Compounds > belactosin a
Page last updated: 2024-11-13

belactosin a

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Description

belactosin A: isolated from Streptomyces; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID25053219
CHEMBL ID491636
MeSH IDM0360001

Synonyms (3)

Synonym
CHEMBL491636
belactosin a
bdbm50430990

Research Excerpts

Overview

Belactosin A is a potent proteasome inhibitor isolated from Streptomyces metabolites.

ExcerptReferenceRelevance
"Belactosin A is a potent proteasome inhibitor isolated from Streptomyces metabolites. "( Affinity labeling of the proteasome by a belactosin A derived inhibitor.
Hasegawa, M; Ikeda, S; Kinoshita, K; Matsumura, U; Mizukami, T; Nishimura, C; Shionyu, M, 2008)		2.05

Actions

ExcerptReferenceRelevance
"Belactosin A did not inhibit yeast Cdc28 kinase and human cyclin-dependent kinase in vitro."( A new structural class of proteasome inhibitors identified by microbial screening using yeast-based assay.
Akinaga, S; Asai, A; Funakoshi, M; Kobayashi, H; Mizukami, T; Sharma, SV; Tsujita, T; Yamashita, Y, 2004)		1.04
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (38)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Proteasome subunit beta type-11Homo sapiens (human)IC50 (µMol)1.42000.00130.70995.0000AID1128229; AID1152964
26S proteasome non-ATPase regulatory subunit 11Homo sapiens (human)IC50 (µMol)1.42000.00700.71182.0000AID1128229; AID1152964
26S proteasome non-ATPase regulatory subunit 12Homo sapiens (human)IC50 (µMol)1.42000.00700.71182.0000AID1128229; AID1152964
26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)IC50 (µMol)1.42000.00701.09812.5000AID1128229; AID1152964
Proteasome subunit alpha type-7Homo sapiens (human)IC50 (µMol)1.42000.00130.70995.0000AID1128229; AID1152964
26S proteasome non-ATPase regulatory subunit 3Homo sapiens (human)IC50 (µMol)1.42000.00700.71182.0000AID1128229; AID1152964
26S proteasome regulatory subunit 6AHomo sapiens (human)IC50 (µMol)1.42000.00700.71182.0000AID1128229; AID1152964
Proteasome subunit beta type-1Homo sapiens (human)IC50 (µMol)1.42000.00060.73766.3700AID1128229; AID1152964
Proteasome subunit alpha type-1Homo sapiens (human)IC50 (µMol)1.42000.00130.70995.0000AID1128229; AID1152964
Proteasome subunit alpha type-2Homo sapiens (human)IC50 (µMol)1.42000.00130.70995.0000AID1128229; AID1152964
Proteasome subunit alpha type-3Homo sapiens (human)IC50 (µMol)1.42000.00130.70995.0000AID1128229; AID1152964
Proteasome subunit alpha type-4Homo sapiens (human)IC50 (µMol)1.42000.00130.70995.0000AID1128229; AID1152964
Proteasome subunit beta type-8Homo sapiens (human)IC50 (µMol)1.42000.00130.36985.0000AID1128229; AID1152964
Proteasome subunit beta type-9Homo sapiens (human)IC50 (µMol)1.42000.00100.76115.0000AID1128229; AID1152964
Proteasome subunit alpha type-5Homo sapiens (human)IC50 (µMol)1.42000.00130.70995.0000AID1128229; AID1152964
Proteasome subunit beta type-4Homo sapiens (human)IC50 (µMol)1.42000.00130.70995.0000AID1128229; AID1152964
Proteasome subunit beta type-6Homo sapiens (human)IC50 (µMol)1.42000.00130.69125.0000AID1128229; AID1152964
Proteasome subunit beta type-5Homo sapiens (human)IC50 (µMol)1.42670.00050.939410.0000AID1128229; AID1152964; AID734754
26S proteasome regulatory subunit 7Homo sapiens (human)IC50 (µMol)1.42000.00700.71182.0000AID1128229; AID1152964
Proteasome subunit beta type-10Homo sapiens (human)IC50 (µMol)1.42000.00130.81515.0000AID1128229; AID1152964
26S proteasome regulatory subunit 6BHomo sapiens (human)IC50 (µMol)1.42000.00700.71182.0000AID1128229; AID1152964
26S proteasome non-ATPase regulatory subunit 8Homo sapiens (human)IC50 (µMol)1.42000.00700.71182.0000AID1128229; AID1152964
Proteasome subunit beta type-3Homo sapiens (human)IC50 (µMol)1.42000.00130.70995.0000AID1128229; AID1152964
Proteasome subunit beta type-2Homo sapiens (human)IC50 (µMol)1.42000.00131.39067.9540AID1128229; AID1152964
26S proteasome non-ATPase regulatory subunit 7Homo sapiens (human)IC50 (µMol)1.42000.00700.71182.0000AID1128229; AID1152964
26S proteasome non-ATPase regulatory subunit 4Homo sapiens (human)IC50 (µMol)1.42000.00700.71182.0000AID1128229; AID1152964
26S proteasome complex subunit SEM1Homo sapiens (human)IC50 (µMol)1.42000.00700.71182.0000AID1128229; AID1152964
Proteasome subunit alpha type-6Homo sapiens (human)IC50 (µMol)1.42000.00130.70995.0000AID1128229; AID1152964
26S proteasome regulatory subunit 4Homo sapiens (human)IC50 (µMol)1.42000.00700.71182.0000AID1128229; AID1152964
26S proteasome regulatory subunit 8Homo sapiens (human)IC50 (µMol)1.42000.00700.71182.0000AID1128229; AID1152964
26S proteasome regulatory subunit 10BHomo sapiens (human)IC50 (µMol)1.42000.00700.71182.0000AID1128229; AID1152964
26S proteasome non-ATPase regulatory subunit 2Homo sapiens (human)IC50 (µMol)1.42000.00700.71182.0000AID1128229; AID1152964
26S proteasome non-ATPase regulatory subunit 6Homo sapiens (human)IC50 (µMol)1.42000.00700.71182.0000AID1128229; AID1152964
Proteasomal ubiquitin receptor ADRM1Homo sapiens (human)IC50 (µMol)1.42000.00700.71182.0000AID1128229; AID1152964
Proteasome subunit alpha-type 8Homo sapiens (human)IC50 (µMol)1.42000.00130.70995.0000AID1128229; AID1152964
Proteasome subunit beta type-7Homo sapiens (human)IC50 (µMol)1.42000.00130.68435.0000AID1128229; AID1152964
26S proteasome non-ATPase regulatory subunit 1Homo sapiens (human)IC50 (µMol)1.42000.00700.71182.0000AID1128229; AID1152964
26S proteasome non-ATPase regulatory subunit 13Homo sapiens (human)IC50 (µMol)1.42000.00700.71182.0000AID1128229; AID1152964
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (49)

Processvia Protein(s)Taxonomy
proteolysisProteasome subunit beta type-11Homo sapiens (human)
T cell differentiation in thymusProteasome subunit beta type-11Homo sapiens (human)
CD8-positive, alpha-beta T cell differentiationProteasome subunit beta type-11Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processProteasome subunit beta type-11Homo sapiens (human)
ubiquitin-dependent protein catabolic process26S proteasome non-ATPase regulatory subunit 11Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process26S proteasome non-ATPase regulatory subunit 11Homo sapiens (human)
proteasome assembly26S proteasome non-ATPase regulatory subunit 11Homo sapiens (human)
stem cell differentiation26S proteasome non-ATPase regulatory subunit 11Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process26S proteasome non-ATPase regulatory subunit 12Homo sapiens (human)
double-strand break repair via homologous recombination26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
double-strand break repair via nonhomologous end joining26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
ubiquitin-dependent protein catabolic process26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
response to ethanol26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
regulation of proteasomal protein catabolic process26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
protein K63-linked deubiquitination26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
protein deubiquitination26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processProteasome subunit alpha type-7Homo sapiens (human)
regulation of protein catabolic process26S proteasome non-ATPase regulatory subunit 3Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process26S proteasome non-ATPase regulatory subunit 3Homo sapiens (human)
ubiquitin-dependent protein catabolic process26S proteasome non-ATPase regulatory subunit 3Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process26S proteasome regulatory subunit 6AHomo sapiens (human)
modulation by host of viral transcription26S proteasome regulatory subunit 6AHomo sapiens (human)
positive regulation of transcription by RNA polymerase II26S proteasome regulatory subunit 6AHomo sapiens (human)
positive regulation of proteasomal protein catabolic process26S proteasome regulatory subunit 6AHomo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processProteasome subunit beta type-1Homo sapiens (human)
proteolysis involved in protein catabolic processProteasome subunit beta type-1Homo sapiens (human)
immune system processProteasome subunit alpha type-1Homo sapiens (human)
negative regulation of inflammatory response to antigenic stimulusProteasome subunit alpha type-1Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processProteasome subunit alpha type-1Homo sapiens (human)
response to virusProteasome subunit alpha type-2Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processProteasome subunit alpha type-2Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processProteasome subunit alpha type-3Homo sapiens (human)
regulation of endopeptidase activityProteasome subunit alpha type-3Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processProteasome subunit alpha type-4Homo sapiens (human)
antigen processing and presentationProteasome subunit beta type-8Homo sapiens (human)
fat cell differentiationProteasome subunit beta type-8Homo sapiens (human)
regulation of endopeptidase activityProteasome subunit beta type-8Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processProteasome subunit beta type-8Homo sapiens (human)
immune system processProteasome subunit beta type-9Homo sapiens (human)
regulation of cysteine-type endopeptidase activityProteasome subunit beta type-9Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processProteasome subunit beta type-9Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processProteasome subunit alpha type-5Homo sapiens (human)
negative regulation of inflammatory response to antigenic stimulusProteasome subunit beta type-4Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processProteasome subunit beta type-4Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processProteasome subunit beta type-6Homo sapiens (human)
proteolysisProteasome subunit beta type-5Homo sapiens (human)
response to oxidative stressProteasome subunit beta type-5Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processProteasome subunit beta type-5Homo sapiens (human)
osteoblast differentiation26S proteasome regulatory subunit 7Homo sapiens (human)
ubiquitin-dependent protein catabolic process26S proteasome regulatory subunit 7Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process26S proteasome regulatory subunit 7Homo sapiens (human)
positive regulation of proteasomal protein catabolic process26S proteasome regulatory subunit 7Homo sapiens (human)
cell morphogenesisProteasome subunit beta type-10Homo sapiens (human)
humoral immune responseProteasome subunit beta type-10Homo sapiens (human)
T cell proliferationProteasome subunit beta type-10Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processProteasome subunit beta type-10Homo sapiens (human)
blastocyst development26S proteasome regulatory subunit 6BHomo sapiens (human)
proteolysis26S proteasome regulatory subunit 6BHomo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process26S proteasome regulatory subunit 6BHomo sapiens (human)
positive regulation of proteasomal protein catabolic process26S proteasome regulatory subunit 6BHomo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process26S proteasome non-ATPase regulatory subunit 8Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processProteasome subunit beta type-3Homo sapiens (human)
response to organonitrogen compoundProteasome subunit beta type-2Homo sapiens (human)
response to organic cyclic compoundProteasome subunit beta type-2Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processProteasome subunit beta type-2Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process26S proteasome non-ATPase regulatory subunit 7Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process26S proteasome non-ATPase regulatory subunit 4Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processProteasome subunit alpha type-6Homo sapiens (human)
regulation of inflammatory responseProteasome subunit alpha type-6Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activityProteasome subunit alpha type-6Homo sapiens (human)
proteolysis involved in protein catabolic processProteasome subunit alpha type-6Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process26S proteasome regulatory subunit 4Homo sapiens (human)
positive regulation of proteasomal protein catabolic process26S proteasome regulatory subunit 4Homo sapiens (human)
regulation of transcription by RNA polymerase II26S proteasome regulatory subunit 8Homo sapiens (human)
negative regulation of programmed cell death26S proteasome regulatory subunit 8Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process26S proteasome regulatory subunit 8Homo sapiens (human)
negative regulation of DNA-templated transcription26S proteasome regulatory subunit 8Homo sapiens (human)
positive regulation of DNA-templated transcription26S proteasome regulatory subunit 8Homo sapiens (human)
positive regulation of proteasomal protein catabolic process26S proteasome regulatory subunit 8Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process26S proteasome regulatory subunit 10BHomo sapiens (human)
positive regulation of inclusion body assembly26S proteasome regulatory subunit 10BHomo sapiens (human)
positive regulation of proteasomal protein catabolic process26S proteasome regulatory subunit 10BHomo sapiens (human)
ERAD pathway26S proteasome regulatory subunit 10BHomo sapiens (human)
positive regulation of RNA polymerase II transcription preinitiation complex assembly26S proteasome regulatory subunit 10BHomo sapiens (human)
regulation of protein catabolic process26S proteasome non-ATPase regulatory subunit 2Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process26S proteasome non-ATPase regulatory subunit 2Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process26S proteasome non-ATPase regulatory subunit 6Homo sapiens (human)
transcription elongation by RNA polymerase IIProteasomal ubiquitin receptor ADRM1Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processProteasomal ubiquitin receptor ADRM1Homo sapiens (human)
proteasome assemblyProteasomal ubiquitin receptor ADRM1Homo sapiens (human)
spermatogenesisProteasome subunit alpha-type 8Homo sapiens (human)
proteasomal protein catabolic processProteasome subunit alpha-type 8Homo sapiens (human)
cell differentiationProteasome subunit alpha-type 8Homo sapiens (human)
meiotic cell cycleProteasome subunit alpha-type 8Homo sapiens (human)
regulation of meiosis IProteasome subunit alpha-type 8Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processProteasome subunit alpha-type 8Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processProteasome subunit beta type-7Homo sapiens (human)
regulation of protein catabolic process26S proteasome non-ATPase regulatory subunit 1Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process26S proteasome non-ATPase regulatory subunit 1Homo sapiens (human)
meiosis I26S proteasome non-ATPase regulatory subunit 13Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process26S proteasome non-ATPase regulatory subunit 13Homo sapiens (human)
ubiquitin-dependent protein catabolic process26S proteasome non-ATPase regulatory subunit 13Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (32)

Processvia Protein(s)Taxonomy
threonine-type endopeptidase activityProteasome subunit beta type-11Homo sapiens (human)
protein bindingProteasome subunit beta type-11Homo sapiens (human)
peptidase activityProteasome subunit beta type-11Homo sapiens (human)
endopeptidase activityProteasome subunit beta type-11Homo sapiens (human)
protein binding26S proteasome non-ATPase regulatory subunit 11Homo sapiens (human)
structural molecule activity26S proteasome non-ATPase regulatory subunit 11Homo sapiens (human)
protein binding26S proteasome non-ATPase regulatory subunit 12Homo sapiens (human)
protein binding26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
metallopeptidase activity26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
metal ion binding26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
endopeptidase activator activity26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
K63-linked deubiquitinase activity26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
proteasome binding26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
metal-dependent deubiquitinase activity26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
protein bindingProteasome subunit alpha type-7Homo sapiens (human)
identical protein bindingProteasome subunit alpha type-7Homo sapiens (human)
protein binding26S proteasome non-ATPase regulatory subunit 3Homo sapiens (human)
enzyme regulator activity26S proteasome non-ATPase regulatory subunit 3Homo sapiens (human)
protein binding26S proteasome regulatory subunit 6AHomo sapiens (human)
ATP binding26S proteasome regulatory subunit 6AHomo sapiens (human)
ATP hydrolysis activity26S proteasome regulatory subunit 6AHomo sapiens (human)
proteasome-activating activity26S proteasome regulatory subunit 6AHomo sapiens (human)
identical protein binding26S proteasome regulatory subunit 6AHomo sapiens (human)
protein bindingProteasome subunit beta type-1Homo sapiens (human)
lipopolysaccharide bindingProteasome subunit alpha type-1Homo sapiens (human)
protein bindingProteasome subunit alpha type-1Homo sapiens (human)
protein bindingProteasome subunit alpha type-2Homo sapiens (human)
protein bindingProteasome subunit alpha type-3Homo sapiens (human)
ubiquitin protein ligase bindingProteasome subunit alpha type-3Homo sapiens (human)
protein bindingProteasome subunit alpha type-4Homo sapiens (human)
threonine-type endopeptidase activityProteasome subunit beta type-8Homo sapiens (human)
protein bindingProteasome subunit beta type-8Homo sapiens (human)
endopeptidase activityProteasome subunit beta type-8Homo sapiens (human)
threonine-type endopeptidase activityProteasome subunit beta type-9Homo sapiens (human)
protein bindingProteasome subunit beta type-9Homo sapiens (human)
endopeptidase activityProteasome subunit beta type-9Homo sapiens (human)
protein bindingProteasome subunit alpha type-5Homo sapiens (human)
lipopolysaccharide bindingProteasome subunit beta type-4Homo sapiens (human)
protein bindingProteasome subunit beta type-4Homo sapiens (human)
endopeptidase activityProteasome subunit beta type-6Homo sapiens (human)
threonine-type endopeptidase activityProteasome subunit beta type-6Homo sapiens (human)
protein bindingProteasome subunit beta type-6Homo sapiens (human)
cadherin bindingProteasome subunit beta type-6Homo sapiens (human)
threonine-type endopeptidase activityProteasome subunit beta type-5Homo sapiens (human)
protein bindingProteasome subunit beta type-5Homo sapiens (human)
peptidase activityProteasome subunit beta type-5Homo sapiens (human)
endopeptidase activityProteasome subunit beta type-5Homo sapiens (human)
protein binding26S proteasome regulatory subunit 7Homo sapiens (human)
ATP binding26S proteasome regulatory subunit 7Homo sapiens (human)
ATP hydrolysis activity26S proteasome regulatory subunit 7Homo sapiens (human)
proteasome-activating activity26S proteasome regulatory subunit 7Homo sapiens (human)
threonine-type endopeptidase activityProteasome subunit beta type-10Homo sapiens (human)
protein bindingProteasome subunit beta type-10Homo sapiens (human)
endopeptidase activityProteasome subunit beta type-10Homo sapiens (human)
protein binding26S proteasome regulatory subunit 6BHomo sapiens (human)
ATP binding26S proteasome regulatory subunit 6BHomo sapiens (human)
ATP hydrolysis activity26S proteasome regulatory subunit 6BHomo sapiens (human)
proteasome-activating activity26S proteasome regulatory subunit 6BHomo sapiens (human)
protein binding26S proteasome non-ATPase regulatory subunit 8Homo sapiens (human)
protein bindingProteasome subunit beta type-3Homo sapiens (human)
protein bindingProteasome subunit beta type-2Homo sapiens (human)
peptidase activity26S proteasome non-ATPase regulatory subunit 7Homo sapiens (human)
metal-dependent deubiquitinase activity26S proteasome non-ATPase regulatory subunit 7Homo sapiens (human)
protein binding26S proteasome non-ATPase regulatory subunit 7Homo sapiens (human)
protein homodimerization activity26S proteasome non-ATPase regulatory subunit 7Homo sapiens (human)
RNA binding26S proteasome non-ATPase regulatory subunit 4Homo sapiens (human)
protein binding26S proteasome non-ATPase regulatory subunit 4Homo sapiens (human)
identical protein binding26S proteasome non-ATPase regulatory subunit 4Homo sapiens (human)
molecular adaptor activity26S proteasome non-ATPase regulatory subunit 4Homo sapiens (human)
polyubiquitin modification-dependent protein binding26S proteasome non-ATPase regulatory subunit 4Homo sapiens (human)
RNA bindingProteasome subunit alpha type-6Homo sapiens (human)
endopeptidase activityProteasome subunit alpha type-6Homo sapiens (human)
protein bindingProteasome subunit alpha type-6Homo sapiens (human)
purine ribonucleoside triphosphate bindingProteasome subunit alpha type-6Homo sapiens (human)
NF-kappaB bindingProteasome subunit alpha type-6Homo sapiens (human)
RNA binding26S proteasome regulatory subunit 4Homo sapiens (human)
protein binding26S proteasome regulatory subunit 4Homo sapiens (human)
ATP binding26S proteasome regulatory subunit 4Homo sapiens (human)
ATP hydrolysis activity26S proteasome regulatory subunit 4Homo sapiens (human)
proteasome-activating activity26S proteasome regulatory subunit 4Homo sapiens (human)
protein binding26S proteasome regulatory subunit 8Homo sapiens (human)
ATP binding26S proteasome regulatory subunit 8Homo sapiens (human)
transcription factor binding26S proteasome regulatory subunit 8Homo sapiens (human)
ATP hydrolysis activity26S proteasome regulatory subunit 8Homo sapiens (human)
thyrotropin-releasing hormone receptor binding26S proteasome regulatory subunit 8Homo sapiens (human)
proteasome-activating activity26S proteasome regulatory subunit 8Homo sapiens (human)
general transcription initiation factor binding26S proteasome regulatory subunit 8Homo sapiens (human)
DNA-binding transcription factor binding26S proteasome regulatory subunit 8Homo sapiens (human)
protein binding26S proteasome regulatory subunit 10BHomo sapiens (human)
ATP binding26S proteasome regulatory subunit 10BHomo sapiens (human)
ATP hydrolysis activity26S proteasome regulatory subunit 10BHomo sapiens (human)
protein-macromolecule adaptor activity26S proteasome regulatory subunit 10BHomo sapiens (human)
proteasome-activating activity26S proteasome regulatory subunit 10BHomo sapiens (human)
identical protein binding26S proteasome regulatory subunit 10BHomo sapiens (human)
protein binding26S proteasome non-ATPase regulatory subunit 2Homo sapiens (human)
enzyme regulator activity26S proteasome non-ATPase regulatory subunit 2Homo sapiens (human)
protein binding26S proteasome non-ATPase regulatory subunit 6Homo sapiens (human)
protease bindingProteasomal ubiquitin receptor ADRM1Homo sapiens (human)
protein bindingProteasomal ubiquitin receptor ADRM1Homo sapiens (human)
endopeptidase activator activityProteasomal ubiquitin receptor ADRM1Homo sapiens (human)
proteasome bindingProteasomal ubiquitin receptor ADRM1Homo sapiens (human)
molecular function inhibitor activityProteasomal ubiquitin receptor ADRM1Homo sapiens (human)
threonine-type endopeptidase activityProteasome subunit beta type-7Homo sapiens (human)
protein bindingProteasome subunit beta type-7Homo sapiens (human)
endopeptidase activityProteasome subunit beta type-7Homo sapiens (human)
protein binding26S proteasome non-ATPase regulatory subunit 1Homo sapiens (human)
enzyme regulator activity26S proteasome non-ATPase regulatory subunit 1Homo sapiens (human)
ubiquitin protein ligase binding26S proteasome non-ATPase regulatory subunit 1Homo sapiens (human)
structural molecule activity26S proteasome non-ATPase regulatory subunit 13Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (38)

Processvia Protein(s)Taxonomy
cytosolProteasome subunit beta type-11Homo sapiens (human)
proteasome core complex, beta-subunit complexProteasome subunit beta type-11Homo sapiens (human)
nucleusProteasome subunit beta type-11Homo sapiens (human)
cytosolProteasome subunit beta type-11Homo sapiens (human)
proteasome complex26S proteasome non-ATPase regulatory subunit 11Homo sapiens (human)
extracellular region26S proteasome non-ATPase regulatory subunit 11Homo sapiens (human)
nucleus26S proteasome non-ATPase regulatory subunit 11Homo sapiens (human)
nucleoplasm26S proteasome non-ATPase regulatory subunit 11Homo sapiens (human)
cytosol26S proteasome non-ATPase regulatory subunit 11Homo sapiens (human)
membrane26S proteasome non-ATPase regulatory subunit 11Homo sapiens (human)
secretory granule lumen26S proteasome non-ATPase regulatory subunit 11Homo sapiens (human)
ficolin-1-rich granule lumen26S proteasome non-ATPase regulatory subunit 11Homo sapiens (human)
proteasome accessory complex26S proteasome non-ATPase regulatory subunit 11Homo sapiens (human)
proteasome regulatory particle, lid subcomplex26S proteasome non-ATPase regulatory subunit 11Homo sapiens (human)
proteasome complex26S proteasome non-ATPase regulatory subunit 12Homo sapiens (human)
extracellular region26S proteasome non-ATPase regulatory subunit 12Homo sapiens (human)
nucleoplasm26S proteasome non-ATPase regulatory subunit 12Homo sapiens (human)
cytosol26S proteasome non-ATPase regulatory subunit 12Homo sapiens (human)
membrane26S proteasome non-ATPase regulatory subunit 12Homo sapiens (human)
secretory granule lumen26S proteasome non-ATPase regulatory subunit 12Homo sapiens (human)
extracellular exosome26S proteasome non-ATPase regulatory subunit 12Homo sapiens (human)
ficolin-1-rich granule lumen26S proteasome non-ATPase regulatory subunit 12Homo sapiens (human)
proteasome regulatory particle26S proteasome non-ATPase regulatory subunit 12Homo sapiens (human)
proteasome accessory complex26S proteasome non-ATPase regulatory subunit 12Homo sapiens (human)
proteasome regulatory particle, lid subcomplex26S proteasome non-ATPase regulatory subunit 12Homo sapiens (human)
cytoplasm26S proteasome non-ATPase regulatory subunit 12Homo sapiens (human)
proteasome complex26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
extracellular region26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
nucleus26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
nucleoplasm26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
cytosol26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
secretory granule lumen26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
ficolin-1-rich granule lumen26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
proteasome regulatory particle, lid subcomplex26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
proteasome accessory complex26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
cytosolic proteasome complex26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
nucleus26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)
nucleusProteasome subunit alpha type-7Homo sapiens (human)
cytoplasmProteasome subunit alpha type-7Homo sapiens (human)
proteasome complexProteasome subunit alpha type-7Homo sapiens (human)
nucleusProteasome subunit alpha type-7Homo sapiens (human)
nucleoplasmProteasome subunit alpha type-7Homo sapiens (human)
cytosolProteasome subunit alpha type-7Homo sapiens (human)
extracellular exosomeProteasome subunit alpha type-7Homo sapiens (human)
postsynapseProteasome subunit alpha type-7Homo sapiens (human)
proteasome core complexProteasome subunit alpha type-7Homo sapiens (human)
proteasome core complex, alpha-subunit complexProteasome subunit alpha type-7Homo sapiens (human)
proteasome complex26S proteasome non-ATPase regulatory subunit 3Homo sapiens (human)
extracellular region26S proteasome non-ATPase regulatory subunit 3Homo sapiens (human)
nucleus26S proteasome non-ATPase regulatory subunit 3Homo sapiens (human)
nucleoplasm26S proteasome non-ATPase regulatory subunit 3Homo sapiens (human)
cytosol26S proteasome non-ATPase regulatory subunit 3Homo sapiens (human)
membrane26S proteasome non-ATPase regulatory subunit 3Homo sapiens (human)
secretory granule lumen26S proteasome non-ATPase regulatory subunit 3Homo sapiens (human)
extracellular exosome26S proteasome non-ATPase regulatory subunit 3Homo sapiens (human)
ficolin-1-rich granule lumen26S proteasome non-ATPase regulatory subunit 3Homo sapiens (human)
proteasome accessory complex26S proteasome non-ATPase regulatory subunit 3Homo sapiens (human)
proteasome regulatory particle, lid subcomplex26S proteasome non-ATPase regulatory subunit 3Homo sapiens (human)
proteasome complex26S proteasome regulatory subunit 6AHomo sapiens (human)
P-body26S proteasome regulatory subunit 6AHomo sapiens (human)
extracellular region26S proteasome regulatory subunit 6AHomo sapiens (human)
nucleus26S proteasome regulatory subunit 6AHomo sapiens (human)
nucleoplasm26S proteasome regulatory subunit 6AHomo sapiens (human)
cytosol26S proteasome regulatory subunit 6AHomo sapiens (human)
membrane26S proteasome regulatory subunit 6AHomo sapiens (human)
secretory granule lumen26S proteasome regulatory subunit 6AHomo sapiens (human)
ficolin-1-rich granule lumen26S proteasome regulatory subunit 6AHomo sapiens (human)
proteasome accessory complex26S proteasome regulatory subunit 6AHomo sapiens (human)
proteasome regulatory particle, base subcomplex26S proteasome regulatory subunit 6AHomo sapiens (human)
nucleusProteasome subunit beta type-1Homo sapiens (human)
cytoplasmProteasome subunit beta type-1Homo sapiens (human)
proteasome complexProteasome subunit beta type-1Homo sapiens (human)
extracellular regionProteasome subunit beta type-1Homo sapiens (human)
nucleusProteasome subunit beta type-1Homo sapiens (human)
nucleoplasmProteasome subunit beta type-1Homo sapiens (human)
cytosolProteasome subunit beta type-1Homo sapiens (human)
secretory granule lumenProteasome subunit beta type-1Homo sapiens (human)
extracellular exosomeProteasome subunit beta type-1Homo sapiens (human)
ficolin-1-rich granule lumenProteasome subunit beta type-1Homo sapiens (human)
proteasome core complexProteasome subunit beta type-1Homo sapiens (human)
proteasome core complex, beta-subunit complexProteasome subunit beta type-1Homo sapiens (human)
nucleusProteasome subunit alpha type-1Homo sapiens (human)
cytoplasmProteasome subunit alpha type-1Homo sapiens (human)
proteasome complexProteasome subunit alpha type-1Homo sapiens (human)
nucleusProteasome subunit alpha type-1Homo sapiens (human)
nucleoplasmProteasome subunit alpha type-1Homo sapiens (human)
centrosomeProteasome subunit alpha type-1Homo sapiens (human)
cytosolProteasome subunit alpha type-1Homo sapiens (human)
extracellular exosomeProteasome subunit alpha type-1Homo sapiens (human)
proteasome core complexProteasome subunit alpha type-1Homo sapiens (human)
proteasome core complex, alpha-subunit complexProteasome subunit alpha type-1Homo sapiens (human)
nucleusProteasome subunit alpha type-2Homo sapiens (human)
cytoplasmProteasome subunit alpha type-2Homo sapiens (human)
proteasome complexProteasome subunit alpha type-2Homo sapiens (human)
P-bodyProteasome subunit alpha type-2Homo sapiens (human)
extracellular regionProteasome subunit alpha type-2Homo sapiens (human)
nucleusProteasome subunit alpha type-2Homo sapiens (human)
nucleoplasmProteasome subunit alpha type-2Homo sapiens (human)
cytosolProteasome subunit alpha type-2Homo sapiens (human)
secretory granule lumenProteasome subunit alpha type-2Homo sapiens (human)
extracellular exosomeProteasome subunit alpha type-2Homo sapiens (human)
ficolin-1-rich granule lumenProteasome subunit alpha type-2Homo sapiens (human)
proteasome core complexProteasome subunit alpha type-2Homo sapiens (human)
proteasome core complex, alpha-subunit complexProteasome subunit alpha type-2Homo sapiens (human)
nucleusProteasome subunit alpha type-3Homo sapiens (human)
cytoplasmProteasome subunit alpha type-3Homo sapiens (human)
proteasome complexProteasome subunit alpha type-3Homo sapiens (human)
nucleusProteasome subunit alpha type-3Homo sapiens (human)
nucleoplasmProteasome subunit alpha type-3Homo sapiens (human)
cytoplasmProteasome subunit alpha type-3Homo sapiens (human)
cytosolProteasome subunit alpha type-3Homo sapiens (human)
extracellular exosomeProteasome subunit alpha type-3Homo sapiens (human)
proteasome core complexProteasome subunit alpha type-3Homo sapiens (human)
proteasome core complex, alpha-subunit complexProteasome subunit alpha type-3Homo sapiens (human)
synapseProteasome subunit alpha type-3Homo sapiens (human)
nucleusProteasome subunit alpha type-4Homo sapiens (human)
cytoplasmProteasome subunit alpha type-4Homo sapiens (human)
proteasome complexProteasome subunit alpha type-4Homo sapiens (human)
P-bodyProteasome subunit alpha type-4Homo sapiens (human)
nucleusProteasome subunit alpha type-4Homo sapiens (human)
nucleoplasmProteasome subunit alpha type-4Homo sapiens (human)
cytosolProteasome subunit alpha type-4Homo sapiens (human)
intracellular membrane-bounded organelleProteasome subunit alpha type-4Homo sapiens (human)
extracellular exosomeProteasome subunit alpha type-4Homo sapiens (human)
proteasome core complexProteasome subunit alpha type-4Homo sapiens (human)
proteasome core complex, alpha-subunit complexProteasome subunit alpha type-4Homo sapiens (human)
cytosolProteasome subunit alpha type-4Homo sapiens (human)
nucleoplasmProteasome subunit beta type-8Homo sapiens (human)
cytosolProteasome subunit beta type-8Homo sapiens (human)
extracellular exosomeProteasome subunit beta type-8Homo sapiens (human)
proteasome complexProteasome subunit beta type-8Homo sapiens (human)
proteasome core complexProteasome subunit beta type-8Homo sapiens (human)
proteasome core complex, beta-subunit complexProteasome subunit beta type-8Homo sapiens (human)
spermatoproteasome complexProteasome subunit beta type-8Homo sapiens (human)
nucleusProteasome subunit beta type-8Homo sapiens (human)
cytosolProteasome subunit beta type-8Homo sapiens (human)
nucleoplasmProteasome subunit beta type-9Homo sapiens (human)
cytosolProteasome subunit beta type-9Homo sapiens (human)
extracellular exosomeProteasome subunit beta type-9Homo sapiens (human)
proteasome complexProteasome subunit beta type-9Homo sapiens (human)
proteasome core complexProteasome subunit beta type-9Homo sapiens (human)
proteasome core complex, beta-subunit complexProteasome subunit beta type-9Homo sapiens (human)
spermatoproteasome complexProteasome subunit beta type-9Homo sapiens (human)
cytosolProteasome subunit beta type-9Homo sapiens (human)
nucleusProteasome subunit beta type-9Homo sapiens (human)
nucleusProteasome subunit alpha type-5Homo sapiens (human)
cytoplasmProteasome subunit alpha type-5Homo sapiens (human)
proteasome complexProteasome subunit alpha type-5Homo sapiens (human)
extracellular regionProteasome subunit alpha type-5Homo sapiens (human)
nucleusProteasome subunit alpha type-5Homo sapiens (human)
nucleoplasmProteasome subunit alpha type-5Homo sapiens (human)
cytosolProteasome subunit alpha type-5Homo sapiens (human)
secretory granule lumenProteasome subunit alpha type-5Homo sapiens (human)
extracellular exosomeProteasome subunit alpha type-5Homo sapiens (human)
ficolin-1-rich granule lumenProteasome subunit alpha type-5Homo sapiens (human)
proteasome core complexProteasome subunit alpha type-5Homo sapiens (human)
proteasome core complex, alpha-subunit complexProteasome subunit alpha type-5Homo sapiens (human)
nucleusProteasome subunit beta type-4Homo sapiens (human)
cytoplasmProteasome subunit beta type-4Homo sapiens (human)
proteasome complexProteasome subunit beta type-4Homo sapiens (human)
nucleusProteasome subunit beta type-4Homo sapiens (human)
nucleoplasmProteasome subunit beta type-4Homo sapiens (human)
mitochondrionProteasome subunit beta type-4Homo sapiens (human)
cytosolProteasome subunit beta type-4Homo sapiens (human)
ciliary basal bodyProteasome subunit beta type-4Homo sapiens (human)
extracellular exosomeProteasome subunit beta type-4Homo sapiens (human)
proteasome core complexProteasome subunit beta type-4Homo sapiens (human)
proteasome core complex, beta-subunit complexProteasome subunit beta type-4Homo sapiens (human)
cytosolProteasome subunit beta type-4Homo sapiens (human)
nucleusProteasome subunit beta type-6Homo sapiens (human)
cytoplasmProteasome subunit beta type-6Homo sapiens (human)
proteasome complexProteasome subunit beta type-6Homo sapiens (human)
nucleusProteasome subunit beta type-6Homo sapiens (human)
nucleoplasmProteasome subunit beta type-6Homo sapiens (human)
mitochondrionProteasome subunit beta type-6Homo sapiens (human)
cytosolProteasome subunit beta type-6Homo sapiens (human)
extracellular exosomeProteasome subunit beta type-6Homo sapiens (human)
proteasome core complexProteasome subunit beta type-6Homo sapiens (human)
proteasome core complex, beta-subunit complexProteasome subunit beta type-6Homo sapiens (human)
cytosolProteasome subunit beta type-6Homo sapiens (human)
nucleusProteasome subunit beta type-5Homo sapiens (human)
cytoplasmProteasome subunit beta type-5Homo sapiens (human)
proteasome complexProteasome subunit beta type-5Homo sapiens (human)
nucleusProteasome subunit beta type-5Homo sapiens (human)
nucleoplasmProteasome subunit beta type-5Homo sapiens (human)
centrosomeProteasome subunit beta type-5Homo sapiens (human)
cytosolProteasome subunit beta type-5Homo sapiens (human)
extracellular exosomeProteasome subunit beta type-5Homo sapiens (human)
proteasome core complexProteasome subunit beta type-5Homo sapiens (human)
proteasome core complex, beta-subunit complexProteasome subunit beta type-5Homo sapiens (human)
cytosolProteasome subunit beta type-5Homo sapiens (human)
proteasome complex26S proteasome regulatory subunit 7Homo sapiens (human)
P-body26S proteasome regulatory subunit 7Homo sapiens (human)
extracellular region26S proteasome regulatory subunit 7Homo sapiens (human)
nucleus26S proteasome regulatory subunit 7Homo sapiens (human)
nucleoplasm26S proteasome regulatory subunit 7Homo sapiens (human)
cytoplasm26S proteasome regulatory subunit 7Homo sapiens (human)
cytosol26S proteasome regulatory subunit 7Homo sapiens (human)
membrane26S proteasome regulatory subunit 7Homo sapiens (human)
secretory granule lumen26S proteasome regulatory subunit 7Homo sapiens (human)
cytoplasmic ribonucleoprotein granule26S proteasome regulatory subunit 7Homo sapiens (human)
ficolin-1-rich granule lumen26S proteasome regulatory subunit 7Homo sapiens (human)
proteasome accessory complex26S proteasome regulatory subunit 7Homo sapiens (human)
proteasome regulatory particle, base subcomplex26S proteasome regulatory subunit 7Homo sapiens (human)
nucleoplasmProteasome subunit beta type-10Homo sapiens (human)
cytosolProteasome subunit beta type-10Homo sapiens (human)
proteasome complexProteasome subunit beta type-10Homo sapiens (human)
proteasome core complexProteasome subunit beta type-10Homo sapiens (human)
proteasome core complex, beta-subunit complexProteasome subunit beta type-10Homo sapiens (human)
spermatoproteasome complexProteasome subunit beta type-10Homo sapiens (human)
cytosolProteasome subunit beta type-10Homo sapiens (human)
nucleusProteasome subunit beta type-10Homo sapiens (human)
proteasome complex26S proteasome regulatory subunit 6BHomo sapiens (human)
nucleus26S proteasome regulatory subunit 6BHomo sapiens (human)
nucleoplasm26S proteasome regulatory subunit 6BHomo sapiens (human)
cytosol26S proteasome regulatory subunit 6BHomo sapiens (human)
membrane26S proteasome regulatory subunit 6BHomo sapiens (human)
inclusion body26S proteasome regulatory subunit 6BHomo sapiens (human)
synapse26S proteasome regulatory subunit 6BHomo sapiens (human)
proteasome accessory complex26S proteasome regulatory subunit 6BHomo sapiens (human)
cytosolic proteasome complex26S proteasome regulatory subunit 6BHomo sapiens (human)
proteasome regulatory particle, base subcomplex26S proteasome regulatory subunit 6BHomo sapiens (human)
proteasome complex26S proteasome non-ATPase regulatory subunit 8Homo sapiens (human)
nucleus26S proteasome non-ATPase regulatory subunit 8Homo sapiens (human)
nucleoplasm26S proteasome non-ATPase regulatory subunit 8Homo sapiens (human)
cytosol26S proteasome non-ATPase regulatory subunit 8Homo sapiens (human)
proteasome regulatory particle26S proteasome non-ATPase regulatory subunit 8Homo sapiens (human)
proteasome regulatory particle, lid subcomplex26S proteasome non-ATPase regulatory subunit 8Homo sapiens (human)
proteasome accessory complex26S proteasome non-ATPase regulatory subunit 8Homo sapiens (human)
nucleus26S proteasome non-ATPase regulatory subunit 8Homo sapiens (human)
nucleusProteasome subunit beta type-3Homo sapiens (human)
cytoplasmProteasome subunit beta type-3Homo sapiens (human)
proteasome complexProteasome subunit beta type-3Homo sapiens (human)
nucleusProteasome subunit beta type-3Homo sapiens (human)
nucleoplasmProteasome subunit beta type-3Homo sapiens (human)
cytosolProteasome subunit beta type-3Homo sapiens (human)
extracellular exosomeProteasome subunit beta type-3Homo sapiens (human)
proteasome core complexProteasome subunit beta type-3Homo sapiens (human)
proteasome core complex, beta-subunit complexProteasome subunit beta type-3Homo sapiens (human)
cytosolProteasome subunit beta type-3Homo sapiens (human)
nucleusProteasome subunit beta type-2Homo sapiens (human)
cytoplasmProteasome subunit beta type-2Homo sapiens (human)
proteasome complexProteasome subunit beta type-2Homo sapiens (human)
nucleusProteasome subunit beta type-2Homo sapiens (human)
nucleoplasmProteasome subunit beta type-2Homo sapiens (human)
cytosolProteasome subunit beta type-2Homo sapiens (human)
membraneProteasome subunit beta type-2Homo sapiens (human)
extracellular exosomeProteasome subunit beta type-2Homo sapiens (human)
proteasome core complexProteasome subunit beta type-2Homo sapiens (human)
proteasome core complex, beta-subunit complexProteasome subunit beta type-2Homo sapiens (human)
cytosolProteasome subunit beta type-2Homo sapiens (human)
proteasome complex26S proteasome non-ATPase regulatory subunit 7Homo sapiens (human)
extracellular region26S proteasome non-ATPase regulatory subunit 7Homo sapiens (human)
nucleus26S proteasome non-ATPase regulatory subunit 7Homo sapiens (human)
nucleoplasm26S proteasome non-ATPase regulatory subunit 7Homo sapiens (human)
cytosol26S proteasome non-ATPase regulatory subunit 7Homo sapiens (human)
membrane26S proteasome non-ATPase regulatory subunit 7Homo sapiens (human)
secretory granule lumen26S proteasome non-ATPase regulatory subunit 7Homo sapiens (human)
extracellular exosome26S proteasome non-ATPase regulatory subunit 7Homo sapiens (human)
ficolin-1-rich granule lumen26S proteasome non-ATPase regulatory subunit 7Homo sapiens (human)
proteasome regulatory particle26S proteasome non-ATPase regulatory subunit 7Homo sapiens (human)
proteasome complex26S proteasome non-ATPase regulatory subunit 4Homo sapiens (human)
nucleoplasm26S proteasome non-ATPase regulatory subunit 4Homo sapiens (human)
cytosol26S proteasome non-ATPase regulatory subunit 4Homo sapiens (human)
proteasome accessory complex26S proteasome non-ATPase regulatory subunit 4Homo sapiens (human)
proteasome regulatory particle, base subcomplex26S proteasome non-ATPase regulatory subunit 4Homo sapiens (human)
nucleus26S proteasome non-ATPase regulatory subunit 4Homo sapiens (human)
cytosol26S proteasome non-ATPase regulatory subunit 4Homo sapiens (human)
nucleoplasm26S proteasome complex subunit SEM1Homo sapiens (human)
cytosol26S proteasome complex subunit SEM1Homo sapiens (human)
nucleusProteasome subunit alpha type-6Homo sapiens (human)
cytoplasmProteasome subunit alpha type-6Homo sapiens (human)
proteasome complexProteasome subunit alpha type-6Homo sapiens (human)
P-bodyProteasome subunit alpha type-6Homo sapiens (human)
nucleusProteasome subunit alpha type-6Homo sapiens (human)
nucleoplasmProteasome subunit alpha type-6Homo sapiens (human)
cytosolProteasome subunit alpha type-6Homo sapiens (human)
ribosomeProteasome subunit alpha type-6Homo sapiens (human)
nuclear matrixProteasome subunit alpha type-6Homo sapiens (human)
myofibrilProteasome subunit alpha type-6Homo sapiens (human)
sarcomereProteasome subunit alpha type-6Homo sapiens (human)
extracellular exosomeProteasome subunit alpha type-6Homo sapiens (human)
proteasome core complexProteasome subunit alpha type-6Homo sapiens (human)
proteasome core complex, alpha-subunit complexProteasome subunit alpha type-6Homo sapiens (human)
proteasome complex26S proteasome regulatory subunit 4Homo sapiens (human)
nucleus26S proteasome regulatory subunit 4Homo sapiens (human)
nucleoplasm26S proteasome regulatory subunit 4Homo sapiens (human)
cytosol26S proteasome regulatory subunit 4Homo sapiens (human)
membrane26S proteasome regulatory subunit 4Homo sapiens (human)
proteasome accessory complex26S proteasome regulatory subunit 4Homo sapiens (human)
proteasome regulatory particle, base subcomplex26S proteasome regulatory subunit 4Homo sapiens (human)
proteasome complex26S proteasome regulatory subunit 8Homo sapiens (human)
nucleus26S proteasome regulatory subunit 8Homo sapiens (human)
nucleoplasm26S proteasome regulatory subunit 8Homo sapiens (human)
cytoplasm26S proteasome regulatory subunit 8Homo sapiens (human)
cytosol26S proteasome regulatory subunit 8Homo sapiens (human)
membrane26S proteasome regulatory subunit 8Homo sapiens (human)
cytoplasmic vesicle26S proteasome regulatory subunit 8Homo sapiens (human)
extracellular exosome26S proteasome regulatory subunit 8Homo sapiens (human)
blood microparticle26S proteasome regulatory subunit 8Homo sapiens (human)
proteasome accessory complex26S proteasome regulatory subunit 8Homo sapiens (human)
proteasome regulatory particle, base subcomplex26S proteasome regulatory subunit 8Homo sapiens (human)
proteasome complex26S proteasome regulatory subunit 10BHomo sapiens (human)
nucleus26S proteasome regulatory subunit 10BHomo sapiens (human)
nucleoplasm26S proteasome regulatory subunit 10BHomo sapiens (human)
cytosol26S proteasome regulatory subunit 10BHomo sapiens (human)
membrane26S proteasome regulatory subunit 10BHomo sapiens (human)
inclusion body26S proteasome regulatory subunit 10BHomo sapiens (human)
extracellular exosome26S proteasome regulatory subunit 10BHomo sapiens (human)
proteasome accessory complex26S proteasome regulatory subunit 10BHomo sapiens (human)
cytosolic proteasome complex26S proteasome regulatory subunit 10BHomo sapiens (human)
proteasome regulatory particle, base subcomplex26S proteasome regulatory subunit 10BHomo sapiens (human)
proteasome complex26S proteasome non-ATPase regulatory subunit 2Homo sapiens (human)
extracellular region26S proteasome non-ATPase regulatory subunit 2Homo sapiens (human)
nucleoplasm26S proteasome non-ATPase regulatory subunit 2Homo sapiens (human)
cytosol26S proteasome non-ATPase regulatory subunit 2Homo sapiens (human)
membrane26S proteasome non-ATPase regulatory subunit 2Homo sapiens (human)
secretory granule lumen26S proteasome non-ATPase regulatory subunit 2Homo sapiens (human)
extracellular exosome26S proteasome non-ATPase regulatory subunit 2Homo sapiens (human)
ficolin-1-rich granule lumen26S proteasome non-ATPase regulatory subunit 2Homo sapiens (human)
proteasome regulatory particle26S proteasome non-ATPase regulatory subunit 2Homo sapiens (human)
proteasome accessory complex26S proteasome non-ATPase regulatory subunit 2Homo sapiens (human)
proteasome storage granule26S proteasome non-ATPase regulatory subunit 2Homo sapiens (human)
proteasome regulatory particle, base subcomplex26S proteasome non-ATPase regulatory subunit 2Homo sapiens (human)
nucleus26S proteasome non-ATPase regulatory subunit 2Homo sapiens (human)
proteasome complex26S proteasome non-ATPase regulatory subunit 6Homo sapiens (human)
extracellular region26S proteasome non-ATPase regulatory subunit 6Homo sapiens (human)
nucleoplasm26S proteasome non-ATPase regulatory subunit 6Homo sapiens (human)
cytosol26S proteasome non-ATPase regulatory subunit 6Homo sapiens (human)
secretory granule lumen26S proteasome non-ATPase regulatory subunit 6Homo sapiens (human)
ficolin-1-rich granule lumen26S proteasome non-ATPase regulatory subunit 6Homo sapiens (human)
proteasome accessory complex26S proteasome non-ATPase regulatory subunit 6Homo sapiens (human)
proteasome regulatory particle26S proteasome non-ATPase regulatory subunit 6Homo sapiens (human)
proteasome complexProteasomal ubiquitin receptor ADRM1Homo sapiens (human)
nucleoplasmProteasomal ubiquitin receptor ADRM1Homo sapiens (human)
cytosolProteasomal ubiquitin receptor ADRM1Homo sapiens (human)
plasma membraneProteasomal ubiquitin receptor ADRM1Homo sapiens (human)
proteasome regulatory particle, lid subcomplexProteasomal ubiquitin receptor ADRM1Homo sapiens (human)
nucleusProteasome subunit alpha-type 8Homo sapiens (human)
cytosolProteasome subunit alpha-type 8Homo sapiens (human)
extracellular exosomeProteasome subunit alpha-type 8Homo sapiens (human)
proteasome core complex, alpha-subunit complexProteasome subunit alpha-type 8Homo sapiens (human)
spermatoproteasome complexProteasome subunit alpha-type 8Homo sapiens (human)
nucleusProteasome subunit alpha-type 8Homo sapiens (human)
nucleusProteasome subunit beta type-7Homo sapiens (human)
cytoplasmProteasome subunit beta type-7Homo sapiens (human)
proteasome complexProteasome subunit beta type-7Homo sapiens (human)
extracellular regionProteasome subunit beta type-7Homo sapiens (human)
nucleusProteasome subunit beta type-7Homo sapiens (human)
nucleoplasmProteasome subunit beta type-7Homo sapiens (human)
cytosolProteasome subunit beta type-7Homo sapiens (human)
nuclear bodyProteasome subunit beta type-7Homo sapiens (human)
secretory granule lumenProteasome subunit beta type-7Homo sapiens (human)
ficolin-1-rich granule lumenProteasome subunit beta type-7Homo sapiens (human)
proteasome core complexProteasome subunit beta type-7Homo sapiens (human)
proteasome core complex, beta-subunit complexProteasome subunit beta type-7Homo sapiens (human)
cytosolProteasome subunit beta type-7Homo sapiens (human)
proteasome complex26S proteasome non-ATPase regulatory subunit 1Homo sapiens (human)
extracellular region26S proteasome non-ATPase regulatory subunit 1Homo sapiens (human)
nucleoplasm26S proteasome non-ATPase regulatory subunit 1Homo sapiens (human)
cytosol26S proteasome non-ATPase regulatory subunit 1Homo sapiens (human)
membrane26S proteasome non-ATPase regulatory subunit 1Homo sapiens (human)
azurophil granule lumen26S proteasome non-ATPase regulatory subunit 1Homo sapiens (human)
proteasome regulatory particle26S proteasome non-ATPase regulatory subunit 1Homo sapiens (human)
proteasome accessory complex26S proteasome non-ATPase regulatory subunit 1Homo sapiens (human)
nucleus26S proteasome non-ATPase regulatory subunit 1Homo sapiens (human)
proteasome regulatory particle, base subcomplex26S proteasome non-ATPase regulatory subunit 1Homo sapiens (human)
proteasome storage granule26S proteasome non-ATPase regulatory subunit 1Homo sapiens (human)
proteasome complex26S proteasome non-ATPase regulatory subunit 13Homo sapiens (human)
extracellular region26S proteasome non-ATPase regulatory subunit 13Homo sapiens (human)
nucleus26S proteasome non-ATPase regulatory subunit 13Homo sapiens (human)
nucleoplasm26S proteasome non-ATPase regulatory subunit 13Homo sapiens (human)
cytosol26S proteasome non-ATPase regulatory subunit 13Homo sapiens (human)
membrane26S proteasome non-ATPase regulatory subunit 13Homo sapiens (human)
secretory granule lumen26S proteasome non-ATPase regulatory subunit 13Homo sapiens (human)
ficolin-1-rich granule lumen26S proteasome non-ATPase regulatory subunit 13Homo sapiens (human)
proteasome regulatory particle26S proteasome non-ATPase regulatory subunit 13Homo sapiens (human)
proteasome accessory complex26S proteasome non-ATPase regulatory subunit 13Homo sapiens (human)
cytosol26S proteasome non-ATPase regulatory subunit 13Homo sapiens (human)
proteasome regulatory particle, lid subcomplex26S proteasome non-ATPase regulatory subunit 13Homo sapiens (human)
nucleus26S proteasome non-ATPase regulatory subunit 13Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID734754Inhibition of chymotrypsin-like activity of human 20S proteasome beta 5 subunit using Suc-LLVY-AMC as substrate after 60 mins by fluorescence assay2013Journal of medicinal chemistry, May-09, Volume: 56, Issue:9
Potent proteasome inhibitors derived from the unnatural cis-cyclopropane isomer of Belactosin A: synthesis, biological activity, and mode of action.
AID348488Growth inhibition of human HeLa cells after 48 hrs by MTT assay2008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
Affinity labeling of the proteasome by a belactosin A derived inhibitor.
AID1225669Inhibition of chymotrypsin-like activity of rabbit 20S proteasome using Suc-LLVY-AMC as substrate after 2 hrs by fluorescence assay2015Journal of natural products, Apr-24, Volume: 78, Issue:4
Cystargolides, 20S Proteasome Inhibitors Isolated from Kitasatospora cystarginea.
AID348491Inhibition of trypsin-like activity of 20S proteasome in human erythrocytes2008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
Affinity labeling of the proteasome by a belactosin A derived inhibitor.
AID734751Inhibition of chymotrypsin-like activity of human constitutive 20S proteasome beta 5 subunit using biotin-(CH2)4-Leu-Leu-Leu-epoxyketone as substrate at 0.3 uM incubated for 5 mins prior to substrate addition measured after 1 hr by ELISA2013Journal of medicinal chemistry, May-09, Volume: 56, Issue:9
Potent proteasome inhibitors derived from the unnatural cis-cyclopropane isomer of Belactosin A: synthesis, biological activity, and mode of action.
AID599460Antiproliferative activity against human HeLaS3 cells after 72 hrs2009Bioorganic & medicinal chemistry letters, Jun-15, Volume: 19, Issue:12
Synthesis and biological evaluation of boron peptide analogues of Belactosin C as proteasome inhibitors.
AID348490Inhibition of chymotrypsin-like activity of 20S proteasome in human erythrocytes2008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
Affinity labeling of the proteasome by a belactosin A derived inhibitor.
AID759863Inhibition of chymotrypsin-like activity of human 20S proteasome using succinyl-Leu-Leu-Val-Tyr-4-methylcoumaryl-7-amide as substrate after 60 mins by fluorescence assay2013Journal of medicinal chemistry, Jul-25, Volume: 56, Issue:14
Investigation of the noncovalent binding mode of covalent proteasome inhibitors around the transition state by combined use of cyclopropylic strain-based conformational restriction and computational modeling.
AID734749Inhibition of chymotrypsin-like activity of human 20S immunoproteasome beta 5 subunit using biotin-(CH2)4-Leu-Leu-Leu-epoxyketone as substrate at 0.3 uM incubated for 5 mins prior to substrate addition measured after 1 hr by ELISA2013Journal of medicinal chemistry, May-09, Volume: 56, Issue:9
Potent proteasome inhibitors derived from the unnatural cis-cyclopropane isomer of Belactosin A: synthesis, biological activity, and mode of action.
AID759861Inhibition proteasome (unknown origin)2013Journal of medicinal chemistry, Jul-25, Volume: 56, Issue:14
Investigation of the noncovalent binding mode of covalent proteasome inhibitors around the transition state by combined use of cyclopropylic strain-based conformational restriction and computational modeling.
AID1152964Inhibition of chymotrypsin-like of human 20S proteasome using chromophoric Suc-LLVY-AMC as substrate after 60 mins by fluorescence assay2014Bioorganic & medicinal chemistry, Jun-15, Volume: 22, Issue:12
Development of a new class of proteasome inhibitors with an epoxyketone warhead: Rational hybridization of non-peptidic belactosin derivatives and peptide epoxyketones.
AID348489Inhibition of PGPH catalytic activity of 20S proteasome in human erythrocytes2008Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20
Affinity labeling of the proteasome by a belactosin A derived inhibitor.
AID1128229Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate2014Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6
Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's11 (45.83)29.6817
2010's12 (50.00)24.3611
2020's1 (4.17)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.29

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.29 (24.57)
Research Supply Index3.22 (2.92)
Research Growth Index5.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.29)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.17%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other23 (95.83%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbamates
[no description available]		2.0810amino-acid anion
glycine
[no description available]		2.0110alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
alanine
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.		7.7230alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
cyclopropane
cyclopropane : A cycloalkane composed of three carbon atoms to form a ring.		3.0240cycloalkane;
cyclopropanes		inhalation anaesthetic
acetylcysteine
N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.		2.0210acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
ruthenium
Ruthenium: A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.		2.0810iron group element atom;
platinum group metal atom
alkenes
[no description available]		2.0810
cyclopropylamine
cyclopropylamine: RN given refers to parent cpd. cyclopropylamine : A primary aliphatic amine that consists of cyclopropane bearing a single amino substituent.		2.0810primary aliphatic aminemouse metabolite
bortezomib
[no description available]		340amino acid amide;
L-phenylalanine derivative;
pyrazines		antineoplastic agent;
antiprotozoal drug;
protease inhibitor;
proteasome inhibitor
benzyloxycarbonylleucyl-leucyl-leucine aldehyde
benzyloxycarbonylleucyl-leucyl-leucine aldehyde: proteasome inhibitor. N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal : A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.		2.4520amino aldehyde;
carbamate ester;
tripeptide		proteasome inhibitor
alpha-chymotrypsin
Chymotrypsin: A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.		2.0510
pironetin
pironetin: a microbial secondary metabolite having the activity of shortening plant height from Streptomyces sp.; structure in first source		3.1610aliphatic alcohol
lactacystin
[no description available]		2.7530lactam;
S-substituted L-cysteine
clasto-lactacystin beta-lactone
clasto-lactacystin beta-lactone: active metabolite of lactacystin; inhibits 20 S proteasome; structure in first source		2.0810
malayamycin a
malayamycin A: from Streptomyces malaysiensis; structure in first source		3.1610
crocacin
crocacin: isolated from myxobacterium, Chondromyces crocatus; structure given in first source		3.1610
belactosin c
belactosin C: isolated from Streptomyces; structure in first source		8.4470
marizomib
marizomib: a proteasome inhibitor from a marine bacterium Salinospora; structure in first source		2.0810beta-lactone;
gamma-lactam;
organic heterobicyclic compound;
organochlorine compound;
salinosporamide		antineoplastic agent;
proteasome inhibitor
carfilzomib
[no description available]		2.7930epoxide;
morpholines;
tetrapeptide		antineoplastic agent;
proteasome inhibitor
hypoglycin a
hypoglycin: RN given refers to cpd without isomeric designation. hypoglycin A : A diastereoisomeric mixture of (2S,4R)- and (2S,4S)- hypoglycin A, found in the edible part of the fruit of the Ackee, Blighia sapida (where the 2S,4R diastereoisomer is more dominant (17% d.e.) than its 2S,4S counterpart) as well as in the sycamore maple tree (Acer pseudoplatanus).		2.0110L-alpha-amino acid
pr-957
[no description available]		2.110
delanzomib
[no description available]		2.110C-terminal boronic acid peptide;
phenylpyridine;
secondary alcohol;
threonine derivative		antineoplastic agent;
apoptosis inducer;
proteasome inhibitor
pr-957
PR-957: immunoproteasome inhibitor; inhibits Lmp7 protein; structure in first source		2.0810
mln 9708
[no description available]		2.110
hormaomycin
hormaomycin: antibacterial and antimalarial peptide from Streptomyces griseoflavus; structure in first source		7.5320
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.0410
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.0410