05	1
Encephalitis, Polio [description not available]	2.06	1
Poliomyelitis An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)	2.06	1

2-ethylbenzimidazole

Cross-References

Synonyms (53)

Protein Targets (5)

Potency Measurements

Inhibition Measurements

Biological Processes (11)

Molecular Functions (4)

Ceullar Components (2)

Bioassays (42)

Research

Studies (12)

Market Indicators

Research Demand Index: 11.68

Study Types

2-ethylbenzimidazole

Cross-References

Synonyms (53)

Protein Targets (5)

Potency Measurements

Inhibition Measurements

Biological Processes (11)

Molecular Functions (4)

Ceullar Components (2)

Bioassays (42)

Research

Studies (12)

Market Indicators

Research Demand Index: 11.68

Study Types

Related Drugs (23)

Related Conditions (4)