Page last updated: 2024-11-12
beta-3-oxindolylalanine
Description
beta-3-oxindolylalanine: main intermediate in tryptophan degration occurring in acid hydrolysis of protein [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 13393248 |
| CHEMBL ID | 4283109 |
| SCHEMBL ID | 1226606 |
| MeSH ID | M0058637 |
Synonyms (9)
| Synonym |
|---|
| 16008-59-6 |
| beta-3-oxindolylalanine |
| SCHEMBL1226606 |
| 2,3-dihydro-2-oxo-tryptophan |
| (2s)-2-amino-3-(2-oxo-1,3-dihydroindol-3-yl)propanoic acid |
| 236094-74-9 |
| (2s)-2-amino-3-(2-oxoindolin-3-yl)propanoic acid |
| CHEMBL4283109 |
| (2s)-2-amino-3-(2-oxo-2,3-dihydro-1h-indol-3-yl)propanoic acid |
Protein Targets (2)
Inhibition Measurements
Biological Processes (22)
| Process | via Protein(s) | Taxonomy |
|---|
| regulation of activated T cell proliferation | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| positive regulation of T cell tolerance induction | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| positive regulation of chronic inflammatory response | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| positive regulation of type 2 immune response | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| tryptophan catabolic process | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| inflammatory response | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| female pregnancy | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| tryptophan catabolic process to kynurenine | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| response to lipopolysaccharide | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| negative regulation of interleukin-10 production | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| positive regulation of interleukin-12 production | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| multicellular organismal response to stress | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| kynurenic acid biosynthetic process | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| swimming behavior | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| T cell proliferation | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| negative regulation of T cell proliferation | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| negative regulation of T cell apoptotic process | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| positive regulation of T cell apoptotic process | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| 'de novo' NAD biosynthetic process from tryptophan | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| tryptophan catabolic process to kynurenine | Tryptophan 2,3-dioxygenase | Homo sapiens (human) |
| protein homotetramerization | Tryptophan 2,3-dioxygenase | Homo sapiens (human) |
| response to nitroglycerin | Tryptophan 2,3-dioxygenase | Homo sapiens (human) |
| tryptophan catabolic process to acetyl-CoA | Tryptophan 2,3-dioxygenase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] |
Molecular Functions (9)
| Process | via Protein(s) | Taxonomy |
|---|
| electron transfer activity | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| heme binding | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| indoleamine 2,3-dioxygenase activity | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| metal ion binding | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| tryptophan 2,3-dioxygenase activity | Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) |
| tryptophan 2,3-dioxygenase activity | Tryptophan 2,3-dioxygenase | Homo sapiens (human) |
| protein binding | Tryptophan 2,3-dioxygenase | Homo sapiens (human) |
| amino acid binding | Tryptophan 2,3-dioxygenase | Homo sapiens (human) |
| oxygen binding | Tryptophan 2,3-dioxygenase | Homo sapiens (human) |
| heme binding | Tryptophan 2,3-dioxygenase | Homo sapiens (human) |
| identical protein binding | Tryptophan 2,3-dioxygenase | Homo sapiens (human) |
| metal ion binding | Tryptophan 2,3-dioxygenase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] |
Ceullar Components (4)
Bioassays (4)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID1416457 | Inhibition of recombinant human IDO1 assessed as reduction in conversion of L-tryptophan to kynurenine by methylene blue dye based spectrometric method | 2017 | MedChemComm, Aug-01, Volume: 8, Issue:8
| Synthesis and evaluation of oxindoles as promising inhibitors of the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1. |
| AID1416458 | Inhibition of recombinant human IDO1 assessed as reduction in conversion of L-tryptophan to kynurenine after 1 hr by methylene blue dye based HPLC method | 2017 | MedChemComm, Aug-01, Volume: 8, Issue:8
| Synthesis and evaluation of oxindoles as promising inhibitors of the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1. |
| AID1416470 | Selectivity ratio of IC50 for human TDO to IC50 for human IDO1 | 2017 | MedChemComm, Aug-01, Volume: 8, Issue:8
| Synthesis and evaluation of oxindoles as promising inhibitors of the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1. |
| AID1416469 | Inhibition of recombinant human TDO assessed as reduction in conversion of L-tryptophan to kynurenine by methylene blue dye based spectrometric method | 2017 | MedChemComm, Aug-01, Volume: 8, Issue:8
| Synthesis and evaluation of oxindoles as promising inhibitors of the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.53
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.53 (24.57) | | Research Supply Index | 1.79 (2.92) | | Research Growth Index | 4.32 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |